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CNR1 cannabinoid receptor 1 [ Homo sapiens (human) ]

Gene ID: 1268, updated on 4-May-2020

Summary

Official Symbol
CNR1provided by HGNC
Official Full Name
cannabinoid receptor 1provided by HGNC
Primary source
HGNC:HGNC:2159
See related
Ensembl:ENSG00000118432 MIM:114610
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CB1; CNR; CB-R; CB1A; CB1R; CANN6; CB1K5
Summary
This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene. [provided by RefSeq, May 2009]
Expression
Biased expression in brain (RPKM 6.2), fat (RPKM 2.7) and 12 other tissues See more
Orthologs

Genomic context

See CNR1 in Genome Data Viewer
Location:
6q15
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (88139864..88167349, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (88849583..88876063, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986541 Neighboring gene sperm acrosome associated 1 Neighboring gene ribosomal protein S14 pseudogene 9 Neighboring gene ACTB pseudogene 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env CB1 or CB2 receptor agonists significantly inhibit HIV-1 gp120-induced decrease proliferation and increase apoptosis of human neural progenitor cells (hNPCs), indicating that CB1 or CB2 receptors are required for the effects of gp120 on hNPCs PubMed
env HIV-1 gp120 downregulates expression of cannabinoid receptor 1 (CB1) in human brain micro vascular endothelial cells (HBMEC) PubMed
Tat tat HIV-1 Tat upregulates the expression of CB1 and CB2 cannabinoid receptors in retinal cells, which is suppressed by endocannabinoids, N-arachidonoylethanolamide and 2-arachidonoylglycerol PubMed
tat CB1 and CB2 endocannabinoid receptors are involved in HIV-1 Tat-induced cleavage of PARP1 and CASP3 in retinal cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cannabinoid receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cannabinoid receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
drug binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS
Traceable Author Statement
more info
PubMed 
adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adenylate cyclase-modulating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
aging IEA
Inferred from Electronic Annotation
more info
 
axonal fasciculation IEA
Inferred from Electronic Annotation
more info
 
cannabinoid signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cannabinoid signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
glucose homeostasis IEA
Inferred from Electronic Annotation
more info
 
induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 
maternal process involved in female pregnancy IEA
Inferred from Electronic Annotation
more info
 
memory IEA
Inferred from Electronic Annotation
more info
 
negative regulation of action potential IEA
Inferred from Electronic Annotation
more info
 
negative regulation of blood pressure IEA
Inferred from Electronic Annotation
more info
 
negative regulation of dopamine secretion IEA
Inferred from Electronic Annotation
more info
 
negative regulation of fatty acid beta-oxidation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of mast cell activation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of nitric-oxide synthase activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of serotonin secretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of acute inflammatory response to antigenic stimulus IEA
Inferred from Electronic Annotation
more info
 
positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of blood pressure IEA
Inferred from Electronic Annotation
more info
 
positive regulation of fever generation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neuron projection development IEA
Inferred from Electronic Annotation
more info
 
regulation of feeding behavior IEA
Inferred from Electronic Annotation
more info
 
regulation of insulin secretion IEA
Inferred from Electronic Annotation
more info
 
regulation of metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of penile erection IEA
Inferred from Electronic Annotation
more info
 
regulation of synaptic transmission, GABAergic IEA
Inferred from Electronic Annotation
more info
 
regulation of synaptic transmission, glutamatergic IEA
Inferred from Electronic Annotation
more info
 
response to cocaine IEA
Inferred from Electronic Annotation
more info
 
response to ethanol IEA
Inferred from Electronic Annotation
more info
 
response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
response to morphine IEA
Inferred from Electronic Annotation
more info
 
response to nicotine IEA
Inferred from Electronic Annotation
more info
 
response to nutrient IEA
Inferred from Electronic Annotation
more info
 
retrograde trans-synaptic signaling by endocannabinoid IEA
Inferred from Electronic Annotation
more info
 
sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
trans-synaptic signaling by endocannabinoid, modulating synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
GABA-ergic synapse IEA
Inferred from Electronic Annotation
more info
 
actin cytoskeleton IDA
Inferred from Direct Assay
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
growth cone IEA
Inferred from Electronic Annotation
more info
 
integral component of mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
integral component of presynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
membrane raft IEA
Inferred from Electronic Annotation
more info
 
mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
cannabinoid receptor 1
Names
cannabinoid receptor 1 (brain)
central cannabinoid receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001160226.3NP_001153698.1  cannabinoid receptor 1 isoform a

