NRP1 neuropilin 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: NRP1provided by HGNC
Official Full Name: neuropilin 1provided by HGNC
Primary source: HGNC:HGNC:8004
See related: Ensembl:ENSG00000099250 MIM:602069
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NP1; NRP; BDCA4; CD304; VEGF165R
Summary: This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. This protein has also been determined to act as a co-receptor for SARS-CoV-2 (which causes COVID-19) to infect host cells. [provided by RefSeq, Nov 2020]
Annotation information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in SARS-CoV-2 infection.
Expression: Broad expression in placenta (RPKM 53.3), fat (RPKM 49.6) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 10p11.22

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
109.20210226	current	GRCh38.p13 (GCF_000001405.39)	10	NC_000010.11 (33177493..33334667, complement)
105.20201022	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (33466421..33623595, complement)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ablation of neuropilin-1 improves the therapeutic response in conventional drug-resistant glioblastoma multiforme.
Title: Ablation of neuropilin-1 improves the therapeutic response in conventional drug-resistant glioblastoma multiforme.
More that ACE2? NRP1 may play a central role in the underlying pathophysiological mechanism of olfactory dysfunction in COVID-19 and its association with enhanced survival.
Title: More that ACE2? NRP1 may play a central role in the underlying pathophysiological mechanism of olfactory dysfunction in COVID-19 and its association with enhanced survival.
Selection and characterization of specific nanobody against neuropilin-1 for inhibition of angiogenesis.
Title: Selection and characterization of specific nanobody against neuropilin-1 for inhibition of angiogenesis.
Neuropilin1, a novel independent prognostic factor and therapeutic target in triple-negative breast cancer.
Title: Neuropilin1, a novel independent prognostic factor and therapeutic target in triple-negative breast cancer.
The role of Neuropilin-1 in COVID-19.
Title: The role of Neuropilin-1 in COVID-19.
SARS-CoV-2 spike protein co-opts VEGF-A/neuropilin-1 receptor signaling to induce analgesia.
Title: SARS-CoV-2 spike protein co-opts VEGF-A/neuropilin-1 receptor signaling to induce analgesia.
High-Expression of Neuropilin 1 Correlates to Estrogen-Induced Epithelial-Mesenchymal Transition of Endometrial Cells in Adenomyosis.
Title: High-Expression of Neuropilin 1 Correlates to Estrogen-Induced Epithelial-Mesenchymal Transition of Endometrial Cells in Adenomyosis.
Neuropilin-1 is a host factor for SARS-CoV-2 infection.
Title: Neuropilin-1 is a host factor for SARS-CoV-2 infection.
Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity.
Title: Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity.
Serum and tissue expression of neuropilin 1 in precancerous and malignant vocal fold lesions.
Title: Serum and tissue expression of neuropilin 1 in precancerous and malignant vocal fold lesions.

Submit: New GeneRIF Correction See all GeneRIFs (263)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
DOCK4 and CEACAM21 as novel schizophrenia candidate genes in the Jewish population. GeneReviews: Not available
Genome-wide association study identifies loci on 12q24 and 13q32 associated with tetralogy of Fallot. GeneReviews: Not available
Genome-wide meta-analysis identifies new susceptibility loci for migraine. GeneReviews: Not available

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of neuropilin 1 (NRP1) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Nef	nef	HIV-1 Nef upregulates VEGFR2 and its co-receptor neuropilin-1 and downregulates the expression of semaphorin 3a in podocytes	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH70034 (e-PCR)
- UniSTS:22785

