Format

Send to:

Choose Destination

CNR1 cannabinoid receptor 1 [ Homo sapiens (human) ]

Gene ID: 1268, updated on 17-Sep-2017
Official Symbol
CNR1provided by HGNC
Official Full Name
cannabinoid receptor 1provided by HGNC
Primary source
HGNC:HGNC:2159
See related
Ensembl:ENSG00000118432 MIM:114610; Vega:OTTHUMG00000015184
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CB1; CNR; CB-R; CB1A; CB1R; CANN6; CB1K5
Summary
This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene. [provided by RefSeq, May 2009]
Orthologs
Location:
6q15
Exon count:
7
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 6 NC_000006.12 (88139864..88167429, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (88849583..88876063, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986541 Neighboring gene sperm acrosome associated 1 Neighboring gene ribosomal protein S14 pseudogene 9 Neighboring gene actin, beta pseudogene 8

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env CB1 or CB2 receptor agonists significantly inhibit HIV-1 gp120-induced decrease proliferation and increase apoptosis of human neural progenitor cells (hNPCs), indicating that CB1 or CB2 receptors are required for the effects of gp120 on hNPCs PubMed
env HIV-1 gp120 downregulates expression of cannabinoid receptor 1 (CB1) in human brain micro vascular endothelial cells (HBMEC) PubMed
Tat tat HIV-1 Tat upregulates the expression of CB1 and CB2 cannabinoid receptors in retinal cells, which is suppressed by endocannabinoids, N-arachidonoylethanolamide and 2-arachidonoylglycerol PubMed
tat CB1 and CB2 endocannabinoid receptors are involved in HIV-1 Tat-induced cleavage of PARP1 and CASP3 in retinal cells PubMed

Go to the HIV-1, Human Interaction Database

  • Brain-Derived Neurotrophic Factor (BDNF) signaling pathway, organism-specific biosystem (from WikiPathways)
    Brain-Derived Neurotrophic Factor (BDNF) signaling pathway, organism-specific biosystemBrain-derived neurotrophic factor (BDNF) is a neurotrophin essential for growth, differentiation, plasticity, and survival of neurons. BDNF is also required for processes such as energy metabolism, b...
  • Cell-type Dependent Selectivity of CCK2R Signaling, organism-specific biosystem (from WikiPathways)
    Cell-type Dependent Selectivity of CCK2R Signaling, organism-specific biosystemThis pathway is based on Figure 7 of "Cell-Type Specific CCK2 Receptor Signaling Underlies the Cholecystokinin-Mediated Selective Excitation of Hippocampal Parvalbumin-Positive Fast-Spiking Basket Ce...
  • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
    Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
  • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
    GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...
  • GPCRs, Other, organism-specific biosystem (from WikiPathways)
    GPCRs, Other, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...
  • N-cadherin signaling events, organism-specific biosystem (from Pathway Interaction Database)
    N-cadherin signaling events, organism-specific biosystem
    N-cadherin signaling events
  • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, organism-specific biosystem
    Neuroactive ligand-receptor interaction
  • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, conserved biosystem
    Neuroactive ligand-receptor interaction
  • Rap1 signaling pathway, organism-specific biosystem (from KEGG)
    Rap1 signaling pathway, organism-specific biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
  • Rap1 signaling pathway, conserved biosystem (from KEGG)
    Rap1 signaling pathway, conserved biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
  • Retrograde endocannabinoid signaling, organism-specific biosystem (from KEGG)
    Retrograde endocannabinoid signaling, organism-specific biosystemEndogenous cannabinoids (endocannabinoids) serve as retrograde messengers at synapses in various regions of the brain. The family of endocannabinoids includes at least five derivatives of arachidonic...
  • Retrograde endocannabinoid signaling, conserved biosystem (from KEGG)
    Retrograde endocannabinoid signaling, conserved biosystemEndogenous cannabinoids (endocannabinoids) serve as retrograde messengers at synapses in various regions of the brain. The family of endocannabinoids includes at least five derivatives of arachidonic...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
  • Small Ligand GPCRs, organism-specific biosystem (from WikiPathways)
    Small Ligand GPCRs, organism-specific biosystem
    Small Ligand GPCRs
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cannabinoid receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
drug binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS
Traceable Author Statement
more info
PubMed 
adenylate cyclase-modulating G-protein coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
aging IEA
Inferred from Electronic Annotation
more info
 
