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Stxbp4 syntaxin binding protein 4 [ Mus musculus (house mouse) ]

Gene ID: 20913, updated on 9-Mar-2023

Summary

Official Symbol
Stxbp4provided by MGI
Official Full Name
syntaxin binding protein 4provided by MGI
Primary source
MGI:MGI:1342296
See related
Ensembl:ENSMUSG00000020546 AllianceGenome:MGI:1342296
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Synip; 6030470M02Rik
Summary
Predicted to enable syntaxin binding activity. Acts upstream of or within several processes, including cellular response to interferon-gamma; insulin receptor signaling pathway; and regulation of glucose transmembrane transport. Located in phagocytic vesicle. Orthologous to human STXBP4 (syntaxin binding protein 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 1.5), limb E14.5 (RPKM 1.3) and 26 other tissues See more
Orthologs
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Genomic context

See Stxbp4 in Genome Data Viewer
Location:
11; 11 D
Exon count:
23
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (90367318..90528962, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (90476492..90638136, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene hepatic leukemia factor Neighboring gene predicted gene, 34850 Neighboring gene eukaryotic translation initiation factor 2C, 2 pseudogene Neighboring gene cytochrome c oxidase assembly protein 11, copper chaperone Neighboring gene target of myb1-like 1 (chicken) Neighboring gene predicted gene, 34938

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (1)  1 citation
  • Targeted (1) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables syntaxin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables syntaxin binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to type II interferon IDA
Inferred from Direct Assay
more info
PubMed 
involved_in insulin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within insulin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell cycle G1/S phase transition ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of keratinocyte proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein targeting IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of glucose transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of insulin secretion involved in cellular response to glucose stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of insulin secretion involved in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in Schaffer collateral - CA1 synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in phagocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
syntaxin-binding protein 4
Names
STX4-interacting protein
syntaxin 4-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011505.3NP_035635.1  syntaxin-binding protein 4

    See identical proteins and their annotated locations for NP_035635.1

    Status: VALIDATED

    Source sequence(s)
    AL646046
    Consensus CDS
    CCDS25242.1
    UniProtKB/Swiss-Prot
    Q8CFL1, Q9WV89
    Related
    ENSMUSP00000116191.2, ENSMUST00000143203.8
    Conserved Domains (3) summary
    cd00992
    Location:2194
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:502531
    WW; WW domain
    pfam08467
    Location:189393
    Luteo_P1-P2; Luteovirus RNA polymerase P1-P2/replicase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    90367318..90528962 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245750.2XP_030101610.1  syntaxin-binding protein 4 isoform X6

    Conserved Domains (2) summary
    TIGR02169
    Location:75240
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam00397
    Location:277306
    WW; WW domain
  2. XM_006532736.5XP_006532799.1  syntaxin-binding protein 4 isoform X1

    Related
    ENSMUSP00000020858.8, ENSMUST00000020858.14
    Conserved Domains (2) summary
    cd00992
    Location:2194
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    TIGR02169
    Location:300465
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
  3. XM_006532738.5XP_006532801.1  syntaxin-binding protein 4 isoform X3

    Conserved Domains (2) summary
    cd00992
    Location:2194
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    TIGR02169
    Location:300465
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
  4. XM_006532737.5XP_006532800.1  syntaxin-binding protein 4 isoform X2

    Conserved Domains (2) summary
    cd00992
    Location:2194
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    TIGR02169
    Location:300465
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
  5. XM_006532739.5XP_006532802.1  syntaxin-binding protein 4 isoform X4

    Conserved Domains (1) summary
    cd00992
    Location:2194
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  6. XM_006532740.5XP_006532803.1  syntaxin-binding protein 4 isoform X5

    Conserved Domains (1) summary
    cd00992
    Location:2194
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

RNA

  1. XR_388390.4 RNA Sequence