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Ren renin [ Rattus norvegicus (Norway rat) ]

Gene ID: 24715, updated on 3-Jun-2018
Official Symbol
Renprovided by RGD
Official Full Name
reninprovided by RGD
Primary source
RGD:3554
See related
Ensembl:ENSRNOG00000002937 Vega:OTTRNOG00000000631
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ren1; RENAA; RATRENAA
Summary
catalyzes the cleavage of a Leu-Xaa bond in angiotensinogen to generate angiotensin [RGD, Feb 2006]
Expression
Restricted expression toward (RPKM 164.4) See more
Orthologs
See Ren in Genome Data Viewer
Location:
13q13
Exon count:
9
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (50502724..50513953, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 13 NC_005112.3 (55555583..55566812, complement)

Chromosome 13 - NC_005112.4Genomic Context describing neighboring genes Neighboring gene SRY box 13 Neighboring gene ethanolamine kinase 2 Neighboring gene uncharacterized LOC102550525 Neighboring gene KiSS-1 metastasis-suppressor Neighboring gene golgi transport 1A Neighboring gene pleckstrin homology domain containing A6

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • ACE Inhibitor Pathway, organism-specific biosystem (from WikiPathways)
    ACE Inhibitor Pathway, organism-specific biosystemThe renin-angiotensin-aldosterone system (RAAS) is central to the control of blood pressure and the target of several types of anti-hypertensive drugs. This pathway depicts a simplified representatio...
  • Metabolism of Angiotensinogen to Angiotensins, organism-specific biosystem (from REACTOME)
    Metabolism of Angiotensinogen to Angiotensins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Peptide hormone metabolism, organism-specific biosystem (from REACTOME)
    Peptide hormone metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Renin - Angiotensin System, organism-specific biosystem (from WikiPathways)
    Renin - Angiotensin System, organism-specific biosystemThis pathway is based on the [http://www.genome.jp/dbget-bin/show_pathway?map04614+C15850 KEGG pathway] of renin-angiotensin and the [http://www.ambion.com/tools/pathway/pathway.php?pathway=Renin-Ang...
  • Renin secretion, organism-specific biosystem (from KEGG)
    Renin secretion, organism-specific biosystemThe aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in extracellular fluid volume and blood pressure homeostasis of the body. R...
  • Renin secretion, conserved biosystem (from KEGG)
    Renin secretion, conserved biosystemThe aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in extracellular fluid volume and blood pressure homeostasis of the body. R...
  • Renin-angiotensin system, organism-specific biosystem (from KEGG)
    Renin-angiotensin system, organism-specific biosystemThe renin-angiotensin system (RAS) is a peptidergic system with endocrine characteristics regarding to the regulation of the blood pressure and hydro-electrolytic balance. In the classical RAS, the ...
  • Renin-angiotensin system, conserved biosystem (from KEGG)
    Renin-angiotensin system, conserved biosystemThe renin-angiotensin system (RAS) is a peptidergic system with endocrine characteristics regarding to the regulation of the blood pressure and hydro-electrolytic balance. In the classical RAS, the ...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
aspartic-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
aspartic-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
insulin-like growth factor receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
peptidase activity ISO
Inferred from Sequence Orthology
more info
 
signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
amyloid-beta metabolic process IEP
Inferred from Expression Pattern
more info
PubMed 
angiotensin maturation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
angiotensin maturation IDA
Inferred from Direct Assay
more info
PubMed 
angiotensin maturation ISO
Inferred from Sequence Orthology
more info
 
cell maturation IEA
Inferred from Electronic Annotation
more info
 
cell maturation ISO
Inferred from Sequence Orthology
more info
 
cellular response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
drinking behavior IEA
Inferred from Electronic Annotation
more info
 
drinking behavior ISO
Inferred from Sequence Orthology
more info
 
NOT establishment of blood-nerve barrier ISO
Inferred from Sequence Orthology
more info
 
hormone-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
hormone-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
kidney development ISO
Inferred from Sequence Orthology
more info
 
male gonad development IEA
Inferred from Electronic Annotation
more info
 
male gonad development ISO
Inferred from Sequence Orthology
more info
 
mesonephros development IEA
Inferred from Electronic Annotation
more info
 
mesonephros development ISO
Inferred from Sequence Orthology
more info
 
proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteolysis ISO
Inferred from Sequence Orthology
more info
 
regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
regulation of blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of blood pressure TAS
Traceable Author Statement
more info
PubMed 
regulation of blood volume by renin-angiotensin ISO
Inferred from Sequence Orthology
more info
 
renin-angiotensin regulation of aldosterone production IEA
Inferred from Electronic Annotation
more info
 
renin-angiotensin regulation of aldosterone production ISO
Inferred from Sequence Orthology
more info
 
response to cAMP IDA
Inferred from Direct Assay
more info
PubMed 
response to cGMP IDA
Inferred from Direct Assay
more info
PubMed 
response to drug IDA
Inferred from Direct Assay
more info
PubMed 
response to immobilization stress IEP
Inferred from Expression Pattern
more info
PubMed 
response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
response to organic substance ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
apical part of cell IEA
Inferred from Electronic Annotation
more info
 
apical part of cell ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
intracellular ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
renin
Names
angiotensinogenase
renin 1 structural
NP_036774.4

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012642.4NP_036774.4  renin precursor

    See identical proteins and their annotated locations for NP_036774.4

    Status: PROVISIONAL

    Source sequence(s)
    BC078878
    UniProtKB/Swiss-Prot
    P08424
    Related
    ENSRNOP00000003951.2, OTTRNOP00000000438, ENSRNOT00000003951.4, OTTRNOT00000000894
    Conserved Domains (3) summary
    cd05487
    Location:76401
    renin_like; Renin stimulates production of angiotensin and thus affects blood pressure
    pfam00026
    Location:83401
    Asp; Eukaryotic aspartyl protease
    pfam07966
    Location:3164
    A1_Propeptide; A1 Propeptide

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005112.4 Reference Rnor_6.0 Primary Assembly

    Range
    50502724..50513953 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000081.1 Alternate Rn_Celera

    Range
    45129122..45139889
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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