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Kat2a K(lysine) acetyltransferase 2A [ Mus musculus (house mouse) ]

Gene ID: 14534, updated on 12-Mar-2019

Summary

Official Symbol
Kat2aprovided by MGI
Official Full Name
K(lysine) acetyltransferase 2Aprovided by MGI
Primary source
MGI:MGI:1343101
See related
Ensembl:ENSMUSG00000020918
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gcn5; Gcn5l2; mmGCN5; AW212720; 1110051E14Rik
Expression
Ubiquitous expression in adrenal adult (RPKM 33.5), ovary adult (RPKM 29.4) and 28 other tissues See more
Orthologs

Genomic context

See Kat2a in Genome Data Viewer
Location:
11 D; 11 63.53 cM
Exon count:
18
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (100704746..100712478, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (100566062..100573768, complement)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene zinc finger protein 385C Neighboring gene DEAH (Asp-Glu-Ala-His) box polypeptide 58, opposite strand Neighboring gene predicted gene, 38483 Neighboring gene DEXH (Asp-Glu-X-His) box polypeptide 58 Neighboring gene heat shock protein, alpha-crystallin-related, B9 Neighboring gene RAB5C, member RAS oncogene family

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
H3 histone acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
H3 histone acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
N-acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
chromatin binding ISO
Inferred from Sequence Orthology
more info
 
histone acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
histone acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to histone acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
histone acetyltransferase activity (H4-K12 specific) IDA
Inferred from Direct Assay
more info
PubMed 
histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
 
histone succinyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
peptide-lysine-N-acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity, transferring acyl groups IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
alpha-tubulin acetylation ISO
Inferred from Sequence Orthology
more info
 
cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
histone H3 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
histone H3 acetylation ISO
Inferred from Sequence Orthology
more info
 
histone H3-K14 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
histone H4-K12 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
histone acetylation IEA
Inferred from Electronic Annotation
more info
 
histone deubiquitination ISO
Inferred from Sequence Orthology
more info
 
histone succinylation ISO
Inferred from Sequence Orthology
more info
 
in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
internal peptidyl-lysine acetylation ISO
Inferred from Sequence Orthology
more info
 
intracellular distribution of mitochondria ISO
Inferred from Sequence Orthology
more info
 
long-term memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
metencephalon development IMP
Inferred from Mutant Phenotype
more info
PubMed 
midbrain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of centriole replication ISO
Inferred from Sequence Orthology
more info
 
nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
neural tube closure IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cardiac muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell projection organization ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of histone acetylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
regulation of T cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein stability ISO
Inferred from Sequence Orthology
more info
 
regulation of regulatory T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
somitogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
somitogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
telencephalon development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Ada2/Gcn5/Ada3 transcription activator complex IDA
Inferred from Direct Assay
more info
PubMed 
Ada2/Gcn5/Ada3 transcription activator complex ISO
Inferred from Sequence Orthology
more info
 
STAGA complex IDA
Inferred from Direct Assay
more info
PubMed 
STAGA complex ISO
Inferred from Sequence Orthology
more info
 
centrosome ISO
Inferred from Sequence Orthology
more info
 
chromosome IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
mitotic spindle IDA
Inferred from Direct Assay
more info
PubMed 
nuclear chromatin ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with oxoglutarate dehydrogenase complex ISO
Inferred from Sequence Orthology
more info
 
transcription factor TFTC complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
histone acetyltransferase KAT2A
Names
GCN5 general control of amino acid synthesis-like 2
PCAF-B/GCN5
general control of amino acid synthesis 5-like 2
general control of amino acid synthesis protein 5-like 2
general control of amino acid synthesis, yeast homolog-like 2
general control of amino acid synthesis-like 2
histone acetyltransferase GCN5
histone succinyltransferase KAT2A
lysine acetyltransferase 2A
NP_001033099.1
NP_064388.2
XP_017169759.1
XP_017169760.1
XP_017169761.1
XP_017169762.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001038010.2NP_001033099.1  histone acetyltransferase KAT2A isoform b

    See identical proteins and their annotated locations for NP_001033099.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a.
    Source sequence(s)
    AK155842, AL591469, AV014576
    Consensus CDS
    CCDS25432.1
    UniProtKB/TrEMBL
    Q6P3Z8
    Related
    ENSMUSP00000006973.5, ENSMUST00000006973.11
    Conserved Domains (4) summary
    cd05509
    Location:724823
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    COG5076
    Location:484824
    COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
    pfam00583
    Location:547619
    Acetyltransf_1; Acetyltransferase (GNAT) family
    pfam06466
    Location:81330
    PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain
  2. NM_020004.5NP_064388.2  histone acetyltransferase KAT2A isoform a

    See identical proteins and their annotated locations for NP_064388.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK155842, AK158079, AL591469, AV014576
    Consensus CDS
    CCDS25433.1
    UniProtKB/Swiss-Prot
    Q9JHD2
    UniProtKB/TrEMBL
    Q6P3Z8
    Related
    ENSMUSP00000099407.3, ENSMUST00000103118.3
    Conserved Domains (4) summary
    cd05509
    Location:725824
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    COG5076
    Location:485825
    COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
    pfam00583
    Location:548620
    Acetyltransf_1; Acetyltransferase (GNAT) family
    pfam06466
    Location:81330
    PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

    Range
    100704746..100712478 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017314271.1XP_017169760.1  histone acetyltransferase KAT2A isoform X2

  2. XM_017314270.1XP_017169759.1  histone acetyltransferase KAT2A isoform X1

  3. XM_017314273.1XP_017169762.1  histone acetyltransferase KAT2A isoform X4

  4. XM_017314272.1XP_017169761.1  histone acetyltransferase KAT2A isoform X3

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