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Sun2 Sad1 and UNC84 domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 223697, updated on 2-Nov-2024

Summary

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Official Symbol
Sun2provided by MGI
Official Full Name
Sad1 and UNC84 domain containing 2provided by MGI
Primary source
MGI:MGI:2443011
See related
Ensembl:ENSMUSG00000042524 AllianceGenome:MGI:2443011
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Unc84b; C030011B15; B230369L08Rik
Summary
Enables identical protein binding activity. Involved in centrosome localization; nuclear migration; and positive regulation of cell migration. Located in chromosome, telomeric region; condensed nuclear chromosome; and nuclear inner membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; skeletal muscle; and skin. Orthologous to human SUN2 (Sad1 and UNC84 domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in thymus adult (RPKM 77.8), spleen adult (RPKM 46.2) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Sun2 in Genome Data Viewer
Location:
15 E1; 15 37.85 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (79608269..79626757, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (79724068..79742536, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene Josephin domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E389 Neighboring gene GTP binding protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E7390 Neighboring gene predicted gene 16576 Neighboring gene dynein, axonemal, light chain 4 Neighboring gene STARR-positive B cell enhancer ABC_E390

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Nuclear membrane protein SUN2 promotes replication of flaviviruses through modulating cytoskeleton reorganization mediated by NS1. Huang Y, et al. Nat Commun, 2024 Jan 5. PMID 38177122, Free PMC Article
  2. Disulfide bond in SUN2 regulates dynamic remodeling of LINC complexes at the nuclear envelope. Sharma R, et al. Life Sci Alliance, 2023 Aug. PMID 37188462, Free PMC Article
  3. Ablation of SUN2-containing LINC complexes drives cardiac hypertrophy without interstitial fibrosis. Stewart RM, et al. Mol Biol Cell, 2019 Jul 1. PMID 31091167, Free PMC Article
  4. Suppression of SUN2 by DNA methylation is associated with HSCs activation and hepatic fibrosis. Chen X, et al. Cell Death Dis, 2018 Oct 3. PMID 30282980, Free PMC Article
  5. SUN1/2 controls macrophage polarization via modulating nuclear size and stiffness. Jiao S, et al. Nat Commun, 2023 Oct 12. PMID 37828059, Free PMC Article

See all (60) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Nuclear membrane protein SUN2 promotes replication of flaviviruses through modulating cytoskeleton reorganization mediated by NS1.
    Title: Nuclear membrane protein SUN2 promotes replication of flaviviruses through modulating cytoskeleton reorganization mediated by NS1.
  2. Disulfide bond in SUN2 regulates dynamic remodeling of LINC complexes at the nuclear envelope.
    Title: Disulfide bond in SUN2 regulates dynamic remodeling of LINC complexes at the nuclear envelope.
  3. SUN1/2 Are Essential for RhoA/ROCK-Regulated Actomyosin Activity in Isolated Vascular Smooth Muscle Cells.
    Title: SUN1/2 Are Essential for RhoA/ROCK-Regulated Actomyosin Activity in Isolated Vascular Smooth Muscle Cells.
  4. A-type lamins and SUN2 play antagonistic roles in the modulation of profibrotic signaling through opposite effects on MAN1 levels at the nuclear lamina.
    Title: Ablation of SUN2-containing LINC complexes drives cardiac hypertrophy without interstitial fibrosis.
  5. Inhibition of protein kinase B (AKT) phosphorylation may be a crucial pathway for SUN2-mediated HSCs activation.
    Title: Suppression of SUN2 by DNA methylation is associated with HSCs activation and hepatic fibrosis.
  6. a fragment of SUN2 containing CC1, CC2, and the SUN domain model is reported.
    Title: A molecular model for LINC complex regulation: activation of SUN2 for KASH binding.
  7. our results clearly indicate that SUN1 and SUN2, at least partially, fulfill redundant meiotic functions
    Title: Analysis of meiosis in SUN1 deficient mice reveals a distinct role of SUN2 in mammalian meiotic LINC complex formation and function.
  8. Sun2 has a role in DNA damage response.
    Title: Inner nuclear envelope proteins SUN1 and SUN2 play a prominent role in the DNA damage response.
  9. Syne-2, SUN1 and SUN2 play critical roles during interkinetic nuclear migration and photoreceptor cell migration in the mouse retina development.
    Title: KASH protein Syne-2/Nesprin-2 and SUN proteins SUN1/2 mediate nuclear migration during mammalian retinal development.
  10. Nesprins, but not sun proteins, switch isoforms at the nuclear envelope during muscle development
    Title: Nesprins, but not sun proteins, switch isoforms at the nuclear envelope during muscle development.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (4)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytoskeleton-nuclear membrane anchor activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables lamin binding IEA
Inferred from Electronic Annotation
more info
  
