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Agt angiotensinogen [ Rattus norvegicus (Norway rat) ]

Gene ID: 24179, updated on 30-Sep-2021

Summary

Official Symbol
Agtprovided by RGD
Official Full Name
angiotensinogenprovided by RGD
Primary source
RGD:2069
See related
EnsemblRapid:ENSRNOG00000018445
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ang; PAT; ANRT; AngII
Summary
plays a role in regulation of blood pressure [RGD, Feb 2006]
Expression
Biased expression in Liver (RPKM 1715.0), Brain (RPKM 350.7) and 2 other tissues See more
Orthologs
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Genomic context

See Agt in Genome Data Viewer
Location:
19q12
Exon count:
7
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (52529139..52549618, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (57321594..57333460, complement)

Chromosome 19 - NC_051354.1Genomic Context describing neighboring genes Neighboring gene piggyBac transposable element derived 5 Neighboring gene uncharacterized LOC108348970 Neighboring gene component of oligomeric golgi complex 2 Neighboring gene calpain 9 Neighboring gene similar to RIKEN cDNA 2310022B05 Neighboring gene uncharacterized LOC120098646

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • MGC105326

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables hormone activity IDA
Inferred from Direct Assay
more info
PubMed 
enables receptor ligand activity ISO
Inferred from Sequence Orthology
more info
 
enables receptor ligand activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables sodium channel regulator activity ISO
Inferred from Sequence Orthology
more info
 
enables type 1 angiotensin receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables type 2 angiotensin receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within activation of NF-kappaB-inducing kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in activation of phospholipase C activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in aging IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in angiotensin-activated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in angiotensin-activated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in angiotensin-mediated drinking behavior IDA
Inferred from Direct Assay
more info
PubMed 
involved_in angiotensin-mediated drinking behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure ISO
Inferred from Sequence Orthology
more info
 
involved_in artery smooth muscle contraction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in associative learning IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within astrocyte activation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within blood vessel development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within brain renin-angiotensin system ISO
Inferred from Sequence Orthology
more info
 
NOT acts_upstream_of_or_within branching involved in ureteric bud morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within branching involved in ureteric bud morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in cell growth involved in cardiac muscle cell development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell surface receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to angiotensin IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular sodium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within drinking behavior ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within establishment of blood-nerve barrier ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within excretion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within extracellular matrix organization ISO
Inferred from Sequence Orthology
more info
 
involved_in female pregnancy IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in fibroblast proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within hormone metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within kidney development ISO
Inferred from Sequence Orthology
more info
 
involved_in kidney development ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neurotrophin TRK receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of tissue remodeling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in operant conditioning IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within ovarian follicle rupture ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within peristalsis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of L-arginine import across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of L-lysine import across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of activation of Janus kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of blood pressure IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of branching involved in ureteric bud morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cardiac muscle cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cardiac muscle hypertrophy IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of catalytic activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cellular protein metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cholesterol esterification ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytokine production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytosolic calcium ion concentration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of epidermal growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of extracellular matrix constituent secretion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of fibroblast proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of gap junction assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of insulin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of membrane hyperpolarization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of multicellular organism growth ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of nitric oxide biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of organ growth ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase signaling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of protein kinase C activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of renal sodium excretion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of renal sodium excretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of superoxide anion generation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of vascular associated smooth muscle cell migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of vascular associated smooth muscle cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein import into nucleus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of calcium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cardiac conduction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of extracellular matrix assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of heart rate IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of long-term neuronal synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of norepinephrine secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of renal output by angiotensin ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of renal sodium excretion IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of systemic arterial blood pressure by circulatory renin-angiotensin ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transmission of nerve impulse IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure ISO
Inferred from Sequence Orthology
more info
 
involved_in renal system process ISO
Inferred from Sequence Orthology
more info
 
involved_in renin-angiotensin regulation of aldosterone production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within renin-angiotensin regulation of aldosterone production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to cold ISO
Inferred from Sequence Orthology
more info
 
involved_in response to estradiol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to muscle activity involved in regulation of muscle adaptation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to salt stress ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within smooth muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in smooth muscle cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in stress-activated MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in uterine smooth muscle contraction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in vasoconstriction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in vasodilation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
NOT located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
angiotensinogen
Names
angiotensin II
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
serpin A8

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_134432.2NP_602308.1  angiotensinogen precursor

    See identical proteins and their annotated locations for NP_602308.1

    Status: PROVISIONAL

    Source sequence(s)
    BC078741
    UniProtKB/Swiss-Prot
    P01015
    Related
    ENSRNOP00000024917.4, ENSRNOT00000024917.5
    Conserved Domains (1) summary
    cd02054
    Location:28475
    serpinA8_AGT; serpin family A member 8, angiotensinogen

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051354.1 Reference mRatBN7.2 Primary Assembly

    Range
    52529139..52549618 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039097466.1XP_038953394.1  angiotensinogen isoform X1

    Conserved Domains (1) summary
    cd02054
    Location:40487
    serpinA8_AGT; serpin family A member 8, angiotensinogen
  2. XM_008772597.3XP_008770819.1  angiotensinogen isoform X2

    See identical proteins and their annotated locations for XP_008770819.1

    UniProtKB/Swiss-Prot
    P01015
    Conserved Domains (1) summary
    cd02054
    Location:28475
    serpinA8_AGT; serpin family A member 8, angiotensinogen
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