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Sun2 Sad1 and UNC84 domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 223697, updated on 9-May-2024

Summary

Official Symbol
Sun2provided by MGI
Official Full Name
Sad1 and UNC84 domain containing 2provided by MGI
Primary source
MGI:MGI:2443011
See related
Ensembl:ENSMUSG00000042524 AllianceGenome:MGI:2443011
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Unc84b; C030011B15; B230369L08Rik
Summary
Enables identical protein binding activity. Involved in centrosome localization; nuclear migration; and positive regulation of cell migration. Located in chromosome, telomeric region; condensed nuclear chromosome; and nuclear inner membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; liver and biliary system; and skeletal muscle. Orthologous to human SUN2 (Sad1 and UNC84 domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 77.8), spleen adult (RPKM 46.2) and 26 other tissues See more
Orthologs
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Genomic context

See Sun2 in Genome Data Viewer
Location:
15 E1; 15 37.85 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (79608269..79626757, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (79724068..79742536, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene Josephin domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E389 Neighboring gene GTP binding protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E7390 Neighboring gene predicted gene 16576 Neighboring gene dynein, axonemal, light chain 4 Neighboring gene STARR-positive B cell enhancer ABC_E390

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (4)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytoskeleton-nuclear membrane anchor activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables lamin binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-membrane adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in chromosome, telomeric region IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
 
located_in condensed nuclear chromosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in condensed nuclear chromosome ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
part_of meiotic nuclear membrane microtubule tethering complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of meiotic nuclear membrane microtubule tethering complex ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear envelope TAS
Traceable Author Statement
more info
 
located_in nuclear inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
SUN domain-containing protein 2
Names
protein unc-84 homolog B
sad1/unc-84 protein-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001205345.1NP_001192274.1  SUN domain-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001192274.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC118227
    Consensus CDS
    CCDS56993.1
    UniProtKB/Swiss-Prot
    Q3TBU0, Q3U160, Q6B4H2, Q8BJS4
    UniProtKB/TrEMBL
    Q6A022
    Related
    ENSMUSP00000047864.8, ENSMUST00000046259.14
    Conserved Domains (1) summary
    pfam07738
    Location:595729
    Sad1_UNC; Sad1 / UNC-like C-terminal
  2. NM_001205346.1NP_001192275.1  SUN domain-containing protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001192275.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC118227
    Consensus CDS
    CCDS56992.1
    UniProtKB/TrEMBL
    Q6A022
    Related
    ENSMUSP00000098006.4, ENSMUST00000100439.10
    Conserved Domains (1) summary
    pfam07738
    Location:593727
    Sad1_UNC; Sad1 / UNC-like C-terminal
  3. NM_194342.3NP_919323.2  SUN domain-containing protein 2 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an exon in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AC118227
    Consensus CDS
    CCDS27649.1
    UniProtKB/TrEMBL
    Q6A022
    Related
    ENSMUSP00000086724.5, ENSMUST00000089311.11
    Conserved Domains (1) summary
    pfam07738
    Location:563697
    Sad1_UNC; Sad1 / UNC-like C-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    79608269..79626757 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248502.2XP_030104362.1  SUN domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    Q6A022
    Conserved Domains (3) summary
    COG1196
    Location:251525
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam07738
    Location:561695
    Sad1_UNC; Sad1 / UNC-like C-terminal
    pfam18580
    Location:461518
    Sun2_CC2; SUN2 coiled coil domain 2
  2. XM_006520811.5XP_006520874.1  SUN domain-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    Q6A022
    Conserved Domains (3) summary
    COG1196
    Location:235509
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam07738
    Location:545679
    Sad1_UNC; Sad1 / UNC-like C-terminal
    pfam18580
    Location:445502
    Sun2_CC2; SUN2 coiled coil domain 2
  3. XM_036159355.1XP_036015248.1  SUN domain-containing protein 2 isoform X3

    UniProtKB/TrEMBL
    Q4QQM3
    Conserved Domains (2) summary
    COG1196
    Location:283465
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd21435
    Location:412465
    SUN_cc1; coiled-coil domain 1 of SUN domain-containing proteins