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Nrp1 neuropilin 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 246331, updated on 22-Sep-2022

Summary

Official Symbol
Nrp1provided by RGD
Official Full Name
neuropilin 1provided by RGD
Primary source
RGD:621588
See related
Ensembl:ENSRNOG00000010744 AllianceGenome:RGD:621588
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Nrp
Summary
Enables semaphorin receptor activity. Involved in negative regulation of axon extension involved in axon guidance and response to wounding. Located in cell surface; growth cone; and neuronal cell body. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human NRP1 (neuropilin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 672.2), Heart (RPKM 513.5) and 9 other tissues See more
Orthologs
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Try the new Transcript table

Genomic context

See Nrp1 in Genome Data Viewer
Location:
19q12
Exon count:
19
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (56359455..56514628)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (61332351..61486166)

Chromosome 19 - NC_051354.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102548408 Neighboring gene uncharacterized LOC120098511 Neighboring gene uncharacterized LOC120098512 Neighboring gene uncharacterized LOC102548537 Neighboring gene integrin subunit beta 1 Neighboring gene small nucleolar RNA SNORA17

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables growth factor binding IEA
Inferred from Electronic Annotation
more info
 
enables growth factor binding ISO
Inferred from Sequence Orthology
more info
 
enables heparin binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables semaphorin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables semaphorin receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables semaphorin receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables semaphorin receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables semaphorin receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables vascular endothelial growth factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables vascular endothelial growth factor binding ISO
Inferred from Sequence Orthology
more info
 
enables vascular endothelial growth factor receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables vascular endothelial growth factor receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables vascular endothelial growth factor receptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in VEGF-activated neuropilin signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in VEGF-activated neuropilin signaling pathway involved in axon guidance ISO
Inferred from Sequence Orthology
more info
 
involved_in actin cytoskeleton reorganization ISO
Inferred from Sequence Orthology
more info
 
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in angiogenesis involved in coronary vascular morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in animal organ morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in artery morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of axon extension ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of axon extension involved in axon guidance ISO
Inferred from Sequence Orthology
more info
 
involved_in axon extension involved in axon guidance ISO
Inferred from Sequence Orthology
more info
 
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in axon guidance IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within axon guidance ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within axonal fasciculation ISO
Inferred from Sequence Orthology
more info
 
involved_in axonogenesis involved in innervation ISO
Inferred from Sequence Orthology
more info
 
involved_in basal dendrite arborization ISO
Inferred from Sequence Orthology
more info
 
involved_in basal dendrite development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within branching involved in blood vessel morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in branching involved in blood vessel morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in branchiomotor neuron axon guidance ISO
Inferred from Sequence Orthology
more info
 
NOT involved_in cardiac neural crest cell migration involved in outflow tract morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in cell migration involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to hepatocyte growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to vascular endothelial growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in commissural neuron axon guidance ISO
Inferred from Sequence Orthology
more info
 
involved_in coronary artery morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within dendrite development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within dichotomous subdivision of terminal units involved in salivary gland branching ISO
Inferred from Sequence Orthology
more info
 
involved_in dorsal root ganglion morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in endothelial cell chemotaxis IEA
Inferred from Electronic Annotation
more info
 
involved_in endothelial cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in facial nerve structural organization ISO
Inferred from Sequence Orthology
more info
 
involved_in facioacoustic ganglion development ISO
Inferred from Sequence Orthology
more info
 
involved_in gonadotrophin-releasing hormone neuronal migration to the hypothalamus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within heart development ISO
Inferred from Sequence Orthology
more info
 
involved_in hepatocyte growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in integrin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in motor neuron axon guidance ISO
Inferred from Sequence Orthology
more info
 
involved_in motor neuron migration ISO
Inferred from Sequence Orthology
more info
 
involved_in motor neuron migration ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within negative regulation of axon extension ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of axon extension involved in axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of axon extension involved in axon guidance ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in nerve development ISO
Inferred from Sequence Orthology
more info
 
involved_in nervous system development NAS
Non-traceable Author Statement
more info
PubMed 
involved_in neural crest cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neural crest cell migration involved in autonomic nervous system development ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron development ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron migration ISO
Inferred from Sequence Orthology
more info
 
involved_in neuropilin signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in otic placode development ISO
Inferred from Sequence Orthology
more info
 
