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Nature. 1987 Dec 10-16;330(6148):537-43.

Growth hormone receptor and serum binding protein: purification, cloning and expression.

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  • 1Department of Developmental Biology, Genentech, Inc., South San Francisco, California.


A putative growth hormone receptor from rabbit liver and the growth hormone binding protein from rabbit serum have the same amino-terminal amino-acid sequence, indicating that the binding protein corresponds to the extracellular hormone-binding domain of the liver receptor. The complete amino-acid sequences derived from complementary DNA clones encoding the putative human and rabbit growth hormone receptors are not similar to other known proteins, demonstrating a new class of transmembrane receptors.

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