Cnr1 cannabinoid receptor 1 (brain) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cnr1provided by MGI
Official Full Name: cannabinoid receptor 1 (brain)provided by MGI
Primary source: MGI:MGI:104615
See related: Ensembl:ENSMUSG00000044288 AllianceGenome:MGI:104615
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CB1; CB-R; CB1A; CB1B; CB1R
Summary: Enables cannabinoid receptor activity and voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels. Involved in cannabinoid signaling pathway; retrograde trans-synaptic signaling by endocannabinoid; and trans-synaptic signaling by endocannabinoid, modulating synaptic transmission. Acts upstream of or within axonal fasciculation and glucose homeostasis. Located in several cellular components, including GABA-ergic synapse; growth cone; and presynaptic membrane. Is integral component of mitochondrial membrane and integral component of presynaptic membrane. Is active in glutamatergic synapse and presynapse. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in obesity; schizophrenia; and type 2 diabetes mellitus. Orthologous to human CNR1 (cannabinoid receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cerebellum adult (RPKM 24.0), CNS E18 (RPKM 17.4) and 7 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 4 A5; 4 16.28 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (33923171..33948831)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (33923171..33948831)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Regional redistribution of CB1 cannabinoid receptors in human foetal brains with Down's syndrome and their functional modifications in Ts65Dn[+/+] mice.
Title: Regional redistribution of CB1 cannabinoid receptors in human foetal brains with Down's syndrome and their functional modifications in Ts65Dn(+/+) mice.
Altered glial expression of the cannabinoid 1 receptor in the subiculum of a mouse model of Alzheimer's disease.
Title: Altered glial expression of the cannabinoid 1 receptor in the subiculum of a mouse model of Alzheimer's disease.
Global cannabinoid receptor 1 deficiency affects disuse-induced bone loss in a site-specific and sex-dependent manner.
Title: Global cannabinoid receptor 1 deficiency affects disuse-induced bone loss in a site-specific and sex-dependent manner.
Cannabinoid CB1 Receptors Are Expressed in a Subset of Dopamine Neurons and Underlie Cannabinoid-Induced Aversion, Hypoactivity, and Anxiolytic Effects in Mice.
Title: Cannabinoid CB1 Receptors Are Expressed in a Subset of Dopamine Neurons and Underlie Cannabinoid-Induced Aversion, Hypoactivity, and Anxiolytic Effects in Mice.
Hippocampal Deletion of CB1 Receptor Impairs Social Memory and Leads to Age-Related Changes in the Hippocampus of Adult Mice.
Title: Hippocampal Deletion of CB1 Receptor Impairs Social Memory and Leads to Age-Related Changes in the Hippocampus of Adult Mice.
Genetic Manipulation of CB1 Cannabinoid Receptors Reveals a Role in Maintaining Proper Skeletal Muscle Morphology and Function in Mice.
Title: Genetic Manipulation of CB1 Cannabinoid Receptors Reveals a Role in Maintaining Proper Skeletal Muscle Morphology and Function in Mice.
Diet-Induced Gut Barrier Dysfunction Is Exacerbated in Mice Lacking Cannabinoid 1 Receptors in the Intestinal Epithelium.
Title: Diet-Induced Gut Barrier Dysfunction Is Exacerbated in Mice Lacking Cannabinoid 1 Receptors in the Intestinal Epithelium.
alpha-Dystrobrevin knockout mice have increased motivation for appetitive reward and altered brain cannabinoid receptor 1 expression.
Title: α-Dystrobrevin knockout mice have increased motivation for appetitive reward and altered brain cannabinoid receptor 1 expression.
Sex-specific characteristics of cells expressing the cannabinoid 1 receptor in the dorsal horn of the lumbar spinal cord.
Title: Sex-specific characteristics of cells expressing the cannabinoid 1 receptor in the dorsal horn of the lumbar spinal cord.
Cannabinoid Receptor 1 Is Required for Neurodevelopment of Striosome-Dendron Bouquets.
Title: Cannabinoid Receptor 1 Is Required for Neurodevelopment of Striosome-Dendron Bouquets.

Submit: New GeneRIF Correction See all GeneRIFs (414)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (22) 1 citation
Endonuclease-mediated (6)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

Cnr1 (e-PCR), detects polymorphism
- UniSTS:141363

PMC123076P1 (e-PCR)
- UniSTS:270436

PMC193595P1 (e-PCR)
- UniSTS:271751

PMC166293P1 (e-PCR)
- UniSTS:271579

Homology

Homologs of the Cnr1 gene: The Cnr1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 497 organisms have orthologs with human gene Cnr1
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables cannabinoid receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables cannabinoid receptor activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in aging	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within axonal fasciculation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cannabinoid signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cannabinoid signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glucose homeostasis	IPI Inferred from Physical Interaction more info	PubMed
involved_in learning or memory	ISO Inferred from Sequence Orthology more info
involved_in memory	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of action potential	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of dopamine secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fatty acid beta-oxidation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mast cell activation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of monoatomic ion transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of nitric-oxide synthase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of serotonin secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of acute inflammatory response to antigenic stimulus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fever generation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in regulation of feeding behavior	ISO Inferred from Sequence Orthology more info
involved_in regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of lipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of penile erection	ISO Inferred from Sequence Orthology more info
involved_in regulation of presynaptic cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of presynaptic cytosolic calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic transmission, GABAergic	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic transmission, glutamatergic	ISO Inferred from Sequence Orthology more info
involved_in response to cocaine	ISO Inferred from Sequence Orthology more info
involved_in response to ethanol	ISO Inferred from Sequence Orthology more info
involved_in response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in response to morphine	ISO Inferred from Sequence Orthology more info
involved_in response to nicotine	ISO Inferred from Sequence Orthology more info
involved_in retrograde trans-synaptic signaling by endocannabinoid	IDA Inferred from Direct Assay more info	PubMed
involved_in retrograde trans-synaptic signaling by endocannabinoid	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of pain	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
involved_in trans-synaptic signaling by endocannabinoid, modulating synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in GABA-ergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: cannabinoid receptor 1

