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GHR growth hormone receptor [ Homo sapiens (human) ]

Gene ID: 2690, updated on 8-Oct-2024

Summary

Official Symbol
GHRprovided by HGNC
Official Full Name
growth hormone receptorprovided by HGNC
Primary source
HGNC:HGNC:4263
See related
Ensembl:ENSG00000112964 MIM:600946; AllianceGenome:HGNC:4263
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GHBP; GHIP
Summary
This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011]
Expression
Biased expression in fat (RPKM 43.6), liver (RPKM 35.0) and 7 other tissues See more
Orthologs
NEW
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Genomic context

See GHR in Genome Data Viewer
Location:
5p13.1-p12
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (42423439..42721878)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (42678916..42974806)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (42423541..42721980)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene MPRA-validated peak5238 silencer Neighboring gene F-box protein 4 Neighboring gene methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase pseudogene 6 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:42078724-42079249 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:42090075-42091274 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_85089 Neighboring gene long intergenic non-protein coding RNA 2996 Neighboring gene NANOG hESC enhancer GRCh37_chr5:42225166-42225693 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_85146 Neighboring gene NANOG hESC enhancer GRCh37_chr5:42288621-42289193 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_85179 Neighboring gene GHR upstream promoter region module A Neighboring gene zinc finger protein 35 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:42508817-42509317 Neighboring gene SERPINE1 mRNA binding protein 1 pseudogene 6 Neighboring gene GHR downstream promoter region module B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:42756975-42757476 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:42757477-42757976 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:42803834-42804334 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:42804335-42804835 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:42812153-42812718 Neighboring gene uncharacterized LOC124900970 Neighboring gene coiled-coil domain containing 152 Neighboring gene selenoprotein P

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Hypercholesterolemia, familial, 1
MedGen: C0745103 OMIM: 143890 GeneReviews: Familial Hypercholesterolemia
not available
Laron-type isolated somatotropin defect
MedGen: C0271568 OMIM: 262500 GeneReviews: Not available
not available
Short stature due to partial GHR deficiency
MedGen: C1858656 OMIM: 604271 GeneReviews: Not available
not available

EBI GWAS Catalog

Description
Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX.
EBI GWAS Catalog
Genetic association with overall survival of taxane-treated lung cancer patients - A genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study.
EBI GWAS Catalog
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
EBI GWAS Catalog
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
EBI GWAS Catalog
Variants in TF and HFE explain approximately 40% of genetic variation in serum-transferrin levels.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables SH2 domain binding IEA
Inferred from Electronic Annotation
more info
 
enables cytokine binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables growth factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables growth hormone receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables growth hormone receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables lipid binding EXP
Inferred from Experiment
more info
PubMed 
enables peptide hormone binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables peptide hormone binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables proline-rich region binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein phosphatase binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cartilage development involved in endochondral bone morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in cell surface receptor signaling pathway via JAK-STAT ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to hormone stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to insulin stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in growth hormone receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in growth hormone receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in growth hormone receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hormone metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hormone-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in insulin-like growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of positive regulation of MAP kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of peptidyl-tyrosine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of receptor signaling pathway via JAK-STAT IBA
Inferred from Biological aspect of Ancestor
more info
 
NOT involved_in receptor internalization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in receptor internalization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of multicellular organism growth ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of response to nutrient levels IEA
Inferred from Electronic Annotation
more info
 
NOT involved_in response to cycloheximide IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to cycloheximide IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to estradiol IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to food IEA
Inferred from Electronic Annotation
more info
 
involved_in response to glucocorticoid IEA
Inferred from Electronic Annotation
more info
 
involved_in response to gravity IEA
Inferred from Electronic Annotation
more info
 
involved_in response to interleukin-1 IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_positive_effect taurine metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic ribonucleoprotein granule IDA
Inferred from Direct Assay
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space IMP
Inferred from Mutant Phenotype
more info
PubMed 
part_of growth hormone receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of growth hormone receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
part_of receptor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
growth hormone receptor
Names
GH receptor
growth hormone binding protein
mutant growth hormone receptor
serum binding protein
somatotropin receptor

