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NRP1 neuropilin 1 [ Homo sapiens (human) ]

Gene ID: 8829, updated on 7-Mar-2021

Summary

Official Symbol
NRP1provided by HGNC
Official Full Name
neuropilin 1provided by HGNC
Primary source
HGNC:HGNC:8004
See related
Ensembl:ENSG00000099250 MIM:602069
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NP1; NRP; BDCA4; CD304; VEGF165R
Summary
This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. This protein has also been determined to act as a co-receptor for SARS-CoV-2 (which causes COVID-19) to infect host cells. [provided by RefSeq, Nov 2020]
Annotation information
Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in SARS-CoV-2 infection.
Expression
Broad expression in placenta (RPKM 53.3), fat (RPKM 49.6) and 24 other tissues See more
Orthologs
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Genomic context

See NRP1 in Genome Data Viewer
Location:
10p11.22
Exon count:
18
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (33177493..33334667, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (33466421..33623595, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ITGB1 divergent transcript Neighboring gene ribosomal protein L7a pseudogene 53 Neighboring gene ITGB1 adjacent tumor promoting lncRNA Neighboring gene RNA, 7SL, cytoplasmic 398, pseudogene Neighboring gene uncharacterized LOC105376489 Neighboring gene long intergenic non-protein coding RNA 2628

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
DOCK4 and CEACAM21 as novel schizophrenia candidate genes in the Jewish population.
GeneReviews: Not available
Genome-wide association study identifies loci on 12q24 and 13q32 associated with tetralogy of Fallot.
GeneReviews: Not available
Genome-wide meta-analysis identifies new susceptibility loci for migraine.
GeneReviews: Not available

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of neuropilin 1 (NRP1) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Nef nef HIV-1 Nef upregulates VEGFR2 and its co-receptor neuropilin-1 and downregulates the expression of semaphorin 3a in podocytes PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp781F1414, DKFZp686A03134

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
coreceptor activity TAS
Traceable Author Statement
more info
PubMed 
cytokine binding NAS
Non-traceable Author Statement
more info
PubMed 
growth factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
growth factor binding TAS
Traceable Author Statement
more info
PubMed 
heparin binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
semaphorin receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
vascular endothelial growth factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
vascular endothelial growth factor-activated receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
vascular endothelial growth factor-activated receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
VEGF-activated neuropilin signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
VEGF-activated neuropilin signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
actin cytoskeleton reorganization IMP
Inferred from Mutant Phenotype
more info
PubMed 
angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
angiogenesis involved in coronary vascular morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
animal organ morphogenesis TAS
Traceable Author Statement
more info
PubMed 
artery morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
axon extension involved in axon guidance ISS
Inferred from Sequence or Structural Similarity
more info
 
axon guidance NAS
Non-traceable Author Statement
more info
PubMed 
axonogenesis involved in innervation ISS
Inferred from Sequence or Structural Similarity
more info
 
basal dendrite arborization ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
basal dendrite development ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
branching involved in blood vessel morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
cell migration involved in sprouting angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
cellular response to hepatocyte growth factor stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to vascular endothelial growth factor stimulus ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
commissural neuron axon guidance ISS
Inferred from Sequence or Structural Similarity
more info
 
endothelial cell chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
endothelial tip cell fate specification ISS
Inferred from Sequence or Structural Similarity
more info
 
hepatocyte growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
integrin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
motor neuron migration ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of axon extension involved in axon guidance IEA
Inferred from Electronic Annotation
more info
 
nerve development ISS
Inferred from Sequence or Structural Similarity
more info
 
neural crest cell migration involved in autonomic nervous system development ISS
Inferred from Sequence or Structural Similarity
more info
 
neuron migration ISS
Inferred from Sequence or Structural Similarity
more info
 
neuropilin signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
outflow tract septum morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
platelet-derived growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of actin cytoskeleton reorganization IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of axon extension involved in axon guidance ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cytokine activity TAS
Traceable Author Statement
more info
PubMed 
positive regulation of endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of endothelial cell migration TAS
Traceable Author Statement
more info
PubMed 
positive regulation of endothelial cell proliferation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of filopodium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of focal adhesion assembly IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of peptidyl-tyrosine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of retinal ganglion cell axon guidance ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of smooth muscle cell migration TAS
Traceable Author Statement
more info
PubMed 
positive regulation of stress fiber assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of substrate adhesion-dependent cell spreading IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein localization to early endosome ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
regulation of Cdc42 protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of retinal ganglion cell axon guidance ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of vesicle-mediated transport TAS
Traceable Author Statement
more info
PubMed 
response to wounding IEA
Inferred from Electronic Annotation
more info
 
retina vasculature morphogenesis in camera-type eye ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
retinal ganglion cell axon guidance ISS
Inferred from Sequence or Structural Similarity
more info
 
semaphorin-plexin signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
semaphorin-plexin signaling pathway involved in neuron projection guidance ISS
Inferred from Sequence or Structural Similarity
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
sprouting angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
substrate adhesion-dependent cell spreading IMP
Inferred from Mutant Phenotype
more info
PubMed 
substrate-dependent cell migration, cell extension IMP
Inferred from Mutant Phenotype
more info
PubMed 
sympathetic ganglion development ISS
Inferred from Sequence or Structural Similarity
more info
 
