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KAT2A lysine acetyltransferase 2A [ Homo sapiens (human) ]

Gene ID: 2648, updated on 9-Feb-2020

Summary

Official Symbol
KAT2Aprovided by HGNC
Official Full Name
lysine acetyltransferase 2Aprovided by HGNC
Primary source
HGNC:HGNC:4201
See related
Ensembl:ENSG00000108773 MIM:602301
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GCN5; hGCN5; GCN5L2; PCAF-b
Summary
KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).[supplied by OMIM, Sep 2009]
Expression
Ubiquitous expression in ovary (RPKM 41.6), adrenal (RPKM 30.6) and 25 other tissues See more
Orthologs

Genomic context

See KAT2A in Genome Data Viewer
Location:
17q21.2
Exon count:
18
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (42113111..42121367, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (40265129..40273382, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene chromosome 17 open reading frame 113 Neighboring gene DExH-box helicase 58 Neighboring gene heat shock protein family B (small) member 9 Neighboring gene RAB5C, member RAS oncogene family Neighboring gene uncharacterized LOC105371781 Neighboring gene Sharpr-MPRA regulatory region 9875

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 NL4-3 replication requires KAT2A as replication is inhibited when KAT2A is deleted through CRISPR/Cas9 genome editing PubMed
Knockdown of K(lysine) acetyltransferase 2A (KAT2A; GCN5L2) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat The K19A, K41Q, and K51A mutations decrease HIV-1 Tat binding to hGCN5, whereas the K50Q and K50R mutations increase the binding PubMed
tat hGCN5 enhances HIV-1 Tat-mediated transactivation of the HIV-1 LTR promoter PubMed
tat HIV-1 Tat is acetylated by hGCN5 on lysine's 50 and 51 PubMed
tat Binding of HIV-1 Tat to hGCN5 is mediated by amino acids 20-48 of Tat (includes cysteine rich, core, and minimal activation domains of Tat) and by amino acids 111-151 (histone acetyltransferase domain) and 389-476 (bromodomain) of hGCN5 PubMed
tat HIV-1 Tat inhibits the histone acetyltransferase and transcriptional activation activities of hGCN5, an effect mediated by amino acids 86-101 of Tat PubMed
tat HIV-1 Tat recruits hGCN5, as well as other known cellular acetyltransferases, to the HIV-1 LTR promoter, an effect involved in the acetylation of histones H3 and H4, and HIV-1 transcriptional activation PubMed
integrase gag-pol HIV-1 IN binds to GCN5, which requires the C-terminal region (amino acids 244-288) of IN PubMed
gag-pol GCN5 acetylates lysine's 258, 264, 266, and 273 of HIV-1 IN and stimulates the catalytic activity of IN PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC102791

Gene Ontology Provided by GOA

Function Evidence Code Pubs
H3 histone acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
histone acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to histone acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
histone acetyltransferase activity TAS
Traceable Author Statement
more info
 
histone acetyltransferase activity (H4-K12 specific) IEA
Inferred from Electronic Annotation
more info
 
histone deacetylase binding IPI
Inferred from Physical Interaction
more info
PubMed 
histone succinyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
peptide-lysine-N-acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase binding IEA
Inferred from Electronic Annotation
more info
 
transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
alpha-tubulin acetylation IEA
Inferred from Electronic Annotation
more info
 
cell proliferation IEA
Inferred from Electronic Annotation
more info
 
cellular response to nerve growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to tumor necrosis factor IEA
Inferred from Electronic Annotation
more info
 
chromatin remodeling TAS
Traceable Author Statement
more info
PubMed 
cytokine production ISS
Inferred from Sequence or Structural Similarity
more info
 
heart development ISS
Inferred from Sequence or Structural Similarity
more info
 
histone H3 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
histone H3-K14 acetylation IEA
Inferred from Electronic Annotation
more info
 
histone H4-K12 acetylation IEA
Inferred from Electronic Annotation
more info
 
histone deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
histone succinylation IDA
Inferred from Direct Assay
more info
PubMed 
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
internal peptidyl-lysine acetylation IDA
Inferred from Direct Assay
more info
PubMed 
intracellular distribution of mitochondria IEA
Inferred from Electronic Annotation
more info
 
limb development ISS
Inferred from Sequence or Structural Similarity
more info
 
long-term memory ISS
Inferred from Sequence or Structural Similarity
more info
 
metencephalon development IEA
Inferred from Electronic Annotation
more info
 
midbrain development IEA
Inferred from Electronic Annotation
more info
 
multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
negative regulation of centriole replication IDA
Inferred from Direct Assay
more info
PubMed 
neural tube closure IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cardiac muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell projection organization IEA
Inferred from Electronic Annotation
more info
 
positive regulation of gene expression, epigenetic TAS
Traceable Author Statement
more info
 
positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
positive regulation of histone acetylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
protein deubiquitination TAS
Traceable Author Statement
more info
 
regulation of T cell activation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of protein stability IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of regulatory T cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of synaptic plasticity ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
response to nutrient levels IEA
Inferred from Electronic Annotation
more info
 
response to organic cyclic compound IEA
Inferred from Electronic Annotation
more info
 
somitogenesis IEA
Inferred from Electronic Annotation
more info
 
telencephalon development IEA
Inferred from Electronic Annotation
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Ada2/Gcn5/Ada3 transcription activator complex IDA
Inferred from Direct Assay
more info
PubMed 
STAGA complex IDA
Inferred from Direct Assay
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space HDA PubMed 
mitotic spindle IEA
Inferred from Electronic Annotation
more info
 
nuclear chromatin IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with oxoglutarate dehydrogenase complex IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor TFTC complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
histone acetyltransferase KAT2A
Names
GCN5 (general control of amino-acid synthesis, yeast, homolog)-like 2
General control of amino acid synthesis, yeast, homolog-like 2
K(lysine) acetyltransferase 2A
STAF97
general control of amino acid synthesis protein 5-like 2
histone acetyltransferase GCN5
histone glutaryltransferase KAT2A
histone succinyltransferase KAT2A
hsGCN5
NP_001363156.1
NP_066564.2
XP_006721881.1
XP_016879937.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001376227.1NP_001363156.1  histone acetyltransferase KAT2A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC105024
  2. NM_021078.3NP_066564.2  histone acetyltransferase KAT2A isoform 1

    See identical proteins and their annotated locations for NP_066564.2

    Status: VALIDATED

    Source sequence(s)
    AC105024, BC105977, DB497139
    Consensus CDS
    CCDS11417.1
    UniProtKB/Swiss-Prot
    Q92830
    Related
    ENSP00000225916.5, ENST00000225916.10
    Conserved Domains (4) summary
    cd05509
    Location:732831
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    COG5076
    Location:492832
    COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
    pfam00583
    Location:555627
    Acetyltransf_1; Acetyltransferase (GNAT) family
    pfam06466
    Location:86335
    PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    42113111..42121367 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006721818.4XP_006721881.1  histone acetyltransferase KAT2A isoform X2

    See identical proteins and their annotated locations for XP_006721881.1

    Conserved Domains (3) summary
    cd05509
    Location:372471
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    COG5076
    Location:131472
    COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
    pfam00583
    Location:194266
    Acetyltransf_1; Acetyltransferase (GNAT) family
  2. XM_017024448.1XP_016879937.1  histone acetyltransferase KAT2A isoform X3

    UniProtKB/Swiss-Prot
    Q92830
    Conserved Domains (3) summary
    cd05509
    Location:371470
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    COG5076
    Location:131471
    COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
    pfam00583
    Location:194266
    Acetyltransf_1; Acetyltransferase (GNAT) family
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