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Phlpp2 PH domain and leucine rich repeat protein phosphatase 2 [ Mus musculus (house mouse) ]

Gene ID: 244650, updated on 18-Apr-2024

Summary

Official Symbol
Phlpp2provided by MGI
Official Full Name
PH domain and leucine rich repeat protein phosphatase 2provided by MGI
Primary source
MGI:MGI:2444928
See related
Ensembl:ENSMUSG00000031732 AllianceGenome:MGI:2444928
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Phlppl; C130044A18Rik
Summary
Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in signal transduction. Predicted to be located in several cellular components, including intercellular bridge; mitotic spindle; and nucleoplasm. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in cerebellum; hippocampus; liver; and retina outer nuclear layer. Orthologous to human PHLPP2 (PH domain and leucine rich repeat protein phosphatase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in large intestine adult (RPKM 7.7), small intestine adult (RPKM 6.5) and 27 other tissues See more
Orthologs
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Genomic context

Location:
8 D3; 8 57.33 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (110595149..110671303)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (109868517..109944671)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene adaptor protein complex AP-1, gamma 1 subunit Neighboring gene predicted gene, 17344 Neighboring gene small nucleolar RNA, C/D box 71 Neighboring gene predicted gene, 25321 Neighboring gene STARR-seq mESC enhancer starr_22662 Neighboring gene STARR-positive B cell enhancer ABC_E6682 Neighboring gene STARR-positive B cell enhancer ABC_E6683 Neighboring gene STARR-positive B cell enhancer ABC_E10522 Neighboring gene MARVEL (membrane-associating) domain containing 3 Neighboring gene STARR-positive B cell enhancer ABC_E8263 Neighboring gene STARR-seq mESC enhancer starr_22664 Neighboring gene 40S ribosomal protein S24 pseudogene Neighboring gene tyrosine aminotransferase

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA0931

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in photoreceptor inner segment ISO
Inferred from Sequence Orthology
more info
 
located_in photoreceptor outer segment membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
PH domain leucine-rich repeat-containing protein phosphatase 2
Names
GTPase activating protein and VPS9 domains 1
NP_001116066.2
XP_006531073.1
XP_030099411.1
XP_036009935.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122594.2NP_001116066.2  PH domain leucine-rich repeat-containing protein phosphatase 2

    See identical proteins and their annotated locations for NP_001116066.2

    Status: VALIDATED

    Source sequence(s)
    AC122807, AI481772, AK048472
    Consensus CDS
    CCDS57644.1
    UniProtKB/Swiss-Prot
    Q148U6, Q8BX96, Q8BXA7
    UniProtKB/TrEMBL
    J3QM82
    Related
    ENSMUSP00000136166.2, ENSMUST00000179721.8
    Conserved Domains (5) summary
    cd00116
    Location:447714
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    cd00143
    Location:8161065
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    cd13322
    Location:181275
    PH_PHLPP-like; PH domain leucine-rich repeat protein phosphatase family Pleckstrin homology-like domain
    sd00033
    Location:514535
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:676735
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    110595149..110671303
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531010.4XP_006531073.1  PH domain leucine-rich repeat-containing protein phosphatase 2 isoform X2

    Conserved Domains (4) summary
    PLN00113
    Location:280758
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    cd13322
    Location:181275
    PH_PHLPP-like; PH domain leucine-rich repeat protein phosphatase family Pleckstrin homology-like domain
    sd00033
    Location:514535
    LRR_RI; leucine-rich repeat [structural motif]
    cd17241
    Location:66174
    RA_PHLPP2; Ras-associating (RA) domain found in PH domain leucine-rich repeat-containing protein phosphatase 2 (PHLPP2)
  2. XM_036154042.1XP_036009935.1  PH domain leucine-rich repeat-containing protein phosphatase 2 isoform X1

    UniProtKB/Swiss-Prot
    Q148U6, Q8BX96, Q8BXA7
    Conserved Domains (4) summary
    PLN00113
    Location:114592
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    cd00143
    Location:650899
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    cd13322
    Location:15109
    PH_PHLPP-like; PH domain leucine-rich repeat protein phosphatase family Pleckstrin homology-like domain
    sd00033
    Location:348369
    LRR_RI; leucine-rich repeat [structural motif]
  3. XM_030243551.1XP_030099411.1  PH domain leucine-rich repeat-containing protein phosphatase 2 isoform X3

    Conserved Domains (3) summary
    PRK15370
    Location:12208
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    cd00143
    Location:243492
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    sd00033
    Location:929
    LRR_RI; leucine-rich repeat [structural motif]