GATA3 GATA binding protein 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: GATA3provided by HGNC
Official Full Name: GATA binding protein 3provided by HGNC
Primary source: HGNC:HGNC:4172
See related: Ensembl:ENSG00000107485 MIM:131320; Vega:OTTHUMG00000017640
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HDR; HDRS
Summary: This gene encodes a protein which belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is an important regulator of T-cell development and plays an important role in endothelial cell biology. Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia. [provided by RefSeq, Nov 2009]
Expression: Biased expression in skin (RPKM 54.6), urinary bladder (RPKM 20.0) and 7 other tissues See more
Orthologs: mouse all

Genomic context

Location:: 10p14

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
109	current	GRCh38.p12 (GCF_000001405.38)	10	NC_000010.11 (8045420..8075201)
105	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (8087294..8117164)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

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GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

GATA 3 is more sensitive marker than mammaglobin and GCDFP-15 for diagnosing metastatic breast carcinoma in cytological cell block materials
Title: Can GATA3 Immunocytochemistry be Utilized as a Reliable Diagnostic Marker for Metastatic Breast Carcinoma in Cytological Materials? A Comparative Study with Mammaglobin and GCDFP-15 Expression.
This study demonstrates consistent GATA-3 staining in walthard nests, rare staining in adenomatoid tumors, and is otherwise rarely positive in normal urologic and gynecologic mesothelia. Furthermore, GATA-3 is uniformly positive in epididymi and negative in efferent ductules which may reflect the embryological evolvement of these tissues.
Title: Expression of GATA-3 in Testicular and Gynecologic Mesothelial Neoplastic and Non-neoplastic Tissues.
GATA3 staining to differentiate primary cutaneous apocrine cribriform carcinoma from skin breast cancer metastasis has a high negative predictive value
Title: GATA3 staining in primary cutaneous apocrine cribriform carcinoma: Usefulness to differentiate it from breast cancer metastasis.
GATA3 mutations, recently observed in breast cancer, encode active transcription factors.
Title: Mutant GATA3 Actively Promotes the Growth of Normal and Malignant Mammary Cells.
KMT1A positively regulated the self-renewal and tumorigenicity of human Bladder cancer stem cells via KMT1A-GATA3-STAT3 circuit, in which KMT1A could be a promising target for bladder cancer therapy.
Title: The KMT1A-GATA3-STAT3 Circuit Is a Novel Self-Renewal Signaling of Human Bladder Cancer Stem Cells.
Defective sirtuin-1 was found to increase IL-4 expression through acetylation of GATA-3 in patients with severe asthma compared with healthy controls.
Title: Defective sirtuin-1 increases IL-4 expression through acetylation of GATA-3 in patients with severe asthma.
GATA3 activation was diminished upon cultivation of T cells with RNase 7.
Title: RNase 7 downregulates TH2 cytokine production by activated human T cells.
overexpression of GATA3 and FOXA1 cooperate with PPAR activation to drive transdifferentiation of a basal bladder cancer cells to a luminial phenotype.
Title: FOXA1, GATA3 and PPARɣ Cooperate to Drive Luminal Subtype in Bladder Cancer: A Molecular Analysis of Established Human Cell Lines.
The data have demonstrated that GATA3 is by far the most reliable breast-specific immunomarker in both surgical and cytological specimens
Title: Utility of different immunostains for diagnosis of metastatic breast carcinomas in both surgical and cytological specimens.
GATA3 interacts with and is acetylated by the acetyltransferase CBP. The major acetylated site of GATA3 in lung adenocarcinoma cells is lysine 119.
Title: GATA3 acetylation at K119 by CBP inhibits cell migration and invasion in lung adenocarcinoma.

Submit: New GeneRIF Correction See all GeneRIFs (294)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Barakat syndrome MedGen: C1840333 OMIM: 146255 GeneReviews: Not available	Compare labs

Copy number response

Description
Copy number response Triplosensitivity No evidence available (Last evaluated (2011-10-28) ClinGen Genome Curation PagePubMed Haploinsufficency Sufficient evidence for dosage pathogenicity (Last evaluated (2011-10-28) ClinGen Genome Curation PagePubMed

