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Nrp1 neuropilin 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 246331, updated on 2-Oct-2018

Summary

Official Symbol
Nrp1provided by RGD
Official Full Name
neuropilin 1provided by RGD
Primary source
RGD:621588
See related
Ensembl:ENSRNOG00000010744
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Nrp
Summary
transmembrane protein that acts as a receptor for semaphorin III; may play a role in neuronal development [RGD, Feb 2006]
Expression
Biased expression in Lung (RPKM 672.2), Heart (RPKM 513.5) and 9 other tissues See more
Orthologs

Genomic context

See Nrp1 in Genome Data Viewer
Location:
19q12
Exon count:
19
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (61332351..61486166)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 19 NC_005118.3 (71984687..72138092)

Chromosome 19 - NC_005118.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103694361 Neighboring gene uncharacterized LOC102548408 Neighboring gene uncharacterized LOC103694362 Neighboring gene uncharacterized LOC102548537 Neighboring gene uncharacterized LOC108348982 Neighboring gene collagen alpha-1(I) chain-like Neighboring gene integrin subunit beta 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
GTPase activator activity ISO
Inferred from Sequence Orthology
more info
 
growth factor binding ISO
Inferred from Sequence Orthology
more info
 
heparin binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
semaphorin receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
semaphorin receptor activity ISO
Inferred from Sequence Orthology
more info
 
semaphorin receptor activity TAS
Traceable Author Statement
more info
PubMed 
vascular endothelial growth factor binding IEA
Inferred from Electronic Annotation
more info
 
vascular endothelial growth factor binding ISO
Inferred from Sequence Orthology
more info
 
vascular endothelial growth factor-activated receptor activity IEA
Inferred from Electronic Annotation
more info
 
vascular endothelial growth factor-activated receptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
VEGF-activated neuropilin signaling pathway ISO
Inferred from Sequence Orthology
more info
 
VEGF-activated neuropilin signaling pathway involved in axon guidance IEA
Inferred from Electronic Annotation
more info
 
VEGF-activated neuropilin signaling pathway involved in axon guidance ISO
Inferred from Sequence Orthology
more info
 
actin cytoskeleton reorganization IEA
Inferred from Electronic Annotation
more info
 
actin cytoskeleton reorganization ISO
Inferred from Sequence Orthology
more info
 
angiogenesis ISO
Inferred from Sequence Orthology
more info
 
angiogenesis involved in coronary vascular morphogenesis IEA
Inferred from Electronic Annotation
more info
 
angiogenesis involved in coronary vascular morphogenesis ISO
Inferred from Sequence Orthology
more info
 
artery morphogenesis ISO
Inferred from Sequence Orthology
more info
 
axon extension involved in axon guidance IEA
Inferred from Electronic Annotation
more info
 
axon extension involved in axon guidance ISO
Inferred from Sequence Orthology
more info
 
axon guidance ISO
Inferred from Sequence Orthology
more info
 
axonal fasciculation IEA
Inferred from Electronic Annotation
more info
 
axonal fasciculation ISO
Inferred from Sequence Orthology
more info
 
axonogenesis involved in innervation IEA
Inferred from Electronic Annotation
more info
 
axonogenesis involved in innervation ISO
Inferred from Sequence Orthology
more info
 
basal dendrite arborization IEA
Inferred from Electronic Annotation
more info
 
basal dendrite arborization ISO
Inferred from Sequence Orthology
more info
 
basal dendrite development ISO
Inferred from Sequence Orthology
more info
 
branching involved in blood vessel morphogenesis IEA
Inferred from Electronic Annotation
more info
 
branching involved in blood vessel morphogenesis ISO
Inferred from Sequence Orthology
more info
 
branchiomotor neuron axon guidance IEA
Inferred from Electronic Annotation
more info
 
branchiomotor neuron axon guidance ISO
Inferred from Sequence Orthology
more info
 
NOT cardiac neural crest cell migration involved in outflow tract morphogenesis ISO
Inferred from Sequence Orthology
more info
 
cell migration ISO
Inferred from Sequence Orthology
more info
 
cell migration involved in sprouting angiogenesis IEA
Inferred from Electronic Annotation
more info
 
cell migration involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
cellular response to hepatocyte growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to hepatocyte growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to vascular endothelial growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
commissural neuron axon guidance IEA
Inferred from Electronic Annotation
more info
 
commissural neuron axon guidance ISO
Inferred from Sequence Orthology
more info
 
coronary artery morphogenesis IEA
Inferred from Electronic Annotation
more info
 
coronary artery morphogenesis ISO
Inferred from Sequence Orthology
more info
 
dendrite development ISO
Inferred from Sequence Orthology
more info
 
dichotomous subdivision of terminal units involved in salivary gland branching IEA
Inferred from Electronic Annotation
more info
 
dichotomous subdivision of terminal units involved in salivary gland branching ISO
Inferred from Sequence Orthology
more info
 
dorsal root ganglion morphogenesis IEA
Inferred from Electronic Annotation
more info
 
dorsal root ganglion morphogenesis ISO
Inferred from Sequence Orthology
more info
 
