NRP1 neuropilin 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: NRP1provided by HGNC
Official Full Name: neuropilin 1provided by HGNC
Primary source: HGNC:HGNC:8004
See related: Ensembl:ENSG00000099250 MIM:602069
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NP1; NRP; BDCA4; CD304; VEGF165R
Summary: This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
Expression: Broad expression in placenta (RPKM 53.3), fat (RPKM 49.6) and 24 other tissues See more
Orthologs: mouse all

Genomic context

Location:: 10p11.22

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
109.20190607	current	GRCh38.p13 (GCF_000001405.39)	10	NC_000010.11 (33177491..33334905, complement)
105	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (33466419..33623833, complement)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Authors demonstrate the presence of homo-interactions between NRP1 molecules, as well as hetero-interactions between NRP1 and VEGFR2 molecules, in the plasma membrane. Our results underscore the complex nature of the interactions between self-associating receptors, co-receptors, and their ligands in the plasma membrane.
Title: Interactions between NRP1 and VEGFR2 molecules in the plasma membrane.
NRP1 was confirmed be the downstream target of miR-9, and inversely modulated by miR-9 in ALL. NRP1 upregulation reversed the anti-cancer regulations of miR-9 on ALL in vitro proliferation and cell-cycle progression.
Title: MicroRNA-9 suppresses cancer proliferation and cell cycle progression in acute lymphoblastic leukemia with inverse association of neuropilin-1.
The article highlights the diverse NRP1 and NRP2 ligands and interacting partners on endothelial cells, which are relevant in the context of the tumor vasculature and the tumor microenvironment. (Review)
Title: Neuropilins in the Context of Tumor Vasculature.
NRP1 can form complexes with FYN and have the correlation changes in odontoblast differentiation of dental pulp stem cells (DPSCs). Therefore, the study surmise that in the progress of dental caries, NRP1 interacts with FYN, by expanding inflammation and inhibition of odontoblast differentiation of DPSCs through nuclear factor kappa B signaling pathway.
Title: The Role of Neuropilin-1-FYN Interaction in Odontoblast Differentiation of Dental Pulp Stem Cells.
High NRP1 expression promotes esophageal squamous cancer progression.
Title: Neuropilin-1 contributes to esophageal squamous cancer progression via promoting P65-dependent cell proliferation.
These findings support that diminished levels of NRP1 contribute to the development of TOF, likely through its function in mediating VEGF signal and vasculogenesis.
Title: NRP1 haploinsufficiency predisposes to the development of Tetralogy of Fallot.
VEGF-A interacts with NRP-1 and GIPC1 to regulate alpha6/beta4-integrin, FAK, Src, PI3K/PDK1, LATS1 signaling to increase YAP1/Np63alpha accumulation.
Title: NRP-1 interacts with GIPC1 and α6/β4-integrins to increase YAP1/∆Np63α-dependent epidermal cancer stem cell survival.
The bevacizumab-independent VEGF/NRP1/ARHGAP17/Cdc42 regulatory network plays important roles in malignant behavior of breast cancer.
Title: Long isoform of VEGF stimulates cell migration of breast cancer by filopodia formation via NRP1/ARHGAP17/Cdc42 regulatory network.
Study reports a novel mechanism correlating high baseline NRP-1 with upregulated TNC/ITGB3 signaling, but decreased ABCG2 expression, which sensitizes breast cancer cells to adriamycin/cyclophosphamide.
Title: Neuropilin-1 promotes the oncogenic Tenascin-C/integrin β3 pathway and modulates chemoresistance in breast cancer cells.
This work supports the importance of NRP-1-associated molecules in circulation to characterize poor prognosis breast cancer and emphasizes on their role as favorable drug targets.
Title: Neuropilin-1 Associated Molecules in the Blood Distinguish Poor Prognosis Breast Cancer: A Cross-Sectional Study.