NHGRI GWAS Catalog

Description
A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3). NHGRI GWA Catalog NHGRI GWA CatalogPubMed
A meta-analysis of Hodgkin lymphoma reveals 19p13.3 TCF3 as a novel susceptibility locus. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Genetics of rheumatoid arthritis contributes to biology and drug discovery. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Genome-wide diet-gene interaction analyses for risk of colorectal cancer. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Identification of susceptibility loci for colorectal cancer in a genome-wide meta-analysis. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Meta-analysis of genome-wide association studies identifies six new Loci for serum calcium concentrations. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Variation at 10p12.2 and 10p14 influences risk of childhood B-cell acute lymphoblastic leukemia and phenotype. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Variation at 3p24.1 and 6q23.3 influences the risk of Hodgkin's lymphoma. NHGRI GWA Catalog NHGRI GWA CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Nef	nef	Amino acids 19-26 of HIV-1 Nef mediate the binding of Nef to murine GATA-1 and GATA-3 in vitro, suggesting Nef may act as a nuclear regulatory factor through binding to human GATA-1 and GATA-3	PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

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Adipogenesis, organism-specific biosystem (from WikiPathways)
Adipogenesis, organism-specific biosystemThe different classess of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compo...
C-MYB transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
C-MYB transcription factor network, organism-specific biosystem
C-MYB transcription factor network
Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem (from Pathway Interaction Database)
Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
Deubiquitination, organism-specific biosystem (from REACTOME)
Deubiquitination, organism-specific biosystemUbiquitination, the modification of proteins by the covalent attachment of ubiquitin (Ub), is a key regulatory mechanism for many many cellular processes, including protein degradation by the 26S pro...
Development and heterogeneity of the ILC family, organism-specific biosystem (from WikiPathways)
Development and heterogeneity of the ILC family, organism-specific biosystemDevelopment and heterogeneity of the ILC family. ILCs develop from distinct progenitors in the fetal liver or bone marrow and then develop into mature ILCs in the periphery. Different transcription f...
Factors involved in megakaryocyte development and platelet production, organism-specific biosystem (from REACTOME)
Factors involved in megakaryocyte development and platelet production, organism-specific biosystemMegakaryocytes (MKs) give rise to circulating platelets (thrombocytes) through terminal differentiation of MKs which release cytoplasmic fragments as circulating platelets. As MKs mature they underg...
Glucocorticoid receptor regulatory network, organism-specific biosystem (from Pathway Interaction Database)
Glucocorticoid receptor regulatory network, organism-specific biosystem
Glucocorticoid receptor regulatory network
Hemostasis, organism-specific biosystem (from REACTOME)
Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
IL-4 Signaling Pathway, organism-specific biosystem (from WikiPathways)
IL-4 Signaling Pathway, organism-specific biosystemIL-4 is a glycoprotein which is composed of 129 amino acids and has a molecular weight of 20kDa. IL-4 and IL-13 are produced by CD4+ cells and exhibit significant functional overlap. Both these cytok...
IL27-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
IL27-mediated signaling events, organism-specific biosystem
IL27-mediated signaling events
Immune System, organism-specific biosystem (from REACTOME)
Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
Inflammatory bowel disease (IBD), organism-specific biosystem (from KEGG)
Inflammatory bowel disease (IBD), organism-specific biosystemInflammatory bowel disease (IBD), which includes Crohn disease (CD) and ulcerative colitis (UC), is characterized by chronic inflammation of the gastrointestinal tract due to environmental and geneti...
Inflammatory bowel disease (IBD), conserved biosystem (from KEGG)
Inflammatory bowel disease (IBD), conserved biosystemInflammatory bowel disease (IBD), which includes Crohn disease (CD) and ulcerative colitis (UC), is characterized by chronic inflammation of the gastrointestinal tract due to environmental and geneti...
Interleukin-4 and 13 signaling, organism-specific biosystem (from REACTOME)
Interleukin-4 and 13 signaling, organism-specific biosystemInterleukin-4 (IL4) is a principal regulatory cytokine during the immune response, crucially important in allergy and asthma (Nelms et al. 1999). When resting T cells are antigen-activated and expand...
Mesodermal Commitment Pathway, organism-specific biosystem (from WikiPathways)
Mesodermal Commitment Pathway, organism-specific biosystemModel depicting mesodermal specification based on the literature and highly enriched gene expression profiles via comparison across dozens of independent induced and embryonic pluripotent stem cell l...
Metabolism of proteins, organism-specific biosystem (from REACTOME)
Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
Notch Signaling Pathway, organism-specific biosystem (from WikiPathways)
Notch Signaling Pathway, organism-specific biosystemThe Notch pathway is an evolutionally conserved signaling pathway which plays an important role in diverse developmental and physiological processes. These include cell-fate determination, tissue pat...
Notch signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
Notch signaling pathway, organism-specific biosystem
Notch signaling pathway
Post-translational protein modification, organism-specific biosystem (from REACTOME)
Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
Preimplantation Embryo, organism-specific biosystem (from WikiPathways)
Preimplantation Embryo, organism-specific biosystemThe source of this pathway is RNA-Seq data from single-cell pre-implantation embryos (Supplemental Table 1): http://www.nature.com/nsmb/journal/v20/n9/full/nsmb.2660.html Analysis options for runnin...
Regulation of nuclear SMAD2/3 signaling, organism-specific biosystem (from Pathway Interaction Database)
Regulation of nuclear SMAD2/3 signaling, organism-specific biosystem
Regulation of nuclear SMAD2/3 signaling
Signaling by Interleukins, organism-specific biosystem (from REACTOME)
Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways, organism-specific biosystem (from WikiPathways)
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways, organism-specific biosystemIn this model, we provide an integrated view of Sudden Infant Death Syndrome (SIDS) at the level of implicated tissues, signaling networks and genetics. The purpose of this model is to serve as an ov...
T-Cell antigen Receptor (TCR) Signaling Pathway, organism-specific biosystem (from WikiPathways)
T-Cell antigen Receptor (TCR) Signaling Pathway, organism-specific biosystemThe T-cell antigen receptor (TCR) complex is composed of a ligand-binding subunit, the ? and ? chains, and a signaling subunit, namely the CD3?, ? and ? chains and the TCR? chain. This complex partic...
Th1 and Th2 cell differentiation, organism-specific biosystem (from KEGG)
Th1 and Th2 cell differentiation, organism-specific biosystemImmunity to different classes of microorganisms is orchestrated by separate lineages of effector T helper (TH)-cells, which differentiate from naive CD4+ precursor cells in response to cues provided ...
Th1 and Th2 cell differentiation, conserved biosystem (from KEGG)
Th1 and Th2 cell differentiation, conserved biosystemImmunity to different classes of microorganisms is orchestrated by separate lineages of effector T helper (TH)-cells, which differentiate from naive CD4+ precursor cells in response to cues provided ...
Th17 cell differentiation, organism-specific biosystem (from KEGG)
Th17 cell differentiation, organism-specific biosystemInterleukin (IL)-17-producing helper T (Th17) cells serve as a subset of CD4+ T cells involved in epithelial cell- and neutrophil mediated immune responses against extracellular microbes and in the p...
Th17 cell differentiation, conserved biosystem (from KEGG)
Th17 cell differentiation, conserved biosystemInterleukin (IL)-17-producing helper T (Th17) cells serve as a subset of CD4+ T cells involved in epithelial cell- and neutrophil mediated immune responses against extracellular microbes and in the p...
Ub-specific processing proteases, organism-specific biosystem (from REACTOME)
Ub-specific processing proteases, organism-specific biosystemUb-specific processing proteases (USPs) are the largest of the DUB families with more than 50 members in humans. The USP catalytic domain varies considerably in size and consists of six conserved mo...

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G20258 (e-PCR)
- UniSTS:11781

A005A11 (e-PCR)
- UniSTS:11782

SHGC-34122 (e-PCR)
- UniSTS:65804

RH17471 (e-PCR)
- UniSTS:65805

GATA3_1519 (e-PCR)
- UniSTS:277271

RH78856 (e-PCR)
- UniSTS:2362

D10S2148 (e-PCR)
- UniSTS:71540

Homology

Homologs of the GATA3 gene: The GATA3 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 236 organisms have orthologs with human gene GATA3
The Hierarchical Catalog of Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
DNA binding	TAS Traceable Author Statement more info	PubMed
DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
DNA-binding transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info	PubMed
DNA-binding transcription factor activity, RNA polymerase II-specific	ISA Inferred from Sequence Alignment more info
DNA-binding transcription factor activity, RNA polymerase II-specific	ISM Inferred from Sequence Model more info	PubMed
DNA-binding transcription factor activity, RNA polymerase II-specific	NAS Non-traceable Author Statement more info	PubMed
E-box binding	IDA Inferred from Direct Assay more info	PubMed
HMG box domain binding	IPI Inferred from Physical Interaction more info	PubMed
RNA polymerase II proximal promoter sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
RNA polymerase II proximal promoter sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enhancer sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
interleukin-2 receptor binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein dimerization activity	IEA Inferred from Electronic Annotation more info
proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
proximal promoter sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed
transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
transcription regulatory region DNA binding	IDA Inferred from Direct Assay more info	PubMed
transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
T cell receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
T-helper 2 cell differentiation	IEA Inferred from Electronic Annotation more info
TOR signaling	ISS Inferred from Sequence or Structural Similarity more info
anatomical structure formation involved in morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
anatomical structure morphogenesis	TAS Traceable Author Statement more info	PubMed
aortic valve morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
axon guidance	IEA Inferred from Electronic Annotation more info
blood coagulation	TAS Traceable Author Statement more info
canonical Wnt signaling pathway involved in metanephric kidney development	ISS Inferred from Sequence or Structural Similarity more info
cardiac right ventricle morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
cell fate determination	ISS Inferred from Sequence or Structural Similarity more info
cell maturation	IEA Inferred from Electronic Annotation more info
cellular response to BMP stimulus	IEA Inferred from Electronic Annotation more info
cellular response to interferon-alpha	IEP Inferred from Expression Pattern more info	PubMed
cellular response to interleukin-4	IBA Inferred from Biological aspect of Ancestor more info	PubMed
cellular response to interleukin-4	IEP Inferred from Expression Pattern more info	PubMed
cellular response to tumor necrosis factor	IEP Inferred from Expression Pattern more info	PubMed
chromatin remodeling	IEA Inferred from Electronic Annotation more info
cochlea development	IEA Inferred from Electronic Annotation more info
cytokine-mediated signaling pathway	TAS Traceable Author Statement more info
defense response	TAS Traceable Author Statement more info	PubMed
developmental growth	IEA Inferred from Electronic Annotation more info
ear development	IMP Inferred from Mutant Phenotype more info	PubMed
embryonic hemopoiesis	IEA Inferred from Electronic Annotation more info
erythrocyte differentiation	IEA Inferred from Electronic Annotation more info
humoral immune response	IEA Inferred from Electronic Annotation more info
in utero embryonic development	IEA Inferred from Electronic Annotation more info
innate immune response	IEA Inferred from Electronic Annotation more info
inner ear morphogenesis	IEA Inferred from Electronic Annotation more info
interferon-gamma secretion	IEA Inferred from Electronic Annotation more info
interleukin-4 secretion	IEA Inferred from Electronic Annotation more info
kidney development	IMP Inferred from Mutant Phenotype more info	PubMed
lens development in camera-type eye	IEA Inferred from Electronic Annotation more info
lymphocyte migration	IDA Inferred from Direct Assay more info	PubMed
male gonad development	ISS Inferred from Sequence or Structural Similarity more info
mast cell differentiation	IEA Inferred from Electronic Annotation more info
mesenchymal to epithelial transition	IDA Inferred from Direct Assay more info	PubMed
mesonephros development	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of DNA demethylation	IEA Inferred from Electronic Annotation more info
negative regulation of cell cycle	IBA Inferred from Biological aspect of Ancestor more info	PubMed
negative regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of cell motility	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of cell proliferation involved in mesonephros development	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of endothelial cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of interferon-gamma production	IEA Inferred from Electronic Annotation more info
