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TNP1 transition protein 1 [ Homo sapiens (human) ]

Gene ID: 7141, updated on 17-Jun-2019

Summary

Official Symbol
TNP1provided by HGNC
Official Full Name
transition protein 1provided by HGNC
Primary source
HGNC:HGNC:11951
See related
Ensembl:ENSG00000118245 MIM:190231
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TP1
Summary
Transition protein-1 is a spermatid-specific product of the haploid genome which replaces histone and is itself replaced in the mature sperm by the protamines (see PRM1, MIM 182880; PRM2, MIM 182890) (Luerssen et al., 1990 [PubMed 2249851]).[supplied by OMIM, Mar 2008]
Expression
Restricted expression toward testis (RPKM 903.2) See more
Orthologs

Genomic context

See TNP1 in Genome Data Viewer
Location:
2q35
Exon count:
2
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (216859458..216860064, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (217724181..217724782, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928278 Neighboring gene RNA, 5S ribosomal pseudogene 120 Neighboring gene fatty acid binding protein 5 pseudogene 14 Neighboring gene uncharacterized LOC105373876 Neighboring gene long intergenic non-protein coding RNA 1921

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies four loci associated with eruption of permanent teeth.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromatin remodeling IDA
Inferred from Direct Assay
more info
PubMed 
chromatin silencing IEP
Inferred from Expression Pattern
more info
PubMed 
fertilization, exchange of chromosomal proteins TAS
Traceable Author Statement
more info
PubMed 
flagellated sperm motility IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
nucleosome disassembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein processing ISS
Inferred from Sequence or Structural Similarity
more info
 
sexual reproduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
single strand break repair IDA
Inferred from Direct Assay
more info
PubMed 
spermatid development IDA
Inferred from Direct Assay
more info
PubMed 
spermatid nucleus differentiation TAS
Traceable Author Statement
more info
PubMed 
spermatid nucleus elongation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spermatid nucleus elongation IMP
Inferred from Mutant Phenotype
more info
PubMed 
spermatogenesis, exchange of chromosomal proteins ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
male germ cell nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear nucleosome ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleosome IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
spermatid nuclear transition protein 1
Names
STP-1
TP-1
transition protein 1 (during histone to protamine replacement)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003284.4NP_003275.1  spermatid nuclear transition protein 1

    See identical proteins and their annotated locations for NP_003275.1

    Status: VALIDATED

    Source sequence(s)
    AC007557, BC029516
    Consensus CDS
    CCDS2406.1
    UniProtKB/Swiss-Prot
    P09430
    UniProtKB/TrEMBL
    Q4ZG82
    Related
    ENSP00000236979.2, ENST00000236979.2
    Conserved Domains (1) summary
    pfam02079
    Location:252
    TP1; Nuclear transition protein 1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    216859458..216860064 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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