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SUN2 Sad1 and UNC84 domain containing 2 [ Homo sapiens (human) ]

Gene ID: 25777, updated on 3-Nov-2024

Summary

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Official Symbol
SUN2provided by HGNC
Official Full Name
Sad1 and UNC84 domain containing 2provided by HGNC
Primary source
HGNC:HGNC:14210
See related
Ensembl:ENSG00000100242 MIM:613569; AllianceGenome:HGNC:14210
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UNC84B; rab5IP
Summary
SUN1 (MIM 607723) and SUN2 are inner nuclear membrane (INM) proteins that play a major role in nuclear-cytoplasmic connection by formation of a 'bridge' across the nuclear envelope, known as the LINC complex, via interaction with the conserved luminal KASH domain of nesprins (e.g., SYNE1; MIM 608441) located in the outer nuclear membrane (ONM). The LINC complex provides a direct connection between the nuclear lamina and the cytoskeleton, which contributes to nuclear positioning and cellular rigidity (summary by Haque et al., 2010 [PubMed 19933576]).[supplied by OMIM, Nov 2010]
Expression
Ubiquitous expression in fat (RPKM 47.2), bone marrow (RPKM 33.2) and 25 other tissues See more
Orthologs
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Genomic context

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See SUN2 in Genome Data Viewer
Location:
22q13.1
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (38734734..38755998, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (39204948..39226213, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (39130739..39152003, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13726 Neighboring gene Josephin domain containing 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:39100707-39101392 Neighboring gene hESC enhancers GRCh37_chr22:39101393-39102078 and GRCh37_chr22:39102079-39102764 Neighboring gene GTP binding protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19017 Neighboring gene peroxiredoxin 3 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19018 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19019 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13730 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13731 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19020 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:39156221-39157045 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19022 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:39175672-39176172 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13732 Neighboring gene dynein axonemal light chain 4 Neighboring gene neuronal pentraxin receptor Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13733

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. SUN2 exerts tumor suppressor functions by suppressing the Warburg effect in lung cancer. Lv XB, et al. Sci Rep, 2015 Dec 10. PMID 26658802, Free PMC Article
  2. Splicing factors control triple-negative breast cancer cell mitosis through SUN2 interaction and sororin intron retention. Koedoot E, et al. J Exp Clin Cancer Res, 2021 Mar 1. PMID 33648524, Free PMC Article
  3. A mass spectrometry-based proteomic approach for identification of serine/threonine-phosphorylated proteins by enrichment with phospho-specific antibodies: identification of a novel protein, Frigg, as a protein kinase A substrate. Grønborg M, et al. Mol Cell Proteomics, 2002 Jul. PMID 12239280
  4. SUN2 Modulates the Propagation of HSV-1. Cruz-Palomar K, et al. J Virol, 2022 May 11. PMID 35435724, Free PMC Article
  5. Structure of Sad1-UNC84 homology (SUN) domain defines features of molecular bridge in nuclear envelope. Zhou Z, et al. J Biol Chem, 2012 Feb 17. PMID 22170055, Free PMC Article

See all (142) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SUN2 Modulates the Propagation of HSV-1.
    Title: SUN2 Modulates the Propagation of HSV-1.
  2. FBXO2 targets glycosylated SUN2 for ubiquitination and degradation to promote ovarian cancer development.
    Title: FBXO2 targets glycosylated SUN2 for ubiquitination and degradation to promote ovarian cancer development.
  3. Downregulation of SUN2 promotes metastasis of colon cancer by activating BDNF/TrkB signalling by interacting with SIRT1.
    Title: Downregulation of SUN2 promotes metastasis of colon cancer by activating BDNF/TrkB signalling by interacting with SIRT1.
  4. The SUN2-nesprin-2 LINC complex and KIF20A function in the Golgi dispersal.
    Title: The SUN2-nesprin-2 LINC complex and KIF20A function in the Golgi dispersal.
  5. Splicing factors control triple-negative breast cancer cell mitosis through SUN2 interaction and sororin intron retention.
    Title: Splicing factors control triple-negative breast cancer cell mitosis through SUN2 interaction and sororin intron retention.
  6. Structural Analysis of Different LINC Complexes Reveals Distinct Binding Modes.
    Title: Structural Analysis of Different LINC Complexes Reveals Distinct Binding Modes.
  7. SUN1/2 Are Essential for RhoA/ROCK-Regulated Actomyosin Activity in Isolated Vascular Smooth Muscle Cells.
    Title: SUN1/2 Are Essential for RhoA/ROCK-Regulated Actomyosin Activity in Isolated Vascular Smooth Muscle Cells.
  8. a fragment of SUN2 containing CC1, CC2, and the SUN domain model is reported.
    Title: A molecular model for LINC complex regulation: activation of SUN2 for KASH binding.
  9. SUN2 is a novel chromatin reassembly factor that helps to maintain chromatin in a repressive state and consequently inhibits HIV-1 transcription.
    Title: SUN2 Modulates HIV-1 Infection and Latency through Association with Lamin A/C To Maintain the Repressive Chromatin.
  10. While Sun1 and Sun2 in HeLa cells are each able to bind KASH-domains, Sun1 is more efficiently incorporated into LINC complexes under normal growth conditions. Furthermore, the balance of Sun1 and Sun2 incorporated into LINC complexes is cell type-specific and is correlated with SRF/Mkl1-dependent gene expression.
    Title: Differential incorporation of SUN-domain proteins into LINC complexes is coupled to gene expression.
Submit: New GeneRIF Correction See all GeneRIFs (27)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
HIV-1 replication, specifically nuclear import, is inhibited by SUN2 overexpression as it changes nuclear shape in cell lines and primary cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0668, MGC133055, MGC133056