negative regulation of interleukin-2 production	IEA Inferred from Electronic Annotation more info
negative regulation of mammary gland epithelial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
negative regulation of transcription, DNA-templated	IBA Inferred from Biological aspect of Ancestor more info	PubMed
negative regulation of transcription, DNA-templated	IMP Inferred from Mutant Phenotype more info	PubMed
nephric duct formation	ISS Inferred from Sequence or Structural Similarity more info
nephric duct morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
neuron migration	IEA Inferred from Electronic Annotation more info
norepinephrine biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
otic vesicle development	IEA Inferred from Electronic Annotation more info
parathyroid gland development	IEA Inferred from Electronic Annotation more info
parathyroid hormone secretion	IEA Inferred from Electronic Annotation more info
pharyngeal system development	ISS Inferred from Sequence or Structural Similarity more info
phosphatidylinositol 3-kinase signaling	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of T cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of T-helper 2 cell cytokine production	IEA Inferred from Electronic Annotation more info
positive regulation of endothelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of histone H3-K14 acetylation	IEA Inferred from Electronic Annotation more info
positive regulation of histone H3-K9 acetylation	IEA Inferred from Electronic Annotation more info
positive regulation of interleukin-13 secretion	IDA Inferred from Direct Assay more info	PubMed
positive regulation of interleukin-13 secretion	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of interleukin-4 production	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of interleukin-5 secretion	IDA Inferred from Direct Assay more info	PubMed
positive regulation of protein kinase B signaling	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of thyroid hormone generation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of transcription regulatory region DNA binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
positive regulation of transcription regulatory region DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of transcription, DNA-templated	IDA Inferred from Direct Assay more info	PubMed
positive regulation of transcription, DNA-templated	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of transcription, DNA-templated	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of ureteric bud formation	ISS Inferred from Sequence or Structural Similarity more info
post-embryonic development	IEA Inferred from Electronic Annotation more info
pro-T cell differentiation	IEA Inferred from Electronic Annotation more info
protein deubiquitination	TAS Traceable Author Statement more info
regulation of CD4-positive, alpha-beta T cell differentiation	IEA Inferred from Electronic Annotation more info
regulation of cellular response to X-ray	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of cytokine biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
regulation of establishment of cell polarity	IEA Inferred from Electronic Annotation more info
regulation of hematopoietic stem cell differentiation	TAS Traceable Author Statement more info
regulation of histone H3-K27 methylation	IEA Inferred from Electronic Annotation more info
regulation of histone H3-K4 methylation	IEA Inferred from Electronic Annotation more info
regulation of nephron tubule epithelial cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
regulation of neuron apoptotic process	IEA Inferred from Electronic Annotation more info
regulation of neuron projection development	IEA Inferred from Electronic Annotation more info
response to estrogen	IEP Inferred from Expression Pattern more info	PubMed
response to ethanol	IEA Inferred from Electronic Annotation more info
response to gamma radiation	IEA Inferred from Electronic Annotation more info
response to virus	IEP Inferred from Expression Pattern more info	PubMed
signal transduction	ISS Inferred from Sequence or Structural Similarity more info
sympathetic nervous system development	ISS Inferred from Sequence or Structural Similarity more info
thymic T cell selection	IEA Inferred from Electronic Annotation more info
thymus development	IEA Inferred from Electronic Annotation more info
transcription by RNA polymerase II	TAS Traceable Author Statement more info	PubMed
type IV hypersensitivity	IEA Inferred from Electronic Annotation more info
ureter maturation	IEA Inferred from Electronic Annotation more info
ureteric bud formation	ISS Inferred from Sequence or Structural Similarity more info
uterus development	ISS Inferred from Sequence or Structural Similarity more info
ventricular septum development	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
nuclear chromatin	IDA Inferred from Direct Assay more info	PubMed
nucleoplasm	IDA Inferred from Direct Assay more info
nucleoplasm	TAS Traceable Author Statement more info
nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: trans-acting T-cell-specific transcription factor GATA-3

