Zfp277 zinc finger protein 277 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zfp277provided by MGI
Official Full Name: zinc finger protein 277provided by MGI
Primary source: MGI:MGI:1890393
See related: Ensembl:ENSMUSG00000055917 AllianceGenome:MGI:1890393
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NIRF4; Znf277; 2410017E24Rik
Summary: Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within cellular response to hydrogen peroxide and regulation of cellular senescence. Predicted to be located in chromosome; cytoplasm; and nucleolus. Is expressed in early conceptus and genitourinary system. Orthologous to human ZNF277 (zinc finger protein 277). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in bladder adult (RPKM 6.2), CNS E18 (RPKM 5.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 B1; 12 18.06 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (40365045..40495789, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (40315046..40445790, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Our results identify a novel candidate mouse gene, Zfp277, whose expression pattern is compatible with a role in mediating divergent effects of Chrm3 and Chrm1 gene ablation on murine intestinal neoplasia.
Title: Divergent effects of muscarinic receptor subtype gene ablation on murine colon tumorigenesis reveals association of M3R and zinc finger protein 277 expression in colon neoplasia.
Zfp277 in the transcriptional regulation of the Ink4a/Arf locus and the recruitment of PRC1 to the Ink4a/Arf locus
Title: A novel zinc finger protein Zfp277 mediates transcriptional repression of the Ink4a/arf locus through polycomb repressive complex 1.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

px-37e10 (e-PCR)
- UniSTS:258390

px-72g5 (e-PCR)
- UniSTS:258181

px-24g4 (e-PCR)
- UniSTS:257458

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to hydrogen peroxide	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cellular senescence	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: zinc finger protein 277

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172575.3 → NP_766163.2 zinc finger protein 277 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC123855, AK077401, BY206876

Consensus CDS

CCDS36435.1

UniProtKB/Swiss-Prot

E9Q6D6, Q3U0V6, Q3UM86, Q80UK2, Q8BVL5, Q8BVX7

Related

ENSMUSP00000064226.9, ENSMUST00000069692.10

Conserved Domains (2) summary

sd00020
Location:353 → 375

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam12756
Location:302 → 389

zf-C2H2_2; C2H2 type zinc-finger (2 copies)
NM_178845.3 → NP_849173.2 zinc finger protein 277 isoform 2

See identical proteins and their annotated locations for NP_849173.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting protein (isoform 2) is shorter than isoform 1.

Source sequence(s)

AC123855, AK075945, BY206876

Consensus CDS

CCDS25894.1

UniProtKB/TrEMBL

Q3U0V6, Q8BVX7

Related

ENSMUSP00000068032.8, ENSMUST00000069637.15

Conserved Domains (2) summary

sd00020
Location:227 → 249

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam12756
Location:176 → 263

zf-C2H2_2; C2H2 type zinc-finger (2 copies)