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SUN2 Sad1 and UNC84 domain containing 2 [ Homo sapiens (human) ]

Gene ID: 25777, updated on 17-Jun-2019

Summary

Official Symbol
SUN2provided by HGNC
Official Full Name
Sad1 and UNC84 domain containing 2provided by HGNC
Primary source
HGNC:HGNC:14210
See related
Ensembl:ENSG00000100242 MIM:613569
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UNC84B
Summary
SUN1 (MIM 607723) and SUN2 are inner nuclear membrane (INM) proteins that play a major role in nuclear-cytoplasmic connection by formation of a 'bridge' across the nuclear envelope, known as the LINC complex, via interaction with the conserved luminal KASH domain of nesprins (e.g., SYNE1; MIM 608441) located in the outer nuclear membrane (ONM). The LINC complex provides a direct connection between the nuclear lamina and the cytoskeleton, which contributes to nuclear positioning and cellular rigidity (summary by Haque et al., 2010 [PubMed 19933576]).[supplied by OMIM, Nov 2010]
Expression
Ubiquitous expression in fat (RPKM 47.2), bone marrow (RPKM 33.2) and 25 other tissues See more
Orthologs

Genomic context

See SUN2 in Genome Data Viewer
Location:
22q13.1
Exon count:
22
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (38734727..38756014, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (39130719..39162338, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene translocase of outer mitochondrial membrane 22 Neighboring gene Josephin domain containing 1 Neighboring gene GTP binding protein 1 Neighboring gene peroxiredoxin 3 pseudogene 1 Neighboring gene dynein axonemal light chain 4 Neighboring gene neuronal pentraxin receptor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 replication, specifically nuclear import, is inhibited by SUN2 overexpression as it changes nuclear shape in cell lines and primary cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Cell Cycle, organism-specific biosystem (from REACTOME)
    Cell Cycle, organism-specific biosystem
    Cell Cycle
  • Meiosis, organism-specific biosystem (from REACTOME)
    Meiosis, organism-specific biosystemDuring meiosis the replicated chromosomes of a single diploid cell are segregated into 4 haploid daughter cells by two successive divisions, meiosis I and meiosis II. In meiosis I, the distinguishing...
  • Meiotic synapsis, organism-specific biosystem (from REACTOME)
    Meiotic synapsis, organism-specific biosystemMeiotic synapsis is the stable physical pairing of homologous chromosomes that begins in leptonema of prophase I and lasts until anaphase of prophase I. First, short segments of axial elements form a...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0668, MGC133055, MGC133056

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
lamin binding IDA
Inferred from Direct Assay
more info
PubMed 
microtubule binding TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein membrane anchor IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
centrosome localization ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoskeletal anchoring at nuclear membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoskeletal anchoring at nuclear membrane IDA
Inferred from Direct Assay
more info
PubMed 
meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
mitotic spindle organization TAS
Traceable Author Statement
more info
PubMed 
nuclear envelope organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear envelope organization IGI
Inferred from Genetic Interaction
more info
PubMed 
nuclear matrix anchoring at nuclear membrane IDA
Inferred from Direct Assay
more info
PubMed 
nuclear migration TAS
Traceable Author Statement
more info
PubMed 
nuclear migration along microfilament ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
condensed nuclear chromosome IEA
Inferred from Electronic Annotation
more info
 
endosome membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of nuclear inner membrane IEA
Inferred from Electronic Annotation
more info
 
meiotic nuclear membrane microtubule tethering complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
meiotic nuclear membrane microtubule tethering complex IDA
Inferred from Direct Assay
more info
PubMed 
nuclear chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
 
nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
nuclear envelope TAS
Traceable Author Statement
more info
PubMed 
nuclear membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
SUN domain-containing protein 2
Names
Sad1 unc-84 domain protein 2
nuclear envelope protein
protein unc-84 homolog B
rab5-interacting protein
rab5IP
sad1/unc-84 protein-like 2
unc-84 homolog B

