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PHLPP2 PH domain and leucine rich repeat protein phosphatase 2 [ Homo sapiens (human) ]

Gene ID: 23035, updated on 8-Jul-2021

Summary

Official Symbol
PHLPP2provided by HGNC
Official Full Name
PH domain and leucine rich repeat protein phosphatase 2provided by HGNC
Primary source
HGNC:HGNC:29149
See related
Ensembl:ENSG00000040199 MIM:611066
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PPM3B; PHLPPL
Expression
Broad expression in small intestine (RPKM 11.5), colon (RPKM 5.9) and 22 other tissues See more
Orthologs
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Genomic context

See PHLPP2 in Genome Data Viewer
Location:
16q22.2
Exon count:
20
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (71644924..71724701, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (71678827..71758604, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371334 Neighboring gene MARVEL domain containing 3 Neighboring gene RNA, U6 small nuclear 208, pseudogene Neighboring gene small nucleolar RNA, H/ACA box 70D Neighboring gene adaptor related protein complex 1 subunit gamma 1 Neighboring gene small nucleolar RNA, C/D box 71 Neighboring gene parathymosin pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0931

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in hippocampus development IEA
Inferred from Electronic Annotation
more info
 
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in intercellular bridge IDA
Inferred from Direct Assay
more info
 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitotic spindle IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in photoreceptor inner segment IEA
Inferred from Electronic Annotation
more info
 
located_in photoreceptor outer segment membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
PH domain leucine-rich repeat-containing protein phosphatase 2
Names
protein phosphatase, Mg2+/Mn2+ dependent 3B
NP_001275932.1
NP_055835.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289003.1NP_001275932.1  PH domain leucine-rich repeat-containing protein phosphatase 2 isoform 2

    See identical proteins and their annotated locations for NP_001275932.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AB023148, AC009097, BC129927
    Consensus CDS
    CCDS73910.1
    UniProtKB/Swiss-Prot
    Q6ZVD8
    Related
    ENSP00000377159.2, ENST00000393524.6
    Conserved Domains (5) summary
    cd00116
    Location:444660
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    cd00143
    Location:717966
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    cd13322
    Location:149243
    PH_PHLPP-like; PH domain leucine-rich repeat protein phosphatase family Pleckstrin homology-like domain
    sd00033
    Location:442461
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:572636
    LRR_8; Leucine rich repeat
  2. NM_015020.3NP_055835.2  PH domain leucine-rich repeat-containing protein phosphatase 2 isoform 1

    See identical proteins and their annotated locations for NP_055835.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC009097, BC129927, BX647823
    Consensus CDS
    CCDS32479.1
    UniProtKB/Swiss-Prot
    Q6ZVD8
    Related
    ENSP00000457991.1, ENST00000568954.5
    Conserved Domains (6) summary
    cd00116
    Location:313606
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    cd00143
    Location:7841033
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    cd13322
    Location:149243
    PH_PHLPP-like; PH domain leucine-rich repeat protein phosphatase family Pleckstrin homology-like domain
    sd00033
    Location:482503
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:645685
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:645703
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    71644924..71724701 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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