Names: GATA-binding factor 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_015859.1 RefSeqGene

Range

5001..25498

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001002295.1 → NP_001002295.1 trans-acting T-cell-specific transcription factor GATA-3 isoform 1

See identical proteins and their annotated locations for NP_001002295.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AI024501, AI686327, BC003070, BC006793, BC006839, BG287052, BM152193

Consensus CDS

CCDS31143.1

UniProtKB/Swiss-Prot

P23771

Related

ENSP00000368632.3, OTTHUMP00000019070, ENST00000379328.8, OTTHUMT00000046718

Conserved Domains (2) summary

smart00401
Location:313 → 362

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd00202
Location:317 → 367

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
NM_002051.2 → NP_002042.1 trans-acting T-cell-specific transcription factor GATA-3 isoform 2

See identical proteins and their annotated locations for NP_002042.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the mid-coding region, compared to variant 1, resulting in an isoform (2) that is 1 aa shorter than isoform 1.

Source sequence(s)

AI024501, AI686327, BC006793, BC006839, BG287052, BM152193

Consensus CDS

CCDS7083.1

UniProtKB/Swiss-Prot

P23771

Related

ENSP00000341619.3, OTTHUMP00000019071, ENST00000346208.4, OTTHUMT00000046719

Conserved Domains (2) summary

smart00401
Location:312 → 361

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd00202
Location:316 → 366

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

NC_000010.11 Reference GRCh38.p12 Primary Assembly

Range

8045420..8075201

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005252443.5 → XP_005252500.1 trans-acting T-cell-specific transcription factor GATA-3 isoform X1

See identical proteins and their annotated locations for XP_005252500.1

UniProtKB/Swiss-Prot

P23771

Conserved Domains (2) summary

smart00401
Location:313 → 362

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd00202
Location:317 → 367

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
XM_005252442.2 → XP_005252499.1 trans-acting T-cell-specific transcription factor GATA-3 isoform X1

See identical proteins and their annotated locations for XP_005252499.1

UniProtKB/Swiss-Prot

P23771

Conserved Domains (2) summary

smart00401
Location:313 → 362

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd00202
Location:317 → 367

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C