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PLA2G2D phospholipase A2 group IID [ Homo sapiens (human) ]

Gene ID: 26279, updated on 10-Oct-2019

Summary

Official Symbol
PLA2G2Dprovided by HGNC
Official Full Name
phospholipase A2 group IIDprovided by HGNC
Primary source
HGNC:HGNC:9033
See related
Ensembl:ENSG00000117215 MIM:605630
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPLASH; sPLA2S; PLA2IID; sPLA2-IID
Summary
This gene encodes a secreted member of the phospholipase A2 family, and is found in a cluster of related family members on chromosome 1. Phospholipase A2 family members hydrolyze the sn-2 fatty acid ester bond of glycerophospholipids to produce lysophospholipids and free fatty acid. This gene may be involved in inflammation and immune response, and in weight loss associated with chronic obstructive pulmonary disease. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]
Expression
Biased expression in lymph node (RPKM 63.3), appendix (RPKM 10.7) and 2 other tissues See more
Orthologs

Genomic context

See PLA2G2D in Genome Data Viewer
Location:
1p36.12
Exon count:
4
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (20111939..20119566, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (20439143..20446059, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene phospholipase A2 group IIA Neighboring gene prenylcysteine oxidase 1 pseudogene Neighboring gene phospholipase A2 group V Neighboring gene phospholipase A2 group IIF Neighboring gene phospholipase A2 group IIC

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 causes an activation of phospholipase A2, resulting in the increased release of arachidonic acid, which may sensitize the NMDA receptor PubMed
env HIV-1 gp120 induces a specific phospholipase A2 (PLA2) activation in lymphocytes through binding to CD4, but this effect is not sufficient to accomplish virus/cell fusion PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
calcium-dependent phospholipase A2 activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
heparan sulfate proteoglycan binding IEA
Inferred from Electronic Annotation
more info
 
heparin binding IEA
Inferred from Electronic Annotation
more info
 
phospholipase A2 activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) IEA
Inferred from Electronic Annotation
more info
 
phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) IEA
Inferred from Electronic Annotation
more info
 
phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation IEA
Inferred from Electronic Annotation
more info
 
arachidonic acid secretion IEA
Inferred from Electronic Annotation
more info
 
inflammatory response TAS
Traceable Author Statement
more info
PubMed 
lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of T cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidic acid biosynthetic process TAS
Traceable Author Statement
more info
 
phosphatidylcholine acyl-chain remodeling TAS
Traceable Author Statement
more info
 
phosphatidylethanolamine acyl-chain remodeling TAS
Traceable Author Statement
more info
 
phosphatidylglycerol acyl-chain remodeling TAS
Traceable Author Statement
more info
 
phosphatidylinositol acyl-chain remodeling TAS
Traceable Author Statement
more info
 
phosphatidylserine acyl-chain remodeling TAS
Traceable Author Statement
more info
 
phospholipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
extracellular region TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
group IID secretory phospholipase A2
Names
GIID sPLA2
phosphatidylcholine 2-acylhydrolase 2D
secretory phospholipase A2s
secretory-type PLA, stroma-associated homolog
NP_001258743.1
NP_036532.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271814.1NP_001258743.1  group IID secretory phospholipase A2 isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an internal exon in the coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK026347, AK310156, BC025706, DC295429
    Consensus CDS
    CCDS72721.1
    UniProtKB/Swiss-Prot
    Q9UNK4
    UniProtKB/TrEMBL
    A0A087WZT4
    Related
    ENSP00000482871.1, ENST00000617227.1
    Conserved Domains (1) summary
    cl05417
    Location:2162
    PLA2_like; PLA2_like: Phospholipase A2, a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...
  2. NM_012400.4NP_036532.1  group IID secretory phospholipase A2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_036532.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK026347, AL158172, BC025706, DC295429
    Consensus CDS
    CCDS203.1
    UniProtKB/Swiss-Prot
    Q9UNK4
    Related
    ENSP00000364246.3, ENST00000375105.8
    Conserved Domains (1) summary
    cd00125
    Location:21138
    PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    20111939..20119566 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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