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199579.2NP_001186508.1  SUN domain-containing protein 2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK304188, AL021707, BC094797, BX537962, CB988569, CD365855
    Consensus CDS
    CCDS56231.1
    UniProtKB/Swiss-Prot
    Q9UH99
    UniProtKB/TrEMBL
    B4E2A6
    Related
    ENSP00000385616.1, ENST00000405018.5
    Conserved Domains (3) summary
    pfam07738
    Location:602736
    Sad1_UNC; Sad1 / UNC-like C-terminal
    pfam08703
    Location:321479
    PLC-beta_C; PLC-beta C terminal
    cl23720
    Location:349477
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
  2. NM_001199580.2NP_001186509.1  SUN domain-containing protein 2 isoform b

    See identical proteins and their annotated locations for NP_001186509.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AK304188, AL021707, BX537962, CD365855, DC400744
    Consensus CDS
    CCDS13978.1
    UniProtKB/Swiss-Prot
    Q9UH99
    UniProtKB/TrEMBL
    A0A024R1P7, B4E2A6
    Related
    ENSP00000385740.1, ENST00000405510.5
    Conserved Domains (2) summary
    pfam07738
    Location:581715
    Sad1_UNC; Sad1 / UNC-like C-terminal
    cl25732
    Location:271547
    SMC_N; RecF/RecN/SMC N terminal domain
  3. NM_015374.3NP_056189.1  SUN domain-containing protein 2 isoform b

    See identical proteins and their annotated locations for NP_056189.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AK304188, BC094797, BX537962, CB988569, CD365855, CN299688
    Consensus CDS
    CCDS13978.1
    UniProtKB/Swiss-Prot
    Q9UH99
    UniProtKB/TrEMBL
    A0A024R1P7, B4E2A6
    Related
    ENSP00000383992.1, ENST00000406622.5
    Conserved Domains (2) summary
    pfam07738
    Location:581715
    Sad1_UNC; Sad1 / UNC-like C-terminal
    cl25732
    Location:271547
    SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    38734727..38756014 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011530104.2XP_011528406.1  SUN domain-containing protein 2 isoform X3

    Conserved Domains (2) summary
    pfam07738
    Location:535669
    Sad1_UNC; Sad1 / UNC-like C-terminal
    cl25732
    Location:225501
    SMC_N; RecF/RecN/SMC N terminal domain
  2. XM_024452205.1XP_024307973.1  SUN domain-containing protein 2 isoform X5

    Conserved Domains (2) summary
    pfam07738
    Location:581715
    Sad1_UNC; Sad1 / UNC-like C-terminal
    cl25732
    Location:271547
    SMC_N; RecF/RecN/SMC N terminal domain
  3. XM_024452206.1XP_024307974.1  SUN domain-containing protein 2 isoform X3

    Conserved Domains (2) summary
    pfam07738
    Location:535669
    Sad1_UNC; Sad1 / UNC-like C-terminal
    cl25732
    Location:225501
    SMC_N; RecF/RecN/SMC N terminal domain
  4. XM_011530105.2XP_011528407.1  SUN domain-containing protein 2 isoform X6

    Conserved Domains (3) summary
    pfam07738
    Location:570704
    Sad1_UNC; Sad1 / UNC-like C-terminal
    pfam08703
    Location:289447
    PLC-beta_C; PLC-beta C terminal
    cl23720
    Location:317445
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
  5. XM_024452203.1XP_024307971.1  SUN domain-containing protein 2 isoform X1

    Conserved Domains (2) summary
    pfam07738
    Location:674808
    Sad1_UNC; Sad1 / UNC-like C-terminal
    cl25732
    Location:364640
    SMC_N; RecF/RecN/SMC N terminal domain
  6. XM_024452204.1XP_024307972.1  SUN domain-containing protein 2 isoform X4

    Conserved Domains (2) summary
    pfam07738
    Location:616750
    Sad1_UNC; Sad1 / UNC-like C-terminal
    cl25732
    Location:306582
    SMC_N; RecF/RecN/SMC N terminal domain
  7. XM_017028748.1XP_016884237.1  SUN domain-containing protein 2 isoform X2

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