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Ren renin [ Rattus norvegicus (Norway rat) ]

Gene ID: 24715, updated on 2-May-2024

Summary

Official Symbol
Renprovided by RGD
Official Full Name
reninprovided by RGD
Primary source
RGD:3554
See related
Ensembl:ENSRNOG00000002937 AllianceGenome:RGD:3554
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ren1; RENAA; RATRENAA
Summary
Enables endopeptidase activity and insulin-like growth factor receptor binding activity. Involved in several processes, including peptide metabolic process; response to lipopolysaccharide; and response to purine-containing compound. Located in cytoplasm and extracellular space. Used to study hypertension. Biomarker of primary biliary cholangitis. Human ortholog(s) of this gene implicated in essential hypertension; familial juvenile hyperuricemic nephropathy; hand, foot and mouth disease; hypertension; and portal hypertension. Orthologous to human REN (renin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 164.4) See more
Orthologs
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Genomic context

See Ren in Genome Data Viewer
Location:
13q13
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (47348312..47359539)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (44796260..44807491)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (50502724..50513953, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene golgi transport 1A Neighboring gene KiSS-1 metastasis-suppressor Neighboring gene uncharacterized LOC102550525 Neighboring gene ethanolamine kinase 2 Neighboring gene SRY-box transcription factor 13

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables aspartic-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables aspartic-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables aspartic-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables insulin-like growth factor receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables peptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in amyloid-beta metabolic process IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in angiotensin maturation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in angiotensin maturation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within angiotensin maturation ISO
Inferred from Sequence Orthology
more info
 
involved_in angiotensin maturation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell maturation ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within drinking behavior ISO
Inferred from Sequence Orthology
more info
 
NOT acts_upstream_of_or_within establishment of blood-nerve barrier ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within hormone-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in juxtaglomerular apparatus development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in kidney development ISO
Inferred from Sequence Orthology
more info
 
involved_in male gonad development ISO
Inferred from Sequence Orthology
more info
 
involved_in mesonephros development ISO
Inferred from Sequence Orthology
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of blood pressure IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within_positive_effect regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of blood pressure TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within regulation of blood volume by renin-angiotensin ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within renin-angiotensin regulation of aldosterone production ISO
Inferred from Sequence Orthology
more info
 
involved_in response to cAMP IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to cGMP IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to immobilization stress IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to xenobiotic stimulus IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in apical part of cell ISO
Inferred from Sequence Orthology
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
renin
Names
angiotensinogenase
renin 1 structural
NP_036774.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012642.4NP_036774.4  renin precursor

    See identical proteins and their annotated locations for NP_036774.4

    Status: PROVISIONAL

    Source sequence(s)
    BC078878
    UniProtKB/Swiss-Prot
    P08424, Q63497
    UniProtKB/TrEMBL
    A6IC75, A6IC76
    Related
    ENSRNOP00000003951.2, ENSRNOT00000003951.5
    Conserved Domains (2) summary
    cd05487
    Location:76401
    renin_like; Renin stimulates production of angiotensin and thus affects blood pressure
    pfam07966
    Location:3164
    A1_Propeptide; A1 Propeptide

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    47348312..47359539
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)