Submit: New GeneRIF Correction See all GeneRIFs (221)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

NHGRI GWAS Catalog

Description
DOCK4 and CEACAM21 as novel schizophrenia candidate genes in the Jewish population. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Genome-wide association study identifies loci on 12q24 and 13q32 associated with tetralogy of Fallot. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Genome-wide meta-analysis identifies new susceptibility loci for migraine. NHGRI GWA Catalog NHGRI GWA CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of neuropilin 1 (NRP1) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Nef	nef	HIV-1 Nef upregulates VEGFR2 and its co-receptor neuropilin-1 and downregulates the expression of semaphorin 3a in podocytes	PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

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Axon guidance, organism-specific biosystem (from KEGG)
Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
Axon guidance, conserved biosystem (from KEGG)
Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
Axon guidance, organism-specific biosystem (from REACTOME)
Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
CHL1 interactions, organism-specific biosystem (from REACTOME)
CHL1 interactions, organism-specific biosystemClose homolog of L1 (CHL1) is a member of the L1 family of cell adhesion molecules expressed by subpopulations of neurons and glia in the central and peripheral nervous system. CHL1 like L1 promotes ...
CRMPs in Sema3A signaling, organism-specific biosystem (from REACTOME)
CRMPs in Sema3A signaling, organism-specific biosystemCRMPs are a small family of plexinA-interacting cytosolic phosphoproteins identified as mediators of Sema3A signaling and neuronal differentiation. After Sema3A activation Plexin-A bound CRMP's under...
Developmental Biology, organism-specific biosystem (from REACTOME)
Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
HTLV-I infection, organism-specific biosystem (from KEGG)
HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
HTLV-I infection, conserved biosystem (from KEGG)
HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
L1CAM interactions, organism-specific biosystem (from REACTOME)
L1CAM interactions, organism-specific biosystemThe L1 family of cell adhesion molecules (L1CAMs) are a subfamily of the immunoglobulin superfamily of transmembrane receptors, comprised of four structurally related proteins: L1, Close Homolog of L...
Neurophilin interactions with VEGF and VEGFR, organism-specific biosystem (from REACTOME)
Neurophilin interactions with VEGF and VEGFR, organism-specific biosystemThe plasma membrane-associated Neuropilin receptors NRP-1 and -2 bind some of the VEGF proteins and associate with VEGF receptor proteins. NRP-1 binds VEGF-A165, -B, and PLGF-2; NRP-2 also binds VEGF...
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion, organism-specific biosystem (from REACTOME)
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion, organism-specific biosystemSema3A, a prototypical semaphorin, acts as a chemorepellent or a chemoattractant for axons by activating a receptor complex comprising neuropilin-1 as the ligand-binding subunit and plexin-A1 as the ...
Sema3A PAK dependent Axon repulsion, organism-specific biosystem (from REACTOME)
Sema3A PAK dependent Axon repulsion, organism-specific biosystemActivated Rac1 bound to plexin-A might modulate actin dynamics through the sequential phosphorylation and activation of PAK, LIMK1 and cofilin.
Semaphorin interactions, organism-specific biosystem (from REACTOME)
Semaphorin interactions, organism-specific biosystemSemaphorins are a large family of cell surface and secreted guidance molecules divided into eight classes on the basis of their structures. They all have an N-terminal conserved sema domain. Semaphor...
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
Signal transduction by L1, organism-specific biosystem (from REACTOME)
Signal transduction by L1, organism-specific biosystemBesides adhesive roles in cell cell interaction, L1 functions as a signal transducing receptor providing neurons with cues from their environment for axonal growth and guidance. L1 associates with be...
Signaling by VEGF, organism-specific biosystem (from REACTOME)
Signaling by VEGF, organism-specific biosystemIn normal development vascular endothelial growth factors (VEGFs) are crucial regulators of vascular development during embryogenesis (vasculogenesis) and blood-vessel formation in the adult (angioge...
Signaling events mediated by VEGFR1 and VEGFR2, organism-specific biosystem (from Pathway Interaction Database)
Signaling events mediated by VEGFR1 and VEGFR2, organism-specific biosystem
Signaling events mediated by VEGFR1 and VEGFR2
VEGFR1 specific signals, organism-specific biosystem (from Pathway Interaction Database)
VEGFR1 specific signals, organism-specific biosystem
VEGFR1 specific signals