sympathetic neuron projection extension ISS
Inferred from Sequence or Structural Similarity
more info
 
sympathetic neuron projection guidance ISS
Inferred from Sequence or Structural Similarity
more info
 
vascular endothelial growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
vascular endothelial growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
viral entry into host cell IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
axon ISS
Inferred from Sequence or Structural Similarity
more info
 
cell surface IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic vesicle TAS
Traceable Author Statement
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
early endosome ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
extracellular space HDA PubMed 
focal adhesion HDA PubMed 
focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
growth cone IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
 
neuron projection ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
receptor complex TAS
Traceable Author Statement
more info
PubMed 
semaphorin receptor complex NAS
Non-traceable Author Statement
more info
PubMed 
sorting endosome ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
neuropilin-1
Names
transmembrane receptor
vascular endothelial cell growth factor 165 receptor

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030328.1 RefSeqGene

    Range
    5001..162415
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001024628.3NP_001019799.2  neuropilin-1 isoform b precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses a different splice site in the 3' end and contains a different segment for the 3' end of the coding region and the 3' UTR, compared to variant 1. The resulting protein (isoform b) has a shorter C-terminus when compared to isoform a. This variant has also been named S12NRP1 in PubMed ID: 11112349.
    Source sequence(s)
    AL121748, AL353600
    Consensus CDS
    CCDS31180.1
    Related
    ENSP00000363955.4, ENST00000374822.8
  2. NM_001024629.3NP_001019800.2  neuropilin-1 isoform c precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame coding region segment, uses a different splice site in the 3' end and contains a different segment for the 3' end of the coding region and the 3' UTR, compared to variant 1. The resulting protein (isoform c) has a shorter C-terminus when compared to isoform a.
    Source sequence(s)
    AL121748, AL353600
    Consensus CDS
    CCDS31179.1
    Related
    ENSP00000363954.5, ENST00000374821.9
  3. NM_001244972.2NP_001231901.2  neuropilin-1 isoform d precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses two different splice sites in the coding region, compared to variant 1. The resulting protein (isoform d) is shorter when it is compared to isoform a.
    Source sequence(s)
    AL121748, AL353600
  4. NM_001244973.2NP_001231902.2  neuropilin-1 isoform e precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses a different splice site in the coding region, compared to variant 1. The resulting protein (isoform e) is shorter when it is compared to isoform a.
    Source sequence(s)
    AL121748, AL353600
  5. NM_001330068.2NP_001316997.2  neuropilin-1 isoform f precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. It encodes isoform f, which is shorter than isoform a.
    Source sequence(s)
    AL121748, AL353600
    Consensus CDS
    CCDS81448.1
    Related
    ENSP00000379317.1, ENST00000395995.5
  6. NM_003873.7NP_003864.5  neuropilin-1 isoform a precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform a).
    Source sequence(s)
    AL121748, AL353600
    Consensus CDS
    CCDS7177.1
    Related
    ENSP00000364001.2, ENST00000374867.7

RNA

  1. NR_045259.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL121748, AL353600
    Related
    ENST00000374875.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    33177493..33334667 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006717525.2XP_006717588.1  neuropilin-1 isoform X5

    Conserved Domains (6) summary
    cd06263
    Location:615768
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    pfam11980
    Location:808885
    DUF3481; Domain of unknown function (DUF3481)
    smart00137
    Location:610769
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00231
    Location:274424
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00041
    Location:27140
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00057
    Location:277423
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  2. XM_006717524.2XP_006717587.1  neuropilin-1 isoform X4

    Conserved Domains (6) summary
    cd06263
    Location:615769
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    pfam11980
    Location:809886
    DUF3481; Domain of unknown function (DUF3481)
    smart00137
    Location:610770
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00231
    Location:274424
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00041
    Location:27140
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00057
    Location:277423
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  3. XM_006717522.2XP_006717585.1  neuropilin-1 isoform X2

    Conserved Domains (6) summary
    cd06263
    Location:650804
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    pfam11980
    Location:827904
    DUF3481; Domain of unknown function (DUF3481)
    smart00137
    Location:645805
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00231
    Location:274424
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00041
    Location:27140
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00057
    Location:277423
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  4. XM_006717521.2XP_006717584.1  neuropilin-1 isoform X1

    Conserved Domains (6) summary
    cd06263
    Location:650804
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    pfam11980
    Location:844921
    DUF3481; Domain of unknown function (DUF3481)
    smart00137
    Location:645805
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00231
    Location:274424
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00041
    Location:27140
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00057
    Location:277423
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  5. XM_017016866.2XP_016872355.1  neuropilin-1 isoform X6

  6. XM_017016865.2XP_016872354.1  neuropilin-1 isoform X3

  7. XM_011519756.2XP_011518058.1  neuropilin-1 isoform X9

    Conserved Domains (3) summary
    smart00231
    Location:274424
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00041
    Location:27140
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00057
    Location:277423
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  8. XM_011519755.3XP_011518057.1  neuropilin-1 isoform X8

    Conserved Domains (3) summary
    smart00231
    Location:274424
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00041
    Location:27140
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00057
    Location:277423
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  9. XM_006717526.2XP_006717589.1  neuropilin-1 isoform X7

    Conserved Domains (3) summary
    smart00231
    Location:274424
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00041
    Location:27140
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00057
    Location:277423
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
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