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ABTB2 ankyrin repeat and BTB domain containing 2 [ Homo sapiens (human) ]

Gene ID: 25841, updated on 1-Jun-2020

Summary

Official Symbol
ABTB2provided by HGNC
Official Full Name
ankyrin repeat and BTB domain containing 2provided by HGNC
Primary source
HGNC:HGNC:23842
See related
Ensembl:ENSG00000166016
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ABTB2A; BTBD22
Expression
Ubiquitous expression in kidney (RPKM 5.3), adrenal (RPKM 5.3) and 24 other tissues See more
Orthologs

Genomic context

See ABTB2 in Genome Data Viewer
Location:
11p13
Exon count:
17
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (34150987..34358010, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (34172534..34379555, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929918 Neighboring gene cell cycle associated protein 1 Neighboring gene N-acetyltransferase 10 Neighboring gene uncharacterized LOC102723539 Neighboring gene MMADHC pseudogene 2 Neighboring gene CRISPRi-validated cis-regulatory element chr11.1764 Neighboring gene CIR1 pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif upregulates the expression of ankyrin repeat and BTB/POZ domain- containing protein 2 (ABTB2) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp586C1619

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cellular response to toxic substance IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
ankyrin repeat and BTB/POZ domain-containing protein 2
Names
ankyrin repeat and BTB (POZ) domain containing 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145804.3NP_665803.2  ankyrin repeat and BTB/POZ domain-containing protein 2

    See identical proteins and their annotated locations for NP_665803.2

    Status: VALIDATED

    Source sequence(s)
    AC090469, AK291744, AL035079, AL050374
    Consensus CDS
    CCDS7890.2
    UniProtKB/Swiss-Prot
    Q8N961
    Related
    ENSP00000410157.2, ENST00000435224.3
    Conserved Domains (8) summary
    smart00225
    Location:846947
    BTB; Broad-Complex, Tramtrack and Bric a brac
    cd00204
    Location:516670
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd14821
    Location:947991
    SPOP_C_like; BACK-like Domain C-terminal to BTB in speckle-type POZ protein (SPOP) and similar proteins
    pfam00651
    Location:837940
    BTB; BTB/POZ domain
    pfam12796
    Location:526633
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:498542
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:524565
    ANK; ANK repeat [structural motif]
    cl23907
    Location:194242
    H2A; Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    34150987..34358010 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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