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cytoskeleton-nuclear membrane anchor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables lamin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables microtubule binding TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-membrane adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in centrosome localization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic spindle organization TAS
Traceable Author Statement
more info
 PubMed 
involved_in nuclear matrix anchoring at nuclear membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nuclear migration TAS
Traceable Author Statement
more info
 PubMed 
involved_in nuclear migration along microfilament ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell migration ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
  
located_in condensed nuclear chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
  
part_of meiotic nuclear membrane microtubule tethering complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of meiotic nuclear membrane microtubule tethering complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear envelope TAS
Traceable Author Statement
more info
 PubMed 
located_in nuclear inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
SUN domain-containing protein 2
Names
Sad1 unc-84 domain protein 2
nuclear envelope protein
protein unc-84 homolog B
rab5-interacting protein
sad1/unc-84 protein-like 2
unc-84 homolog B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199579.2 → NP_001186508.1  SUN domain-containing protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AK304188, AL021707, BC094797, BX537962, CB988569, CD365855
    Consensus CDS
    CCDS56231.1
    UniProtKB/TrEMBL
    A8K129
    Related
    ENSP00000385616.1, ENST00000405018.5
    Conserved Domains (4) summary
    COG1196
    Location:292 → 568
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam07738
    Location:602 → 736
    Sad1_UNC; Sad1 / UNC-like C-terminal
    cd21438
    Location:421 → 475
    SUN2_cc1; coiled-coil domain 1 of SUN domain-containing protein 2 and similar proteins
    pfam18580
    Location:502 → 559
    Sun2_CC2; SUN2 coiled coil domain 2

  2. NM_001199580.2 → NP_001186509.1  SUN domain-containing protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001186509.1

    Status: VALIDATED

    Source sequence(s)
    AK304188, AL021707, BX537962, CD365855, DC400744
    Consensus CDS
    CCDS13978.1
    UniProtKB/Swiss-Prot
    B0QY62, O75156, Q2NKN8, Q2T9F7, Q504T5, Q6B4H1, Q7Z3E3, Q9UH99
    UniProtKB/TrEMBL
    A8K129
    Related
    ENSP00000385740.1, ENST00000405510.5
    Conserved Domains (4) summary
    COG1196
    Location:271 → 547
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam07738
    Location:581 → 715
    Sad1_UNC; Sad1 / UNC-like C-terminal
    pfam18580
    Location:481 → 538
    Sun2_CC2; SUN2 coiled coil domain 2
    cd21438
    Location:400 → 454
    SUN2_cc1; coiled-coil domain 1 of SUN domain-containing protein 2 and similar proteins

  3. NM_001394427.1 → NP_001381356.1  SUN domain-containing protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL021707
    UniProtKB/TrEMBL
    A8K129
    Conserved Domains (1) summary
    COG1196
    Location:302 → 578
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  4. NM_001394428.1 → NP_001381357.1  SUN domain-containing protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL021707
    Consensus CDS
    CCDS56231.1
    UniProtKB/TrEMBL
    A8K129
    Conserved Domains (4) summary
    COG1196
    Location:292 → 568
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam07738
    Location:602 → 736
    Sad1_UNC; Sad1 / UNC-like C-terminal
    cd21438
    Location:421 → 475
    SUN2_cc1; coiled-coil domain 1 of SUN domain-containing protein 2 and similar proteins
    pfam18580
    Location:502 → 559
    Sun2_CC2; SUN2 coiled coil domain 2