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011688.2 RefSeqGene

    Range
    4516..302955
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000163.5 → NP_000154.1  growth hormone receptor isoform 1 precursor

    See identical proteins and their annotated locations for NP_000154.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also known as V2) and variants 3 through 9 encode the predominant protein (isoform 1).
    Source sequence(s)
    AC113368, AC116343, X06562, Z11801
    Consensus CDS
    CCDS3940.1
    UniProtKB/Swiss-Prot
    P10912, Q9HCX2
    Related
    ENSP00000230882.4, ENST00000230882.9
    Conserved Domains (3) summary
    cd00063
    Location:149 → 250
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam12772
    Location:316 → 617
    GHBP; Growth hormone receptor binding
    cl21522
    Location:49 → 127
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  2. NM_001242399.2 → NP_001229328.1  growth hormone receptor isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as V9B) has an alternate 5' exon, which includes an in-frame AUG start codon, compared to variant 1. The resulting isoform (2) has a longer N-terminus, compared to isoform 1.
    Source sequence(s)
    AC113368, AF230801, X06562
    Consensus CDS
    CCDS75239.1
    UniProtKB/TrEMBL
    A0A087X0H5
    Related
    ENSP00000483403.1, ENST00000620156.4
    Conserved Domains (3) summary
    cd00063
    Location:156 → 257
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam12772
    Location:323 → 624
    GHBP; Growth hormone receptor binding
    cl21522
    Location:56 → 134
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  3. NM_001242400.2 → NP_001229329.1  growth hormone receptor isoform 1 precursor

    See identical proteins and their annotated locations for NP_001229329.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, also known as V9A) has an alternate 5' UTR and encodes the same isoform 1, compared to variant 1.
    Source sequence(s)
    AC113368, AF230800, AF230801, X06562
    Consensus CDS
    CCDS3940.1
    UniProtKB/Swiss-Prot
    P10912, Q9HCX2
    Related
    ENSP00000478291.1, ENST00000615111.4
    Conserved Domains (3) summary
    cd00063
    Location:149 → 250
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam12772
    Location:316 → 617
    GHBP; Growth hormone receptor binding
    cl21522
    Location:49 → 127
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  4. NM_001242401.4 → NP_001229330.1  growth hormone receptor isoform 1 precursor

    See identical proteins and their annotated locations for NP_001229330.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4, also known as V3) has an alternate 5' UTR and encodes the same isoform 1, compared to variant 1.
    Source sequence(s)
    AC113368, AC116343, X06562, Z11851
    Consensus CDS
    CCDS3940.1
    UniProtKB/Swiss-Prot
    P10912, Q9HCX2
    Conserved Domains (3) summary
    cd00063
    Location:149 → 250
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam12772
    Location:316 → 617
    GHBP; Growth hormone receptor binding
    cl21522
    Location:49 → 127
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  5. NM_001242402.2 → NP_001229331.1  growth hormone receptor isoform 1 precursor

    See identical proteins and their annotated locations for NP_001229331.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5, also known as V7) has an alternate 5' UTR exon and encodes the same isoform 1, compared to variant 1.
    Source sequence(s)
    AC113368, AC114941, X06562, Z11853
    Consensus CDS
    CCDS3940.1
    UniProtKB/Swiss-Prot
    P10912, Q9HCX2
    Related
    ENSP00000482373.1, ENST00000618088.4
    Conserved Domains (3) summary
    cd00063
    Location:149 → 250
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam12772
    Location:316 → 617
    GHBP; Growth hormone receptor binding
    cl21522
    Location:49 → 127
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  6. NM_001242403.3 → NP_001229332.1  growth hormone receptor isoform 1 precursor

