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RWDD3 RWD domain containing 3 [ Homo sapiens (human) ]

Gene ID: 25950, updated on 23-Nov-2021

Summary

Official Symbol
RWDD3provided by HGNC
Official Full Name
RWD domain containing 3provided by HGNC
Primary source
HGNC:HGNC:21393
See related
Ensembl:ENSG00000122481 MIM:615875
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RSUME
Expression
Ubiquitous expression in prostate (RPKM 8.1), endometrium (RPKM 7.8) and 25 other tissues See more
Orthologs
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Genomic context

See RWDD3 in Genome Data Viewer
Location:
1p21.3
Exon count:
5
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (95234155..95247225)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (95699711..95712781)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene TLC domain containing 4 Neighboring gene CRISPRi-validated cis-regulatory element chr1.7359 Neighboring gene TLCD4-RWDD3 readthrough Neighboring gene RWDD3 divergent transcript Neighboring gene uncharacterized LOC105378864 Neighboring gene uncharacterized LOC105379825 Neighboring gene long intergenic non-protein coding RNA 1760

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortiu
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough TLCD4-RWDD3

Readthrough gene: TLCD4-RWDD3, Included gene: TLCD4

Homology

Clone Names

  • FLJ51225, DKFZp566K023

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
RWD domain-containing protein 3
Names
RWD domain-containing sumoylation enhancer
RWD-containing sumoylation enhancer

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128142.2NP_001121614.2  RWD domain-containing protein 3 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site and lacks an alternate exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (b) is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AC092802
    Consensus CDS
    CCDS44177.1
    Related
    ENSP00000263893.6, ENST00000263893.10
    Conserved Domains (1) summary
    smart00591
    Location:8114
    RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
  2. NM_001199682.2NP_001186611.2  RWD domain-containing protein 3 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site, which results in a frameshift, compared to variant 1. The encoded isoform (c) is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AC092802
    Conserved Domains (1) summary
    smart00591
    Location:8114
    RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
  3. NM_001278247.2NP_001265176.2  RWD domain-containing protein 3 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains multiple differences compared to variant 1, including containing an alternate exon in the 5' region. It initiates translation at an alternate start site. The encoded isoform (d) is shorter and has distinct N- and C- termini, compared to isoform a.
    Source sequence(s)
    AC092802
    Conserved Domains (1) summary
    smart00591
    Location:199
    RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
  4. NM_001278248.2NP_001265177.2  RWD domain-containing protein 3 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) contains an alternate exon in the 5' region, and initiates translation at an alternate start site, compared to variant 1. The encoded isoform (e) is shorter and has a distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AC092802
    Related
    ENST00000495272.5
    Conserved Domains (1) summary
    smart00591
    Location:199
    RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
  5. NM_015485.5NP_056300.3  RWD domain-containing protein 3 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC092802
    Consensus CDS
    CCDS41357.1
    Related
    ENSP00000359221.4, ENST00000370202.5
    Conserved Domains (1) summary
    smart00591
    Location:8114
    RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain

RNA

  1. NR_103483.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses an alternate splice site at an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC092802
  2. NR_103484.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) contains multiple differences in the internal exons, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region found in variant 1.
    Source sequence(s)
    AA825527, BC016307, BC125142, DC409838
    Related
    ENST00000497058.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    95234155..95247225
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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