involved_in outflow tract septum morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in platelet-derived growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of actin cytoskeleton reorganization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of axon extension involved in axon guidance ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of filopodium assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of filopodium assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of retinal ganglion cell axon guidance ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
 
involved_in postsynapse organization ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to early endosome ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of Cdc42 protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of axon extension involved in axon guidance ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of plasma membrane bounded cell projection organization IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of retinal ganglion cell axon guidance ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of vascular endothelial growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in renal artery morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in response to wounding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to wounding IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in retina vasculature morphogenesis in camera-type eye ISO
Inferred from Sequence Orthology
more info
 
involved_in retinal ganglion cell axon guidance ISO
Inferred from Sequence Orthology
more info
 
involved_in semaphorin-plexin signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within semaphorin-plexin signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in semaphorin-plexin signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in semaphorin-plexin signaling pathway involved in axon guidance ISO
Inferred from Sequence Orthology
more info
 
involved_in semaphorin-plexin signaling pathway involved in neuron projection guidance ISO
Inferred from Sequence Orthology
more info
 
involved_in sensory neuron axon guidance ISO
Inferred from Sequence Orthology
more info
 
involved_in sprouting angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
 
involved_in substrate-dependent cell migration, cell extension ISO
Inferred from Sequence Orthology
more info
 
involved_in sympathetic ganglion development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within sympathetic nervous system development ISO
Inferred from Sequence Orthology
more info
 
involved_in sympathetic neuron projection extension ISO
Inferred from Sequence Orthology
more info
 
involved_in sympathetic neuron projection guidance ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within toxin transport ISO
Inferred from Sequence Orthology
more info
 
involved_in trigeminal ganglion development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within trigeminal nerve morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in trigeminal nerve structural organization ISO
Inferred from Sequence Orthology
more info
 
involved_in vascular endothelial growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in vascular endothelial growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within vascular endothelial growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in vascular endothelial growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in vascular endothelial growth factor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in vasculogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ventral trunk neural crest cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in vestibulocochlear nerve structural organization ISO
Inferred from Sequence Orthology
more info
 
involved_in viral entry into host cell ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in early endosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in growth cone IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane NAS
Non-traceable Author Statement
more info
PubMed 
located_in mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neurofilament ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
located_in sorting endosome ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
neuropilin-1
Names
vascular endothelial cell growth factor 165 receptor

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145098.2NP_659566.1  neuropilin-1 precursor

    See identical proteins and their annotated locations for NP_659566.1

    Status: PROVISIONAL

    Source sequence(s)
    BC085689
    UniProtKB/Swiss-Prot
    Q9QWJ9
    Related
    ENSRNOP00000014492.3, ENSRNOT00000014492.6
    Conserved Domains (6) summary
    cd06263
    Location:650803
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    pfam11980
    Location:842919
    DUF3481; Domain of unknown function (DUF3481)
    smart00137
    Location:645804
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00231
    Location:274424
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00041
    Location:27140
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00057
    Location:277423
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051354.1 Reference mRatBN7.2 Primary Assembly

    Range
    56359455..56514628
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006255825.4XP_006255887.1  neuropilin-1 isoform X1

    See identical proteins and their annotated locations for XP_006255887.1

    UniProtKB/Swiss-Prot
    Q9QWJ9
    Conserved Domains (6) summary
    cd06263
    Location:650803
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    pfam11980
    Location:842919
    DUF3481; Domain of unknown function (DUF3481)
    smart00137
    Location:645804
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00231
    Location:274424
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00041
    Location:27140
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00057
    Location:277423
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  2. XM_006255827.4XP_006255889.1  neuropilin-1 isoform X3

    Related
    ENSRNOP00000075034.2, ENSRNOT00000080465.2
    Conserved Domains (6) summary
    cd06263
    Location:650803
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    pfam11980
    Location:825902
    DUF3481; Domain of unknown function (DUF3481)
    smart00137
    Location:645804
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00231
    Location:274424
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00041
    Location:27140
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00057
    Location:277423
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  3. XM_006255826.4XP_006255888.1  neuropilin-1 isoform X2

    Conserved Domains (6) summary
    cd06263
    Location:643796
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    pfam11980
    Location:835912
    DUF3481; Domain of unknown function (DUF3481)
    smart00137
    Location:638797
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00231
    Location:274424
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00041
    Location:27140
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00057
    Location:277423
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.