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Tnp1 transition protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24839, updated on 2-May-2024

Summary

Official Symbol
Tnp1provided by RGD
Official Full Name
transition protein 1provided by RGD
Primary source
RGD:3884
See related
AllianceGenome:RGD:3884
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA binding activity. Predicted to be involved in several processes, including chromatin organization; regulation of gene expression; and spermatid nucleus elongation. Predicted to act upstream of or within spermatogenesis. Located in male germ cell nucleus. Orthologous to human TNP1 (transition protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 14903.8) See more
Orthologs
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Genomic context

See Tnp1 in Genome Data Viewer
Location:
9q33
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (82043669..82044278, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (74594463..74595072, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (80294837..80295446, complement)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094704 Neighboring gene uncharacterized LOC134480592 Neighboring gene uncharacterized LOC102548134 Neighboring gene ribosomal protein S8, pseudogene 13

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
 
involved_in chromatin remodeling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in flagellated sperm motility ISO
Inferred from Sequence Orthology
more info
 
involved_in flagellated sperm motility ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in heterochromatin formation ISO
Inferred from Sequence Orthology
more info
 
involved_in heterochromatin formation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in nucleosome disassembly ISO
Inferred from Sequence Orthology
more info
 
involved_in nucleosome disassembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of protein processing ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein processing ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in sexual reproduction ISO
Inferred from Sequence Orthology
more info
 
involved_in sexual reproduction ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in single strand break repair ISO
Inferred from Sequence Orthology
more info
 
involved_in single strand break repair ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in sperm DNA condensation ISO
Inferred from Sequence Orthology
more info
 
involved_in sperm DNA condensation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in spermatid development ISO
Inferred from Sequence Orthology
more info
 
involved_in spermatid development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in spermatid nucleus elongation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in spermatid nucleus elongation ISO
Inferred from Sequence Orthology
more info
 
involved_in spermatid nucleus elongation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within spermatogenesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in male germ cell nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in male germ cell nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of nucleosome IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of nucleosome IEA
Inferred from Electronic Annotation
more info
 
part_of nucleosome ISO
Inferred from Sequence Orthology
more info
 
part_of nucleosome ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
spermatid nuclear transition protein 1
Names
STP-1
TP-1
testis-specific basic protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017056.2NP_058752.1  spermatid nuclear transition protein 1

    See identical proteins and their annotated locations for NP_058752.1

    Status: PROVISIONAL

    Source sequence(s)
    BC078850
    UniProtKB/Swiss-Prot
    P02317
    UniProtKB/TrEMBL
    A6JVR3
    Conserved Domains (1) summary
    pfam02079
    Location:252
    TP1; Nuclear transition protein 1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    82043669..82044278 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)