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ZNF385A zinc finger protein 385A [ Homo sapiens (human) ]

Gene ID: 25946, updated on 4-Oct-2020

Summary

Official Symbol
ZNF385Aprovided by HGNC
Official Full Name
zinc finger protein 385Aprovided by HGNC
Primary source
HGNC:HGNC:17521
See related
Ensembl:ENSG00000161642 MIM:609124
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HZF; RZF; ZFP385; ZNF385
Summary
Zinc finger proteins, such as ZNF385A, are regulatory proteins that act as transcription factors, bind single- or double-stranded RNA, or interact with other proteins (Sharma et al., 2004 [PubMed 15527981]).[supplied by OMIM, Oct 2008]
Expression
Broad expression in skin (RPKM 29.1), fat (RPKM 16.9) and 19 other tissues See more
Orthologs

Genomic context

See ZNF385A in Genome Data Viewer
Location:
12q13.13
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (54369134..54391610, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (54762913..54785083, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene COPI coat complex subunit zeta 1 Neighboring gene RNA, 7SL, cytoplasmic 744, pseudogene Neighboring gene uncharacterized LOC102724050 Neighboring gene G protein-coupled receptor 84 Neighboring gene integrin subunit alpha 5 Neighboring gene gametocyte specific factor 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp586G1122

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding HDA PubMed 
mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mRNA 3'-UTR binding ISS
Inferred from Sequence or Structural Similarity
more info
 
p53 binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
Traceable Author Statement
more info
 
apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to DNA damage stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
hemostasis IEA
Inferred from Electronic Annotation
more info
 
learning or memory IEA
Inferred from Electronic Annotation
more info
 
locomotory behavior IEA
Inferred from Electronic Annotation
more info
 
mRNA localization resulting in posttranscriptional regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mRNA localization resulting in posttranscriptional regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
megakaryocyte development ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
PubMed 
platelet alpha granule organization IEA
Inferred from Electronic Annotation
more info
 
platelet formation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cytoplasmic translation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of signal transduction by p53 class mediator TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuronal cell body ISS
Inferred from Sequence or Structural Similarity
more info
 
colocalizes_with nuclear chromatin IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
zinc finger protein 385A
Names
hematopoietic zinc finger protein
retinal zinc finger protein
zinc finger protein 385

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130967.3NP_001124439.1  zinc finger protein 385A isoform a

    See identical proteins and their annotated locations for NP_001124439.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AL117462, BC029752, BM546460
    Consensus CDS
    CCDS44911.1
    UniProtKB/Swiss-Prot
    Q96PM9
    Related
    ENSP00000338927.5, ENST00000338010.9
    Conserved Domains (2) summary
    sd00020
    Location:203225
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:262285
    zf-met; Zinc-finger of C2H2 type
  2. NM_001130968.3NP_001124440.1  zinc finger protein 385A isoform b

    See identical proteins and their annotated locations for NP_001124440.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AK024404, AK296564, AL117462, BC029752, BM546460
    Consensus CDS
    CCDS44910.1
    UniProtKB/Swiss-Prot
    Q96PM9
    UniProtKB/TrEMBL
    A0A024RB56
    Related
    ENSP00000293385.9, ENST00000352268.10
    Conserved Domains (2) summary
    sd00020
    Location:182204
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:181204
    zf-met; Zinc-finger of C2H2 type
  3. NM_001290001.2NP_001276930.1  zinc finger protein 385A isoform d

    See identical proteins and their annotated locations for NP_001276930.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' and 3' coding region, and initiates translation at a downstream start codon, compared to variant 1. The resulting isoform (d) is shorter, compared to isoform a.
    Source sequence(s)
    AC079313, AF304052, AK296564, BP305142
    Consensus CDS
    CCDS76563.1
    UniProtKB/Swiss-Prot
    Q96PM9
    Related
    ENSP00000447162.1, ENST00000551771.5
    Conserved Domains (2) summary
    sd00020
    Location:162184
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:160184
    zf-met; Zinc-finger of C2H2 type
  4. NM_001290002.2NP_001276931.1  zinc finger protein 385A isoform c

