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Spp1 secreted phosphoprotein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25353, updated on 3-Jun-2018
Symbol
Spp1provided by RGD
Full Name
secreted phosphoprotein 1provided by RGD
Primary source
RGD:3752
See related
Ensembl:ENSRNOG00000043451 Vega:OTTRNOG00000000106
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
OSP
Summary
sialoprotein that binds osteosarcoma cells; may play a role in osteoclast cell function [RGD, Feb 2006]
Annotation information
Annotation category: suggests misassembly
Expression
Biased expression in Kidney (RPKM 3427.7), Adrenal (RPKM 462.1) and 1 other tissue See more
Orthologs
See Spp1 in Genome Data Viewer
Location:
14p22
Exon count:
7
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (6673686..6679965, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 14 NC_005113.3 (6653086..6658937, complement)

Chromosome 14 - NC_005113.4Genomic Context describing neighboring genes Neighboring gene similar to THO complex subunit 2 (Tho2) Neighboring gene polycystin 2, transient receptor potential cation channel Neighboring gene uncharacterized LOC100910198 Neighboring gene matrix extracellular phosphoglycoprotein Neighboring gene integrin-binding sialoprotein

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
cytokine activity IEA
Inferred from Electronic Annotation
more info
 
extracellular matrix binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular matrix binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
androgen catabolic process IEA
Inferred from Electronic Annotation
more info
 
androgen catabolic process ISO
Inferred from Sequence Orthology
more info
 
biomineral tissue development IEA
Inferred from Electronic Annotation
more info
 
cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to fluid shear stress ISO
Inferred from Sequence Orthology
more info
 
cellular response to leukemia inhibitory factor ISO
Inferred from Sequence Orthology
more info
 
cellular response to testosterone stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to testosterone stimulus ISO
Inferred from Sequence Orthology
more info
 
inflammatory response IEP
Inferred from Expression Pattern
more info
PubMed 
negative regulation of collateral sprouting of intact axon in response to injury IEP
Inferred from Expression Pattern
more info
PubMed 
neutrophil chemotaxis ISO
Inferred from Sequence Orthology
more info
 
osteoblast differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of bone resorption IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of bone resorption IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell-substrate adhesion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of estradiol secretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of estradiol secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
regulation of signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
response to organic substance IDA
Inferred from Direct Assay
more info
PubMed 
response to steroid hormone IDA
Inferred from Direct Assay
more info
PubMed 
response to vitamin D IEA
Inferred from Electronic Annotation
more info
 
response to vitamin D ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
apical part of cell ISO
Inferred from Sequence Orthology
more info
 
cell projection IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
extracellular space TAS
Traceable Author Statement
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
vesicle IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
osteopontin
Names
SPP-1
Sialoprotein (osteopontin)
bone sialoprotein 1
osteopontin-like

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012881.2NP_037013.2  osteopontin precursor

    See identical proteins and their annotated locations for NP_037013.2

    Status: VALIDATED

    Source sequence(s)
    BC078874, BU759036, CV102664
    UniProtKB/Swiss-Prot
    P08721
    Related
    ENSRNOP00000062358.2, OTTRNOP00000000046, ENSRNOT00000067875.4, OTTRNOT00000000115
    Conserved Domains (1) summary
    pfam00865
    Location:22317
    Osteopontin; Osteopontin

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005113.4 Reference Rnor_6.0 Primary Assembly

    Range
    6673686..6679965 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008769996.2XP_008768218.1  osteopontin isoform X1

    See identical proteins and their annotated locations for XP_008768218.1

    UniProtKB/Swiss-Prot
    P08721
    Related
    ENSRNOP00000068511.1, OTTRNOP00000000107, ENSRNOT00000075989.1, OTTRNOT00000000193
    Conserved Domains (1) summary
    pfam00865
    Location:22317
    Osteopontin; Osteopontin

Alternate Rn_Celera

Genomic

  1. AC_000082.1 Alternate Rn_Celera

    Range
    5447814..5453553 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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