endothelial cell chemotaxis IEA
Inferred from Electronic Annotation
more info
 
endothelial cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
facial nerve structural organization IEA
Inferred from Electronic Annotation
more info
 
facial nerve structural organization ISO
Inferred from Sequence Orthology
more info
 
facioacoustic ganglion development IEA
Inferred from Electronic Annotation
more info
 
facioacoustic ganglion development ISO
Inferred from Sequence Orthology
more info
 
gonadotrophin-releasing hormone neuronal migration to the hypothalamus IEA
Inferred from Electronic Annotation
more info
 
gonadotrophin-releasing hormone neuronal migration to the hypothalamus ISO
Inferred from Sequence Orthology
more info
 
heart development ISO
Inferred from Sequence Orthology
more info
 
hepatocyte growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
hepatocyte growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
integrin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
integrin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
motor neuron axon guidance ISO
Inferred from Sequence Orthology
more info
 
motor neuron migration ISO
Inferred from Sequence Orthology
more info
 
motor neuron migration ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of axon extension ISO
Inferred from Sequence Orthology
more info
 
negative regulation of axon extension involved in axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of axon extension involved in axon guidance ISO
Inferred from Sequence Orthology
more info
 
negative regulation of extrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
nerve development ISO
Inferred from Sequence Orthology
more info
 
nervous system development NAS
Non-traceable Author Statement
more info
PubMed 
neural crest cell migration involved in autonomic nervous system development IEA
Inferred from Electronic Annotation
more info
 
neural crest cell migration involved in autonomic nervous system development ISO
Inferred from Sequence Orthology
more info
 
neuron development ISO
Inferred from Sequence Orthology
more info
 
neuron migration ISO
Inferred from Sequence Orthology
more info
 
neuropilin signaling pathway ISO
Inferred from Sequence Orthology
more info
 
otic placode development IEA
Inferred from Electronic Annotation
more info
 
otic placode development ISO
Inferred from Sequence Orthology
more info
 
outflow tract septum morphogenesis IEA
Inferred from Electronic Annotation
more info
 
outflow tract septum morphogenesis ISO
Inferred from Sequence Orthology
more info
 
platelet-derived growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
platelet-derived growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive chemotaxis IEA
Inferred from Electronic Annotation
more info
 
positive chemotaxis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 
positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of actin cytoskeleton reorganization IEA
Inferred from Electronic Annotation
more info
 
positive regulation of actin cytoskeleton reorganization ISO
Inferred from Sequence Orthology
more info
 
positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of axon extension involved in axon guidance IEA
Inferred from Electronic Annotation
more info
 
positive regulation of axon extension involved in axon guidance ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell migration involved in sprouting angiogenesis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell migration involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of filopodium assembly IEA
Inferred from Electronic Annotation
more info
 
positive regulation of filopodium assembly ISO
Inferred from Sequence Orthology
more info
 
positive regulation of focal adhesion assembly IEA
Inferred from Electronic Annotation
more info
 
positive regulation of focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of retinal ganglion cell axon guidance IEA
Inferred from Electronic Annotation
more info
 
positive regulation of retinal ganglion cell axon guidance ISO
Inferred from Sequence Orthology
more info
 
positive regulation of stress fiber assembly IEA
Inferred from Electronic Annotation
more info
 
positive regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
 
positive regulation of substrate adhesion-dependent cell spreading IEA
Inferred from Electronic Annotation
more info
 
positive regulation of substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
 
postsynapse organization IEA
Inferred from Electronic Annotation
more info
 
postsynapse organization ISO
Inferred from Sequence Orthology
more info
 
protein localization to early endosome IEA
Inferred from Electronic Annotation
more info
 
protein localization to early endosome ISO
Inferred from Sequence Orthology
more info
 
regulation of Cdc42 protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
regulation of Cdc42 protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
regulation of axon extension involved in axon guidance ISO
Inferred from Sequence Orthology
more info
 
regulation of retinal ganglion cell axon guidance ISO
Inferred from Sequence Orthology
more info
 
renal artery morphogenesis IEA
Inferred from Electronic Annotation
more info
 
renal artery morphogenesis ISO
Inferred from Sequence Orthology
more info
 
response to wounding IEP
Inferred from Expression Pattern
more info
PubMed 
retina vasculature morphogenesis in camera-type eye IEA
Inferred from Electronic Annotation
more info
 
retina vasculature morphogenesis in camera-type eye ISO
Inferred from Sequence Orthology
more info
 
retinal ganglion cell axon guidance IEA
Inferred from Electronic Annotation
more info
 
retinal ganglion cell axon guidance ISO
Inferred from Sequence Orthology
more info
 
semaphorin-plexin signaling pathway ISO
Inferred from Sequence Orthology
more info
 
semaphorin-plexin signaling pathway involved in axon guidance IEA
Inferred from Electronic Annotation
more info
 
semaphorin-plexin signaling pathway involved in axon guidance ISO
Inferred from Sequence Orthology
more info
 
