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Zfp668 zinc finger protein 668 [ Mus musculus (house mouse) ]

Gene ID: 244219, updated on 2-Nov-2024

Summary

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Official Symbol
Zfp668provided by MGI
Official Full Name
zinc finger protein 668provided by MGI
Primary source
MGI:MGI:2442943
See related
Ensembl:ENSMUSG00000049728 AllianceGenome:MGI:2442943
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Znf668; E130018B19Rik
Summary
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including central nervous system; early conceptus; and genitourinary system. Orthologous to human ZNF668 (zinc finger protein 668). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in thymus adult (RPKM 4.7), whole brain E14.5 (RPKM 3.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Zfp668 in Genome Data Viewer
Location:
7 F3; 7 69.79 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (127460197..127476008, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (127861025..127876836, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene syntaxin 1B Neighboring gene STARR-positive B cell enhancer ABC_E3755 Neighboring gene syntaxin 4A (placental) Neighboring gene STARR-seq mESC enhancer starr_20194 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:135020325-135020434 Neighboring gene zinc finger protein 646 Neighboring gene serine protease 53 Neighboring gene vitamin K epoxide reductase complex, subunit 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Transcriptional suppression of interleukin-12 gene expression following phagocytosis of apoptotic cells. Kim S, et al. Immunity, 2004 Nov. PMID 15539151
  2. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
  3. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC40890

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA repair ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA repair ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 668

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362189.1 → NP_001349118.1  zinc finger protein 668

    Status: VALIDATED

    Source sequence(s)
    AC149222
    Consensus CDS
    CCDS21881.1
    UniProtKB/Swiss-Prot
    Q3TEM2, Q3U7Y5, Q8C8B7, Q8K2R5
    Related
    ENSMUSP00000101870.2, ENSMUST00000106263.8
    Conserved Domains (2) summary
    COG5048
    Location:65 → 419
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:226 → 246
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001362190.1 → NP_001349119.1  zinc finger protein 668

    Status: VALIDATED

    Source sequence(s)
    AC149222
    Consensus CDS
    CCDS21881.1
    UniProtKB/Swiss-Prot
    Q3TEM2, Q3U7Y5, Q8C8B7, Q8K2R5
    Related
    ENSMUSP00000101869.2, ENSMUST00000106262.2
    Conserved Domains (2) summary
    COG5048
    Location:65 → 419
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:226 → 246
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. NM_001362191.1 → NP_001349120.1  zinc finger protein 668

    Status: VALIDATED

    Source sequence(s)
    AC149222
    Consensus CDS
    CCDS21881.1
    UniProtKB/Swiss-Prot
    Q3TEM2, Q3U7Y5, Q8C8B7, Q8K2R5
    Related
    ENSMUSP00000101868.2, ENSMUST00000106261.8
    Conserved Domains (2) summary
    COG5048
    Location:65 → 419
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:226 → 246
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. NM_001362192.1 → NP_001349121.1  zinc finger protein 668

    Status: VALIDATED

    Source sequence(s)
    AC149222
    Consensus CDS
    CCDS21881.1
    UniProtKB/Swiss-Prot
    Q3TEM2, Q3U7Y5, Q8C8B7, Q8K2R5
    Conserved Domains (2) summary
    COG5048
    Location:65 → 419
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:226 → 246
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. NM_146259.4 → NP_666371.1  zinc finger protein 668

    See identical proteins and their annotated locations for NP_666371.1

    Status: VALIDATED

    Source sequence(s)
    AC149222, AK053438, BB612340
    Consensus CDS
    CCDS21881.1
    UniProtKB/Swiss-Prot
    Q3TEM2, Q3U7Y5, Q8C8B7, Q8K2R5
    Related
    ENSMUSP00000056105.6, ENSMUST00000054415.12
    Conserved Domains (2) summary
    COG5048
    Location:65 → 419
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:226 → 246
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    127460197..127476008 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017322256.3 → XP_017177745.1  zinc finger protein 668 isoform X1

    UniProtKB/Swiss-Prot
    Q3TEM2, Q3U7Y5, Q8C8B7, Q8K2R5
    Conserved Domains (2) summary
    COG5048
    Location:65 → 419
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:226 → 246
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. XM_036153124.1 → XP_036009017.1  zinc finger protein 668 isoform X1

    UniProtKB/Swiss-Prot
    Q3TEM2, Q3U7Y5, Q8C8B7, Q8K2R5
    Conserved Domains (2) summary
    COG5048
    Location:65 → 419
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:226 → 246
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. XM_006507848.4 → XP_006507911.1  zinc finger protein 668 isoform X1

    See identical proteins and their annotated locations for XP_006507911.1

    UniProtKB/Swiss-Prot
    Q3TEM2, Q3U7Y5, Q8C8B7, Q8K2R5
    Conserved Domains (2) summary
    COG5048
    Location:65 → 419
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:226 → 246
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. XM_006507851.5 → XP_006507914.1  zinc finger protein 668 isoform X1

    See identical proteins and their annotated locations for XP_006507914.1

    UniProtKB/Swiss-Prot
    Q3TEM2, Q3U7Y5, Q8C8B7, Q8K2R5
    Conserved Domains (2) summary
    COG5048
    Location:65 → 419
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:226 → 246
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. XM_006507850.4 → XP_006507913.1  zinc finger protein 668 isoform X1

    See identical proteins and their annotated locations for XP_006507913.1

    UniProtKB/Swiss-Prot
    Q3TEM2, Q3U7Y5, Q8C8B7, Q8K2R5
    Conserved Domains (2) summary
    COG5048
    Location:65 → 419
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:226 → 246
    ZF_C2H2; C2H2 Zn finger [structural motif]

  6. XM_030242589.2 → XP_030098449.1  zinc finger protein 668 isoform X1

    UniProtKB/Swiss-Prot
    Q3TEM2, Q3U7Y5, Q8C8B7, Q8K2R5
    Conserved Domains (2) summary
    COG5048
    Location:65 → 419
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:226 → 246
    ZF_C2H2; C2H2 Zn finger [structural motif]

  7. XM_036153123.1 → XP_036009016.1  zinc finger protein 668 isoform X1

    UniProtKB/Swiss-Prot
    Q3TEM2, Q3U7Y5, Q8C8B7, Q8K2R5
    Conserved Domains (2) summary
    COG5048
    Location:65 → 419
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:226 → 246
    ZF_C2H2; C2H2 Zn finger [structural motif]

  8. XM_017322254.3 → XP_017177743.1  zinc finger protein 668 isoform X1

    UniProtKB/Swiss-Prot
    Q3TEM2, Q3U7Y5, Q8C8B7, Q8K2R5
    Conserved Domains (2) summary
    COG5048
    Location:65 → 419
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:226 → 246
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K2R5.1 GenPept UniProtKB/Swiss-Prot:Q8K2R5

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