    See identical proteins and their annotated locations for NP_001276931.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding reigon, and initiates translation at a downstream start codon, compared to variant 1. The resulting isoform (c) has a shorter N-terminus, compared to isoform a. Variants 3, 5, and 6 encode the same protein (isoform c).
    Source sequence(s)
    AL117462, AY461717, DB169664
    Consensus CDS
    CCDS8879.1
    UniProtKB/Swiss-Prot
    Q96PM9
    Related
    ENSP00000446913.1, ENST00000546970.5
    Conserved Domains (2) summary
    sd00020
    Location:183205
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:242265
    zf-met; Zinc-finger of C2H2 type
  5. NM_001290004.2NP_001276933.1  zinc finger protein 385A isoform c

    See identical proteins and their annotated locations for NP_001276933.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The resulting isoform (c) has a shorter N-terminus, compared to isoform a. Variants 3, 5, and 6 encode the same protein (isoform c).
    Source sequence(s)
    AB593085, BM476090, DB169664
    Consensus CDS
    CCDS8879.1
    UniProtKB/Swiss-Prot
    Q96PM9
    Conserved Domains (2) summary
    sd00020
    Location:183205
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:242265
    zf-met; Zinc-finger of C2H2 type
  6. NM_015481.3NP_056296.1  zinc finger protein 385A isoform c

    See identical proteins and their annotated locations for NP_056296.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The resulting isoform (c) has a shorter N-terminus, compared to isoform a. Variants 3, 5, and 6 encode the same protein (isoform c).
    Source sequence(s)
    AC079313, AF304052, BP305142
    Consensus CDS
    CCDS8879.1
    UniProtKB/Swiss-Prot
    Q96PM9
    Related
    ENSP00000377849.2, ENST00000394313.6
    Conserved Domains (2) summary
    sd00020
    Location:183205
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:242265
    zf-met; Zinc-finger of C2H2 type

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    54369134..54391610 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011538171.3XP_011536473.1  zinc finger protein 385A isoform X5

    Conserved Domains (2) summary
    sd00020
    Location:215237
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:214237
    zf-met; Zinc-finger of C2H2 type
  2. XM_011538169.2XP_011536471.1  zinc finger protein 385A isoform X2

    Conserved Domains (2) summary
    sd00020
    Location:199221
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:258281
    zf-met; Zinc-finger of C2H2 type
  3. XM_011538168.2XP_011536470.1  zinc finger protein 385A isoform X1

    Conserved Domains (2) summary
    sd00020
    Location:236258
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:295318
    zf-met; Zinc-finger of C2H2 type
  4. XM_011538170.1XP_011536472.1  zinc finger protein 385A isoform X4

    Conserved Domains (2) summary
    sd00020
    Location:166188
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:225248
    zf-met; Zinc-finger of C2H2 type
  5. XM_024448934.1XP_024304702.1  zinc finger protein 385A isoform X6

    Conserved Domains (2) summary
    sd00020
    Location:162184
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:160184
    zf-met; Zinc-finger of C2H2 type
  6. XM_006719342.2XP_006719405.1  zinc finger protein 385A isoform X3

    See identical proteins and their annotated locations for XP_006719405.1

    UniProtKB/Swiss-Prot
    Q96PM9
    Conserved Domains (2) summary
    sd00020
    Location:183205
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:242265
    zf-met; Zinc-finger of C2H2 type
  7. XM_024448936.1XP_024304704.1  zinc finger protein 385A isoform X7

    Conserved Domains (2) summary
    sd00020
    Location:125147
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:123147
    zf-met; Zinc-finger of C2H2 type
  8. XM_005268783.4XP_005268840.1  zinc finger protein 385A isoform X3

    See identical proteins and their annotated locations for XP_005268840.1

    UniProtKB/Swiss-Prot
    Q96PM9
    Related
    ENSP00000449161.1, ENST00000551109.5
    Conserved Domains (2) summary
    sd00020
    Location:183205
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:242265
    zf-met; Zinc-finger of C2H2 type
  9. XM_024448935.1XP_024304703.1  zinc finger protein 385A isoform X6

    Conserved Domains (2) summary
    sd00020
    Location:162184
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:160184
    zf-met; Zinc-finger of C2H2 type
  10. XM_017019174.1XP_016874663.1  zinc finger protein 385A isoform X3

    UniProtKB/Swiss-Prot
    Q96PM9
    Conserved Domains (2) summary
    sd00020
    Location:183205
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:242265
    zf-met; Zinc-finger of C2H2 type
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