Names: brain-type cannabinoid receptor; striatal cannabinoid receptor type 1 protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001355020.2 → NP_001341949.1 cannabinoid receptor 1

Status: VALIDATED

Source sequence(s)

BX005292

Consensus CDS

CCDS18025.1

UniProtKB/Swiss-Prot

Q5SF33

UniProtKB/TrEMBL

A0A385KNU8, A0A6P7QTJ1, A0A8C6GWM8

Conserved Domains (1) summary

cd15340
Location:118 → 409

7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001355021.2 → NP_001341950.1 cannabinoid receptor 1

Status: VALIDATED

Source sequence(s)

BX005292

Consensus CDS

CCDS18025.1

UniProtKB/Swiss-Prot

Q5SF33

UniProtKB/TrEMBL

A0A385KNU8, A0A6P7QTJ1, A0A8C6GWM8

Conserved Domains (1) summary

cd15340
Location:118 → 409

7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001365881.1 → NP_001352810.1 cannabinoid receptor 1

Status: VALIDATED

Source sequence(s)

BX005292

Consensus CDS

CCDS18025.1

UniProtKB/Swiss-Prot

Q5SF33

UniProtKB/TrEMBL

A0A385KNU8, A0A6P7QTJ1, A0A8C6GWM8

Related

ENSMUSP00000081787.3, ENSMUST00000084736.3

Conserved Domains (1) summary

cd15340
Location:118 → 409

7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_007726.5 → NP_031752.1 cannabinoid receptor 1

See identical proteins and their annotated locations for NP_031752.1

Status: VALIDATED

Source sequence(s)

BX005292

Consensus CDS

CCDS18025.1

UniProtKB/Swiss-Prot

P47746, Q5SF33

UniProtKB/TrEMBL

A0A385KNU8, A0A6P7QTJ1, A0A8C6GWM8

Related

ENSMUSP00000055797.7, ENSMUST00000057188.7

Conserved Domains (1) summary

cd15340
Location:118 → 409

7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

33923171..33948831

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030253149.1 → XP_030109009.1 cannabinoid receptor 1 isoform X1

UniProtKB/Swiss-Prot

Q5SF33

UniProtKB/TrEMBL

A0A385KNU8, A0A6P7QTJ1, A0A8C6GWM8

Conserved Domains (1) summary

cd15340
Location:118 → 409

7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_006537594.4 → XP_006537657.1 cannabinoid receptor 1 isoform X1

See identical proteins and their annotated locations for XP_006537657.1

UniProtKB/Swiss-Prot

P47746, Q5SF33

UniProtKB/TrEMBL

A0A385KNU8, A0A6P7QTJ1, A0A8C6GWM8

Conserved Domains (1) summary

cd15340
Location:118 → 409

7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_006537595.4 → XP_006537658.1 cannabinoid receptor 1 isoform X1

See identical proteins and their annotated locations for XP_006537658.1

UniProtKB/Swiss-Prot

P47746, Q5SF33

UniProtKB/TrEMBL

A0A385KNU8, A0A6P7QTJ1, A0A8C6GWM8

Conserved Domains (1) summary

cd15340
Location:118 → 409

7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_036163625.1 → XP_036019518.1 cannabinoid receptor 1 isoform X1

UniProtKB/Swiss-Prot

Q5SF33

UniProtKB/TrEMBL

A0A385KNU8, A0A6P7QTJ1, A0A8C6GWM8

Conserved Domains (1) summary

cd15340
Location:118 → 409

7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_006537592.5 → XP_006537655.1 cannabinoid receptor 1 isoform X1

See identical proteins and their annotated locations for XP_006537655.1

UniProtKB/Swiss-Prot

P47746, Q5SF33

UniProtKB/TrEMBL

A0A385KNU8, A0A6P7QTJ1, A0A8C6GWM8

Conserved Domains (1) summary

cd15340
Location:118 → 409

7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_036163626.1 → XP_036019519.1 cannabinoid receptor 1 isoform X1

UniProtKB/Swiss-Prot

Q5SF33

UniProtKB/TrEMBL

A0A385KNU8, A0A6P7QTJ1, A0A8C6GWM8

Conserved Domains (1) summary

cd15340
Location:118 → 409

7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_006537591.4 → XP_006537654.1 cannabinoid receptor 1 isoform X1

See identical proteins and their annotated locations for XP_006537654.1

UniProtKB/Swiss-Prot

P47746, Q5SF33

UniProtKB/TrEMBL

A0A385KNU8, A0A6P7QTJ1, A0A8C6GWM8

Conserved Domains (1) summary

cd15340
Location:118 → 409

7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_006537593.4 → XP_006537656.1 cannabinoid receptor 1 isoform X1

See identical proteins and their annotated locations for XP_006537656.1

UniProtKB/Swiss-Prot

P47746, Q5SF33

UniProtKB/TrEMBL

A0A385KNU8, A0A6P7QTJ1, A0A8C6GWM8

Conserved Domains (1) summary

cd15340
Location:118 → 409

7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors