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TNP1 transition protein 1 [ Homo sapiens (human) ]

Gene ID: 7141, updated on 22-Sep-2022

Summary

Official Symbol
TNP1provided by HGNC
Official Full Name
transition protein 1provided by HGNC
Primary source
HGNC:HGNC:11951
See related
Ensembl:ENSG00000118245 MIM:190231; AllianceGenome:HGNC:11951
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TP1
Summary
Transition protein-1 is a spermatid-specific product of the haploid genome which replaces histone and is itself replaced in the mature sperm by the protamines (see PRM1, MIM 182880; PRM2, MIM 182890) (Luerssen et al., 1990 [PubMed 2249851]).[supplied by OMIM, Mar 2008]
Expression
Restricted expression toward testis (RPKM 903.2) See more
Orthologs
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Genomic context

See TNP1 in Genome Data Viewer
Location:
2q35
Exon count:
2
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (216859458..216860064, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (217341898..217342504, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (217724181..217724787, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene IGFBP5 antisense RNA 1 Neighboring gene uncharacterized LOC124907978 Neighboring gene uncharacterized LOC124907979 Neighboring gene uncharacterized LOC124906118 Neighboring gene uncharacterized LOC105373876

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study identifies four loci associated with eruption of permanent teeth.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in chromatin remodeling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in flagellated sperm motility IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in heterochromatin formation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in nucleosome disassembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein processing ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in sexual reproduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in single strand break repair IDA
Inferred from Direct Assay
more info
PubMed 
involved_in sperm DNA condensation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in sperm DNA decondensation TAS
Traceable Author Statement
more info
PubMed 
involved_in spermatid development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in spermatid nucleus differentiation TAS
Traceable Author Statement
more info
PubMed 
involved_in spermatid nucleus elongation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in spermatid nucleus elongation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in male germ cell nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of nucleosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of nucleosome IDA
Inferred from Direct Assay
more info
PubMed 
part_of nucleosome ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
spermatid nuclear transition protein 1
Names
STP-1
TP-1
transition protein 1 (during histone to protamine replacement)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003284.4NP_003275.1  spermatid nuclear transition protein 1

    See identical proteins and their annotated locations for NP_003275.1

    Status: VALIDATED

    Source sequence(s)
    AC007557, BC029516
    Consensus CDS
    CCDS2406.1
    UniProtKB/Swiss-Prot
    P09430
    UniProtKB/TrEMBL
    Q4ZG82
    Related
    ENSP00000236979.2, ENST00000236979.2
    Conserved Domains (1) summary
    pfam02079
    Location:252
    TP1; Nuclear transition protein 1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    216859458..216860064 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    217341898..217342504 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)