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MTG2 mitochondrial ribosome associated GTPase 2 [ Homo sapiens (human) ]

Gene ID: 26164, updated on 5-Aug-2018

Summary

Official Symbol
MTG2provided by HGNC
Official Full Name
mitochondrial ribosome associated GTPase 2provided by HGNC
Primary source
HGNC:HGNC:16239
See related
Ensembl:ENSG00000101181 MIM:610919; Vega:OTTHUMG00000032897
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ObgH1; GTPBP5; dJ1005F21.2
Summary
Small G proteins, such as GTPBP5, act as molecular switches that play crucial roles in the regulation of fundamental cellular processes such as protein synthesis, nuclear transport, membrane trafficking, and signal transduction (Hirano et al., 2006 [PubMed 17054726]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in testis (RPKM 3.6), skin (RPKM 3.3) and 25 other tissues See more
Orthologs

Genomic context

See MTG2 in Genome Data Viewer
Location:
20q13.33
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 20 NC_000020.11 (62182746..62203568)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (60758081..60778624)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene proteasome subunit alpha 7 Neighboring gene SS18L1, nBAF chromatin remodeling complex subunit Neighboring gene histamine receptor H3 Neighboring gene putative uncharacterized protein FLJ44790

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10741, MGC29512

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IEA
Inferred from Electronic Annotation
more info
 
GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
regulation of mitochondrial translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of respiratory system process IMP
Inferred from Mutant Phenotype
more info
PubMed 
ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial ribosome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
mitochondrial ribosome-associated GTPase 2
Names
GTP binding protein 5 (putative)
GTP-binding protein 5
protein obg homolog 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015666.3NP_056481.1  mitochondrial ribosome-associated GTPase 2

    See identical proteins and their annotated locations for NP_056481.1

    Status: VALIDATED

    Source sequence(s)
    BC007885, BC036716, BI087669, BU857001, CB127579, DA970672
    Consensus CDS
    CCDS13492.1
    UniProtKB/Swiss-Prot
    Q9H4K7
    Related
    ENSP00000359859.3, OTTHUMP00000031457, ENST00000370823.7, OTTHUMT00000079989
    Conserved Domains (1) summary
    cl25666
    Location:72385
    HflX; 50S ribosomal subunit-associated GTPase HflX [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p12 Primary Assembly

    Range
    62182746..62203568
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451870.1XP_024307638.1  mitochondrial ribosome-associated GTPase 2 isoform X6

    Conserved Domains (1) summary
    cd01898
    Location:1157
    Obg; Obg GTPase
  2. XM_006723774.3XP_006723837.1  mitochondrial ribosome-associated GTPase 2 isoform X2

    Conserved Domains (1) summary
    cl25666
    Location:88401
    HflX; 50S ribosomal subunit-associated GTPase HflX [Translation, ribosomal structure and biogenesis]
  3. XM_017027808.1XP_016883297.1  mitochondrial ribosome-associated GTPase 2 isoform X5

  4. XM_005260393.1XP_005260450.1  mitochondrial ribosome-associated GTPase 2 isoform X3

    See identical proteins and their annotated locations for XP_005260450.1

    UniProtKB/Swiss-Prot
    Q9H4K7
    Conserved Domains (1) summary
    cl25666
    Location:72385
    HflX; 50S ribosomal subunit-associated GTPase HflX [Translation, ribosomal structure and biogenesis]
  5. XM_024451869.1XP_024307637.1  mitochondrial ribosome-associated GTPase 2 isoform X2

    Conserved Domains (1) summary
    cl25666
    Location:88401
    HflX; 50S ribosomal subunit-associated GTPase HflX [Translation, ribosomal structure and biogenesis]
  6. XM_017027806.1XP_016883295.1  mitochondrial ribosome-associated GTPase 2 isoform X3

    UniProtKB/Swiss-Prot
    Q9H4K7
    Conserved Domains (1) summary
    cl25666
    Location:72385
    HflX; 50S ribosomal subunit-associated GTPase HflX [Translation, ribosomal structure and biogenesis]
  7. XM_017027807.1XP_016883296.1  mitochondrial ribosome-associated GTPase 2 isoform X4

  8. XM_017027805.1XP_016883294.1  mitochondrial ribosome-associated GTPase 2 isoform X1

  9. XM_011528776.1XP_011527078.1  mitochondrial ribosome-associated GTPase 2 isoform X3

    See identical proteins and their annotated locations for XP_011527078.1

    UniProtKB/Swiss-Prot
    Q9H4K7
    Conserved Domains (1) summary
    cl25666
    Location:72385
    HflX; 50S ribosomal subunit-associated GTPase HflX [Translation, ribosomal structure and biogenesis]
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