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NRP1 neuropilin 1 [ Homo sapiens (human) ]

Gene ID: 8829, updated on 22-Sep-2022

Summary

Official Symbol
NRP1provided by HGNC
Official Full Name
neuropilin 1provided by HGNC
Primary source
HGNC:HGNC:8004
See related
Ensembl:ENSG00000099250 MIM:602069; AllianceGenome:HGNC:8004
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NP1; NRP; BDCA4; CD304; VEGF165R
Summary
This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. This protein has also been determined to act as a co-receptor for SARS-CoV-2 (which causes COVID-19) to infect host cells. [provided by RefSeq, Nov 2020]
Annotation information
Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in SARS-CoV-2 infection.
Expression
Broad expression in placenta (RPKM 53.3), fat (RPKM 49.6) and 24 other tissues See more
Orthologs
NEW
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Try the new Transcript table

Genomic context

See NRP1 in Genome Data Viewer
Location:
10p11.22
Exon count:
18
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (33177493..33334667, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (33206293..33363487, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (33466421..33623595, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ITGB1 divergent transcript Neighboring gene ribosomal protein L7a pseudogene 53 Neighboring gene ITGB1 adjacent tumor promoting lncRNA Neighboring gene uncharacterized LOC124902407 Neighboring gene RNA, 7SL, cytoplasmic 398, pseudogene Neighboring gene Sharpr-MPRA regulatory region 15712 Neighboring gene Sharpr-MPRA regulatory region 8853 Neighboring gene uncharacterized LOC105376489

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
DOCK4 and CEACAM21 as novel schizophrenia candidate genes in the Jewish population.
EBI GWAS Catalog
Genome-wide association study identifies loci on 12q24 and 13q32 associated with tetralogy of Fallot.
EBI GWAS Catalog
Genome-wide meta-analysis identifies new susceptibility loci for migraine.
EBI GWAS Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of neuropilin 1 (NRP1) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Nef nef HIV-1 Nef upregulates VEGFR2 and its co-receptor neuropilin-1 and downregulates the expression of semaphorin 3a in podocytes PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp781F1414, DKFZp686A03134

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase activator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables coreceptor activity TAS
Traceable Author Statement
more info
PubMed 
enables cytokine binding NAS
Non-traceable Author Statement
more info
PubMed 
enables growth factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables growth factor binding TAS
Traceable Author Statement
more info
PubMed 
enables heparin binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
enables semaphorin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables semaphorin receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables vascular endothelial growth factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables vascular endothelial growth factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables vascular endothelial growth factor receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables vascular endothelial growth factor receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables vascular endothelial growth factor receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in VEGF-activated neuropilin signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in VEGF-activated neuropilin signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in VEGF-activated neuropilin signaling pathway involved in axon guidance IEA
Inferred from Electronic Annotation
more info
 
involved_in actin cytoskeleton reorganization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in angiogenesis involved in coronary vascular morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in animal organ morphogenesis TAS
Traceable Author Statement
more info
PubMed 
involved_in artery morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in axon extension involved in axon guidance ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in axon guidance NAS
Non-traceable Author Statement
more info
PubMed 
involved_in axonal fasciculation IEA
Inferred from Electronic Annotation
more info
 
involved_in axonogenesis involved in innervation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in basal dendrite arborization ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in basal dendrite development ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in branching involved in blood vessel morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in branchiomotor neuron axon guidance IEA
Inferred from Electronic Annotation
more info
 
involved_in cell migration involved in sprouting angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
involved_in cellular response to hepatocyte growth factor stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to vascular endothelial growth factor stimulus ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in commissural neuron axon guidance ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in coronary artery morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in dichotomous subdivision of terminal units involved in salivary gland branching IEA
Inferred from Electronic Annotation
more info
 
involved_in dorsal root ganglion morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in endothelial cell chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endothelial tip cell fate specification ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in facial nerve structural organization IEA
Inferred from Electronic Annotation
more info
 
involved_in facioacoustic ganglion development IEA
Inferred from Electronic Annotation
more info
 
involved_in gonadotrophin-releasing hormone neuronal migration to the hypothalamus IEA
Inferred from Electronic Annotation
more info
 
