U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Nrp1 neuropilin 1 [ Mus musculus (house mouse) ]

Gene ID: 18186, updated on 24-Jan-2023

Summary

Official Symbol
Nrp1provided by MGI
Official Full Name
neuropilin 1provided by MGI
Primary source
MGI:MGI:106206
See related
Ensembl:ENSMUSG00000025810 AllianceGenome:MGI:106206
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nrp; NP-1; Npn1; NPN-1; C530029I03
Summary
Enables protein kinase binding activity; transmembrane signaling receptor activity; and vascular endothelial growth factor binding activity. Involved in several processes, including nervous system development; regulation of signal transduction; and vasculature development. Acts upstream of or within several processes, including morphogenesis of a branching epithelium; nervous system development; and toxin transport. Located in several cellular components, including endosome; focal adhesion; and neurofilament. Is integral component of postsynaptic membrane. Is expressed in several structures, including cardiovascular system; jaw; lung; nervous system; and sensory organ. Used to study retinal vein occlusion. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human NRP1 (neuropilin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 39.3), subcutaneous fat pad adult (RPKM 21.5) and 24 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Nrp1 in Genome Data Viewer
Location:
8 E2; 8 75.78 cM
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (129085072..129231957)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (128358591..128505476)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32590 Neighboring gene RIKEN cDNA A930035F09 gene Neighboring gene predicted gene, 53472 Neighboring gene microRNA 21c Neighboring gene microRNA 1903 Neighboring gene predicted gene, 32643 Neighboring gene predicted gene, 26002 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables growth factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables growth factor binding ISO
Inferred from Sequence Orthology
more info
 
enables heparin binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables semaphorin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables semaphorin receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables semaphorin receptor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables semaphorin receptor activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables semaphorin receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables vascular endothelial growth factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables vascular endothelial growth factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables vascular endothelial growth factor binding ISO
Inferred from Sequence Orthology
more info
 
enables vascular endothelial growth factor receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables vascular endothelial growth factor receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in VEGF-activated neuropilin signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in VEGF-activated neuropilin signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in VEGF-activated neuropilin signaling pathway involved in axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in actin cytoskeleton reorganization ISO
Inferred from Sequence Orthology
more info
 
involved_in angiogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in angiogenesis involved in coronary vascular morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in animal organ morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in artery morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of axon extension IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of axon extension involved in axon guidance IDA
Inferred from Direct Assay
more info
PubMed 
involved_in axon extension involved in axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within axon guidance IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within axonal fasciculation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in axonogenesis involved in innervation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in basal dendrite arborization IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in basal dendrite development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within blood vessel endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within branching involved in blood vessel morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in branching involved in blood vessel morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in branchiomotor neuron axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT involved_in cardiac neural crest cell migration involved in outflow tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cell migration involved in coronary vasculogenesis IC
Inferred by Curator
more info
PubMed 
involved_in cell migration involved in sprouting angiogenesis IC
Inferred by Curator
more info
PubMed 
involved_in cell migration involved in sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to hepatocyte growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to vascular endothelial growth factor stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in commissural neuron axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in coronary artery morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within dendrite development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within dichotomous subdivision of terminal units involved in salivary gland branching IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within dichotomous subdivision of terminal units involved in salivary gland branching IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dorsal root ganglion morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endothelial cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in facial nerve structural organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in facioacoustic ganglion development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in gonadotrophin-releasing hormone neuronal migration to the hypothalamus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within heart development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in hepatocyte growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in integrin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in integrin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in motor neuron axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in motor neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of axon extension IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of axon extension involved in axon guidance IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of axon extension involved in axon guidance ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of extrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nerve development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in neural crest cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neural crest cell migration involved in autonomic nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuropilin signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuropilin signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in otic placode development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in outflow tract septum morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in platelet-derived growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of actin cytoskeleton reorganization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of axon extension involved in axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell migration involved in sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of endothelial cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of filopodium assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of filopodium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of filopodium assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptidyl-tyrosine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of retinal ganglion cell axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
 