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH70034 (e-PCR)
- UniSTS:22785

RH118801 (e-PCR)
- UniSTS:138782

RH65747 (e-PCR)
- UniSTS:8233

D8S2279 (e-PCR)
- UniSTS:473907

RH46501 (e-PCR)
- UniSTS:53818

SHGC-56598 (e-PCR)
- UniSTS:32317

RH45612 (e-PCR)
- UniSTS:73804

G48212 (e-PCR)
- UniSTS:95309

G20549 (e-PCR)
- UniSTS:74679

A005W14 (e-PCR)
- UniSTS:74680

RH122665 (e-PCR)
- UniSTS:135115

RH120752 (e-PCR)
- UniSTS:132831

D10S1654 (e-PCR), detects polymorphism
- UniSTS:58084

KS608 (e-PCR)
- UniSTS:253179

Homology

Homologs of the NRP1 gene: The NRP1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 264 organisms have orthologs with human gene NRP1
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
GTPase activator activity	IMP Inferred from Mutant Phenotype more info	PubMed
coreceptor activity	TAS Traceable Author Statement more info	PubMed
cytokine binding	NAS Non-traceable Author Statement more info	PubMed
growth factor binding	IPI Inferred from Physical Interaction more info	PubMed
growth factor binding	TAS Traceable Author Statement more info	PubMed
heparin binding	IEA Inferred from Electronic Annotation more info
metal ion binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein kinase binding	IEA Inferred from Electronic Annotation more info
semaphorin receptor activity	NAS Non-traceable Author Statement more info	PubMed
vascular endothelial growth factor binding	IPI Inferred from Physical Interaction more info	PubMed
vascular endothelial growth factor-activated receptor activity	ISS Inferred from Sequence or Structural Similarity more info
vascular endothelial growth factor-activated receptor activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
VEGF-activated neuropilin signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
VEGF-activated neuropilin signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
VEGF-activated neuropilin signaling pathway involved in axon guidance	IEA Inferred from Electronic Annotation more info
actin cytoskeleton reorganization	IMP Inferred from Mutant Phenotype more info	PubMed
angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
angiogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
angiogenesis involved in coronary vascular morphogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
animal organ morphogenesis	TAS Traceable Author Statement more info	PubMed
artery morphogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
axon extension involved in axon guidance	ISS Inferred from Sequence or Structural Similarity more info
axon guidance	NAS Non-traceable Author Statement more info	PubMed
axonal fasciculation	IEA Inferred from Electronic Annotation more info
axonogenesis involved in innervation	ISS Inferred from Sequence or Structural Similarity more info
basal dendrite arborization	ISS Inferred from Sequence or Structural Similarity more info	PubMed
basal dendrite development	ISS Inferred from Sequence or Structural Similarity more info	PubMed
branching involved in blood vessel morphogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
branchiomotor neuron axon guidance	IEA Inferred from Electronic Annotation more info
cell migration involved in sprouting angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
cell-cell signaling	TAS Traceable Author Statement more info	PubMed
cellular response to hepatocyte growth factor stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
cellular response to vascular endothelial growth factor stimulus	ISS Inferred from Sequence or Structural Similarity more info	PubMed
commissural neuron axon guidance	ISS Inferred from Sequence or Structural Similarity more info
coronary artery morphogenesis	IEA Inferred from Electronic Annotation more info
dichotomous subdivision of terminal units involved in salivary gland branching	IEA Inferred from Electronic Annotation more info
dorsal root ganglion morphogenesis	IEA Inferred from Electronic Annotation more info
endothelial cell chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
endothelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
endothelial tip cell fate specification	ISS Inferred from Sequence or Structural Similarity more info
facial nerve structural organization	IEA Inferred from Electronic Annotation more info
facioacoustic ganglion development	IEA Inferred from Electronic Annotation more info
gonadotrophin-releasing hormone neuronal migration to the hypothalamus	IEA Inferred from Electronic Annotation more info
hepatocyte growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
integrin-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
motor neuron migration	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of axon extension involved in axon guidance	IEA Inferred from Electronic Annotation more info
negative regulation of extrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
negative regulation of neuron apoptotic process	IEA Inferred from Electronic Annotation more info
nerve development	ISS Inferred from Sequence or Structural Similarity more info
neural crest cell migration involved in autonomic nervous system development	ISS Inferred from Sequence or Structural Similarity more info
neuron migration	ISS Inferred from Sequence or Structural Similarity more info
neuropilin signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
otic placode development	IEA Inferred from Electronic Annotation more info
