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RWDD3 RWD domain containing 3 [ Homo sapiens (human) ]

Gene ID: 25950, updated on 8-Jul-2018
Official Symbol
RWDD3provided by HGNC
Official Full Name
RWD domain containing 3provided by HGNC
Primary source
HGNC:HGNC:21393
See related
Ensembl:ENSG00000122481 MIM:615875; Vega:OTTHUMG00000010910
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RSUME
Expression
Ubiquitous expression in prostate (RPKM 8.1), endometrium (RPKM 7.8) and 25 other tissues See more
Orthologs
See RWDD3 in Genome Data Viewer
Location:
1p21.3
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (95234155..95247225)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (95699711..95712781)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ALG14, UDP-N-acetylglucosaminyltransferase subunit Neighboring gene uncharacterized LOC101928098 Neighboring gene TMEM56-RWDD3 readthrough Neighboring gene transmembrane protein 56 Neighboring gene uncharacterized LOC101928118 Neighboring gene uncharacterized LOC105378864 Neighboring gene uncharacterized LOC105379825 Neighboring gene long intergenic non-protein coding RNA 1760

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortiu
NHGRI GWA Catalog
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Post-translational protein modification, organism-specific biosystem (from REACTOME)
    Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
  • Processing and activation of SUMO, organism-specific biosystem (from REACTOME)
    Processing and activation of SUMO, organism-specific biosystemThe initial translation products of SUMO1, SUMO2, and SUMO3 are precursors that have extra amino acid residues at the C-terminus (reviewed in Wang and Dasso 2009, Wilkinson and Henley 2010, Hannoun ...
  • SUMO is transferred from E1 to E2 (UBE2I, UBC9), organism-specific biosystem (from REACTOME)
    SUMO is transferred from E1 to E2 (UBE2I, UBC9), organism-specific biosystemSUMO is transferred from cysteine-173 of UBA2 to cysteine-93 of UBC9 (UBE2I) in a transthiolation reaction (reviewed in Wang and Dasso 2009, Wilkinson and Henley 2010, Hannoun et al. 2010, Gareau and...
  • SUMOylation, organism-specific biosystem (from REACTOME)
    SUMOylation, organism-specific biosystemSmall Ubiquitin-like MOdifiers (SUMOs) are a family of 3 proteins (SUMO1,2,3) that are reversibly conjugated to lysine residues of target proteins via a glycine-lysine isopeptide bond (reviewed in Ha...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Readthrough TMEM56-RWDD3

Readthrough gene: TMEM56-RWDD3, Included gene: TMEM56

Homology

Clone Names

  • FLJ51225, DKFZp566K023

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
RWD domain-containing protein 3
Names
RWD domain-containing sumoylation enhancer
RWD-containing sumoylation enhancer

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128142.1NP_001121614.1  RWD domain-containing protein 3 isoform b

    See identical proteins and their annotated locations for NP_001121614.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site and lacks an alternate exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (b) is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AA825527, AK292699, AL050062, CN306675
    Consensus CDS
    CCDS44177.1
    UniProtKB/Swiss-Prot
    Q9Y3V2
    UniProtKB/TrEMBL
    D3DT49
    Related
    ENSP00000263893.6, OTTHUMP00000012585, ENST00000263893.10, OTTHUMT00000030077
    Conserved Domains (1) summary
    pfam05773
    Location:1111
    RWD; RWD domain
  2. NM_001199682.1NP_001186611.1  RWD domain-containing protein 3 isoform c

    See identical proteins and their annotated locations for NP_001186611.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site, which results in a frameshift, compared to variant 1. The encoded isoform (c) is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AA336662, AA825527, BC065813, DC409838
    Conserved Domains (1) summary
    pfam05773
    Location:1111
    RWD; RWD domain
  3. NM_001278247.1NP_001265176.1  RWD domain-containing protein 3 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains multiple differences compared to variant 1, including containing an alternate exon in the 5' region. It initiates translation at an alternate start site. The encoded isoform (d) is shorter and has distinct N- and C- termini, compared to isoform a.
    Source sequence(s)
    AA336662, AA825527, BC125142, DC409838
    UniProtKB/Swiss-Prot
    Q9Y3V2
    Conserved Domains (1) summary
    pfam05773
    Location:2096
    RWD; RWD domain
  4. NM_001278248.1NP_001265177.1  RWD domain-containing protein 3 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) contains an alternate exon in the 5' region, and initiates translation at an alternate start site, compared to variant 1. The encoded isoform (e) is shorter and has a distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AA825527, BC125142, CA454169, CN306675, DC409838
    UniProtKB/Swiss-Prot
    Q9Y3V2
    Conserved Domains (1) summary
    pfam05773
    Location:2096
    RWD; RWD domain
  5. NM_015485.4NP_056300.2  RWD domain-containing protein 3 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AA336253, AA825527, BU858771, DC409838
    Consensus CDS
    CCDS41357.1
    Related
    ENSP00000359221.4, OTTHUMP00000012586, ENST00000370202.4, OTTHUMT00000030078
    Conserved Domains (1) summary
    pfam05773
    Location:1111
    RWD; RWD domain

RNA

  1. NR_103483.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses an alternate splice site at an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA825527, BC010936, CN306675, DC409838
    Related
    ENST00000495272.5
  2. NR_103484.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) contains multiple differences in the internal exons, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region found in variant 1.
    Source sequence(s)
    AA825527, BC016307, BC125142, DC409838
    Related
    ENST00000497058.5

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    95234155..95247225
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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