NRP1 neuropilin 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: NRP1provided by HGNC
Official Full Name: neuropilin 1provided by HGNC
Primary source: HGNC:HGNC:8004
See related: Ensembl:ENSG00000099250 MIM:602069; AllianceGenome:HGNC:8004
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NP1; NRP; BDCA4; CD304; VEGF165R
Summary: This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. This protein has also been determined to act as a co-receptor for SARS-CoV-2 (which causes COVID-19) to infect host cells. [provided by RefSeq, Nov 2020]
Annotation information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in SARS-CoV-2 infection.
Expression: Broad expression in placenta (RPKM 53.3), fat (RPKM 49.6) and 24 other tissues See more
Orthologs: mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 10p11.22

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
110	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (33177493..33334667, complement)
110	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (33206293..33363487, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (33466421..33623595, complement)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Differential dependency of human glioblastoma cells on vascular endothelial growth factorA signaling via neuropilin1.
Title: Differential dependency of human glioblastoma cells on vascular endothelial growth factor‑A signaling via neuropilin‑1.
Immune inactivation by neuropilin-1 predicts clinical outcome and therapeutic benefit in muscle-invasive bladder cancer.
Title: Immune inactivation by neuropilin-1 predicts clinical outcome and therapeutic benefit in muscle-invasive bladder cancer.
Overexpressed Neuropilin-1 in Endothelial Cells Promotes Endothelial Permeability through Interaction with ANGPTL4 and VEGF in Kawasaki Disease.
Title: Overexpressed Neuropilin-1 in Endothelial Cells Promotes Endothelial Permeability through Interaction with ANGPTL4 and VEGF in Kawasaki Disease.
Analysis of PLXNA1, NRP1, and NRP2 variants in a cohort of patients with isolated hypogonadotropic hypogonadism.
Title: Analysis of PLXNA1, NRP1, and NRP2 variants in a cohort of patients with isolated hypogonadotropic hypogonadism.
Neuropilin-1 is over-expressed in claudin-low breast cancer and promotes tumor progression through acquisition of stem cell characteristics and RAS/MAPK pathway activation.
Title: Neuropilin-1 is over-expressed in claudin-low breast cancer and promotes tumor progression through acquisition of stem cell characteristics and RAS/MAPK pathway activation.
Long noncoding RNA RP11-70C1.3 confers chemoresistance of breast cancer cells through miR-6736-3p/NRP-1 axis.
Title: Long noncoding RNA RP11-70C1.3 confers chemoresistance of breast cancer cells through miR-6736-3p/NRP-1 axis.
Neuropilin-1 is required for endothelial cell adhesion to soluble vascular endothelial growth factor receptor 1.
Title: Neuropilin-1 is required for endothelial cell adhesion to soluble vascular endothelial growth factor receptor 1.
Peptides Derived from Vascular Endothelial Growth Factor B Show Potent Binding to Neuropilin-1.
Title: Peptides Derived from Vascular Endothelial Growth Factor B Show Potent Binding to Neuropilin-1.
Contribution of Neuropilin-1 in Radiation-Survived Subclones of NSCLC Cell Line H1299.
Title: Contribution of Neuropilin-1 in Radiation-Survived Subclones of NSCLC Cell Line H1299.
Integration of NRP1, RGS5, and FOXM1 expression, and tumour necrosis, as a postoperative prognostic classifier based on molecular subtypes of clear cell renal cell carcinoma.
Title: Integration of NRP1, RGS5, and FOXM1 expression, and tumour necrosis, as a postoperative prognostic classifier based on molecular subtypes of clear cell renal cell carcinoma.

Submit: New GeneRIF Correction See all GeneRIFs (305)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
DOCK4 and CEACAM21 as novel schizophrenia candidate genes in the Jewish population. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identifies loci on 12q24 and 13q32 associated with tetralogy of Fallot. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide meta-analysis identifies new susceptibility loci for migraine. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

Go to the top of the page Help

Replication interactions

Interaction	Pubs
Knockdown of neuropilin 1 (NRP1) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Nef	nef	HIV-1 Nef upregulates VEGFR2 and its co-receptor neuropilin-1 and downregulates the expression of semaphorin 3a in podocytes	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