axonal fasciculation IEA
Inferred from Electronic Annotation
more info
 
cannabinoid signaling pathway IEA
Inferred from Electronic Annotation
more info
 
glucose homeostasis IEA
Inferred from Electronic Annotation
more info
 
maternal process involved in female pregnancy IEA
Inferred from Electronic Annotation
more info
 
memory IEA
Inferred from Electronic Annotation
more info
 
negative regulation of action potential IEA
Inferred from Electronic Annotation
more info
 
negative regulation of blood pressure IEA
Inferred from Electronic Annotation
more info
 
negative regulation of dopamine secretion IEA
Inferred from Electronic Annotation
more info
 
negative regulation of fatty acid beta-oxidation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of mast cell activation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of nitric-oxide synthase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of acute inflammatory response to antigenic stimulus IEA
Inferred from Electronic Annotation
more info
 
positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of blood pressure IEA
Inferred from Electronic Annotation
more info
 
positive regulation of fever generation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neuron projection development IEA
Inferred from Electronic Annotation
more info
 
regulation of feeding behavior IEA
Inferred from Electronic Annotation
more info
 
regulation of insulin secretion IEA
Inferred from Electronic Annotation
more info
 
regulation of penile erection IEA
Inferred from Electronic Annotation
more info
 
regulation of synaptic transmission, GABAergic IEA
Inferred from Electronic Annotation
more info
 
regulation of synaptic transmission, glutamatergic IEA
Inferred from Electronic Annotation
more info
 
response to cocaine IEA
Inferred from Electronic Annotation
more info
 
response to ethanol IEA
Inferred from Electronic Annotation
more info
 
response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
response to morphine IEA
Inferred from Electronic Annotation
more info
 
response to nicotine IEA
Inferred from Electronic Annotation
more info
 
response to nutrient IEA
Inferred from Electronic Annotation
more info
 
sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
trans-synaptic signaling by endocannabinoid, modulating synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
actin cytoskeleton IDA
Inferred from Direct Assay
more info
 
axon IEA
Inferred from Electronic Annotation
more info
 
growth cone IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
membrane raft IEA
Inferred from Electronic Annotation
more info
 
mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
presynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
cannabinoid receptor 1
Names
cannabinoid receptor 1 (brain)
central cannabinoid receptor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001160226.1NP_001153698.1  cannabinoid receptor 1 isoform a

    See identical proteins and their annotated locations for NP_001153698.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate exon in the 5' UTR, compared to variant 1. Variants 1, 3, 4 and 5 all encode isoform a. This variant was designated CB1B by PubMed ID: 15289816.
    Source sequence(s)
    AL121835, AL136096
    Consensus CDS
    CCDS5015.1
    UniProtKB/Swiss-Prot
    P21554
    UniProtKB/TrEMBL
    S5TLS4
    Conserved Domains (2) summary
    pfam00001
    Location:133397
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:132412
    7tm_4; Olfactory receptor
  2. NM_001160258.1NP_001153730.1  cannabinoid receptor 1 isoform a

    See identical proteins and their annotated locations for NP_001153730.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains two alternate exons in the 5' UTR, compared to variant 1. Variants 1, 3, 4 and 5 all encode isoform a. This variant was designated CB1C by PubMed ID: 15289816.
    Source sequence(s)
    AL121835, AL136096
    Consensus CDS
    CCDS5015.1
    UniProtKB/Swiss-Prot
    P21554
    UniProtKB/TrEMBL
    S5TLS4
    Conserved Domains (2) summary
    pfam00001
    Location:133397
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:132412
    7tm_4; Olfactory receptor
  3. NM_001160259.1NP_001153731.1  cannabinoid receptor 1 isoform a

    See identical proteins and their annotated locations for NP_001153731.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses a different splice site in the 5' UTR, compared to variant 1. Variants 1, 3, 4 and 5 all encode isoform a. This variant was designated CB1D by PubMed ID: 15289816.
    Source sequence(s)
    AL121835, AL136096
    Consensus CDS
    CCDS5015.1
    UniProtKB/Swiss-Prot
    P21554
    UniProtKB/TrEMBL
    S5TLS4
    Conserved Domains (2) summary
    pfam00001
    Location:133397
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:132412
    7tm_4; Olfactory receptor
  4. NM_016083.4NP_057167.2  cannabinoid receptor 1 isoform a