  5. NM_001394429.1 → NP_001381358.1  SUN domain-containing protein 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL021707
    UniProtKB/TrEMBL
    A8K129
    Conserved Domains (1) summary
    COG1196
    Location:286 → 562
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  6. NM_001394430.1 → NP_001381359.1  SUN domain-containing protein 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL021707
    UniProtKB/TrEMBL
    A8K129
    Conserved Domains (1) summary
    COG1196
    Location:286 → 562
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  7. NM_001394431.1 → NP_001381360.1  SUN domain-containing protein 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL021707
    Consensus CDS
    CCDS93166.1
    UniProtKB/TrEMBL
    A8K129, B0QY60
    Conserved Domains (1) summary
    COG1196
    Location:271 → 547
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  8. NM_001394432.1 → NP_001381361.1  SUN domain-containing protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL021707
    Consensus CDS
    CCDS13978.1
    UniProtKB/Swiss-Prot
    B0QY62, O75156, Q2NKN8, Q2T9F7, Q504T5, Q6B4H1, Q7Z3E3, Q9UH99
    UniProtKB/TrEMBL
    A8K129
    Related
    ENSP00000508791.1, ENST00000690927.1
    Conserved Domains (4) summary
    COG1196
    Location:271 → 547
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam07738
    Location:581 → 715
    Sad1_UNC; Sad1 / UNC-like C-terminal
    pfam18580
    Location:481 → 538
    Sun2_CC2; SUN2 coiled coil domain 2
    cd21438
    Location:400 → 454
    SUN2_cc1; coiled-coil domain 1 of SUN domain-containing protein 2 and similar proteins

  9. NM_001394433.1 → NP_001381362.1  SUN domain-containing protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL021707
    Consensus CDS
    CCDS13978.1
    UniProtKB/Swiss-Prot
    B0QY62, O75156, Q2NKN8, Q2T9F7, Q504T5, Q6B4H1, Q7Z3E3, Q9UH99
    UniProtKB/TrEMBL
    A8K129
    Conserved Domains (4) summary
    COG1196
    Location:271 → 547
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam07738
    Location:581 → 715
    Sad1_UNC; Sad1 / UNC-like C-terminal
    pfam18580
    Location:481 → 538
    Sun2_CC2; SUN2 coiled coil domain 2
    cd21438
    Location:400 → 454
    SUN2_cc1; coiled-coil domain 1 of SUN domain-containing protein 2 and similar proteins

  10. NM_001394434.1 → NP_001381363.1  SUN domain-containing protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL021707
    Consensus CDS
    CCDS13978.1
    UniProtKB/Swiss-Prot
    B0QY62, O75156, Q2NKN8, Q2T9F7, Q504T5, Q6B4H1, Q7Z3E3, Q9UH99
    UniProtKB/TrEMBL
    A8K129
    Conserved Domains (4) summary
    COG1196
    Location:271 → 547
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam07738
    Location:581 → 715
    Sad1_UNC; Sad1 / UNC-like C-terminal
    pfam18580
    Location:481 → 538
    Sun2_CC2; SUN2 coiled coil domain 2
    cd21438
    Location:400 → 454
    SUN2_cc1; coiled-coil domain 1 of SUN domain-containing protein 2 and similar proteins

  11. NM_001394435.1 → NP_001381364.1  SUN domain-containing protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL021707
    Consensus CDS
    CCDS13978.1
    UniProtKB/Swiss-Prot
    B0QY62, O75156, Q2NKN8, Q2T9F7, Q504T5, Q6B4H1, Q7Z3E3, Q9UH99
    UniProtKB/TrEMBL
    A8K129
    Conserved Domains (4) summary
    COG1196
    Location:271 → 547
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam07738
    Location:581 → 715
    Sad1_UNC; Sad1 / UNC-like C-terminal
    pfam18580
    Location:481 → 538
    Sun2_CC2; SUN2 coiled coil domain 2
    cd21438
    Location:400 → 454
    SUN2_cc1; coiled-coil domain 1 of SUN domain-containing protein 2 and similar proteins

  12. NM_001394436.1 → NP_001381365.1  SUN domain-containing protein 2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL021707
    UniProtKB/TrEMBL
    A8K129
    Conserved Domains (1) summary
    COG1196
    Location:271 → 521
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  13. NM_001394437.1 → NP_001381366.1  SUN domain-containing protein 2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL021707
    UniProtKB/TrEMBL
    A8K129
    Conserved Domains (1) summary
    COG1196
    Location:271 → 521
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  14. NM_001394438.1 → NP_001381367.1  SUN domain-containing protein 2 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL021707
    UniProtKB/TrEMBL
    A8K129
    Conserved Domains (1) summary
    COG1196
    Location:241 → 517
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  15. NM_001394439.1 → NP_001381368.1  SUN domain-containing protein 2 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL021707
    Consensus CDS
    CCDS93165.1
    UniProtKB/TrEMBL
    B0QY64, B4DIU6
    Conserved Domains (4) summary
    COG1196
    Location:225 → 501
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam07738
    Location:535 → 669
    Sad1_UNC; Sad1 / UNC-like C-terminal
    pfam18580
    Location:435 → 492
    Sun2_CC2; SUN2 coiled coil domain 2
    cd21438
    Location:354 → 408
    SUN2_cc1; coiled-coil domain 1 of SUN domain-containing protein 2 and similar proteins