    See identical proteins and their annotated locations for NP_001229332.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6, also known as V1) has an alternate 5' UTR exon and encodes the same isoform 1, compared to variant 1.
    Source sequence(s)
    AC113368, X06562, Z11802
    Consensus CDS
    CCDS3940.1
    UniProtKB/Swiss-Prot
    P10912, Q9HCX2
    Related
    ENSP00000478332.1, ENST00000612382.4
    Conserved Domains (3) summary
    cd00063
    Location:149 → 250
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam12772
    Location:316 → 617
    GHBP; Growth hormone receptor binding
    cl21522
    Location:49 → 127
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  7. NM_001242404.2 → NP_001229333.1  growth hormone receptor isoform 1 precursor

    See identical proteins and their annotated locations for NP_001229333.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7, also known as V4) has an alternate 5' UTR exon and encodes the same isoform 1, compared to variant 1.
    Source sequence(s)
    AC113368, X06562, Z11849
    Consensus CDS
    CCDS3940.1
    UniProtKB/Swiss-Prot
    P10912, Q9HCX2
    Related
    ENSP00000479846.1, ENST00000612626.4
    Conserved Domains (3) summary
    cd00063
    Location:149 → 250
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam12772
    Location:316 → 617
    GHBP; Growth hormone receptor binding
    cl21522
    Location:49 → 127
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  8. NM_001242405.2 → NP_001229334.1  growth hormone receptor isoform 1 precursor

    See identical proteins and their annotated locations for NP_001229334.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8, also known as V8) has an alternate 5' UTR exon and encodes the same isoform 1, compared to variant 1.
    Source sequence(s)
    AC113368, X06562, Z11848
    Consensus CDS
    CCDS3940.1
    UniProtKB/Swiss-Prot
    P10912, Q9HCX2
    Related
    ENSP00000442206.2, ENST00000537449.5
    Conserved Domains (3) summary
    cd00063
    Location:149 → 250
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam12772
    Location:316 → 617
    GHBP; Growth hormone receptor binding
    cl21522
    Location:49 → 127
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  9. NM_001242406.2 → NP_001229335.1  growth hormone receptor isoform 1 precursor

    See identical proteins and their annotated locations for NP_001229335.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9, also known as V5) has an alternate 5' UTR exon and encodes the same isoform 1, compared to variant 1.
    Source sequence(s)
    AC113368, AC114941, X06562, Z11850
    Consensus CDS
    CCDS3940.1
    UniProtKB/Swiss-Prot
    P10912, Q9HCX2
    Conserved Domains (3) summary
    cd00063
    Location:149 → 250
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam12772
    Location:316 → 617
    GHBP; Growth hormone receptor binding
    cl21522
    Location:49 → 127
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  10. NM_001242460.2 → NP_001229389.1  growth hormone receptor isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10), also known as GHRd3, lacks an in-frame coding exon in the 5' region, compared to variant 1. The resulting isoform (3) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AC113368, AC114941, AC116343
    Consensus CDS
    CCDS56364.1
    UniProtKB/Swiss-Prot
    P10912
    Related
    ENSP00000350335.3, ENST00000357703.6
    Conserved Domains (3) summary
    cd00063
    Location:127 → 228
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam12772
    Location:294 → 595
    GHBP; Growth hormone receptor binding
    cl21522
    Location:27 → 105
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  11. NM_001242462.1 → NP_001229391.1  growth hormone receptor isoform 5 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12, also known as GHR1-277) lacks a coding exon in the 3' region, compared to variant 1. The resulting isoform (5) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC113368, X06562
    Consensus CDS
    CCDS75240.1
    UniProtKB/TrEMBL
    A0A087X162
    Related
    ENSP00000483926.1, ENST00000622294.2
    Conserved Domains (2) summary
    cd00063
    Location:149 → 250
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:49 → 127
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    42423439..42721878
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    42678916..42974806
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001242461.1: Suppressed sequence

    Description
    NM_001242461.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.