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STXBP4 syntaxin binding protein 4 [ Homo sapiens (human) ]

Gene ID: 252983, updated on 23-Nov-2021

Summary

Official Symbol
STXBP4provided by HGNC
Official Full Name
syntaxin binding protein 4provided by HGNC
Primary source
HGNC:HGNC:19694
See related
Ensembl:ENSG00000166263 MIM:610415
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Synip
Expression
Ubiquitous expression in kidney (RPKM 1.4), thyroid (RPKM 1.4) and 25 other tissues See more
Orthologs
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Genomic context

See STXBP4 in Genome Data Viewer
Location:
17q22
Exon count:
21
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (54968728..55173632)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (53046126..53250993)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene protein GVQW1-like Neighboring gene target of myb1 like 1 membrane trafficking protein Neighboring gene cytochrome c oxidase copper chaperone COX11 Neighboring gene uncharacterized LOC107985002 Neighboring gene VISTA enhancer hs2291 Neighboring gene Sharpr-MPRA regulatory region 10605 Neighboring gene HLF transcription factor, PAR bZIP family member

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
GeneReviews: Not available
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef Genome-wide shRNA screening identifies STXBP4, which is required for HIV-1 Nef-induced downregulation of CD4 in HeLa CD4+ cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ16496, MGC50337, MGC149829

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables syntaxin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables syntaxin binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular exosome HDA PubMed 
located_in phagocytic vesicle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
syntaxin-binding protein 4
Names
STX4-interacting protein
syntaxin 4 interacting protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178509.6NP_848604.3  syntaxin-binding protein 4

    See identical proteins and their annotated locations for NP_848604.3

    Status: VALIDATED

    Source sequence(s)
    AC005177, AK122865, AK123793, BC041485, CA848494
    Consensus CDS
    CCDS11584.2
    UniProtKB/Swiss-Prot
    Q6ZWJ1
    Related
    ENSP00000365530.2, ENST00000376352.6
    Conserved Domains (4) summary
    cd00992
    Location:2298
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:498527
    WW; WW domain
    pfam06050
    Location:304411
    HGD-D; 2-hydroxyglutaryl-CoA dehydratase, D-component
    pfam08467
    Location:189341
    Luteo_P1-P2; Luteovirus RNA polymerase P1-P2/replicase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    54968728..55173632
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024410.1XP_016879899.1  syntaxin-binding protein 4 isoform X1

  2. XM_005257187.4XP_005257244.1  syntaxin-binding protein 4 isoform X3

    Related
    ENSP00000391087.2, ENST00000434978.6
    Conserved Domains (4) summary
    cd00992
    Location:22100
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:500529
    WW; WW domain
    pfam06050
    Location:306413
    HGD-D; 2-hydroxyglutaryl-CoA dehydratase, D-component
    pfam08467
    Location:191343
    Luteo_P1-P2; Luteovirus RNA polymerase P1-P2/replicase
  3. XM_017024415.1XP_016879904.1  syntaxin-binding protein 4 isoform X6

  4. XM_017024414.2XP_016879903.1  syntaxin-binding protein 4 isoform X6

  5. XM_006721797.4XP_006721860.1  syntaxin-binding protein 4 isoform X7

    Conserved Domains (1) summary
    cd00992
    Location:22100
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  6. XM_017024411.2XP_016879900.1  syntaxin-binding protein 4 isoform X2

  7. XM_017024412.2XP_016879901.1  syntaxin-binding protein 4 isoform X4

  8. XM_006721798.4XP_006721861.1  syntaxin-binding protein 4 isoform X8

    UniProtKB/TrEMBL
    B5MCT9
    Related
    ENSP00000385944.1, ENST00000405898.5
    Conserved Domains (1) summary
    cd00992
    Location:2298
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  9. XM_017024413.1XP_016879902.1  syntaxin-binding protein 4 isoform X5

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