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SPP1 secreted phosphoprotein 1 [ Homo sapiens (human) ]

Gene ID: 6696, updated on 1-Jun-2020

Summary

Official Symbol
SPP1provided by HGNC
Official Full Name
secreted phosphoprotein 1provided by HGNC
Primary source
HGNC:HGNC:11255
See related
Ensembl:ENSG00000118785 MIM:166490
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OPN; BNSP; BSPI; ETA-1
Summary
The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Expression
Biased expression in placenta (RPKM 1043.5), gall bladder (RPKM 1025.4) and 3 other tissues See more
Orthologs

Genomic context

See SPP1 in Genome Data Viewer
Location:
4q22.1
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (87975650..87983411)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (88896802..88904563)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene matrix extracellular phosphoglycoprotein Neighboring gene heat shock protein 90 alpha family class B member 3, pseudogene Neighboring gene SPP1 5' regulatory region Neighboring gene RNA, U1 small nuclear 36, pseudogene Neighboring gene polycystin 2, transient receptor potential cation channel

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC110940

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity IEA
Inferred from Electronic Annotation
more info
 
extracellular matrix binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integrin binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
androgen catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
biomineral tissue development IEA
Inferred from Electronic Annotation
more info
 
cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
cellular response to testosterone stimulus IDA
Inferred from Direct Assay
more info
PubMed 
decidualization TAS
Traceable Author Statement
more info
PubMed 
embryo implantation TAS
Traceable Author Statement
more info
PubMed 
extracellular matrix organization TAS
Traceable Author Statement
more info
 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of collateral sprouting of intact axon in response to injury IEA
Inferred from Electronic Annotation
more info
 
osteoblast differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of bone resorption IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of estradiol secretion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
post-translational protein modification TAS
Traceable Author Statement
more info
 
response to steroid hormone IEA
Inferred from Electronic Annotation
more info
 
response to vitamin D IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
cell projection IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space HDA PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
osteopontin
Names
SPP1/CALPHA1 fusion
early T-lymphocyte activation 1
nephropontin
osteopontin/immunoglobulin alpha 1 heavy chain constant region fusion protein
secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)
secreted phosphoprotein 1 variant 6
urinary stone protein
uropontin

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030362.1 RefSeqGene

    Range
    5001..12762
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000582.2NP_000573.1  osteopontin isoform OPN-b precursor

    See identical proteins and their annotated locations for NP_000573.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 5. The resulting isoform (OPN-b, as described in PubMed: 7837791) has a shorter and distinct N-terminus and lacks an alternate internal segment compared to isoform e.
    Source sequence(s)
    AF052124, BF699765, BX648003, CB117856
    Consensus CDS
    CCDS3626.1
    UniProtKB/Swiss-Prot
    P10451
    UniProtKB/TrEMBL
    A0A024RDE6
    Related
    ENSP00000237623.7, ENST00000237623.11
    Conserved Domains (1) summary
    pfam00865
    Location:21300
    Osteopontin; Osteopontin
  2. NM_001040058.2NP_001035147.1  osteopontin isoform OPN-a precursor

    See identical proteins and their annotated locations for NP_001035147.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR and coding sequence compared to variant 5. The resulting isoform (OPN-a, as described in PubMed: 7837791) has a shorter and distinct N-terminus compared to isoform e.
    Source sequence(s)
    AA665210, BC017387, CB117856
    Consensus CDS
    CCDS43250.1
    UniProtKB/Swiss-Prot
    P10451
    UniProtKB/TrEMBL
    A0A024RDE2
    Related
    ENSP00000378517.3, ENST00000395080.8
    Conserved Domains (1) summary
    pfam00865
    Location:21314
    Osteopontin; Osteopontin
  3. NM_001040060.1NP_001035149.1  osteopontin isoform OPN-c precursor

    See identical proteins and their annotated locations for NP_001035149.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 5. The resulting isoform (OPN-c, as described in PubMed: 7837791) has a shorter and distinct N-terminus and lacks an alternate internal segment compared to isoform e.
    Source sequence(s)
    AA665210, AC131944, BC093033, DA419665
    Consensus CDS
    CCDS34027.1
    UniProtKB/Swiss-Prot
    P10451
    UniProtKB/TrEMBL
    A0A024RDJ0
    Related
    ENSP00000354042.4, ENST00000360804.4
    Conserved Domains (1) summary
    pfam00865
    Location:21287
    Osteopontin; Osteopontin
  4. NM_001251829.1NP_001238758.1  osteopontin isoform 4 precursor

    See identical proteins and their annotated locations for NP_001238758.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and lacks two alternate in-frame exons compared to variant 5. The resulting isoform (4) has a shorter and distinct N-terminus and lacks an alternate internal segment compared to isoform e.
    Source sequence(s)
    AB209987, AC131944, CB117856, JF412667
    UniProtKB/Swiss-Prot
    P10451
    UniProtKB/TrEMBL
    Q3LGB0
    Related
    ENSP00000422973.1, ENST00000508233.5
    Conserved Domains (1) summary
    pfam00865
    Location:26273
    Osteopontin; Osteopontin
  5. NM_001251830.1NP_001238759.1  osteopontin isoform 5

    See identical proteins and their annotated locations for NP_001238759.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) represents the longest transcript and encodes the longest isoform (5).
    Source sequence(s)
    AC131944, AK295491, CB117856, JF412667
    UniProtKB/Swiss-Prot
    P10451
    UniProtKB/TrEMBL
    B7Z351
    Related
    ENST00000509659.5
    Conserved Domains (1) summary
    pfam00865
    Location:43327
    Osteopontin; Osteopontin

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    87975650..87983411
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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