RH70034 (e-PCR)
- UniSTS:22785

RH118801 (e-PCR)
- UniSTS:138782

RH65747 (e-PCR)
- UniSTS:8233

D8S2279 (e-PCR)
- UniSTS:473907

RH46501 (e-PCR)
- UniSTS:53818

SHGC-56598 (e-PCR)
- UniSTS:32317

RH45612 (e-PCR)
- UniSTS:73804

G48212 (e-PCR)
- UniSTS:95309

G20549 (e-PCR)
- UniSTS:74679

A005W14 (e-PCR)
- UniSTS:74680

RH122665 (e-PCR)
- UniSTS:135115

RH120752 (e-PCR)
- UniSTS:132831

D10S1654 (e-PCR), detects polymorphism
- UniSTS:58084

KS608 (e-PCR)
- UniSTS:253179

Homology

Homologs of the NRP1 gene: The NRP1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 448 organisms have orthologs with human gene NRP1
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables GTPase activator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables coreceptor activity	TAS Traceable Author Statement more info	PubMed
enables cytokine binding	NAS Non-traceable Author Statement more info	PubMed
enables growth factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables growth factor binding	TAS Traceable Author Statement more info	PubMed
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables semaphorin receptor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables semaphorin receptor activity	NAS Non-traceable Author Statement more info	PubMed
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables vascular endothelial growth factor binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables vascular endothelial growth factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables vascular endothelial growth factor receptor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables vascular endothelial growth factor receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables vascular endothelial growth factor receptor activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in VEGF-activated neuropilin signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in VEGF-activated neuropilin signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in VEGF-activated neuropilin signaling pathway involved in axon guidance	IEA Inferred from Electronic Annotation more info
involved_in actin cytoskeleton reorganization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in angiogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in angiogenesis involved in coronary vascular morphogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in animal organ morphogenesis	TAS Traceable Author Statement more info	PubMed
involved_in artery morphogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in axon extension involved in axon guidance	ISS Inferred from Sequence or Structural Similarity more info
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in axon guidance	NAS Non-traceable Author Statement more info	PubMed
involved_in axonal fasciculation	IEA Inferred from Electronic Annotation more info
involved_in axonogenesis involved in innervation	ISS Inferred from Sequence or Structural Similarity more info
involved_in basal dendrite arborization	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in basal dendrite development	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in branching involved in blood vessel morphogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in branchiomotor neuron axon guidance	IEA Inferred from Electronic Annotation more info
involved_in cell migration involved in sprouting angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell-cell signaling	TAS Traceable Author Statement more info	PubMed
involved_in cellular response to hepatocyte growth factor stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to vascular endothelial growth factor stimulus	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in commissural neuron axon guidance	ISS Inferred from Sequence or Structural Similarity more info
involved_in coronary artery morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in dichotomous subdivision of terminal units involved in salivary gland branching	IEA Inferred from Electronic Annotation more info
involved_in dorsal root ganglion morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in endothelial cell chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endothelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endothelial tip cell fate specification	ISS Inferred from Sequence or Structural Similarity more info
involved_in facial nerve structural organization	IEA Inferred from Electronic Annotation more info
involved_in facioacoustic ganglion development	IEA Inferred from Electronic Annotation more info
involved_in gonadotrophin-releasing hormone neuronal migration to the hypothalamus	IEA Inferred from Electronic Annotation more info
involved_in hepatocyte growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in integrin-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in motor neuron migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of axon extension involved in axon guidance	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of extrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of neuron apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in nerve development	ISS Inferred from Sequence or Structural Similarity more info
involved_in neural crest cell migration	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in neural crest cell migration involved in autonomic nervous system development	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuropilin signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in otic placode development	IEA Inferred from Electronic Annotation more info
involved_in outflow tract septum morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in platelet-derived growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of actin cytoskeleton reorganization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of axon extension involved in axon guidance	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell migration involved in sprouting angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytokine activity	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of endothelial cell migration	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of endothelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of endothelial cell migration	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of endothelial cell proliferation	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of filopodium assembly	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of filopodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of focal adhesion assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of peptidyl-tyrosine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of retinal ganglion cell axon guidance	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of smooth muscle cell migration	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of stress fiber assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of substrate adhesion-dependent cell spreading	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in postsynapse organization	IEA Inferred from Electronic Annotation more info
involved_in protein localization to early endosome	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in regulation of Cdc42 protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of catalytic activity	IEA Inferred from Electronic Annotation more info
involved_in regulation of retinal ganglion cell axon guidance	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of vascular endothelial growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in regulation of vesicle-mediated transport	TAS Traceable Author Statement more info	PubMed
involved_in renal artery morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in response to wounding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in retina vasculature morphogenesis in camera-type eye	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in retinal ganglion cell axon guidance	ISS Inferred from Sequence or Structural Similarity more info
involved_in semaphorin-plexin signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in semaphorin-plexin signaling pathway involved in axon guidance	IEA Inferred from Electronic Annotation more info
involved_in semaphorin-plexin signaling pathway involved in neuron projection guidance	ISS Inferred from Sequence or Structural Similarity more info
involved_in sensory neuron axon guidance	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in sprouting angiogenesis	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in sprouting angiogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in substrate adhesion-dependent cell spreading	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in substrate-dependent cell migration, cell extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sympathetic ganglion development	ISS Inferred from Sequence or Structural Similarity more info
involved_in sympathetic neuron projection extension	ISS Inferred from Sequence or Structural Similarity more info
involved_in sympathetic neuron projection guidance	ISS Inferred from Sequence or Structural Similarity more info
involved_in toxin transport	IEA Inferred from Electronic Annotation more info
involved_in trigeminal ganglion development	IEA Inferred from Electronic Annotation more info
involved_in trigeminal nerve structural organization	IEA Inferred from Electronic Annotation more info
involved_in vascular endothelial growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in vascular endothelial growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vasculogenesis	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in ventral trunk neural crest cell migration	IEA Inferred from Electronic Annotation more info
involved_in vestibulocochlear nerve structural organization	IEA Inferred from Electronic Annotation more info
involved_in viral entry into host cell	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in axon	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasmic vesicle	TAS Traceable Author Statement more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in early endosome	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in extracellular space	HDA more info	PubMed
located_in focal adhesion	HDA more info	PubMed
is_active_in focal adhesion	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in focal adhesion	IDA Inferred from Direct Assay more info	PubMed
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
located_in mitochondrial membrane	IEA Inferred from Electronic Annotation more info
located_in neurofilament	IEA Inferred from Electronic Annotation more info
located_in neuron projection	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
part_of receptor complex	TAS Traceable Author Statement more info	PubMed
part_of semaphorin receptor complex	NAS Non-traceable Author Statement more info	PubMed
located_in sorting endosome	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: neuropilin-1

