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Spp1 secreted phosphoprotein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25353, updated on 22-May-2022

Summary

Symbol
Spp1provided by RGD
Full Name
secreted phosphoprotein 1provided by RGD
Primary source
RGD:3752
See related
Ensembl:ENSRNOG00000043451 AllianceGenome:RGD:3752
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
OSP
Summary
Predicted to enable extracellular matrix binding activity and integrin binding activity. Involved in several processes, including negative regulation of collateral sprouting of intact axon in response to injury; osteoblast differentiation; and positive regulation of bone resorption. Located in several cellular components, including extracellular space; perinuclear region of cytoplasm; and vesicle. Used to study several diseases, including encephalomyelitis; myocarditis; radiculopathy; renovascular hypertension; and visual epilepsy. Biomarker of autosomal dominant polycystic kidney disease; calcinosis; and glomerulosclerosis. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); biliary atresia; coronary artery disease (multiple); disease of cellular proliferation (multiple); and hepatitis. Orthologous to human SPP1 (secreted phosphoprotein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 3427.7), Adrenal (RPKM 462.1) and 1 other tissue See more
Orthologs
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Genomic context

See Spp1 in Genome Data Viewer
Location:
14p22
Exon count:
7
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (5308885..5315120, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (6673686..6679965, complement)

Chromosome 14 - NC_051349.1Genomic Context describing neighboring genes Neighboring gene similar to THO complex subunit 2 (Tho2) Neighboring gene polycystin 2, transient receptor potential cation channel Neighboring gene uncharacterized LOC100910198 Neighboring gene matrix extracellular phosphoglycoprotein Neighboring gene integrin-binding sialoprotein

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 
enables extracellular matrix binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables extracellular matrix binding ISO
Inferred from Sequence Orthology
more info
 
enables integrin binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in androgen catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in bone mineralization ISO
Inferred from Sequence Orthology
more info
 
involved_in calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in cell differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within cellular calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular chloride ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular phosphate ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to fluid shear stress ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to leukemia inhibitory factor ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to testosterone stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular sodium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within collecting duct development ISO
Inferred from Sequence Orthology
more info
 
involved_in inflammatory response IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in negative regulation of collateral sprouting of intact axon in response to injury IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within neutrophil chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in osteoblast differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of bone resorption IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of bone resorption IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell-substrate adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of estradiol secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
involved_in response to macrophage colony-stimulating factor IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to organic substance IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to steroid hormone IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to vitamin D ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within urate biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in apical part of cell ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space TAS
Traceable Author Statement
more info
PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in vesicle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
osteopontin
Names
SPP-1
Sialoprotein (osteopontin)
bone sialoprotein 1
osteopontin-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012881.2NP_037013.2  osteopontin precursor

    See identical proteins and their annotated locations for NP_037013.2

    Status: VALIDATED

    Source sequence(s)
    BC078874, BU759036, CV102664
    UniProtKB/Swiss-Prot
    P08721
    Related
    ENSRNOP00000062358.2, ENSRNOT00000067875.5
    Conserved Domains (1) summary
    pfam00865
    Location:22317
    Osteopontin; Osteopontin

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051349.1 Reference mRatBN7.2 Primary Assembly

    Range
    5308885..5315120 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008769996.3XP_008768218.1  osteopontin isoform X1

    See identical proteins and their annotated locations for XP_008768218.1

    UniProtKB/Swiss-Prot
    P08721
    Conserved Domains (1) summary
    pfam00865
    Location:22317
    Osteopontin; Osteopontin