outflow tract septum morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
platelet-derived growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
positive chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info	PubMed
positive regulation of GTPase activity	IEA Inferred from Electronic Annotation more info
positive regulation of actin cytoskeleton reorganization	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of axon extension involved in axon guidance	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of cell migration involved in sprouting angiogenesis	IEA Inferred from Electronic Annotation more info
positive regulation of cytokine activity	TAS Traceable Author Statement more info	PubMed
positive regulation of endothelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of endothelial cell migration	TAS Traceable Author Statement more info	PubMed
positive regulation of endothelial cell proliferation	TAS Traceable Author Statement more info	PubMed
positive regulation of filopodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of focal adhesion assembly	IDA Inferred from Direct Assay more info	PubMed
positive regulation of peptidyl-tyrosine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of retinal ganglion cell axon guidance	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of smooth muscle cell migration	TAS Traceable Author Statement more info	PubMed
positive regulation of stress fiber assembly	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of substrate adhesion-dependent cell spreading	IMP Inferred from Mutant Phenotype more info	PubMed
postsynapse organization	IEA Inferred from Electronic Annotation more info
protein localization to early endosome	ISS Inferred from Sequence or Structural Similarity more info	PubMed
regulation of Cdc42 protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of retinal ganglion cell axon guidance	ISS Inferred from Sequence or Structural Similarity more info
regulation of vesicle-mediated transport	TAS Traceable Author Statement more info	PubMed
renal artery morphogenesis	IEA Inferred from Electronic Annotation more info
response to wounding	IEA Inferred from Electronic Annotation more info
retina vasculature morphogenesis in camera-type eye	ISS Inferred from Sequence or Structural Similarity more info	PubMed
retinal ganglion cell axon guidance	ISS Inferred from Sequence or Structural Similarity more info
semaphorin-plexin signaling pathway	NAS Non-traceable Author Statement more info	PubMed
semaphorin-plexin signaling pathway involved in axon guidance	IEA Inferred from Electronic Annotation more info
semaphorin-plexin signaling pathway involved in neuron projection guidance	ISS Inferred from Sequence or Structural Similarity more info
sensory neuron axon guidance	IEA Inferred from Electronic Annotation more info
signal transduction	TAS Traceable Author Statement more info	PubMed
sprouting angiogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
substrate adhesion-dependent cell spreading	IMP Inferred from Mutant Phenotype more info	PubMed
substrate-dependent cell migration, cell extension	IMP Inferred from Mutant Phenotype more info	PubMed
sympathetic ganglion development	ISS Inferred from Sequence or Structural Similarity more info
sympathetic neuron projection extension	ISS Inferred from Sequence or Structural Similarity more info
sympathetic neuron projection guidance	ISS Inferred from Sequence or Structural Similarity more info
toxin transport	IEA Inferred from Electronic Annotation more info
trigeminal ganglion development	IEA Inferred from Electronic Annotation more info
trigeminal nerve structural organization	IEA Inferred from Electronic Annotation more info
vascular endothelial growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
vascular endothelial growth factor receptor signaling pathway	TAS Traceable Author Statement more info
ventral trunk neural crest cell migration	IEA Inferred from Electronic Annotation more info
vestibulocochlear nerve structural organization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
axon	ISS Inferred from Sequence or Structural Similarity more info
cell surface	IEA Inferred from Electronic Annotation more info
cytoplasmic vesicle	TAS Traceable Author Statement more info	PubMed
cytosol	IDA Inferred from Direct Assay more info	PubMed
early endosome	ISS Inferred from Sequence or Structural Similarity more info	PubMed
extracellular space	HDA more info	PubMed
focal adhesion	HDA more info	PubMed
focal adhesion	IDA Inferred from Direct Assay more info	PubMed
glutamatergic synapse	IEA Inferred from Electronic Annotation more info
growth cone	IEA Inferred from Electronic Annotation more info
integral component of postsynaptic membrane	IEA Inferred from Electronic Annotation more info
neurofilament	IEA Inferred from Electronic Annotation more info
neuron projection	ISS Inferred from Sequence or Structural Similarity more info	PubMed
neuronal cell body	IEA Inferred from Electronic Annotation more info
plasma membrane	IDA Inferred from Direct Assay more info	PubMed
plasma membrane	TAS Traceable Author Statement more info
receptor complex	TAS Traceable Author Statement more info	PubMed
semaphorin receptor complex	NAS Non-traceable Author Statement more info	PubMed
sorting endosome	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: neuropilin-1

Names: transmembrane receptor; vascular endothelial cell growth factor 165 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_030328.1 RefSeqGene

Range

5001..162415

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001024628.2 → NP_001019799.1 neuropilin-1 isoform b precursor

See identical proteins and their annotated locations for NP_001019799.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses a different splice site in the 3' end and contains a different segment for the 3' end of the coding region and the 3' UTR, compared to variant 1. The resulting protein (isoform b) has a shorter C-terminus when compared to isoform a. This variant has also been named S12NRP1 in PubMed ID: 11112349.

Source sequence(s)

AA973607, AL698999, BC007533, CR749333, DA702852

Consensus CDS

CCDS31180.1

UniProtKB/Swiss-Prot

O14786

UniProtKB/TrEMBL

Q68DN3

Related

ENSP00000363955.4, ENST00000374822.8

Conserved Domains (2) summary

cd00041
Location:27 → 140

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00057
Location:277 → 423

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
NM_001024629.2 → NP_001019800.1 neuropilin-1 isoform c precursor

See identical proteins and their annotated locations for NP_001019800.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame coding region segment, uses a different splice site in the 3' end and contains a different segment for the 3' end of the coding region and the 3' UTR, compared to variant 1. The resulting protein (isoform c) has a shorter C-terminus when compared to isoform a.

Source sequence(s)

AA973607, AL698999, BC007737, CR749333, DA702852

Consensus CDS

CCDS31179.1

UniProtKB/Swiss-Prot

O14786

UniProtKB/TrEMBL

Q68DN3

Related

ENSP00000363954.5, ENST00000374821.9

Conserved Domains (2) summary

cd00041
Location:27 → 140

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00057
Location:277 → 423

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
NM_001244972.1 → NP_001231901.1 neuropilin-1 isoform d precursor

Status: REVIEWED

Description

Transcript Variant: This variant (4) uses two different splice sites in the coding region, compared to variant 1. The resulting protein (isoform d) is shorter when it is compared to isoform a.

Source sequence(s)

AB209641, AK292822, AL353600, BX648250

UniProtKB/TrEMBL

A8K9V7, Q59F20

Conserved Domains (6) summary

cd06263
Location:643 → 797

MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...

pfam11980
Location:837 → 914

DUF3481; Domain of unknown function (DUF3481)

smart00137
Location:638 → 798

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00231
Location:274 → 424

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

cd00041
Location:27 → 140

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00057
Location:277 → 423

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
NM_001244973.1 → NP_001231902.1 neuropilin-1 isoform e precursor

Status: REVIEWED

Description

Transcript Variant: This variant (5) uses a different splice site in the coding region, compared to variant 1. The resulting protein (isoform e) is shorter when it is compared to isoform a.

Source sequence(s)

AB209641, AL121748, AL353600, BX648250

UniProtKB/TrEMBL

Q59F20

Conserved Domains (6) summary

cd06263
Location:643 → 796

MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...

pfam11980
Location:836 → 913

DUF3481; Domain of unknown function (DUF3481)

smart00137
Location:638 → 797

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00231
Location:274 → 424

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

cd00041
Location:27 → 140

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00057
Location:277 → 423

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
NM_001330068.1 → NP_001316997.1 neuropilin-1 isoform f precursor

Status: REVIEWED

Description

Transcript Variant: This variant (7) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. It encodes isoform f, which is shorter than isoform a.

Source sequence(s)

AF018956, AL121748, AL353600, AY249243, BU858030, BX648250

Consensus CDS

CCDS81448.1

UniProtKB/Swiss-Prot

O14786

UniProtKB/TrEMBL

Q6X907

Related

ENSP00000379317.1, ENST00000395995.5
NM_003873.6 → NP_003864.4 neuropilin-1 isoform a precursor

See identical proteins and their annotated locations for NP_003864.4

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform a).

Source sequence(s)

AB209641, BX648025, BX648250, CR749333

Consensus CDS

CCDS7177.1

UniProtKB/Swiss-Prot

O14786

UniProtKB/TrEMBL

Q59F20, Q68DN3, Q6AWA9

Related

ENSP00000364001.2, ENST00000374867.7

Conserved Domains (6) summary

cd06263
Location:650 → 803

MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...

pfam11980
Location:843 → 920

DUF3481; Domain of unknown function (DUF3481)

smart00137
Location:645 → 804

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00231
Location:274 → 424

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

cd00041
Location:27 → 140

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00057
Location:277 → 423

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

RNA

NR_045259.1 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (6) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AB209641, AL121748, AL353600, AL833608, BX648250

Related

ENST00000374875.5

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

NC_000010.11 Reference GRCh38.p13 Primary Assembly

Range

33177491..33334905 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006717525.2 → XP_006717588.1 neuropilin-1 isoform X5

Conserved Domains (6) summary

cd06263
Location:615 → 768

MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...

pfam11980
Location:808 → 885

DUF3481; Domain of unknown function (DUF3481)

smart00137
Location:610 → 769

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00231
Location:274 → 424

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

cd00041
Location:27 → 140

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00057
Location:277 → 423

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
XM_006717524.2 → XP_006717587.1 neuropilin-1 isoform X4

Conserved Domains (6) summary

cd06263
Location:615 → 769

MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...

pfam11980
Location:809 → 886

DUF3481; Domain of unknown function (DUF3481)

smart00137
Location:610 → 770

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00231
Location:274 → 424

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

cd00041
Location:27 → 140

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00057
Location:277 → 423

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
XM_006717522.2 → XP_006717585.1 neuropilin-1 isoform X2

Conserved Domains (6) summary

cd06263
Location:650 → 804

MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...

pfam11980
Location:827 → 904

DUF3481; Domain of unknown function (DUF3481)

smart00137
Location:645 → 805

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00231
Location:274 → 424

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

cd00041
Location:27 → 140

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00057
Location:277 → 423

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
XM_006717521.2 → XP_006717584.1 neuropilin-1 isoform X1

Conserved Domains (6) summary

cd06263
Location:650 → 804

MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...

pfam11980
Location:844 → 921

DUF3481; Domain of unknown function (DUF3481)

smart00137
Location:645 → 805

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00231
Location:274 → 424

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

cd00041
Location:27 → 140

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00057
Location:277 → 423

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
XM_017016866.2 → XP_016872355.1 neuropilin-1 isoform X6
XM_017016865.2 → XP_016872354.1 neuropilin-1 isoform X3
XM_011519756.2 → XP_011518058.1 neuropilin-1 isoform X9

Conserved Domains (3) summary

smart00231
Location:274 → 424

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

cd00041
Location:27 → 140

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00057
Location:277 → 423

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
XM_011519755.3 → XP_011518057.1 neuropilin-1 isoform X8

Conserved Domains (3) summary

smart00231
Location:274 → 424

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

cd00041
Location:27 → 140

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00057
Location:277 → 423

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
XM_006717526.2 → XP_006717589.1 neuropilin-1 isoform X7

Conserved Domains (3) summary

smart00231
Location:274 → 424

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

cd00041
Location:27 → 140

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00057
Location:277 → 423

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.