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MTG2 mitochondrial ribosome associated GTPase 2 [ Homo sapiens (human) ]

Gene ID: 26164, updated on 23-Nov-2021

Summary

Official Symbol
MTG2provided by HGNC
Official Full Name
mitochondrial ribosome associated GTPase 2provided by HGNC
Primary source
HGNC:HGNC:16239
See related
Ensembl:ENSG00000101181 MIM:610919
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ObgH1; GTPBP5; dJ1005F21.2
Summary
Small G proteins, such as GTPBP5, act as molecular switches that play crucial roles in the regulation of fundamental cellular processes such as protein synthesis, nuclear transport, membrane trafficking, and signal transduction (Hirano et al., 2006 [PubMed 17054726]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in testis (RPKM 3.6), skin (RPKM 3.3) and 25 other tissues See more
Orthologs
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Try the new Transcript table

Genomic context

See MTG2 in Genome Data Viewer
Location:
20q13.33
Exon count:
12
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (62183028..62203568)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (60758084..60778624)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene proteasome 20S subunit alpha 7 Neighboring gene Sharpr-MPRA regulatory region 1753 Neighboring gene SS18L1 subunit of BAF chromatin remodeling complex Neighboring gene histamine receptor H3 Neighboring gene uncharacterized LOC105369209

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10741, MGC29512

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in regulation of mitochondrial translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of respiratory system process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial ribosome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
mitochondrial ribosome-associated GTPase 2
Names
GTP binding protein 5 (putative)
GTP-binding protein 5
protein obg homolog 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001384347.1NP_001371276.1  mitochondrial ribosome-associated GTPase 2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL078633
    Conserved Domains (1) summary
    TIGR02729
    Location:90403
    Obg_CgtA; Obg family GTPase CgtA
  2. NM_001384348.1NP_001371277.1  mitochondrial ribosome-associated GTPase 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL078633
    Conserved Domains (1) summary
    TIGR02729
    Location:72271
    Obg_CgtA; Obg family GTPase CgtA
  3. NM_015666.4NP_056481.1  mitochondrial ribosome-associated GTPase 2 isoform 2

    See identical proteins and their annotated locations for NP_056481.1

    Status: VALIDATED

    Source sequence(s)
    AL078633
    Consensus CDS
    CCDS13492.1
    UniProtKB/Swiss-Prot
    Q9H4K7
    Related
    ENSP00000359859.3, ENST00000370823.8
    Conserved Domains (1) summary
    TIGR02729
    Location:72385
    Obg_CgtA; Obg family GTPase CgtA

RNA

  1. NR_169197.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL078633
  2. NR_169198.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL078633
    Related
    ENST00000467101.5
  3. NR_169199.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL078633
  4. NR_169200.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL078633
  5. NR_169201.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL078633
  6. NR_169202.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL078633
  7. NR_169203.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL078633
  8. NR_169204.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL078633
  9. NR_169205.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL078633
  10. NR_169206.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL078633
  11. NR_169207.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL078633
  12. NR_169208.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL078633
  13. NR_169209.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL078633
  14. NR_169210.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL078633

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    62183028..62203568
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027808.1XP_016883297.1  mitochondrial ribosome-associated GTPase 2 isoform X5

  2. XM_024451869.1XP_024307637.1  mitochondrial ribosome-associated GTPase 2 isoform X2

    Conserved Domains (1) summary
    TIGR02729
    Location:88401
    Obg_CgtA; Obg family GTPase CgtA
  3. XM_017027806.1XP_016883295.1  mitochondrial ribosome-associated GTPase 2 isoform X3

    UniProtKB/Swiss-Prot
    Q9H4K7
    Conserved Domains (1) summary
    TIGR02729
    Location:72385
    Obg_CgtA; Obg family GTPase CgtA
  4. XM_017027807.1XP_016883296.1  mitochondrial ribosome-associated GTPase 2 isoform X4

  5. XM_017027805.1XP_016883294.1  mitochondrial ribosome-associated GTPase 2 isoform X1

  6. XM_011528776.1XP_011527078.1  mitochondrial ribosome-associated GTPase 2 isoform X3

    See identical proteins and their annotated locations for XP_011527078.1

    UniProtKB/Swiss-Prot
    Q9H4K7
    Conserved Domains (1) summary
    TIGR02729
    Location:72385
    Obg_CgtA; Obg family GTPase CgtA
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