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Zfp277 zinc finger protein 277 [ Mus musculus (house mouse) ]

Gene ID: 246196, updated on 5-Mar-2024

Summary

Official Symbol
Zfp277provided by MGI
Official Full Name
zinc finger protein 277provided by MGI
Primary source
MGI:MGI:1890393
See related
Ensembl:ENSMUSG00000055917 AllianceGenome:MGI:1890393
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NIRF4; Znf277; 2410017E24Rik
Summary
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within cellular response to hydrogen peroxide and regulation of cellular senescence. Is expressed in early conceptus and genitourinary system. Orthologous to human ZNF277 (zinc finger protein 277). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 6.2), CNS E18 (RPKM 5.9) and 28 other tissues See more
Orthologs
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Genomic context

See Zfp277 in Genome Data Viewer
Location:
12 B1; 12 18.06 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (40365045..40495789, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (40315046..40445790, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:40949998-40950107 Neighboring gene STARR-seq mESC enhancer starr_31954 Neighboring gene STARR-positive B cell enhancer mm9_chr12:40983751-40984051 Neighboring gene STARR-seq mESC enhancer starr_31955 Neighboring gene predicted gene 7008 Neighboring gene predicted gene, 40403 Neighboring gene STARR-seq mESC enhancer starr_31956 Neighboring gene STARR-seq mESC enhancer starr_31957 Neighboring gene STARR-seq mESC enhancer starr_31958 Neighboring gene STARR-positive B cell enhancer mm9_chr12:41172293-41172594 Neighboring gene predicted gene, 40406 Neighboring gene STARR-seq mESC enhancer starr_31959 Neighboring gene STARR-seq mESC enhancer starr_31960 Neighboring gene dedicator of cytokinesis 4 Neighboring gene STARR-seq mESC enhancer starr_31961 Neighboring gene STARR-seq mESC enhancer starr_31962 Neighboring gene STARR-seq mESC enhancer starr_31963 Neighboring gene STARR-seq mESC enhancer starr_31965 Neighboring gene STARR-seq mESC enhancer starr_31966 Neighboring gene predicted gene, 19441

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172575.3NP_766163.2  zinc finger protein 277 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC123855, AK077401, BY206876
    Consensus CDS
    CCDS36435.1
    UniProtKB/Swiss-Prot
    E9Q6D6, Q3U0V6, Q3UM86, Q80UK2, Q8BVL5, Q8BVX7
    Related
    ENSMUSP00000064226.9, ENSMUST00000069692.10
    Conserved Domains (2) summary
    sd00020
    Location:353375
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12756
    Location:302389
    zf-C2H2_2; C2H2 type zinc-finger (2 copies)
  2. NM_178845.3NP_849173.2  zinc finger protein 277 isoform 2

    See identical proteins and their annotated locations for NP_849173.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting protein (isoform 2) is shorter than isoform 1.
    Source sequence(s)
    AC123855, AK075945, BY206876
    Consensus CDS
    CCDS25894.1
    UniProtKB/TrEMBL
    Q3U0V6, Q8BVX7
    Related
    ENSMUSP00000068032.8, ENSMUST00000069637.15
    Conserved Domains (2) summary
    sd00020
    Location:227249
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12756
    Location:176263
    zf-C2H2_2; C2H2 type zinc-finger (2 copies)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    40365045..40495789 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)