enables lamin binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-membrane adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in centrosome localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within nuclear envelope organization ISO
Inferred from Sequence Orthology
more info
  
involved_in nuclear matrix anchoring at nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
involved_in nuclear matrix anchoring at nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in nuclear migration along microfilament IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome, telomeric region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
  
located_in condensed nuclear chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in condensed nuclear chromosome ISO
Inferred from Sequence Orthology
more info
  
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
  
part_of meiotic nuclear membrane microtubule tethering complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of meiotic nuclear membrane microtubule tethering complex IEA
Inferred from Electronic Annotation
more info
  
part_of meiotic nuclear membrane microtubule tethering complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with nuclear envelope ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear envelope TAS
Traceable Author Statement
more info
  
located_in nuclear inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
SUN domain-containing protein 2
Names
protein unc-84 homolog B
sad1/unc-84 protein-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001205345.1 → NP_001192274.1  SUN domain-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001192274.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC118227
    Consensus CDS
    CCDS56993.1
    UniProtKB/Swiss-Prot
    Q3TBU0, Q3U160, Q6B4H2, Q8BJS4
    UniProtKB/TrEMBL
    Q6A022
    Related
    ENSMUSP00000047864.8, ENSMUST00000046259.14
    Conserved Domains (1) summary
    pfam07738
    Location:595 → 729
    Sad1_UNC; Sad1 / UNC-like C-terminal

  2. NM_001205346.1 → NP_001192275.1  SUN domain-containing protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001192275.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC118227
    Consensus CDS
    CCDS56992.1
    UniProtKB/TrEMBL
    Q6A022
    Related
    ENSMUSP00000098006.4, ENSMUST00000100439.10
    Conserved Domains (1) summary
    pfam07738
    Location:593 → 727
    Sad1_UNC; Sad1 / UNC-like C-terminal

  3. NM_194342.3 → NP_919323.2  SUN domain-containing protein 2 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an exon in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AC118227
    Consensus CDS
    CCDS27649.1
    UniProtKB/TrEMBL
    Q6A022
    Related
    ENSMUSP00000086724.5, ENSMUST00000089311.11
    Conserved Domains (1) summary
    pfam07738
    Location:563 → 697
    Sad1_UNC; Sad1 / UNC-like C-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    79608269..79626757 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248502.2 → XP_030104362.1  SUN domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    Q6A022
    Conserved Domains (3) summary
    COG1196
    Location:251 → 525
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam07738
    Location:561 → 695
    Sad1_UNC; Sad1 / UNC-like C-terminal
    pfam18580
    Location:461 → 518
    Sun2_CC2; SUN2 coiled coil domain 2

  2. XM_006520811.5 → XP_006520874.1  SUN domain-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    Q6A022
    Conserved Domains (3) summary
    COG1196
    Location:235 → 509
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam07738
    Location:545 → 679
    Sad1_UNC; Sad1 / UNC-like C-terminal
    pfam18580
    Location:445 → 502
    Sun2_CC2; SUN2 coiled coil domain 2

  3. XM_036159355.1 → XP_036015248.1  SUN domain-containing protein 2 isoform X3

    UniProtKB/TrEMBL
    Q4QQM3
    Conserved Domains (2) summary
    COG1196
    Location:283 → 465
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd21435
    Location:412 → 465
    SUN_cc1; coiled-coil domain 1 of SUN domain-containing proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BJS4.3 GenPept UniProtKB/Swiss-Prot:Q8BJS4

Gene LinkOut

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