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Txnrd2 thioredoxin reductase 2 [ Mus musculus (house mouse) ]

Gene ID: 26462, updated on 18-Apr-2024

Summary

Official Symbol
Txnrd2provided by MGI
Official Full Name
thioredoxin reductase 2provided by MGI
Primary source
MGI:MGI:1347023
See related
Ensembl:ENSMUSG00000075704 AllianceGenome:MGI:1347023
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TGR; Tr3; Trxr2; Trxrd2; ESTM573010
Summary
The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes a mitochondrial form important for scavenging reactive oxygen species in mitochondria. It functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2017]
Expression
Ubiquitous expression in liver E14.5 (RPKM 41.1), liver E14 (RPKM 39.1) and 27 other tissues See more
Orthologs
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Genomic context

Location:
16 A3; 16 11.41 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (18245167..18297823)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (18426417..18479073)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene armadillo repeat gene deleted in velocardiofacial syndrome Neighboring gene STARR-seq mESC enhancer starr_40280 Neighboring gene predicted gene 15764 Neighboring gene catechol-O-methyltransferase Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:18460133-18460376 Neighboring gene STARR-seq mESC enhancer starr_40284 Neighboring gene STARR-seq mESC enhancer starr_40285 Neighboring gene guanine nucleotide binding protein (G protein), beta polypeptide 1-like Neighboring gene VISTA enhancer mm321 Neighboring gene predicted gene, 35369 Neighboring gene T-box 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Gene trapped (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables thioredoxin-disulfide reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables thioredoxin-disulfide reductase (NADPH) activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cell redox homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell redox homeostasis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to oxygen radical TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in axon ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
thioredoxin reductase 2, mitochondrial
Names
TR beta
thioredoxin reductase TR3
NP_001340072.1
NP_038739.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001353143.1NP_001340072.1  thioredoxin reductase 2, mitochondrial isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame coding exon in the 3' region compared to variant 1. The resulting shorter isoform (2) is missing an internal protein segment compared to isoform 1.
    Source sequence(s)
    AB027566, AF412308, BF465261
    Consensus CDS
    CCDS88895.1
    UniProtKB/TrEMBL
    A0A0U1RPV8
    Related
    ENSMUSP00000146143.3, ENSMUST00000206606.3
    Conserved Domains (1) summary
    cl27343
    Location:43496
    Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
  2. NM_013711.3NP_038739.2  thioredoxin reductase 2, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_038739.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB027566, BF465261
    Consensus CDS
    CCDS79434.1
    UniProtKB/TrEMBL
    A0A0M3HEQ0
    Related
    ENSMUSP00000111269.4, ENSMUST00000115606.9
    Conserved Domains (4) summary
    TIGR01438
    Location:43527
    TGR; thioredoxin and glutathione reductase selenoprotein
    pfam00070
    Location:223289
    Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
    pfam02852
    Location:399508
    Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerization domain
    cl21454
    Location:4370
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    18245167..18297823
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)