involved_in postsynapse organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in postsynapse organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization to early endosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of Cdc42 protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of Cdc42 protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of axon extension involved in axon guidance IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of retinal ganglion cell axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of vascular endothelial growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in renal artery morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to wounding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within retina vasculature development in camera-type eye IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in retina vasculature morphogenesis in camera-type eye IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in retinal ganglion cell axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within semaphorin-plexin signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within semaphorin-plexin signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in semaphorin-plexin signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in semaphorin-plexin signaling pathway involved in axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in semaphorin-plexin signaling pathway involved in neuron projection guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sensory neuron axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sprouting angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
 
involved_in substrate-dependent cell migration, cell extension ISO
Inferred from Sequence Orthology
more info
 
involved_in sympathetic ganglion development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within sympathetic nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sympathetic neuron projection extension IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sympathetic neuron projection guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within toxin transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in trigeminal ganglion development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within trigeminal nerve morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in trigeminal nerve structural organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vascular endothelial growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within vascular endothelial growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vascular endothelial growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vascular endothelial growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in vascular endothelial growth factor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in vasculogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ventral trunk neural crest cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vestibulocochlear nerve structural organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in viral entry into host cell ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in early endosome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in growth cone ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in neurofilament IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
is_active_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in sorting endosome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
neuropilin-1
Names
A5 protein
Neuropilin-1 precursor (A5 protein)
transmembrane receptor

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001358959.1NP_001345888.1  neuropilin-1 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC102856, AC139349, AK164378
    Conserved Domains (4) summary
    cd00041
    Location:27140
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00057
    Location:277423
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    pfam00629
    Location:643803
    MAM; MAM domain, meprin/A5/mu
    pfam11980
    Location:838916
    DUF3481; C-terminal domain of neuropilin glycoprotein
  2. NM_001358960.1NP_001345889.1  neuropilin-1 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC102856, AC139349, AK164378
    Conserved Domains (4) summary
    cd00041
    Location:27140
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00057
    Location:277423
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    pfam00629
    Location:650810
    MAM; MAM domain, meprin/A5/mu
    pfam11980
    Location:828906
    DUF3481; C-terminal domain of neuropilin glycoprotein
  3. NM_008737.2NP_032763.2  neuropilin-1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_032763.2

    Status: VALIDATED

    Source sequence(s)
    AC102856, AK164378, BC060129
    Consensus CDS
    CCDS22790.1
    UniProtKB/Swiss-Prot
    P97333, Q6PAR3
    Related
    ENSMUSP00000026917.9, ENSMUST00000026917.10
    Conserved Domains (4) summary
    cd00041
    Location:27140
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00057
    Location:277423
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    pfam00629
    Location:650810
    MAM; MAM domain, meprin/A5/mu
    pfam11980
    Location:845923
    DUF3481; C-terminal domain of neuropilin glycoprotein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    129085072..129231957
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530766.4XP_006530829.1  neuropilin-1 isoform X1

    See identical proteins and their annotated locations for XP_006530829.1

    UniProtKB/Swiss-Prot
    P97333, Q6PAR3
    Conserved Domains (4) summary
    cd00041
    Location:27140
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00057
    Location:277423
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    pfam00629
    Location:650810
    MAM; MAM domain, meprin/A5/mu
    pfam11980
    Location:845923
    DUF3481; C-terminal domain of neuropilin glycoprotein
  2. XM_030243349.2XP_030099209.1  neuropilin-1 isoform X1

    UniProtKB/Swiss-Prot
    Q6PAR3
    Conserved Domains (4) summary
    cd00041
    Location:27140
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00057
    Location:277423
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    pfam00629
    Location:650810
    MAM; MAM domain, meprin/A5/mu
    pfam11980
    Location:845923
    DUF3481; C-terminal domain of neuropilin glycoprotein
  3. XM_036153814.1XP_036009707.1  neuropilin-1 isoform X2

    Conserved Domains (4) summary
    smart00137
    Location:638797
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    cd00041
    Location:27140
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00057
    Location:277423
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    pfam11980
    Location:821899
    DUF3481; C-terminal domain of neuropilin glycoprotein
  4. XM_006530768.4XP_006530831.1  neuropilin-1 isoform X3

    Conserved Domains (2) summary
    cd00041
    Location:27140
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00057
    Location:277423
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.