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ADGRA2 adhesion G protein-coupled receptor A2 [ Homo sapiens (human) ]

Gene ID: 25960, updated on 22-Aug-2020

Summary

Official Symbol
ADGRA2provided by HGNC
Official Full Name
adhesion G protein-coupled receptor A2provided by HGNC
Primary source
HGNC:HGNC:17849
See related
Ensembl:ENSG00000020181 MIM:606823
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TEM5; GPR124
Expression
Broad expression in prostate (RPKM 39.9), fat (RPKM 36.6) and 23 other tissues See more
Orthologs

Genomic context

See ADGRA2 in Genome Data Viewer
Location:
8p11.23
Exon count:
19
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (37796883..37844896)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (37654401..37701504)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 13802 Neighboring gene pyridoxal phosphate binding protein Neighboring gene uncharacterized LOC105379381 Neighboring gene VISTA enhancer hs1665 Neighboring gene BRF2 RNA polymerase III transcription initiation factor subunit Neighboring gene RAB11 family interacting protein 1 Neighboring gene RNA, 7SL, cytoplasmic 709, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Loci at chromosomes 13, 19 and 20 influence age at natural menopause.
GeneReviews: Not available
Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14390, KIAA1531, DKFZp434C211, DKFZp434J0911

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
central nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
central nervous system development ISS
Inferred from Sequence or Structural Similarity
more info
 
endothelial cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of vascular endothelial growth factor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of endothelial cell migration IEA
Inferred from Electronic Annotation
more info
 
regulation of angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of establishment of blood-brain barrier ISS
Inferred from Sequence or Structural Similarity
more info
 
sprouting angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sprouting angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
Wnt signalosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Wnt signalosome IDA
Inferred from Direct Assay
more info
PubMed 
cell surface IEA
Inferred from Electronic Annotation
more info
 
filopodium IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
adhesion G protein-coupled receptor A2
Names
G-protein coupled receptor 124
tumor endothelial marker 5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032777.10NP_116166.9  adhesion G protein-coupled receptor A2 precursor

    See identical proteins and their annotated locations for NP_116166.9

    Status: VALIDATED

    Source sequence(s)
    AC130304, AC138356, AF378755, AI346793, AL110244, AY090637, DA569569
    Consensus CDS
    CCDS6097.2
    UniProtKB/Swiss-Prot
    Q96PE1
    UniProtKB/TrEMBL
    Q6YN44
    Related
    ENSP00000406367.2, ENST00000412232.3
    Conserved Domains (8) summary
    smart00082
    Location:192227
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:87190
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:86109
    LRR_1; leucine-rich repeat [structural motif]
    pfam01825
    Location:708752
    GPS; GPCR proteolysis site, GPS, motif
    pfam13855
    Location:88144
    LRR_8; Leucine rich repeat
    cl02422
    Location:351417
    HRM; Hormone receptor domain
    cl11960
    Location:257343
    Ig; Immunoglobulin domain
    cl21561
    Location:778946
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    37796883..37844896
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544481.2XP_011542783.1  adhesion G protein-coupled receptor A2 isoform X1

    Conserved Domains (8) summary
    smart00082
    Location:192227
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:87190
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:86109
    LRR_1; leucine-rich repeat [structural motif]
    pfam01825
    Location:708752
    GPS; GPCR proteolysis site, GPS, motif
    pfam13855
    Location:88144
    LRR_8; Leucine rich repeat
    cl02422
    Location:351417
    HRM; Hormone receptor domain
    cl11960
    Location:257343
    Ig; Immunoglobulin domain
    cl21561
    Location:778969
    7tm_4; Olfactory receptor
  2. XM_011544483.2XP_011542785.1  adhesion G protein-coupled receptor A2 isoform X3

    See identical proteins and their annotated locations for XP_011542785.1

    UniProtKB/TrEMBL
    D3DSW5
    Conserved Domains (8) summary
    smart00082
    Location:192227
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:87190
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:86109
    LRR_1; leucine-rich repeat [structural motif]
    pfam01825
    Location:708752
    GPS; GPCR proteolysis site, GPS, motif
    pfam13855
    Location:88144
    LRR_8; Leucine rich repeat
    cl02422
    Location:351417
    HRM; Hormone receptor domain
    cl11960
    Location:257343
    Ig; Immunoglobulin domain
    cl21561
    Location:778916
    7tm_4; Olfactory receptor
  3. XM_011544482.2XP_011542784.1  adhesion G protein-coupled receptor A2 isoform X2

    Conserved Domains (8) summary
    smart00082
    Location:168203
    LRRCT; Leucine rich repeat C-terminal domain
    sd00031
    Location:88109
    LRR_1; leucine-rich repeat [structural motif]
    pfam01825
    Location:684728
    GPS; GPCR proteolysis site, GPS, motif
    pfam12799
    Location:110149
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:88142
    LRR_8; Leucine rich repeat
    cl02422
    Location:327393
    HRM; Hormone receptor domain
    cl11960
    Location:233319
    Ig; Immunoglobulin domain
    cl21561
    Location:754945
    7tm_4; Olfactory receptor
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