RH118801 (e-PCR)
- UniSTS:138782

RH65747 (e-PCR)
- UniSTS:8233

D8S2279 (e-PCR)
- UniSTS:473907

RH46501 (e-PCR)
- UniSTS:53818

SHGC-56598 (e-PCR)
- UniSTS:32317

RH45612 (e-PCR)
- UniSTS:73804

G48212 (e-PCR)
- UniSTS:95309

G20549 (e-PCR)
- UniSTS:74679

A005W14 (e-PCR)
- UniSTS:74680

RH122665 (e-PCR)
- UniSTS:135115

RH120752 (e-PCR)
- UniSTS:132831

D10S1654 (e-PCR), detects polymorphism
- UniSTS:58084

KS608 (e-PCR)
- UniSTS:253179

Homology

Homologs of the NRP1 gene: The NRP1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 339 organisms have orthologs with human gene NRP1
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
GTPase activator activity	IMP Inferred from Mutant Phenotype more info	PubMed
coreceptor activity	TAS Traceable Author Statement more info	PubMed
cytokine binding	NAS Non-traceable Author Statement more info	PubMed
growth factor binding	IPI Inferred from Physical Interaction more info	PubMed
growth factor binding	TAS Traceable Author Statement more info	PubMed
heparin binding	IEA Inferred from Electronic Annotation more info
metal ion binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
semaphorin receptor activity	NAS Non-traceable Author Statement more info	PubMed
vascular endothelial growth factor binding	IPI Inferred from Physical Interaction more info	PubMed
vascular endothelial growth factor-activated receptor activity	ISS Inferred from Sequence or Structural Similarity more info
vascular endothelial growth factor-activated receptor activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
VEGF-activated neuropilin signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
VEGF-activated neuropilin signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
actin cytoskeleton reorganization	IMP Inferred from Mutant Phenotype more info	PubMed
angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
angiogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
angiogenesis involved in coronary vascular morphogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
animal organ morphogenesis	TAS Traceable Author Statement more info	PubMed
artery morphogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
axon extension involved in axon guidance	ISS Inferred from Sequence or Structural Similarity more info
axon guidance	NAS Non-traceable Author Statement more info	PubMed
axonogenesis involved in innervation	ISS Inferred from Sequence or Structural Similarity more info
basal dendrite arborization	ISS Inferred from Sequence or Structural Similarity more info	PubMed
basal dendrite development	ISS Inferred from Sequence or Structural Similarity more info	PubMed
branching involved in blood vessel morphogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
cell migration involved in sprouting angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
cell-cell signaling	TAS Traceable Author Statement more info	PubMed
cellular response to hepatocyte growth factor stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
cellular response to vascular endothelial growth factor stimulus	ISS Inferred from Sequence or Structural Similarity more info	PubMed
commissural neuron axon guidance	ISS Inferred from Sequence or Structural Similarity more info
endothelial cell chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
endothelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
endothelial tip cell fate specification	ISS Inferred from Sequence or Structural Similarity more info
hepatocyte growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
integrin-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
motor neuron migration	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of axon extension involved in axon guidance	IEA Inferred from Electronic Annotation more info
nerve development	ISS Inferred from Sequence or Structural Similarity more info
neural crest cell migration involved in autonomic nervous system development	ISS Inferred from Sequence or Structural Similarity more info
neuron migration	ISS Inferred from Sequence or Structural Similarity more info
neuropilin signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
outflow tract septum morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
platelet-derived growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