involved_in hepatocyte growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in integrin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in motor neuron migration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of axon extension involved in axon guidance IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of extrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in nerve development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in neural crest cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neural crest cell migration involved in autonomic nervous system development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in neuron migration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in neuropilin signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in otic placode development IEA
Inferred from Electronic Annotation
more info
 
involved_in outflow tract septum morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in platelet-derived growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in positive regulation of actin cytoskeleton reorganization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of axon extension involved in axon guidance ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cell migration involved in sprouting angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cytokine activity TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of endothelial cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of endothelial cell migration TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of endothelial cell proliferation TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of filopodium assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of filopodium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of focal adhesion assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of peptidyl-tyrosine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of retinal ganglion cell axon guidance ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of smooth muscle cell migration TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of stress fiber assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of substrate adhesion-dependent cell spreading IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in postsynapse organization IEA
Inferred from Electronic Annotation
more info
 
involved_in protein localization to early endosome ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in regulation of Cdc42 protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of retinal ganglion cell axon guidance ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of vascular endothelial growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of vesicle-mediated transport TAS
Traceable Author Statement
more info
PubMed 
involved_in renal artery morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in response to wounding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in retina vasculature morphogenesis in camera-type eye ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in retinal ganglion cell axon guidance ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in semaphorin-plexin signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
involved_in semaphorin-plexin signaling pathway involved in axon guidance IEA
Inferred from Electronic Annotation
more info
 
involved_in semaphorin-plexin signaling pathway involved in neuron projection guidance ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in sensory neuron axon guidance IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction TAS
Traceable Author Statement
more info
PubMed 
involved_in sprouting angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in sprouting angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in substrate adhesion-dependent cell spreading IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in substrate-dependent cell migration, cell extension IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sympathetic ganglion development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in sympathetic neuron projection extension ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in sympathetic neuron projection guidance ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in toxin transport IEA
Inferred from Electronic Annotation
more info
 
involved_in trigeminal ganglion development IEA
Inferred from Electronic Annotation
more info
 
involved_in trigeminal nerve structural organization IEA
Inferred from Electronic Annotation
more info
 
involved_in vascular endothelial growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in vascular endothelial growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vasculogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ventral trunk neural crest cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in vestibulocochlear nerve structural organization IEA
Inferred from Electronic Annotation
more info
 
involved_in viral entry into host cell IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in axon ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytoplasmic vesicle TAS
Traceable Author Statement
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in early endosome ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in extracellular space HDA PubMed 
located_in focal adhesion HDA PubMed 
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neurofilament IEA
Inferred from Electronic Annotation
more info
 
located_in neuron projection ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
part_of receptor complex TAS
Traceable Author Statement
more info
PubMed 
part_of semaphorin receptor complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in sorting endosome ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
neuropilin-1
Names
transmembrane receptor
vascular endothelial cell growth factor 165 receptor

