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Cep104 centrosomal protein 104 [ Rattus norvegicus (Norway rat) ]

Gene ID: 246295, updated on 17-Aug-2024

Summary

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Official Symbol
Cep104provided by RGD
Official Full Name
centrosomal protein 104provided by RGD
Primary source
RGD:708505
See related
EnsemblRapid:ENSRNOG00000025000 AllianceGenome:RGD:708505
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
GlyBP
Summary
Enables glutamate binding activity; glycine binding activity; and thienylcyclohexylpiperidine binding activity. Predicted to be located in centriole. Predicted to be active in cilium. Human ortholog(s) of this gene implicated in Joubert syndrome 25. Orthologous to human CEP104 (centrosomal protein 104). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 113.5), Adrenal (RPKM 79.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
5q36
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (169817383..169849681)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (164534773..164567260)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (171262278..171294560)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 1 open reading frame 174 Neighboring gene DNA fragmentation factor subunit beta Neighboring gene leucine rich repeat containing 47 Neighboring gene uncharacterized LOC120103048 Neighboring gene small integral membrane protein 1 (Vel blood group) Neighboring gene coiled-coil domain containing 27

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A synaptic membrane glycine-, glutamate- and thienylcyclohexylpiperidine-binding protein: isolation and immunochemical characterization. Babcock KK, et al. Neurochem Int, 1996 Nov. PMID 8939461
  2. Cloning of the cDNA for a brain glycine-, glutamate- and thienylcyclohexylpiperidine-binding protein. Kumar KN, et al. Biochem Biophys Res Commun, 1995 Nov 2. PMID 7488117
  3. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. Jakobsen L, et al. EMBO J, 2011 Apr 20. PMID 21399614, Free PMC Article
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables glutamate binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables glycine binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables thienylcyclohexylpiperidine binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in centriole IEA
Inferred from Electronic Annotation
more info
  
located_in centriole ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in spindle pole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
centrosomal protein of 104 kDa
Names
gly-, L-Glu and TCP-binding protein
glycine-, glutamate- and thienylcyclohexylpiperidine-binding protein
glycine-, glutamate-, thienylcyclohexylpiperidine-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145082.2 → NP_659550.2  centrosomal protein of 104 kDa

    Status: VALIDATED

    Source sequence(s)
    AA924538, BI289406, CB544954, CB792008, CK843167, CO390283, CV797293, DV722335, FM108776, JAXUCZ010000005, U53513
    UniProtKB/Swiss-Prot
    A0A0G2JUH6, D3Z8X7, Q62965
    Related
    ENSRNOP00000034972.6, ENSRNOT00000031138.7
    Conserved Domains (2) summary
    PHA03247
    Location:300 → 418
    PHA03247; large tegument protein UL36; Provisional
    sd00044
    Location:431 → 468
    HEAT; HEAT repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    169817383..169849681
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039109277.2 → XP_038965205.1  centrosomal protein of 104 kDa isoform X2

    UniProtKB/Swiss-Prot
    A0A0G2JUH6, D3Z8X7, Q62965
    UniProtKB/TrEMBL
    A0A1P0QEF5
    Related
    ENSRNOP00000069101.2, ENSRNOT00000077307.3
    Conserved Domains (2) summary
    PHA03247
    Location:300 → 418
    PHA03247; large tegument protein UL36; Provisional
    sd00044
    Location:431 → 468
    HEAT; HEAT repeat [structural motif]

  2. XM_039109278.2 → XP_038965206.1  centrosomal protein of 104 kDa isoform X3

    UniProtKB/Swiss-Prot
    A0A0G2JUH6, D3Z8X7, Q62965
    Related
    ENSRNOP00000077236.2, ENSRNOT00000108344.2
    Conserved Domains (2) summary
    PHA03247
    Location:300 → 418
    PHA03247; large tegument protein UL36; Provisional
    sd00044
    Location:431 → 468
    HEAT; HEAT repeat [structural motif]

  3. XM_039109276.2 → XP_038965204.1  centrosomal protein of 104 kDa isoform X1

    UniProtKB/Swiss-Prot
    A0A0G2JUH6, D3Z8X7, Q62965
    UniProtKB/TrEMBL
    A0A8L2QJT0
    Conserved Domains (2) summary
    PHA03247
    Location:300 → 418
    PHA03247; large tegument protein UL36; Provisional
    sd00044
    Location:431 → 468
    HEAT; HEAT repeat [structural motif]

  4. XM_039109279.2 → XP_038965207.1  centrosomal protein of 104 kDa isoform X4

    UniProtKB/TrEMBL
    A0A8I5Y1C2
    Related
    ENSRNOP00000077901.2, ENSRNOT00000109206.2
    Conserved Domains (2) summary
    PHA03247
    Location:251 → 369
    PHA03247; large tegument protein UL36; Provisional
    sd00044
    Location:382 → 419
    HEAT; HEAT repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D3Z8X7.3 GenPept UniProtKB/Swiss-Prot:D3Z8X7

Gene LinkOut

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