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Tnp1 transition protein 1 [ Mus musculus (house mouse) ]

Gene ID: 21958, updated on 1-Mar-2024

Summary

Official Symbol
Tnp1provided by MGI
Official Full Name
transition protein 1provided by MGI
Primary source
MGI:MGI:98784
See related
Ensembl:ENSMUSG00000026182 AllianceGenome:MGI:98784
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TP1; Tp-1; Stp-1
Summary
Predicted to enable DNA binding activity. Involved in positive regulation of protein processing and spermatogenesis, exchange of chromosomal proteins. Acts upstream of or within spermatogenesis. Located in nucleus. Part of nucleosome. Is expressed in testis. Orthologous to human TNP1 (transition protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 1508.1) See more
Orthologs
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Genomic context

See Tnp1 in Genome Data Viewer
Location:
1 C3; 1 36.94 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (73054233..73055058, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (73015074..73015899, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_01297 Neighboring gene exportin 5 pseudogene Neighboring gene predicted gene, 31137 Neighboring gene testicular germ cell expressed HSF2 interacting lncRNA Neighboring gene STARR-seq mESC enhancer starr_01299 Neighboring gene predicted gene, 53561

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
 
involved_in flagellated sperm motility ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in nucleosome disassembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sexual reproduction ISO
Inferred from Sequence Orthology
more info
 
involved_in single strand break repair ISO
Inferred from Sequence Orthology
more info
 
involved_in sperm DNA condensation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in spermatid development ISO
Inferred from Sequence Orthology
more info
 
involved_in spermatid nucleus elongation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in spermatid nucleus elongation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in male germ cell nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in male germ cell nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in male germ cell nucleus TAS
Traceable Author Statement
more info
PubMed 
part_of nucleosome IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of nucleosome IDA
Inferred from Direct Assay
more info
PubMed 
part_of nucleosome ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
spermatid nuclear transition protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009407.2NP_033433.1  spermatid nuclear transition protein 1

    See identical proteins and their annotated locations for NP_033433.1

    Status: VALIDATED

    Source sequence(s)
    BC048494, BF152963
    Consensus CDS
    CCDS35611.1
    UniProtKB/Swiss-Prot
    P10856
    UniProtKB/TrEMBL
    Q545L6
    Related
    ENSMUSP00000027374.6, ENSMUST00000027374.7
    Conserved Domains (1) summary
    pfam02079
    Location:252
    TP1; Nuclear transition protein 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    73054233..73055058 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)