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Zfp385a zinc finger protein 385A [ Mus musculus (house mouse) ]

Gene ID: 29813, updated on 26-Sep-2022

Summary

Official Symbol
Zfp385aprovided by MGI
Official Full Name
zinc finger protein 385Aprovided by MGI
Primary source
MGI:MGI:1352495
See related
Ensembl:ENSMUSG00000000552 AllianceGenome:MGI:1352495
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hzf; Zfp385; Znf385a
Summary
Enables mRNA 3'-UTR binding activity. Involved in apoptotic process and cellular response to DNA damage stimulus. Acts upstream of or within several processes, including myeloid cell differentiation; platelet alpha granule organization; and posttranscriptional regulation of gene expression. Located in dendrite and neuronal cell body. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Orthologous to human ZNF385A (zinc finger protein 385A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 30.8), cerebellum adult (RPKM 17.9) and 27 other tissues See more
Orthologs
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Genomic context

See Zfp385a in Genome Data Viewer
Location:
15; 15 F3
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (103222322..103248513, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (103313895..103340086, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene coatomer protein complex, subunit zeta 1 Neighboring gene predicted gene, 41406 Neighboring gene G protein-coupled receptor 84 Neighboring gene integrin alpha 5 (fibronectin receptor alpha) Neighboring gene microRNA 6963 Neighboring gene gametocyte specific factor 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables p53 binding ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to DNA damage stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hemostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within intracellular mRNA localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within learning or memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mRNA localization resulting in post-transcriptional regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within mRNA localization resulting in post-transcriptional regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within megakaryocyte development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in megakaryocyte development NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within platelet alpha granule organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within platelet formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of cytoplasmic translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of translation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 385A
Names
hematopoietic zinc finger protein
zinc finger protein 385

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356627.2NP_001343556.1  zinc finger protein 385A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC164069
    Consensus CDS
    CCDS88860.1
    Related
    ENSMUSP00000155498.2, ENSMUST00000229373.2
    Conserved Domains (2) summary
    sd00020
    Location:183205
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:241265
    zf-met; Zinc-finger of C2H2 type
  2. NM_001411887.1NP_001398816.1  zinc finger protein 385A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC164069
  3. NM_001411888.1NP_001398817.1  zinc finger protein 385A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC164069
  4. NM_001411889.1NP_001398818.1  zinc finger protein 385A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC164069
  5. NM_013866.3NP_038894.2  zinc finger protein 385A isoform 1

    See identical proteins and their annotated locations for NP_038894.2

    Status: VALIDATED

    Source sequence(s)
    AC164069
    Consensus CDS
    CCDS49743.1
    UniProtKB/Swiss-Prot
    Q8VD12, Q9QY68
    Related
    ENSMUSP00000130176.2, ENSMUST00000168828.3
    Conserved Domains (2) summary
    sd00020
    Location:203225
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:262285
    zf-met; Zinc-finger of C2H2 type

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    103222322..103248513 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159455.1XP_036015348.1  zinc finger protein 385A isoform X2

    Conserved Domains (2) summary
    sd00020
    Location:183205
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:241265
    zf-met; Zinc-finger of C2H2 type
  2. XM_006521053.4XP_006521116.1  zinc finger protein 385A isoform X2

    See identical proteins and their annotated locations for XP_006521116.1

    UniProtKB/Swiss-Prot
    Q8VD12
    Conserved Domains (2) summary
    sd00020
    Location:183205
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:241265
    zf-met; Zinc-finger of C2H2 type
  3. XM_011245656.4XP_011243958.1  zinc finger protein 385A isoform X2

    See identical proteins and their annotated locations for XP_011243958.1

    UniProtKB/Swiss-Prot
    Q8VD12
    Conserved Domains (2) summary
    sd00020
    Location:183205
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:241265
    zf-met; Zinc-finger of C2H2 type
  4. XM_006521054.5XP_006521117.1  zinc finger protein 385A isoform X3

    UniProtKB/TrEMBL
    A0A2R8VHX5
    Related
    ENSMUSP00000155501.2, ENSMUST00000229551.2
    Conserved Domains (2) summary
    sd00020
    Location:164186
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:223246
    zf-met; Zinc-finger of C2H2 type
  5. XM_006521056.3XP_006521119.1  zinc finger protein 385A isoform X4

    See identical proteins and their annotated locations for XP_006521119.1

    Conserved Domains (2) summary
    sd00020
    Location:154176
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:213236
    zf-met; Zinc-finger of C2H2 type
  6. XM_036159454.1XP_036015347.1  zinc finger protein 385A isoform X1

    Conserved Domains (2) summary
    sd00020
    Location:236258
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:294318
    zf-met; Zinc-finger of C2H2 type
  7. XM_006521055.5XP_006521118.1  zinc finger protein 385A isoform X4

    See identical proteins and their annotated locations for XP_006521118.1

    Conserved Domains (2) summary
    sd00020
    Location:154176
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:213236
    zf-met; Zinc-finger of C2H2 type