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Kat2a K(lysine) acetyltransferase 2A [ Mus musculus (house mouse) ]

Gene ID: 14534, updated on 8-Feb-2024

Summary

Official Symbol
Kat2aprovided by MGI
Official Full Name
K(lysine) acetyltransferase 2Aprovided by MGI
Primary source
MGI:MGI:1343101
See related
Ensembl:ENSMUSG00000020918 AllianceGenome:MGI:1343101
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gcn5; Gcn5l2; mmGCN5; 1110051E14Rik
Summary
Enables H3 histone acetyltransferase activity; chromatin binding activity; and histone acetyltransferase activity (H4-K12 specific). Involved in several processes, including long-term memory; positive regulation of macromolecule metabolic process; and regulation of regulatory T cell differentiation. Acts upstream of or within several processes, including brain development; chordate embryonic development; and histone acetylation. Located in mitotic spindle and nucleus. Part of ATAC complex and SAGA complex. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and hemolymphoid system gland. Orthologous to human KAT2A (lysine acetyltransferase 2A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 33.5), ovary adult (RPKM 29.4) and 28 other tissues See more
Orthologs
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Genomic context

See Kat2a in Genome Data Viewer
Location:
11 D; 11 63.53 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (100595572..100603293, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (100704746..100712485, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 385C Neighboring gene chromosome 11 C17orf113 homolog Neighboring gene predicted gene, 38483 Neighboring gene STARR-positive B cell enhancer ABC_E7063 Neighboring gene STARR-positive B cell enhancer ABC_E9843 Neighboring gene DExH-box helicase 58 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:100575167-100575276 Neighboring gene heat shock protein, alpha-crystallin-related, B9 Neighboring gene RAB5C, member RAS oncogene family Neighboring gene STARR-positive B cell enhancer ABC_E3022

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (9)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables N-acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
Inferred from Electronic Annotation
more info
 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables histone H3 acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables histone H3 acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables histone H3 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables histone H3K18 acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables histone H3K9 acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables histone H3K9 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables histone H4K12 acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables histone acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables histone acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
 
enables histone glutaryltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables histone succinyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables peptide-lysine-N-acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within fibroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of gluconeogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in histone succinylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in internal peptidyl-lysine acetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular distribution of mitochondria ISO
Inferred from Sequence Orthology
more info
 
involved_in long-term memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within metencephalon development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within midbrain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of centriole replication ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gluconeogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neural tube closure IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-lysine glutarylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of cardiac muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell projection organization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of gluconeogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in protein modification process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA repair NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of RNA splicing NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of T cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of bone development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cartilage development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell division IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cell division ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of embryonic development IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of protein stability ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of regulatory T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of tubulin deacetylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within somitogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within somitogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within telencephalon development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of ATAC complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of ATAC complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of ATAC complex ISO
Inferred from Sequence Orthology
more info
 
part_of SAGA complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of SAGA complex ISO
Inferred from Sequence Orthology
more info
 
part_of SAGA complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
part_of chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
part_of histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of histone acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
 
located_in mitotic spindle IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitotic spindle NAS
Non-traceable Author Statement
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of oxoglutarate dehydrogenase complex ISO
Inferred from Sequence Orthology
more info
 
part_of transcription factor TFTC complex ISO
Inferred from Sequence Orthology
more info
 
part_of transcription factor TFTC complex NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
histone acetyltransferase KAT2A
Names
GCN5 general control of amino acid synthesis-like 2
PCAF-B/GCN5
general control of amino acid synthesis 5-like 2
general control of amino acid synthesis protein 5-like 2
general control of amino acid synthesis, yeast homolog-like 2
general control of amino acid synthesis-like 2
histone acetyltransferase GCN5
histone glutaryltransferase KAT2A
histone succinyltransferase KAT2A
lysine acetyltransferase 2A
NP_001033099.1
NP_064388.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001038010.2NP_001033099.1  histone acetyltransferase KAT2A isoform b

    See identical proteins and their annotated locations for NP_001033099.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a.
    Source sequence(s)
    AK155842, AL591469, AV014576
    Consensus CDS
    CCDS25432.1
    UniProtKB/TrEMBL
    Q3UD69, Q6P3Z8
    Related
    ENSMUSP00000006973.6, ENSMUST00000006973.12
    Conserved Domains (4) summary
    cd05509
    Location:724823
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    COG5076
    Location:484824
    COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
    pfam00583
    Location:547619
    Acetyltransf_1; Acetyltransferase (GNAT) family
    pfam06466
    Location:81330
    PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain
  2. NM_020004.5NP_064388.2  histone acetyltransferase KAT2A isoform a

    See identical proteins and their annotated locations for NP_064388.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AK155842, AK158079, AL591469, AV014576
    Consensus CDS
    CCDS25433.1
    UniProtKB/Swiss-Prot
    Q3TZ59, Q9JHD2
    UniProtKB/TrEMBL
    Q3UD69
    Related
    ENSMUSP00000099407.4, ENSMUST00000103118.4
    Conserved Domains (3) summary
    cd05509
    Location:725824
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    COG5076
    Location:485825
    COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
    pfam06466
    Location:84330
    PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain

RNA

  1. NR_166132.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL591469
    Related
    ENSMUST00000153526.8
  2. NR_166133.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL591469

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    100595572..100603293 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)