U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

RBBP7 RB binding protein 7, chromatin remodeling factor [ Homo sapiens (human) ]

Gene ID: 5931, updated on 6-Sep-2022

Summary

Official Symbol
RBBP7provided by HGNC
Official Full Name
RB binding protein 7, chromatin remodeling factorprovided by HGNC
Primary source
HGNC:HGNC:9890
See related
Ensembl:ENSG00000102054 MIM:300825; AllianceGenome:HGNC:9890
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RbAp46
Summary
This protein is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat proteins. It is found among several proteins that binds directly to retinoblastoma protein, which regulates cell proliferation. The encoded protein is found in many histone deacetylase complexes, including mSin3 co-repressor complex. It is also present in protein complexes involved in chromatin assembly. This protein can interact with BRCA1 tumor-suppressor gene and may have a role in the regulation of cell proliferation and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
Expression
Ubiquitous expression in adrenal (RPKM 151.2), testis (RPKM 63.0) and 24 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See RBBP7 in Genome Data Viewer
Location:
Xp22.2
Exon count:
13
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (16844341..16870362, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (16426872..16452877, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (16862464..16888485, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene taxilin gamma Neighboring gene ribosomal protein L12 pseudogene 49 Neighboring gene uncharacterized LOC124905251 Neighboring gene RNA, U4 small nuclear 6, pseudogene Neighboring gene SLC35C2 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat The SIN3/HDAC complex, composed of SIN3A, SAP30, SAP18, HDAC-1 AND -2 and RbAp46/48 except SAP30, is identified to interact with HIV-1 Tat in Jurkat cell PubMed
Vpr vpr HIV-1 Vpr forms a complex by recruiting RbAp46, HAT1, ZIP/sZIP, and Cul4A PubMed
vpr HIV-1 Vpr is identified to have a physical interaction with retinoblastoma binding protein 7 (RBBP7) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC138867, MGC138868

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables histone binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
 
involved_in brain development IC
Inferred by Curator
more info
PubMed 
involved_in cellular heat acclimation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in chromatin remodeling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in histone deacetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in histone deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of DNA-templated transcription IC
Inferred by Curator
more info
PubMed 
involved_in negative regulation of cell growth IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell migration IC
Inferred by Curator
more info
PubMed 
involved_in negative regulation of stem cell population maintenance IC
Inferred by Curator
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IC
Inferred by Curator
more info
PubMed 
involved_in negative regulation of transforming growth factor beta receptor signaling pathway IC
Inferred by Curator
more info
PubMed 
involved_in positive regulation of DNA-templated transcription IC
Inferred by Curator
more info
PubMed 
involved_in positive regulation of stem cell population maintenance IC
Inferred by Curator
more info
PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cell fate specification IC
Inferred by Curator
more info
PubMed 
involved_in regulation of stem cell differentiation IC
Inferred by Curator
more info
PubMed 
involved_in response to steroid hormone IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of ATPase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of ESC/E(Z) complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of ESC/E(Z) complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of NURF complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of NuRD complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of NuRD complex IC
Inferred by Curator
more info
PubMed 
part_of NuRD complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of Sin3 complex IC
Inferred by Curator
more info
PubMed 
located_in chromosome, telomeric region IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
part_of histone deacetylase complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IC
Inferred by Curator
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
histone-binding protein RBBP7
Names
G1/S transition control protein-binding protein RbAp46
RBBP-7
histone acetyltransferase type B subunit 2
nucleosome-remodeling factor subunit RBAP46
retinoblastoma-binding protein 7
retinoblastoma-binding protein RbAp46
retinoblastoma-binding protein p46

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198719.2NP_001185648.1  histone-binding protein RBBP7 isoform 1

    See identical proteins and their annotated locations for NP_001185648.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK091911, AL929302, BQ775345, DA924163
    Consensus CDS
    CCDS56598.1
    UniProtKB/Swiss-Prot
    Q16576
    Related
    ENSP00000369424.4, ENST00000380084.8
    Conserved Domains (3) summary
    sd00039
    Location:171218
    7WD40; WD40 repeat [structural motif]
    pfam12265
    Location:62131
    CAF1C_H4-bd; Histone-binding protein RBBP4 or subunit C of CAF1 complex
    cl29593
    Location:166446
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. NM_002893.4NP_002884.1  histone-binding protein RBBP7 isoform 2

    See identical proteins and their annotated locations for NP_002884.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AL929302, BC114501, CN414343, DB460068
    Consensus CDS
    CCDS14179.1
    UniProtKB/Swiss-Prot
    Q16576, Q5JP00
    UniProtKB/TrEMBL
    Q6FHQ0
    Related
    ENSP00000369427.3, ENST00000380087.7
    Conserved Domains (3) summary
    sd00039
    Location:127174
    7WD40; WD40 repeat [structural motif]
    pfam12265
    Location:1887
    CAF1C_H4-bd; Histone-binding protein RBBP4 or subunit C of CAF1 complex
    cl29593
    Location:122402
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    16844341..16870362 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047442292.1XP_047298248.1  histone-binding protein RBBP7 isoform X2

  2. XM_047442291.1XP_047298247.1  histone-binding protein RBBP7 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    16426872..16452877 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)