positive chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info	PubMed
positive regulation of GTPase activity	IEA Inferred from Electronic Annotation more info
positive regulation of actin cytoskeleton reorganization	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of axon extension involved in axon guidance	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of cytokine activity	TAS Traceable Author Statement more info	PubMed
positive regulation of endothelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of endothelial cell migration	TAS Traceable Author Statement more info	PubMed
positive regulation of endothelial cell proliferation	TAS Traceable Author Statement more info	PubMed
positive regulation of filopodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of focal adhesion assembly	IDA Inferred from Direct Assay more info	PubMed
positive regulation of peptidyl-tyrosine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of retinal ganglion cell axon guidance	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of smooth muscle cell migration	TAS Traceable Author Statement more info	PubMed
positive regulation of stress fiber assembly	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of substrate adhesion-dependent cell spreading	IMP Inferred from Mutant Phenotype more info	PubMed
protein localization to early endosome	ISS Inferred from Sequence or Structural Similarity more info	PubMed
regulation of Cdc42 protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of retinal ganglion cell axon guidance	ISS Inferred from Sequence or Structural Similarity more info
regulation of vesicle-mediated transport	TAS Traceable Author Statement more info	PubMed
response to wounding	IEA Inferred from Electronic Annotation more info
retina vasculature morphogenesis in camera-type eye	ISS Inferred from Sequence or Structural Similarity more info	PubMed
retinal ganglion cell axon guidance	ISS Inferred from Sequence or Structural Similarity more info
semaphorin-plexin signaling pathway	NAS Non-traceable Author Statement more info	PubMed
semaphorin-plexin signaling pathway involved in neuron projection guidance	ISS Inferred from Sequence or Structural Similarity more info
signal transduction	TAS Traceable Author Statement more info	PubMed
sprouting angiogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
substrate adhesion-dependent cell spreading	IMP Inferred from Mutant Phenotype more info	PubMed
substrate-dependent cell migration, cell extension	IMP Inferred from Mutant Phenotype more info	PubMed
sympathetic ganglion development	ISS Inferred from Sequence or Structural Similarity more info
sympathetic neuron projection extension	ISS Inferred from Sequence or Structural Similarity more info
sympathetic neuron projection guidance	ISS Inferred from Sequence or Structural Similarity more info
vascular endothelial growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
vascular endothelial growth factor receptor signaling pathway	TAS Traceable Author Statement more info
viral entry into host cell	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
axon	ISS Inferred from Sequence or Structural Similarity more info
cell surface	IEA Inferred from Electronic Annotation more info
cytoplasmic vesicle	TAS Traceable Author Statement more info	PubMed
cytosol	IDA Inferred from Direct Assay more info	PubMed
early endosome	ISS Inferred from Sequence or Structural Similarity more info	PubMed
extracellular space	HDA more info	PubMed
focal adhesion	HDA more info	PubMed
focal adhesion	IDA Inferred from Direct Assay more info	PubMed
growth cone	IEA Inferred from Electronic Annotation more info
integral component of membrane	IEA Inferred from Electronic Annotation more info
mitochondrial membrane	IEA Inferred from Electronic Annotation more info
neuron projection	ISS Inferred from Sequence or Structural Similarity more info	PubMed
neuronal cell body	IEA Inferred from Electronic Annotation more info
plasma membrane	IDA Inferred from Direct Assay more info	PubMed
plasma membrane	TAS Traceable Author Statement more info
receptor complex	TAS Traceable Author Statement more info	PubMed
semaphorin receptor complex	NAS Non-traceable Author Statement more info	PubMed
sorting endosome	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: neuropilin-1

