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Cnr1 cannabinoid receptor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25248, updated on 6-Feb-2024

Summary

Official Symbol
Cnr1provided by RGD
Official Full Name
cannabinoid receptor 1provided by RGD
Primary source
RGD:2369
See related
Ensembl:ENSRNOG00000008223 AllianceGenome:RGD:2369
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
CB1R; SKR6R
Summary
Enables cannabinoid receptor activity. Involved in several processes, including positive regulation of acute inflammatory response; regulation of secretion by cell; and response to alkaloid. Located in membrane raft and plasma membrane. Colocalizes with intracellular membrane-bounded organelle. Used to study several diseases, including Parkinsonism; diabetic neuropathy; impotence; obesity; and peptic ulcer disease. Biomarker of status epilepticus. Human ortholog(s) of this gene implicated in obesity; schizophrenia; and type 2 diabetes mellitus. Orthologous to human CNR1 (cannabinoid receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 374.6), Adrenal (RPKM 99.1) and 2 other tissues See more
Orthologs
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Genomic context

See Cnr1 in Genome Data Viewer
Location:
5q21
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_06 current mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (48408543..48436099)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (49307584..49333064)

Chromosome 5 - NC_051340.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108350950 Neighboring gene BCL2 interacting protein 2, pseudogene 1 Neighboring gene uncharacterized LOC120102853 Neighboring gene U2 spliceosomal RNA Neighboring gene uncharacterized LOC103692331 Neighboring gene sperm acrosome associated 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cannabinoid receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables cannabinoid receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within axonal fasciculation ISO
Inferred from Sequence Orthology
more info
 
involved_in cannabinoid signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cannabinoid signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within glucose homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in learning or memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in maternal process involved in female pregnancy IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in memory IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of action potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of dopamine secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of fatty acid beta-oxidation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of mast cell activation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of monoatomic ion transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of serotonin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of acute inflammatory response to antigenic stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of fever generation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neuron projection development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of feeding behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of lipid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of penile erection IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of presynaptic cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of synaptic transmission, GABAergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of synaptic transmission, glutamatergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to cocaine IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to ethanol IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to nicotine IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to nutrient IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in retrograde trans-synaptic signaling by endocannabinoid ISO
Inferred from Sequence Orthology
more info
 
involved_in spermatogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in trans-synaptic signaling by endocannabinoid, modulating synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in GABA-ergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in growth cone ISO
Inferred from Sequence Orthology
more info
 
located_in membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
located_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cannabinoid receptor 1
Names
CB-R
CB1
Cannabinoid CB1 receptor
brain-type cannabinoid receptor
cannabinoid receptor 1 (brain)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012784.5NP_036916.1  cannabinoid receptor 1

    See identical proteins and their annotated locations for NP_036916.1

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000161
    UniProtKB/Swiss-Prot
    P20272
    UniProtKB/TrEMBL
    A6IIL9
    Related
    ENSRNOP00000081243.1, ENSRNOT00000099728.1
    Conserved Domains (1) summary
    cd15340
    Location:118409
    7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_015227675.2-RS_2023_06

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051340.1 Reference mRatBN7.2 Primary Assembly

    Range
    48408543..48436099
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017593151.2XP_017448640.1  cannabinoid receptor 1 isoform X1

    UniProtKB/Swiss-Prot
    P20272
    UniProtKB/TrEMBL
    A6IIL9
    Related
    ENSRNOP00000079932.1, ENSRNOT00000117169.1
    Conserved Domains (1) summary
    cd15340
    Location:118409
    7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. XM_039109284.1XP_038965212.1  cannabinoid receptor 1 isoform X1

    UniProtKB/Swiss-Prot
    P20272
    UniProtKB/TrEMBL
    A6IIL9
    Related
    ENSRNOP00000085179.1, ENSRNOT00000101534.1
    Conserved Domains (1) summary
    cd15340
    Location:118409
    7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors
  3. XM_006237984.4XP_006238046.1  cannabinoid receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_006238046.1

    UniProtKB/Swiss-Prot
    P20272
    UniProtKB/TrEMBL
    A6IIL9
    Conserved Domains (1) summary
    cd15340
    Location:118409
    7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors