Sun2 Sad1 and UNC84 domain containing 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sun2provided by MGI
Official Full Name: Sad1 and UNC84 domain containing 2provided by MGI
Primary source: MGI:MGI:2443011
See related: Ensembl:ENSMUSG00000042524 AllianceGenome:MGI:2443011
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Unc84b; C030011B15; B230369L08Rik
Summary: Enables identical protein binding activity. Involved in centrosome localization; nuclear migration; and positive regulation of cell migration. Located in chromosome, telomeric region; condensed nuclear chromosome; and nuclear inner membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; liver and biliary system; and skeletal muscle. Orthologous to human SUN2 (Sad1 and UNC84 domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in thymus adult (RPKM 77.8), spleen adult (RPKM 46.2) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15; 15 E1

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (79608269..79626757, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (79724068..79742536, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SUN1/2 Are Essential for RhoA/ROCK-Regulated Actomyosin Activity in Isolated Vascular Smooth Muscle Cells.
Title: SUN1/2 Are Essential for RhoA/ROCK-Regulated Actomyosin Activity in Isolated Vascular Smooth Muscle Cells.
A-type lamins and SUN2 play antagonistic roles in the modulation of profibrotic signaling through opposite effects on MAN1 levels at the nuclear lamina.
Title: Ablation of SUN2-containing LINC complexes drives cardiac hypertrophy without interstitial fibrosis.
Inhibition of protein kinase B (AKT) phosphorylation may be a crucial pathway for SUN2-mediated HSCs activation.
Title: Suppression of SUN2 by DNA methylation is associated with HSCs activation and hepatic fibrosis.
a fragment of SUN2 containing CC1, CC2, and the SUN domain model is reported.
Title: A molecular model for LINC complex regulation: activation of SUN2 for KASH binding.
our results clearly indicate that SUN1 and SUN2, at least partially, fulfill redundant meiotic functions
Title: Analysis of meiosis in SUN1 deficient mice reveals a distinct role of SUN2 in mammalian meiotic LINC complex formation and function.
Sun2 has a role in DNA damage response.
Title: Inner nuclear envelope proteins SUN1 and SUN2 play a prominent role in the DNA damage response.
Syne-2, SUN1 and SUN2 play critical roles during interkinetic nuclear migration and photoreceptor cell migration in the mouse retina development.
Title: KASH protein Syne-2/Nesprin-2 and SUN proteins SUN1/2 mediate nuclear migration during mammalian retinal development.
Nesprins, but not sun proteins, switch isoforms at the nuclear envelope during muscle development
Title: Nesprins, but not sun proteins, switch isoforms at the nuclear envelope during muscle development.
perturbations in lamin A-SUN1 and SUN2 protein interactions may underlie the opposing effects of EDMD and HGPS mutations on nuclear and cellular mechanics
Title: Mammalian SUN protein interaction networks at the inner nuclear membrane and their role in laminopathy disease processes.
indicate that the SUN2-KASH complexes mediate the coupling between the nucleus and the centrosome and provide anchors in the nuclear envelope for cytoplasmic dynein/dynactin during neuronal migration.
Title: SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Homologs of the Sun2 gene: The Sun2 gene is conserved in human, chimpanzee, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 345 organisms have orthologs with human gene Sun2
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytoskeleton-nuclear membrane anchor activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lamin binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-membrane adaptor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Process	Evidence Code	Pubs
involved_in centrosome localization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within meiotic cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nuclear envelope organization	ISO Inferred from Sequence Orthology more info
involved_in nuclear matrix anchoring at nuclear membrane	ISO Inferred from Sequence Orthology more info
involved_in nuclear migration along microfilament	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome, telomeric region	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome, telomeric region	ISO Inferred from Sequence Orthology more info
located_in condensed nuclear chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in condensed nuclear chromosome	ISO Inferred from Sequence Orthology more info
located_in endosome	IEA Inferred from Electronic Annotation more info
part_of meiotic nuclear membrane microtubule tethering complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of meiotic nuclear membrane microtubule tethering complex	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in nuclear envelope	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	TAS Traceable Author Statement more info
located_in nuclear inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: SUN domain-containing protein 2

Names: protein unc-84 homolog B; sad1/unc-84 protein-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001205345.1 → NP_001192274.1 SUN domain-containing protein 2 isoform 1

See identical proteins and their annotated locations for NP_001192274.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC118227

Consensus CDS

CCDS56993.1

UniProtKB/Swiss-Prot

Q6B4H2, Q8BJS4

Related

ENSMUSP00000047864.8, ENSMUST00000046259.14

Conserved Domains (1) summary

pfam07738
Location:595 → 729

Sad1_UNC; Sad1 / UNC-like C-terminal
NM_001205346.1 → NP_001192275.1 SUN domain-containing protein 2 isoform 2

See identical proteins and their annotated locations for NP_001192275.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AC118227

Consensus CDS

CCDS56992.1

UniProtKB/Swiss-Prot

Q8BJS4

Related

ENSMUSP00000098006.4, ENSMUST00000100439.10

Conserved Domains (1) summary

pfam07738
Location:593 → 727

Sad1_UNC; Sad1 / UNC-like C-terminal
NM_194342.3 → NP_919323.2 SUN domain-containing protein 2 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an exon in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.

Source sequence(s)

AC118227

Consensus CDS

CCDS27649.1

UniProtKB/Swiss-Prot

Q8BJS4

Related

ENSMUSP00000086724.5, ENSMUST00000089311.11

Conserved Domains (1) summary

pfam07738
Location:563 → 697

Sad1_UNC; Sad1 / UNC-like C-terminal

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

79608269..79626757 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030248502.2 → XP_030104362.1 SUN domain-containing protein 2 isoform X1

Conserved Domains (3) summary

COG1196
Location:251 → 525

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam07738
Location:561 → 695

Sad1_UNC; Sad1 / UNC-like C-terminal

pfam18580
Location:461 → 518

Sun2_CC2; SUN2 coiled coil domain 2
XM_006520811.5 → XP_006520874.1 SUN domain-containing protein 2 isoform X2

Conserved Domains (3) summary

COG1196
Location:235 → 509

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam07738
Location:545 → 679

Sad1_UNC; Sad1 / UNC-like C-terminal

pfam18580
Location:445 → 502

Sun2_CC2; SUN2 coiled coil domain 2
XM_036159355.1 → XP_036015248.1 SUN domain-containing protein 2 isoform X3

UniProtKB/TrEMBL

Q4QQM3

Conserved Domains (2) summary

COG1196
Location:283 → 465

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd21435
Location:412 → 465

SUN_cc1; coiled-coil domain 1 of SUN domain-containing proteins