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030328.2 RefSeqGene

    Range
    5000..162174
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001024628.3NP_001019799.2  neuropilin-1 isoform b precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses a different splice site in the 3' end and contains a different segment for the 3' end of the coding region and the 3' UTR, compared to variant 1. The resulting protein (isoform b) has a shorter C-terminus when compared to isoform a. This variant has also been named S12NRP1 in PubMed ID: 11112349.
    Source sequence(s)
    AL121748, AL353600
    Consensus CDS
    CCDS31180.1
    Related
    ENSP00000363955.4, ENST00000374822.8
    Conserved Domains (2) summary
    cd00041
    Location:27140
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00057
    Location:277423
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  2. NM_001024629.3NP_001019800.2  neuropilin-1 isoform c precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame coding region segment, uses a different splice site in the 3' end and contains a different segment for the 3' end of the coding region and the 3' UTR, compared to variant 1. The resulting protein (isoform c) has a shorter C-terminus when compared to isoform a.
    Source sequence(s)
    AL121748, AL353600
    Consensus CDS
    CCDS31179.1
    Related
    ENSP00000363954.5, ENST00000374821.9
    Conserved Domains (2) summary
    cd00041
    Location:27140
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00057
    Location:277423
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  3. NM_001244972.2NP_001231901.2  neuropilin-1 isoform d precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses two different splice sites in the coding region, compared to variant 1. The resulting protein (isoform d) is shorter when it is compared to isoform a.
    Source sequence(s)
    AL121748, AL353600
    Conserved Domains (4) summary
    smart00137
    Location:638798
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    cd00041
    Location:27140
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00057
    Location:277423
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    pfam11980
    Location:839917
    DUF3481; C-terminal domain of neuropilin glycoprotein
  4. NM_001244973.2NP_001231902.2  neuropilin-1 isoform e precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses a different splice site in the coding region, compared to variant 1. The resulting protein (isoform e) is shorter when it is compared to isoform a.
    Source sequence(s)
    AL121748, AL353600
    Conserved Domains (4) summary
    smart00137
    Location:638797
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    cd00041
    Location:27140
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00057
    Location:277423
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    pfam11980
    Location:838916
    DUF3481; C-terminal domain of neuropilin glycoprotein
  5. NM_001330068.2NP_001316997.2  neuropilin-1 isoform f precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. It encodes isoform f, which is shorter than isoform a.
    Source sequence(s)
    AL121748, AL353600
    Consensus CDS
    CCDS81448.1
    UniProtKB/TrEMBL
    E9PEP6
    Related
    ENSP00000379317.1, ENST00000395995.5
    Conserved Domains (4) summary
    smart00137
    Location:645804
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    cd00041
    Location:27140
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00057
    Location:277423
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    pfam11980
    Location:828906
    DUF3481; C-terminal domain of neuropilin glycoprotein
  6. NM_003873.7NP_003864.5  neuropilin-1 isoform a precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform a).
    Source sequence(s)
    AL121748, AL353600
    Consensus CDS
    CCDS7177.1
    UniProtKB/Swiss-Prot
    Q96IH5
    Related
    ENSP00000364001.2, ENST00000374867.7
    Conserved Domains (4) summary
    smart00137
    Location:645804
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    cd00041
    Location:27140
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00057
    Location:277423
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    pfam11980
    Location:845923
    DUF3481; C-terminal domain of neuropilin glycoprotein

RNA

  1. NR_045259.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL121748, AL353600
    Related
    ENST00000374875.5

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    33177493..33334667 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047425977.1XP_047281933.1  neuropilin-1 isoform X7

  2. XM_006717525.3XP_006717588.1  neuropilin-1 isoform X6

    Conserved Domains (6) summary
    cd06263
    Location:615768
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    pfam11980
    Location:808885
    DUF3481; Domain of unknown function (DUF3481)
    smart00137
    Location:610769
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00231
    Location:274424
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00041
    Location:27140
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00057
    Location:277423
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  3. XM_006717524.3XP_006717587.1  neuropilin-1 isoform X5

    Conserved Domains (6) summary
    cd06263
    Location:615769
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    pfam11980
    Location:809886
    DUF3481; Domain of unknown function (DUF3481)
    smart00137
    Location:610770
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00231
    Location:274424
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00041
    Location:27140
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00057
    Location:277423
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  4. XM_017016865.3XP_016872354.1  neuropilin-1 isoform X4

  5. XM_047425976.1XP_047281932.1  neuropilin-1 isoform X3

  6. XM_006717522.3XP_006717585.1  neuropilin-1 isoform X2

    Conserved Domains (6) summary
    cd06263
    Location:650804
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    pfam11980
    Location:827904
    DUF3481; Domain of unknown function (DUF3481)
    smart00137
    Location:645805
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00231
    Location:274424
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00041
    Location:27140
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00057
    Location:277423
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  7. XM_006717521.3XP_006717584.1  neuropilin-1 isoform X1

    Conserved Domains (6) summary
    cd06263
    Location:650804
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    pfam11980
    Location:844921
    DUF3481; Domain of unknown function (DUF3481)
    smart00137
    Location:645805
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00231
    Location:274424
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00041
    Location:27140
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00057
    Location:277423
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  8. XM_047425978.1XP_047281934.1  neuropilin-1 isoform X8

  9. XM_011519756.3XP_011518058.1  neuropilin-1 isoform X11

    Conserved Domains (3) summary
    smart00231
    Location:274424
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00041
    Location:27140
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00057
    Location:277423
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  10. XM_011519755.4XP_011518057.1  neuropilin-1 isoform X10

    Conserved Domains (3) summary
    smart00231
    Location:274424
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00041
    Location:27140
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00057
    Location:277423
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  11. XM_006717526.3XP_006717589.1  neuropilin-1 isoform X9

    Conserved Domains (3) summary
    smart00231
    Location:274424
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00041
    Location:27140
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00057
    Location:277423
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    33206293..33363487 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)