Format

Send to:

Choose Destination

TLCD4-RWDD3 TLCD4-RWDD3 readthrough [ Homo sapiens (human) ]

Gene ID: 100527978, updated on 25-Jan-2022

Summary

Official Symbol
TLCD4-RWDD3provided by HGNC
Official Full Name
TLCD4-RWDD3 readthroughprovided by HGNC
Primary source
HGNC:HGNC:49388
See related
Ensembl:ENSG00000271092 AllianceGenome:HGNC:49388
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TMEM56-RWDD3
Summary
This locus represents naturally occurring read-through transcription between the neighboring TMEM56 (transmembrane protein 56) and RWDD3 (RWD domain containing 3) genes on chromosome 1. The read-through transcript encodes a protein that shares sequence identity with the upstream gene product, but it contains a distinct C-terminus due to frameshifts versus the downstream gene coding sequence. [provided by RefSeq, Dec 2010]
Expression
Ubiquitous expression in liver (RPKM 11.5), heart (RPKM 6.5) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See TLCD4-RWDD3 in Genome Data Viewer
Location:
1p21.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (95117923..95244955)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (95583479..95710511)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr1.7358 Neighboring gene TLC domain containing 4 Neighboring gene CRISPRi-validated cis-regulatory element chr1.7359 Neighboring gene RWDD3 divergent transcript Neighboring gene RWD domain containing 3 Neighboring gene Sharpr-MPRA regulatory region 5488 Neighboring gene uncharacterized LOC105378864 Neighboring gene long intergenic non-protein coding RNA 1760

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortiu
EBI GWAS Catalog
Genome-wide association study identifies variants associated with histologic features of nonalcoholic Fatty liver disease.
EBI GWAS Catalog

General protein information

Preferred Names
TMEM56-RWDD3 protein
Names
TMEM56-RWDD3 readthrough

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199691.1NP_001186620.1  TMEM56-RWDD3 protein

    Status: VALIDATED

    Source sequence(s)
    AC092802, BC063464
    UniProtKB/TrEMBL
    S4R434
    Related
    ENSP00000475025.1, ENST00000604534.5
    Conserved Domains (1) summary
    cl02759
    Location:44158
    TRAM_LAG1_CLN8; TLC domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    95117923..95244955
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center