Names: transmembrane receptor; vascular endothelial cell growth factor 165 receptor

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_030328.2 RefSeqGene

Range

5000..162174

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001024628.3 → NP_001019799.2 neuropilin-1 isoform b precursor

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses a different splice site in the 3' end and contains a different segment for the 3' end of the coding region and the 3' UTR, compared to variant 1. The resulting protein (isoform b) has a shorter C-terminus when compared to isoform a. This variant has also been named S12NRP1 in PubMed ID: 11112349.

Source sequence(s)

AL121748, AL353600

Consensus CDS

CCDS31180.1

Related

ENSP00000363955.4, ENST00000374822.8

Conserved Domains (2) summary

cd00041
Location:27 → 140

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00057
Location:277 → 423

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
NM_001024629.3 → NP_001019800.2 neuropilin-1 isoform c precursor

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame coding region segment, uses a different splice site in the 3' end and contains a different segment for the 3' end of the coding region and the 3' UTR, compared to variant 1. The resulting protein (isoform c) has a shorter C-terminus when compared to isoform a.

Source sequence(s)

AL121748, AL353600

Consensus CDS

CCDS31179.1

Related

ENSP00000363954.5, ENST00000374821.9

Conserved Domains (2) summary

cd00041
Location:27 → 140

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00057
Location:277 → 423

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
NM_001244972.2 → NP_001231901.2 neuropilin-1 isoform d precursor

Status: REVIEWED

Description

Transcript Variant: This variant (4) uses two different splice sites in the coding region, compared to variant 1. The resulting protein (isoform d) is shorter when it is compared to isoform a.

Source sequence(s)

AL121748, AL353600

Conserved Domains (4) summary

smart00137
Location:638 → 798

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

cd00041
Location:27 → 140

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00057
Location:277 → 423

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

pfam11980
Location:839 → 917

DUF3481; C-terminal domain of neuropilin glycoprotein
NM_001244973.2 → NP_001231902.2 neuropilin-1 isoform e precursor

Status: REVIEWED

Description

Transcript Variant: This variant (5) uses a different splice site in the coding region, compared to variant 1. The resulting protein (isoform e) is shorter when it is compared to isoform a.

