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Zfp568 zinc finger protein 568 [ Mus musculus (house mouse) ]

Gene ID: 243905, updated on 12-May-2024

Summary

Official Symbol
Zfp568provided by MGI
Official Full Name
zinc finger protein 568provided by MGI
Primary source
MGI:MGI:2142347
See related
Ensembl:ENSMUSG00000074221 AllianceGenome:MGI:2142347
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
chato; Gm1691; Znf568
Summary
Enables transcription cis-regulatory region binding activity and transcription corepressor binding activity. Involved in embryonic placenta morphogenesis and negative regulation of transcription by RNA polymerase II. Acts upstream of or within convergent extension involved in axis elongation; convergent extension involved in neural plate elongation; and regulation of cell communication. Located in nucleus. Is expressed in central nervous system; retina; and skeletal musculature. Orthologous to human ZNF568 (zinc finger protein 568). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in placenta adult (RPKM 18.4), limb E14.5 (RPKM 6.9) and 20 other tissues See more
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Genomic context

See Zfp568 in Genome Data Viewer
Location:
7 B1; 7 17.26 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (29683380..29727707)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (29983955..30028282)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57504 Neighboring gene macrophage migration inhibitory factor, pseudogene Neighboring gene predicted gene, 31735 Neighboring gene STARR-seq mESC enhancer starr_18498 Neighboring gene STARR-seq mESC enhancer starr_18501 Neighboring gene zinc finger protein 14 Neighboring gene STARR-positive B cell enhancer ABC_E8161 Neighboring gene zinc finger protein 82

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription cis-regulatory region binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables transcription corepressor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033355.3NP_001028527.2  zinc finger protein 568 isoform 1

    See identical proteins and their annotated locations for NP_001028527.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1, and encodes isoform (1). Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK143471, AK148548, BC082606, BE456949
    Consensus CDS
    CCDS21077.1
    UniProtKB/Swiss-Prot
    E9PYI1, Q0VGV0, Q3UPK4
    Related
    ENSMUSP00000118387.2, ENSMUST00000148442.8
    Conserved Domains (3) summary
    smart00349
    Location:3494
    KRAB; krueppel associated box
    COG5048
    Location:350665
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:589609
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. NM_001167872.1NP_001161344.1  zinc finger protein 568 isoform 1

    See identical proteins and their annotated locations for NP_001161344.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform (1). Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK148548, BC082606, BE456949
    Consensus CDS
    CCDS21077.1
    UniProtKB/Swiss-Prot
    E9PYI1, Q0VGV0, Q3UPK4
    Conserved Domains (3) summary
    smart00349
    Location:3494
    KRAB; krueppel associated box
    COG5048
    Location:350665
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:589609
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. NM_001167873.1NP_001161345.1  zinc finger protein 568 isoform 2

    See identical proteins and their annotated locations for NP_001161345.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the coding region, compared to variant 1, and encodes a protein (isoform 2) that is 1 aa shorter than isoform 1.
    Source sequence(s)
    AK148548, BC082606, BE456949
    Consensus CDS
    CCDS52176.1
    UniProtKB/Swiss-Prot
    E9PYI1
    Related
    ENSMUSP00000118823.2, ENSMUST00000146074.8
    Conserved Domains (6) summary
    smart00349
    Location:3494
    KRAB; krueppel associated box
    COG5048
    Location:198633
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:588608
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:418440
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:3473
    KRAB; KRAB box
    pfam13465
    Location:432457
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    29683380..29727707
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011250569.4XP_011248871.1  zinc finger protein 568 isoform X1

    See identical proteins and their annotated locations for XP_011248871.1

    UniProtKB/Swiss-Prot
    E9PYI1, Q0VGV0, Q3UPK4
    Related
    ENSMUSP00000073930.6, ENSMUST00000074322.12
    Conserved Domains (3) summary
    smart00349
    Location:3494
    KRAB; krueppel associated box
    COG5048
    Location:350665
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:589609
    ZF_C2H2; C2H2 Zn finger [structural motif]