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Ghr growth hormone receptor [ Mus musculus (house mouse) ]

Gene ID: 14600, updated on 9-Sep-2018

Summary

Official Symbol
Ghrprovided by MGI
Official Full Name
growth hormone receptorprovided by MGI
Primary source
MGI:MGI:95708
See related
Ensembl:ENSMUSG00000055737 Vega:OTTMUSG00000030599
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GHBP; GHR/BP
Expression
Biased expression in subcutaneous fat pad adult (RPKM 66.2), genital fat pad adult (RPKM 39.4) and 12 other tissues See more
Orthologs

Genomic context

See Ghr in Genome Data Viewer
Location:
15 A1; 15 1.84 cM
Exon count:
13
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 15 NC_000081.6 (3317755..3583352, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (3267760..3533230, complement)

Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene selenoprotein P Neighboring gene coiled-coil domain containing 152 Neighboring gene predicted gene, 41254 Neighboring gene predicted gene, 41255 Neighboring gene mediator complex subunit 27 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (11)  1 citation
  • Chemically induced (ENU) (1) 

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
SH2 domain binding ISO
Inferred from Sequence Orthology
more info
 
cytokine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
growth factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
growth factor binding ISO
Inferred from Sequence Orthology
more info
 
growth hormone receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
growth hormone receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
growth hormone receptor activity ISO
Inferred from Sequence Orthology
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
peptide hormone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptide hormone binding IPI
Inferred from Physical Interaction
more info
PubMed 
peptide hormone binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
2-oxoglutarate metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
JAK-STAT cascade ISO
Inferred from Sequence Orthology
more info
 
activation of Janus kinase activity ISO
Inferred from Sequence Orthology
more info
 
activation of MAPK activity ISO
Inferred from Sequence Orthology
more info
 
allantoin metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to hormone stimulus ISO
Inferred from Sequence Orthology
more info
 
citrate metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
creatine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
creatinine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
endocytosis IEA
Inferred from Electronic Annotation
more info
 
fatty acid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
growth hormone receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
growth hormone receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
growth hormone receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
hormone metabolic process ISO
Inferred from Sequence Orthology
more info
 
hormone-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
insulin-like growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
isoleucine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
oxaloacetate metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of JAK-STAT cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of JAK-STAT cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of multicellular organism growth ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptidyl-tyrosine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of multicellular organism growth IDA
Inferred from Direct Assay
more info
PubMed 
response to estradiol ISO
Inferred from Sequence Orthology
more info
 
succinate metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
taurine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
valine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cell surface ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic ribonucleoprotein granule ISO
Inferred from Sequence Orthology
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space HDA PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
extrinsic component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
growth hormone receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
growth hormone receptor complex ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane ISO
Inferred from Sequence Orthology
more info
 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
receptor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
growth hormone receptor
Names
GH receptor
Growth hormone receptor precursor (GH receptor) (GH binding protein) (GHBP) (Serum binding protein)
growth hormone receptor/binding protein, high molecular weight
growth hormone receptor/binding protein, low molecular weight
somatotropin receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001048178.2NP_001041643.1  growth hormone receptor isoform 2 precursor

    See identical proteins and their annotated locations for NP_001041643.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks several exons and uses an alternate 3'-terminal exon, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC113323, AC121307, AK143925, AK148440
    Consensus CDS
    CCDS37024.1
    UniProtKB/Swiss-Prot
    P16882
    UniProtKB/TrEMBL
    Q3UNY8
    Related
    ENSMUSP00000106326.2, OTTMUSP00000039788, ENSMUST00000110698.8, OTTMUST00000075776
    Conserved Domains (2) summary
    cd00063
    Location:157258
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:49135
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  2. NM_001286370.1NP_001273299.1  growth hormone receptor isoform 1 precursor

    See identical proteins and their annotated locations for NP_001273299.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Both variants 1 and 4 encode the same isoform (1).
    Source sequence(s)
    AC166491, AK143886
    Consensus CDS
    CCDS27358.1
    UniProtKB/Swiss-Prot
    P16882
    UniProtKB/TrEMBL
    Q3UP14
    Related
    ENSMUSP00000124064.1, OTTMUSP00000039787, ENSMUST00000161561.7, OTTMUST00000075775
    Conserved Domains (3) summary
    cd00063
    Location:157258
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam12772
    Location:325628
    GHBP; Growth hormone receptor binding
    cl21522
    Location:49135
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  3. NM_010284.3NP_034414.2  growth hormone receptor isoform 1 precursor

    See identical proteins and their annotated locations for NP_034414.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Both variants 1 and 4 encode the same isoform.
    Source sequence(s)
    AC113323, AC166491, AK143925, AK148440
    Consensus CDS
    CCDS27358.1
    UniProtKB/Swiss-Prot
    P16882
    UniProtKB/TrEMBL
    Q3UNY8, Q3UP14
    Related
    ENSMUSP00000069457.4, OTTMUSP00000039789, ENSMUST00000069451.10, OTTMUST00000075779
    Conserved Domains (3) summary
    cd00063
    Location:157258
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam12772
    Location:325628
    GHBP; Growth hormone receptor binding
    cl21522
    Location:49135
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000081.6 Reference GRCm38.p4 C57BL/6J

    Range
    3317755..3583352 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001048147.1: Suppressed sequence

    Description
    NM_001048147.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
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