  16. NM_001394440.1 → NP_001381369.1  SUN domain-containing protein 2 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL021707
    Consensus CDS
    CCDS93165.1
    UniProtKB/TrEMBL
    B0QY64, B4DIU6
    Related
    ENSP00000415588.3, ENST00000456894.6
    Conserved Domains (4) summary
    COG1196
    Location:225 → 501
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam07738
    Location:535 → 669
    Sad1_UNC; Sad1 / UNC-like C-terminal
    pfam18580
    Location:435 → 492
    Sun2_CC2; SUN2 coiled coil domain 2
    cd21438
    Location:354 → 408
    SUN2_cc1; coiled-coil domain 1 of SUN domain-containing protein 2 and similar proteins

  17. NM_001394441.1 → NP_001381370.1  SUN domain-containing protein 2 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL021707
    Consensus CDS
    CCDS93165.1
    UniProtKB/TrEMBL
    B0QY64, B4DIU6
    Conserved Domains (4) summary
    COG1196
    Location:225 → 501
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam07738
    Location:535 → 669
    Sad1_UNC; Sad1 / UNC-like C-terminal
    pfam18580
    Location:435 → 492
    Sun2_CC2; SUN2 coiled coil domain 2
    cd21438
    Location:354 → 408
    SUN2_cc1; coiled-coil domain 1 of SUN domain-containing protein 2 and similar proteins

  18. NM_001394442.1 → NP_001381371.1  SUN domain-containing protein 2 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL021707
    UniProtKB/TrEMBL
    A0A8I5QKM0
    Conserved Domains (1) summary
    TIGR00618
    Location:269 → 417
    sbcc; exonuclease SbcC

  19. NM_001394443.1 → NP_001381372.1  SUN domain-containing protein 2 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AL021707
    Conserved Domains (1) summary
    COG1196
    Location:107 → 383
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  20. NM_001394444.1 → NP_001381373.1  SUN domain-containing protein 2 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AL021707
    UniProtKB/TrEMBL
    A0A8I5QKM0

  21. NM_001394445.1 → NP_001381374.1  SUN domain-containing protein 2 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AL021707
    UniProtKB/TrEMBL
    A0A8I5QKM0

  22. NM_015374.3 → NP_056189.1  SUN domain-containing protein 2 isoform 2

    See identical proteins and their annotated locations for NP_056189.1

    Status: VALIDATED

    Source sequence(s)
    AK304188, BC094797, BX537962, CB988569, CD365855, CN299688
    Consensus CDS
    CCDS13978.1
    UniProtKB/Swiss-Prot
    B0QY62, O75156, Q2NKN8, Q2T9F7, Q504T5, Q6B4H1, Q7Z3E3, Q9UH99
    UniProtKB/TrEMBL
    A8K129
    Related
    ENSP00000508608.1, ENST00000689035.1
    Conserved Domains (4) summary
    COG1196
    Location:271 → 547
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam07738
    Location:581 → 715
    Sad1_UNC; Sad1 / UNC-like C-terminal
    pfam18580
    Location:481 → 538
    Sun2_CC2; SUN2 coiled coil domain 2
    cd21438
    Location:400 → 454
    SUN2_cc1; coiled-coil domain 1 of SUN domain-containing protein 2 and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    38734734..38755998 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017028748.2 → XP_016884237.1  SUN domain-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    A8K129

  2. XM_047441310.1 → XP_047297266.1  SUN domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    B0QY60

  3. XM_047441313.1 → XP_047297269.1  SUN domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    B0QY60

  4. XM_047441312.1 → XP_047297268.1  SUN domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    B0QY60
    Related
    ENSP00000390154.2, ENST00000455125.2

  5. XM_047441311.1 → XP_047297267.1  SUN domain-containing protein 2 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    39204948..39226213 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054325481.1 → XP_054181456.1  SUN domain-containing protein 2 isoform X2

  2. XM_054325480.1 → XP_054181455.1  SUN domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    B0QY60

  3. XM_054325484.1 → XP_054181459.1  SUN domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    B0QY60

  4. XM_054325483.1 → XP_054181458.1  SUN domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    B0QY60

  5. XM_054325482.1 → XP_054181457.1  SUN domain-containing protein 2 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UH99.3 GenPept UniProtKB/Swiss-Prot:Q9UH99

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