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TLCD4 TLC domain containing 4 [ Homo sapiens (human) ]

Gene ID: 148534, updated on 12-Oct-2019

Summary

Official Symbol
TLCD4provided by HGNC
Official Full Name
TLC domain containing 4provided by HGNC
Primary source
HGNC:HGNC:26477
See related
Ensembl:ENSG00000152078
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TMEM56
Expression
Broad expression in liver (RPKM 27.2), heart (RPKM 9.3) and 19 other tissues See more
Orthologs

Genomic context

See TLCD4 in Genome Data Viewer
Location:
1p21.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (95092517..95197607)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (95582894..95663163)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ALG14 UDP-N-acetylglucosaminyltransferase subunit Neighboring gene uncharacterized LOC105378863 Neighboring gene ALG14 antisense RNA 1 Neighboring gene TLCD4-RWDD3 readthrough Neighboring gene uncharacterized LOC101928118 Neighboring gene RWD domain containing 3 Neighboring gene uncharacterized LOC105378864 Neighboring gene long intergenic non-protein coding RNA 1760

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortiu
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough TLCD4-RWDD3

Readthrough gene: TLCD4-RWDD3, Included gene: RWDD3

Homology

Clone Names

  • FLJ31842, MGC102912

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
TLC domain-containing protein 4
Names
transmembrane protein 56

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199679.1NP_001186608.1  TLC domain-containing protein 4

    See identical proteins and their annotated locations for NP_001186608.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC092802, AC095033, AK126344, BC108263, BC139737, BQ575814
    Consensus CDS
    CCDS753.1
    UniProtKB/Swiss-Prot
    Q96MV1
    Conserved Domains (1) summary
    smart00724
    Location:44246
    TLC; TRAM, LAG1 and CLN8 homology domains
  2. NM_152487.3NP_689700.1  TLC domain-containing protein 4

    See identical proteins and their annotated locations for NP_689700.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC092802, AC095033
    Consensus CDS
    CCDS753.1
    UniProtKB/Swiss-Prot
    Q96MV1
    Related
    ENSP00000359222.4, ENST00000370203.9
    Conserved Domains (1) summary
    smart00724
    Location:44246
    TLC; TRAM, LAG1 and CLN8 homology domains

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    95092517..95197607
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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