    See identical proteins and their annotated locations for NP_057167.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a). Variant 1 has also been called CB1A by PubMed ID: 15289816. Variants 1, 3, 4 and 5 all encode isoform a.
    Source sequence(s)
    AL121835, BM682178, BX538191, DA128033, DA768458, X54937, X81120
    Consensus CDS
    CCDS5015.1
    UniProtKB/Swiss-Prot
    P21554
    UniProtKB/TrEMBL
    S5TLS4
    Related
    ENSP00000358513.2, OTTHUMP00000016838, ENST00000369501.2, OTTHUMT00000041461
    Conserved Domains (2) summary
    pfam00001
    Location:133397
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:132412
    7tm_4; Olfactory receptor
  5. NM_033181.3NP_149421.2  cannabinoid receptor 1 isoform b

    See identical proteins and their annotated locations for NP_149421.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an internal segment near the 5' end of the coding region, compared to variant 1. The resulting protein (isoform b) has a shorter and distinct N-terminus compared to isoform a. PubMed ID: 15620723 referred to this variant and its protein as CB1b.
    Source sequence(s)
    AY766182, BM682178, BX538191, DA239984, DA793373, DA799263, X54937, X81120
    Consensus CDS
    CCDS5016.2
    UniProtKB/Swiss-Prot
    P21554
    UniProtKB/TrEMBL
    V5KA96
    Related
    ENSP00000420188.1, OTTHUMP00000214579, ENST00000468898.1, OTTHUMT00000354203
    Conserved Domains (2) summary
    pfam00001
    Location:100364
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:99379
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p7 Primary Assembly

    Range
    88139864..88167429 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017010240.1XP_016865729.1  cannabinoid receptor 1 isoform X1

    UniProtKB/Swiss-Prot
    P21554
    UniProtKB/TrEMBL
    S5TLS4
    Conserved Domains (2) summary
    pfam00001
    Location:133397
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:132412
    7tm_4; Olfactory receptor
  2. XM_006715330.3XP_006715393.1  cannabinoid receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_006715393.1

    UniProtKB/Swiss-Prot
    P21554
    UniProtKB/TrEMBL
    S5TLS4
    Related
    ENSP00000446819.1, OTTHUMP00000016839, ENST00000549890.1, OTTHUMT00000041462
    Conserved Domains (2) summary
    pfam00001
    Location:133397
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:132412
    7tm_4; Olfactory receptor
  3. XM_011535424.1XP_011533726.1  cannabinoid receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_011533726.1

    UniProtKB/Swiss-Prot
    P21554
    UniProtKB/TrEMBL
    S5TLS4
    Conserved Domains (2) summary
    pfam00001
    Location:133397
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:132412
    7tm_4; Olfactory receptor
  4. XM_011535428.1XP_011533730.1  cannabinoid receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_011533730.1

    UniProtKB/Swiss-Prot
    P21554
    UniProtKB/TrEMBL
    S5TLS4
    Related
    ENSP00000358511.2, OTTHUMP00000241184, ENST00000369499.2, OTTHUMT00000404176
    Conserved Domains (2) summary
    pfam00001
    Location:133397
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:132412
    7tm_4; Olfactory receptor
  5. XM_011535425.1XP_011533727.1  cannabinoid receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_011533727.1

    UniProtKB/Swiss-Prot
    P21554
    UniProtKB/TrEMBL
    S5TLS4
    Conserved Domains (2) summary
    pfam00001
    Location:133397
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:132412
    7tm_4; Olfactory receptor
  6. XM_011535426.1XP_011533728.1  cannabinoid receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_011533728.1

    UniProtKB/Swiss-Prot
    P21554
    UniProtKB/TrEMBL
    S5TLS4
    Conserved Domains (2) summary
    pfam00001
    Location:133397
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:132412
    7tm_4; Olfactory receptor
  7. XM_017010238.1XP_016865727.1  cannabinoid receptor 1 isoform X1

    UniProtKB/Swiss-Prot
    P21554
    UniProtKB/TrEMBL
    S5TLS4
    Conserved Domains (2) summary
    pfam00001
    Location:133397
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:132412
    7tm_4; Olfactory receptor
  8. XM_017010239.1XP_016865728.1  cannabinoid receptor 1 isoform X1

    UniProtKB/Swiss-Prot
    P21554
    UniProtKB/TrEMBL
    S5TLS4
    Related
    ENSP00000412192.2, OTTHUMP00000214580, ENST00000428600.2, OTTHUMT00000354204
    Conserved Domains (2) summary
    pfam00001
    Location:133397
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:132412
    7tm_4; Olfactory receptor

Alternate CHM1_1.1

Genomic

  1. NC_018917.2 Alternate CHM1_1.1

    Range
    88947341..88973526 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001160260.1: Suppressed sequence

    Description
    NM_001160260.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Support Center