semaphorin-plexin signaling pathway involved in neuron projection guidance ISO
Inferred from Sequence Orthology
more info
 
sensory neuron axon guidance IEA
Inferred from Electronic Annotation
more info
 
sensory neuron axon guidance ISO
Inferred from Sequence Orthology
more info
 
sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
substrate adhesion-dependent cell spreading IEA
Inferred from Electronic Annotation
more info
 
substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
 
substrate-dependent cell migration, cell extension IEA
Inferred from Electronic Annotation
more info
 
substrate-dependent cell migration, cell extension ISO
Inferred from Sequence Orthology
more info
 
sympathetic ganglion development IEA
Inferred from Electronic Annotation
more info
 
sympathetic ganglion development ISO
Inferred from Sequence Orthology
more info
 
sympathetic nervous system development ISO
Inferred from Sequence Orthology
more info
 
sympathetic neuron projection extension IEA
Inferred from Electronic Annotation
more info
 
sympathetic neuron projection extension ISO
Inferred from Sequence Orthology
more info
 
sympathetic neuron projection guidance IEA
Inferred from Electronic Annotation
more info
 
sympathetic neuron projection guidance ISO
Inferred from Sequence Orthology
more info
 
toxin transport IEA
Inferred from Electronic Annotation
more info
 
toxin transport ISO
Inferred from Sequence Orthology
more info
 
trigeminal ganglion development IEA
Inferred from Electronic Annotation
more info
 
trigeminal ganglion development ISO
Inferred from Sequence Orthology
more info
 
trigeminal nerve morphogenesis ISO
Inferred from Sequence Orthology
more info
 
trigeminal nerve structural organization IEA
Inferred from Electronic Annotation
more info
 
trigeminal nerve structural organization ISO
Inferred from Sequence Orthology
more info
 
vascular endothelial growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
vascular endothelial growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
ventral trunk neural crest cell migration IEA
Inferred from Electronic Annotation
more info
 
ventral trunk neural crest cell migration ISO
Inferred from Sequence Orthology
more info
 
vestibulocochlear nerve structural organization IEA
Inferred from Electronic Annotation
more info
 
vestibulocochlear nerve structural organization ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
axon IDA
Inferred from Direct Assay
more info
PubMed 
axon ISO
Inferred from Sequence Orthology
more info
 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
early endosome IEA
Inferred from Electronic Annotation
more info
 
early endosome ISO
Inferred from Sequence Orthology
more info
 
focal adhesion IEA
Inferred from Electronic Annotation
more info
 
focal adhesion ISO
Inferred from Sequence Orthology
more info
 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
growth cone IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
integral component of postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
neurofilament IEA
Inferred from Electronic Annotation
more info
 
neurofilament ISO
Inferred from Sequence Orthology
more info
 
neuron projection ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
sorting endosome IEA
Inferred from Electronic Annotation
more info
 
sorting endosome ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
neuropilin-1
Names
vascular endothelial cell growth factor 165 receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145098.2NP_659566.1  neuropilin-1 precursor

    See identical proteins and their annotated locations for NP_659566.1

    Status: PROVISIONAL

    Source sequence(s)
    BC085689
    UniProtKB/Swiss-Prot
    Q9QWJ9
    Related
    ENSRNOP00000014492.3, ENSRNOT00000014492.5
    Conserved Domains (6) summary
    cd06263
    Location:650803
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    pfam11980
    Location:842919
    DUF3481; Domain of unknown function (DUF3481)
    smart00137
    Location:645804
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00231
    Location:274424
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00041
    Location:27140
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00057
    Location:277423
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005118.4 Reference Rnor_6.0 Primary Assembly

    Range
    61332351..61486166
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006255825.3XP_006255887.1  neuropilin-1 isoform X1

    See identical proteins and their annotated locations for XP_006255887.1

    UniProtKB/Swiss-Prot
    Q9QWJ9
    Related
    ENSRNOP00000075034.1, ENSRNOT00000080465.1
    Conserved Domains (6) summary
    cd06263
    Location:650803
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    pfam11980
    Location:842919
    DUF3481; Domain of unknown function (DUF3481)
    smart00137
    Location:645804
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00231
    Location:274424
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00041
    Location:27140
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00057
    Location:277423
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  2. XM_006255826.3XP_006255888.1  neuropilin-1 isoform X2

    Conserved Domains (6) summary
    cd06263
    Location:643796
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    pfam11980
    Location:835912
    DUF3481; Domain of unknown function (DUF3481)
    smart00137
    Location:638797
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00231
    Location:274424
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00041
    Location:27140
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00057
    Location:277423
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  3. XM_006255827.3XP_006255889.1  neuropilin-1 isoform X3

    Conserved Domains (6) summary
    cd06263
    Location:650803
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    pfam11980
    Location:825902
    DUF3481; Domain of unknown function (DUF3481)
    smart00137
    Location:645804
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00231
    Location:274424
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00041
    Location:27140
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00057
    Location:277423
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

Alternate Rn_Celera

Genomic

  1. AC_000087.1 Alternate Rn_Celera

    Range
    55693756..55846090
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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