    See identical proteins and their annotated locations for NP_001153698.1

    Status: REVIEWED

    Source sequence(s)
    AL121835, AL136096
    Consensus CDS
    CCDS5015.1
    UniProtKB/Swiss-Prot
    P21554
    UniProtKB/TrEMBL
    S5TLS4
    Conserved Domains (1) summary
    cd15340
    Location:117408
    7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_001160258.3NP_001153730.1  cannabinoid receptor 1 isoform a

    See identical proteins and their annotated locations for NP_001153730.1

    Status: REVIEWED

    Source sequence(s)
    AL121835, AL136096
    Consensus CDS
    CCDS5015.1
    UniProtKB/Swiss-Prot
    P21554
    UniProtKB/TrEMBL
    S5TLS4
    Conserved Domains (1) summary
    cd15340
    Location:117408
    7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors
  3. NM_001160259.3NP_001153731.1  cannabinoid receptor 1 isoform a

    See identical proteins and their annotated locations for NP_001153731.1

    Status: REVIEWED

    Source sequence(s)
    AL121835, AL136096
    Consensus CDS
    CCDS5015.1
    UniProtKB/Swiss-Prot
    P21554
    UniProtKB/TrEMBL
    S5TLS4
    Conserved Domains (1) summary
    cd15340
    Location:117408
    7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors
  4. NM_001365869.2NP_001352798.1  cannabinoid receptor 1 isoform a

    Status: REVIEWED

    Source sequence(s)
    AL121835, AL136096
    Related
    ENSP00000358511.2, ENST00000369499.2
    Conserved Domains (1) summary
    cd15340
    Location:117408
    7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors
  5. NM_001365870.2NP_001352799.1  cannabinoid receptor 1 isoform a

    Status: REVIEWED

    Source sequence(s)
    AL121835, AL136096
    Conserved Domains (1) summary
    cd15340
    Location:117408
    7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors
  6. NM_001365872.2NP_001352801.1  cannabinoid receptor 1 isoform a

    Status: REVIEWED

    Source sequence(s)
    AL121835, AL136096
    Conserved Domains (1) summary
    cd15340
    Location:117408
    7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors
  7. NM_001365874.2NP_001352803.1  cannabinoid receptor 1 isoform a

    Status: REVIEWED

    Source sequence(s)
    AL121835, AL136096
    Related
    ENSP00000412192.2, ENST00000428600.2
    Conserved Domains (1) summary
    cd15340
    Location:117408
    7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors
  8. NM_001370545.1NP_001357474.1  cannabinoid receptor 1 isoform a

    Status: REVIEWED

    Source sequence(s)
    AL121835, AL136096
    Conserved Domains (1) summary
    cd15340
    Location:117408
    7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors
  9. NM_001370546.1NP_001357475.1  cannabinoid receptor 1 isoform a

    Status: REVIEWED

    Source sequence(s)
    AL121835, AL136096
    Conserved Domains (1) summary
    cd15340
    Location:117408
    7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors
  10. NM_001370547.1NP_001357476.1  cannabinoid receptor 1 isoform a

    Status: REVIEWED

    Source sequence(s)
    AL121835, AL136096
    Conserved Domains (1) summary
    cd15340
    Location:117408
    7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors
  11. NM_016083.6NP_057167.2  cannabinoid receptor 1 isoform a

    See identical proteins and their annotated locations for NP_057167.2

    Status: REVIEWED

    Source sequence(s)
    AL121835, AL136096
    Consensus CDS
    CCDS5015.1
    UniProtKB/Swiss-Prot
    P21554
    UniProtKB/TrEMBL
    S5TLS4
    Related
    ENSP00000358513.2, ENST00000369501.2
    Conserved Domains (1) summary
    cd15340
    Location:117408
    7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors
  12. NM_033181.4NP_149421.2  cannabinoid receptor 1 isoform b

    See identical proteins and their annotated locations for NP_149421.2

    Status: REVIEWED

    Source sequence(s)
    AY766182, BM682178, BX538191, DA239984, DA793373, DA799263, X54937, X81120
    Consensus CDS
    CCDS5016.2
    UniProtKB/Swiss-Prot
    P21554
    UniProtKB/TrEMBL
    V5KA96
    Related
    ENSP00000420188.1, ENST00000468898.1
    Conserved Domains (1) summary
    cd15340
    Location:84375
    7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    88139864..88167349 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011535425.2XP_011533727.1  cannabinoid receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_011533727.1

    UniProtKB/Swiss-Prot
    P21554
    UniProtKB/TrEMBL
    S5TLS4
    Conserved Domains (1) summary
    cd15340
    Location:117408
    7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001160260.1: Suppressed sequence

    Description
    NM_001160260.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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