Source sequence(s)

AL121748, AL353600

Conserved Domains (4) summary

smart00137
Location:638 → 797

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

cd00041
Location:27 → 140

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00057
Location:277 → 423

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

pfam11980
Location:838 → 916

DUF3481; C-terminal domain of neuropilin glycoprotein
NM_001330068.2 → NP_001316997.2 neuropilin-1 isoform f precursor

Status: REVIEWED

Description

Transcript Variant: This variant (7) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. It encodes isoform f, which is shorter than isoform a.

Source sequence(s)

AL121748, AL353600

Consensus CDS

CCDS81448.1

UniProtKB/TrEMBL

E9PEP6

Related

ENSP00000379317.1, ENST00000395995.5

Conserved Domains (4) summary

smart00137
Location:645 → 804

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

cd00041
Location:27 → 140

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00057
Location:277 → 423

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

pfam11980
Location:828 → 906

DUF3481; C-terminal domain of neuropilin glycoprotein
NM_003873.7 → NP_003864.5 neuropilin-1 isoform a precursor

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform a).

Source sequence(s)

AL121748, AL353600

Consensus CDS

CCDS7177.1

UniProtKB/Swiss-Prot

Q96IH5

Related

ENSP00000364001.2, ENST00000374867.7

Conserved Domains (4) summary

smart00137
Location:645 → 804

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

cd00041
Location:27 → 140

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00057
Location:277 → 423

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

pfam11980
Location:845 → 923

DUF3481; C-terminal domain of neuropilin glycoprotein

RNA

NR_045259.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (6) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AL121748, AL353600

Related

ENST00000374875.5

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000010.11 Reference GRCh38.p14 Primary Assembly

Range

33177493..33334667 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047425977.1 → XP_047281933.1 neuropilin-1 isoform X7
XM_006717525.3 → XP_006717588.1 neuropilin-1 isoform X6

Conserved Domains (6) summary

cd06263
Location:615 → 768

MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...

pfam11980
Location:808 → 885

DUF3481; Domain of unknown function (DUF3481)

smart00137
Location:610 → 769

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00231
Location:274 → 424

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

cd00041
Location:27 → 140

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00057
Location:277 → 423

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
XM_006717524.3 → XP_006717587.1 neuropilin-1 isoform X5

Conserved Domains (6) summary

cd06263
Location:615 → 769

MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...

pfam11980
Location:809 → 886

DUF3481; Domain of unknown function (DUF3481)

smart00137
Location:610 → 770

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00231
Location:274 → 424

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

cd00041
Location:27 → 140

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00057
Location:277 → 423

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
XM_017016865.3 → XP_016872354.1 neuropilin-1 isoform X4
XM_047425976.1 → XP_047281932.1 neuropilin-1 isoform X3
XM_006717522.3 → XP_006717585.1 neuropilin-1 isoform X2

Conserved Domains (6) summary

cd06263
Location:650 → 804

MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...

pfam11980
Location:827 → 904

DUF3481; Domain of unknown function (DUF3481)

smart00137
Location:645 → 805

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00231
Location:274 → 424

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

cd00041
Location:27 → 140

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00057
Location:277 → 423

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
XM_006717521.3 → XP_006717584.1 neuropilin-1 isoform X1

Conserved Domains (6) summary

cd06263
Location:650 → 804

MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...

pfam11980
Location:844 → 921

DUF3481; Domain of unknown function (DUF3481)

smart00137
Location:645 → 805

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00231
Location:274 → 424

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

cd00041
Location:27 → 140

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00057
Location:277 → 423

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
XM_047425978.1 → XP_047281934.1 neuropilin-1 isoform X8
XM_011519756.3 → XP_011518058.1 neuropilin-1 isoform X11

Conserved Domains (3) summary

smart00231
Location:274 → 424

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

cd00041
Location:27 → 140

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00057
Location:277 → 423

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
XM_011519755.4 → XP_011518057.1 neuropilin-1 isoform X10

Conserved Domains (3) summary

smart00231
Location:274 → 424

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

cd00041
Location:27 → 140

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00057
Location:277 → 423

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
XM_006717526.3 → XP_006717589.1 neuropilin-1 isoform X9

Conserved Domains (3) summary

smart00231
Location:274 → 424

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

cd00041
Location:27 → 140

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00057
Location:277 → 423

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.