Names: transmembrane receptor; vascular endothelial cell growth factor 165 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_030328.1 RefSeqGene

Range

5001..162415

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001024628.3 → NP_001019799.2 neuropilin-1 isoform b precursor

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses a different splice site in the 3' end and contains a different segment for the 3' end of the coding region and the 3' UTR, compared to variant 1. The resulting protein (isoform b) has a shorter C-terminus when compared to isoform a. This variant has also been named S12NRP1 in PubMed ID: 11112349.

Source sequence(s)

AL121748, AL353600

Consensus CDS

CCDS31180.1

Related

ENSP00000363955.4, ENST00000374822.8
NM_001024629.3 → NP_001019800.2 neuropilin-1 isoform c precursor

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame coding region segment, uses a different splice site in the 3' end and contains a different segment for the 3' end of the coding region and the 3' UTR, compared to variant 1. The resulting protein (isoform c) has a shorter C-terminus when compared to isoform a.

Source sequence(s)

AL121748, AL353600

Consensus CDS

CCDS31179.1

Related

ENSP00000363954.5, ENST00000374821.9
NM_001244972.2 → NP_001231901.2 neuropilin-1 isoform d precursor

Status: REVIEWED

Description

Transcript Variant: This variant (4) uses two different splice sites in the coding region, compared to variant 1. The resulting protein (isoform d) is shorter when it is compared to isoform a.

Source sequence(s)

AL121748, AL353600
NM_001244973.2 → NP_001231902.2 neuropilin-1 isoform e precursor

Status: REVIEWED

Description

Transcript Variant: This variant (5) uses a different splice site in the coding region, compared to variant 1. The resulting protein (isoform e) is shorter when it is compared to isoform a.

Source sequence(s)

AL121748, AL353600
NM_001330068.2 → NP_001316997.2 neuropilin-1 isoform f precursor

Status: REVIEWED

Description

Transcript Variant: This variant (7) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. It encodes isoform f, which is shorter than isoform a.

Source sequence(s)

AL121748, AL353600

Consensus CDS

CCDS81448.1

Related

ENSP00000379317.1, ENST00000395995.5
NM_003873.7 → NP_003864.5 neuropilin-1 isoform a precursor

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform a).

Source sequence(s)

AL121748, AL353600

Consensus CDS

CCDS7177.1

Related

ENSP00000364001.2, ENST00000374867.7

RNA

NR_045259.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (6) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AL121748, AL353600

Related

ENST00000374875.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

NC_000010.11 Reference GRCh38.p13 Primary Assembly

Range

33177493..33334667 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006717525.2 → XP_006717588.1 neuropilin-1 isoform X5

Conserved Domains (6) summary

cd06263
Location:615 → 768

MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...

pfam11980
Location:808 → 885

DUF3481; Domain of unknown function (DUF3481)

smart00137
Location:610 → 769

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00231
Location:274 → 424

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

cd00041
Location:27 → 140

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00057
Location:277 → 423

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
XM_006717524.2 → XP_006717587.1 neuropilin-1 isoform X4

Conserved Domains (6) summary

cd06263
Location:615 → 769

MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...

pfam11980
Location:809 → 886

DUF3481; Domain of unknown function (DUF3481)

smart00137
Location:610 → 770

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00231
Location:274 → 424

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

cd00041
Location:27 → 140

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00057
Location:277 → 423

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
XM_006717522.2 → XP_006717585.1 neuropilin-1 isoform X2

Conserved Domains (6) summary

cd06263
Location:650 → 804

MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...

pfam11980
Location:827 → 904

DUF3481; Domain of unknown function (DUF3481)

smart00137
Location:645 → 805

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00231
Location:274 → 424

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

cd00041
Location:27 → 140

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00057
Location:277 → 423

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
XM_006717521.2 → XP_006717584.1 neuropilin-1 isoform X1

Conserved Domains (6) summary

cd06263
Location:650 → 804

MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...

pfam11980
Location:844 → 921

DUF3481; Domain of unknown function (DUF3481)

smart00137
Location:645 → 805

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00231
Location:274 → 424

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

cd00041
Location:27 → 140

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00057
Location:277 → 423

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
XM_017016866.2 → XP_016872355.1 neuropilin-1 isoform X6
XM_017016865.2 → XP_016872354.1 neuropilin-1 isoform X3
XM_011519756.2 → XP_011518058.1 neuropilin-1 isoform X9

Conserved Domains (3) summary

smart00231
Location:274 → 424

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

cd00041
Location:27 → 140

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00057
Location:277 → 423

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
XM_011519755.3 → XP_011518057.1 neuropilin-1 isoform X8

Conserved Domains (3) summary

smart00231
Location:274 → 424

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

cd00041
Location:27 → 140

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00057
Location:277 → 423

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
XM_006717526.2 → XP_006717589.1 neuropilin-1 isoform X7

Conserved Domains (3) summary

smart00231
Location:274 → 424

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

cd00041
Location:27 → 140

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00057
Location:277 → 423

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.