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OLFML2B olfactomedin like 2B [ Homo sapiens (human) ]

Gene ID: 25903, updated on 5-Sep-2021

Summary

Official Symbol
OLFML2Bprovided by HGNC
Official Full Name
olfactomedin like 2Bprovided by HGNC
Primary source
HGNC:HGNC:24558
See related
Ensembl:ENSG00000162745
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes an olfactomedin domain-containing protein. Most olfactomedin domain-containing proteins are secreted glycoproteins. [provided by RefSeq, Dec 2016]
Expression
Broad expression in gall bladder (RPKM 9.8), placenta (RPKM 5.9) and 16 other tissues See more
Orthologs
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Genomic context

See OLFML2B in Genome Data Viewer
Location:
1q23.3
Exon count:
10
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (161983192..162023869, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (161952982..161993659, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATF6 divergent transcript Neighboring gene activating transcription factor 6 Neighboring gene proteasome activator subunit 3 pseudogene Neighboring gene uncharacterized LOC105371475 Neighboring gene nitric oxide synthase 1 adaptor protein Neighboring gene Sharpr-MPRA regulatory region 2282 Neighboring gene microRNA 4654

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Common genetic variation near the phospholamban gene is associated with cardiac repolarisation: meta-analysis of three genome-wide association studies.
GeneReviews: Not available
Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.
GeneReviews: Not available
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
GeneReviews: Not available
Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women.
GeneReviews: Not available

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of olfactomedin-like 2B (OLFML2B) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC51337

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables extracellular matrix binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in extracellular matrix organization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular matrix IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
olfactomedin-like protein 2B
Names
photomedin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052853.1 RefSeqGene

    Range
    5001..46274
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001297713.2NP_001284642.1  olfactomedin-like protein 2B isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) uses an alternate in-frame splice site in the 5' coding region, compared to variant 3. The encoded isoform (1) is shorter than isoform 3.
    Source sequence(s)
    AK301499, AK316154, AL590408, BC067274
    Consensus CDS
    CCDS72966.1
    UniProtKB/Swiss-Prot
    Q68BL8
    UniProtKB/TrEMBL
    B4DWE8, F2Z3N3
    Related
    ENSP00000356917.2, ENST00000367940.2
    Conserved Domains (1) summary
    pfam02191
    Location:499747
    OLF; Olfactomedin-like domain
  2. NM_001347700.2NP_001334629.1  olfactomedin-like protein 2B isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
    Source sequence(s)
    AL391825, AL590408, BC067274
    UniProtKB/Swiss-Prot
    Q68BL8
  3. NM_015441.3NP_056256.1  olfactomedin-like protein 2B isoform 2 precursor

    See identical proteins and their annotated locations for NP_056256.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 3. The encoded isoform (2) is shorter than isoform 3.
    Source sequence(s)
    AL391825, AL590408, BC067274
    Consensus CDS
    CCDS1236.1
    UniProtKB/Swiss-Prot
    Q68BL8
    Related
    ENSP00000294794.3, ENST00000294794.8
    Conserved Domains (3) summary
    pfam02191
    Location:498746
    OLF; Olfactomedin-like domain
    pfam06785
    Location:125252
    UPF0242; Uncharacterized protein family (UPF0242)
    cl25496
    Location:349481
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    161983192..162023869 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011509398.2XP_011507700.1  olfactomedin-like protein 2B isoform X2

    Conserved Domains (1) summary
    pfam02191
    Location:258506
    OLF; Olfactomedin-like domain
  2. XM_017000967.2XP_016856456.1  olfactomedin-like protein 2B isoform X1

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