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Ppp2cb protein phosphatase 2 catalytic subunit beta [ Rattus norvegicus (Norway rat) ]

Gene ID: 24673, updated on 2-May-2024

Summary

Official Symbol
Ppp2cbprovided by RGD
Official Full Name
protein phosphatase 2 catalytic subunit betaprovided by RGD
Primary source
RGD:3381
See related
Ensembl:ENSRNOG00000015182 AllianceGenome:RGD:3381
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pp2a2
Summary
Enables protein C-terminus binding activity and protein serine/threonine phosphatase activity. Involved in several processes, including negative regulation of Ras protein signal transduction; positive regulation of microtubule binding activity; and response to lead ion. Predicted to be located in cytoplasm. Predicted to be part of protein phosphatase type 2A complex. Orthologous to human PPP2CB (protein phosphatase 2 catalytic subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 362.7), Lung (RPKM 325.1) and 9 other tissues See more
Orthologs
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Genomic context

Location:
16q12.3
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (65261178..65282658, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (58558119..58579325, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (62273276..62294767, complement)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482513 Neighboring gene glutathione-disulfide reductase Neighboring gene UBX domain protein 8 Neighboring gene ribosomal protein S25, pseudogene 6 Neighboring gene testis expressed 15, meiosis and synapsis associated

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC94855

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphoprotein phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein heterodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine phosphatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables transmembrane transporter binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of FAR/SIN/STRIPAK complex ISO
Inferred from Sequence Orthology
more info
 
part_of FAR/SIN/STRIPAK complex ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of protein phosphatase type 2A complex ISO
Inferred from Sequence Orthology
more info
 
located_in spindle pole IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
Names
PP2A-beta
protein phosphatase 2, catalytic subunit, beta isozyme
protein phosphatase 2A catalytic alpha subunit
protein phosphatase-2A-beta
NP_058736.1
XP_063131125.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017040.3NP_058736.1  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

    See identical proteins and their annotated locations for NP_058736.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/Swiss-Prot
    P62716, Q6LDK0
    UniProtKB/TrEMBL
    A0A8I5ZZ39
    Related
    ENSRNOP00000020663.1, ENSRNOT00000020663.4
    Conserved Domains (1) summary
    cd07415
    Location:9293
    MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    65261178..65282658 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063275055.1XP_063131125.1  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform isoform X1