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Rbbp7 retinoblastoma binding protein 7, chromatin remodeling factor [ Mus musculus (house mouse) ]

Gene ID: 245688, updated on 12-May-2024

Summary

Official Symbol
Rbbp7provided by MGI
Official Full Name
retinoblastoma binding protein 7, chromatin remodeling factorprovided by MGI
Primary source
MGI:MGI:1194910
See related
Ensembl:ENSMUSG00000031353 AllianceGenome:MGI:1194910
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mRbAp46
Summary
Enables RNA binding activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleus. Part of ESC/E(Z) complex and NuRD complex. Is expressed in several structures, including alimentary system; brain; early embryo; genitourinary system; and hemolymphoid system. Orthologous to human RBBP7 (RB binding protein 7, chromatin remodeling factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in placenta adult (RPKM 217.3), liver E18 (RPKM 180.1) and 21 other tissues See more
Orthologs
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Genomic context

See Rbbp7 in Genome Data Viewer
Location:
X F4; X 74.97 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (161543368..161562086)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (162760372..162779090)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_48212 Neighboring gene predicted gene 15201 Neighboring gene STARR-seq mESC enhancer starr_48213 Neighboring gene STARR-seq mESC enhancer starr_48214 Neighboring gene predicted gene, 23786 Neighboring gene STARR-seq mESC enhancer starr_48215 Neighboring gene STARR-seq mESC enhancer starr_48217 Neighboring gene taxilin gamma Neighboring gene STARR-positive B cell enhancer mm9_chrX:159267245-159267546 Neighboring gene STARR-seq mESC enhancer starr_48218 Neighboring gene pyruvate kinase, muscle pseudogene Neighboring gene predicted gene, 23901

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Gene trapped (1) 
  • Targeted (3)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables histone binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA replication IEA
Inferred from Electronic Annotation
more info
 
involved_in brain development NAS
Non-traceable Author Statement
more info
PubMed 
involved_in cellular heat acclimation ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular heat acclimation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
 
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within chromatin remodeling TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell migration NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of stem cell population maintenance NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of transforming growth factor beta receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of stem cell population maintenance NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell fate specification NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of stem cell differentiation NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
part_of ATPase complex ISO
Inferred from Sequence Orthology
more info
 
part_of ESC/E(Z) complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of ESC/E(Z) complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of ESC/E(Z) complex ISO
Inferred from Sequence Orthology
more info
 
part_of NURF complex ISO
Inferred from Sequence Orthology
more info
 
part_of NuRD complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of NuRD complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of NuRD complex ISO
Inferred from Sequence Orthology
more info
 
part_of NuRD complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
part_of histone deacetylase complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
histone-binding protein RBBP7
Names
G1/S transition control protein-binding protein
RBBP-7
histone acetyltransferase type B subunit 2
nucleosome-remodeling factor subunit RBAP46
retinoblastoma-binding protein 7
retinoblastoma-binding protein p46

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009031.3NP_033057.3  histone-binding protein RBBP7

    See identical proteins and their annotated locations for NP_033057.3

    Status: VALIDATED

    Source sequence(s)
    AK078349, AK135779, CA556887
    Consensus CDS
    CCDS30509.1
    UniProtKB/Swiss-Prot
    A2AFJ0, Q3UX20, Q60973
    UniProtKB/TrEMBL
    Q3UJI2, Q8C5H3
    Related
    ENSMUSP00000033720.6, ENSMUST00000033720.12
    Conserved Domains (3) summary
    sd00039
    Location:127174
    7WD40; WD40 repeat [structural motif]
    pfam12265
    Location:1887
    CAF1C_H4-bd; Histone-binding protein RBBP4 or subunit C of CAF1 complex
    cl29593
    Location:122402
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    161543368..161562086
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030251353.1XP_030107213.1  histone-binding protein RBBP7 isoform X1

    UniProtKB/TrEMBL
    Q3UJI2, Q3UX53, Q8C5H3
    Conserved Domains (3) summary
    sd00039
    Location:93140
    7WD40; WD40 repeat [structural motif]
    pfam12265
    Location:153
    CAF1C_H4-bd; Histone-binding protein RBBP4 or subunit C of CAF1 complex
    cl29593
    Location:88368
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...