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Spp1 secreted phosphoprotein 1 [ Mus musculus (house mouse) ]

Gene ID: 20750, updated on 31-Jan-2023

Summary

Official Symbol
Spp1provided by MGI
Official Full Name
secreted phosphoprotein 1provided by MGI
Primary source
MGI:MGI:98389
See related
Ensembl:ENSMUSG00000029304 AllianceGenome:MGI:98389
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
OP; 2AR; Bsp; Eta; Opn; Ric; BNSP; BSPI; Opnl; Apl-1; ETA-1; Spp-1
Summary
Enables extracellular matrix binding activity. Acts upstream of or within several processes, including cellular ion homeostasis; cellular response to leukemia inhibitory factor; and neutrophil chemotaxis. Located in apical part of cell and cytoplasm. Is expressed in several structures, including alimentary system; brain; metanephros; reproductive system; and skeleton. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); biliary atresia; coronary artery disease (multiple); disease of cellular proliferation (multiple); and hepatitis. Orthologous to human SPP1 (secreted phosphoprotein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney adult (RPKM 580.4), liver E18 (RPKM 36.2) and 1 other tissue See more
Orthologs
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Genomic context

See Spp1 in Genome Data Viewer
Location:
5 E5; 5 50.68 cM
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (104582977..104588919)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (104435111..104441053)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene Ibsp 5' regulatory region Neighboring gene integrin binding sialoprotein Neighboring gene predicted gene, 54330 Neighboring gene matrix extracellular phosphoglycoprotein with ASARM motif (bone) Neighboring gene Spp1 5' regulatory region Neighboring gene polycystin 2, transient receptor potential cation channel Neighboring gene THO complex subunit 2-like

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine activity NAS
Non-traceable Author Statement
more info
PubMed 
enables extracellular matrix binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables extracellular matrix binding IDA
Inferred from Direct Assay
more info
PubMed 
enables integrin binding ISO
Inferred from Sequence Orthology
more info
 
enables ion binding ISO
Inferred from Sequence Orthology
more info
 
enables small molecule binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in androgen catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within biomineral tissue development IEA
Inferred from Electronic Annotation
more info
 
involved_in bone mineralization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in bone mineralization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in calcium ion homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell adhesion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to fluid shear stress IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to testosterone stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within collecting duct development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within intracellular calcium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within intracellular chloride ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within intracellular phosphate ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within intracellular sodium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within neutrophil chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within neutrophil chemotaxis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in ossification IEA
Inferred from Electronic Annotation
more info
 
involved_in osteoblast differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of bone resorption IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of bone resorption ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cell-substrate adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of estradiol secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in response to organic substance ISO
Inferred from Sequence Orthology
more info
 
involved_in response to steroid hormone ISO
Inferred from Sequence Orthology
more info
 
involved_in response to vitamin D ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within urate biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in apical part of cell IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell projection ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
osteopontin
Names
44 kDa bone phosphoprotein
bone sialoprotein 1
calcium oxalate crystal growth inhibitor protein
early T-lymphocyte activation 1 protein
minopontin
osteopontin-like protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204201.1NP_001191130.1  osteopontin isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC124106
    Conserved Domains (1) summary
    pfam00865
    Location:38311
    Osteopontin; Osteopontin
  2. NM_001204202.1NP_001191131.1  osteopontin isoform 2

    See identical proteins and their annotated locations for NP_001191131.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC124106, AI882055, AK150845, AK165965
    UniProtKB/TrEMBL
    Q3UBR1
    Conserved Domains (1) summary
    pfam00865
    Location:38310
    Osteopontin; Osteopontin
  3. NM_001204203.1NP_001191132.1  osteopontin isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC124106
    Consensus CDS
    CCDS57367.1
    UniProtKB/TrEMBL
    F8WIP8
    Related
    ENSMUSP00000084043.7, ENSMUST00000086833.13
    Conserved Domains (1) summary
    pfam00865
    Location:22295
    Osteopontin; Osteopontin
  4. NM_001204233.1NP_001191162.1  osteopontin isoform 4 precursor

    See identical proteins and their annotated locations for NP_001191162.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, uses a downstream in-frame start codon and lacks an exon in the coding region, compared to variant 1. Variants 4 and 5 encode the same isoform (4), which is shorter than isoform 1.
    Source sequence(s)
    AC124106
    Consensus CDS
    CCDS19486.1
    UniProtKB/Swiss-Prot
    P10923, Q91VH4
    UniProtKB/TrEMBL
    Q547B5
    Related
    ENSMUSP00000108367.2, ENSMUST00000112747.2
    Conserved Domains (1) summary
    pfam00865
    Location:22294
    Osteopontin; Osteopontin
  5. NM_009263.3NP_033289.2  osteopontin isoform 4 precursor

    See identical proteins and their annotated locations for NP_033289.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, uses a downstream in-frame start codon and lacks an exon in the coding region, compared to variant 1. Variants 4 and 5 encode the same isoform (4), which is shorter than isoform 1.
    Source sequence(s)
    AC124106, AI882055, AK160540
    Consensus CDS
    CCDS19486.1
    UniProtKB/Swiss-Prot
    P10923, Q91VH4
    UniProtKB/TrEMBL
    Q547B5
    Related
    ENSMUSP00000031243.9, ENSMUST00000031243.15
    Conserved Domains (1) summary
    pfam00865
    Location:22294
    Osteopontin; Osteopontin

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    104582977..104588919
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)