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Agt angiotensinogen [ Rattus norvegicus (Norway rat) ]

Gene ID: 24179, updated on 2-Oct-2018

Summary

Official Symbol
Agtprovided by RGD
Official Full Name
angiotensinogenprovided by RGD
Primary source
RGD:2069
See related
Ensembl:ENSRNOG00000018445
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ang; PAT; ANRT; AngII
Summary
plays a role in regulation of blood pressure [RGD, Feb 2006]
Expression
Biased expression in Liver (RPKM 1715.0), Brain (RPKM 350.7) and 2 other tissues See more
Orthologs

Genomic context

See Agt in Genome Data Viewer
Location:
19q12
Exon count:
6
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (57321594..57333460, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 19 NC_005118.3 (68026182..68038550, complement)

Chromosome 19 - NC_005118.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108348970 Neighboring gene uncharacterized LOC103694359 Neighboring gene component of oligomeric golgi complex 2 Neighboring gene calpain 9 Neighboring gene similar to RIKEN cDNA 2310022B05

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • MGC105326

Gene Ontology Provided by RGD

Function Evidence Code Pubs
hormone activity IDA
Inferred from Direct Assay
more info
PubMed 
serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
type 1 angiotensin receptor binding IEA
Inferred from Electronic Annotation
more info
 
type 1 angiotensin receptor binding ISO
Inferred from Sequence Orthology
more info
 
type 2 angiotensin receptor binding IEA
Inferred from Electronic Annotation
more info
 
type 2 angiotensin receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
activation of NF-kappaB-inducing kinase activity ISO
Inferred from Sequence Orthology
more info
 
activation of phospholipase C activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
aging IEP
Inferred from Expression Pattern
more info
PubMed 
angiotensin-mediated drinking behavior IDA
Inferred from Direct Assay
more info
PubMed 
angiotensin-mediated drinking behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure ISO
Inferred from Sequence Orthology
more info
 
artery smooth muscle contraction IDA
Inferred from Direct Assay
more info
PubMed 
associative learning IDA
Inferred from Direct Assay
more info
PubMed 
astrocyte activation ISO
Inferred from Sequence Orthology
more info
 
blood vessel development ISO
Inferred from Sequence Orthology
more info
 
brain renin-angiotensin system ISO
Inferred from Sequence Orthology
more info
 
branching involved in ureteric bud morphogenesis ISO
Inferred from Sequence Orthology
more info
 
NOT branching involved in ureteric bud morphogenesis ISO
Inferred from Sequence Orthology
more info
 
cell growth involved in cardiac muscle cell development IDA
Inferred from Direct Assay
more info
PubMed 
cell surface receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
cellular response to angiotensin IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular sodium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytokine secretion IDA
Inferred from Direct Assay
more info
PubMed 
drinking behavior ISO
Inferred from Sequence Orthology
more info
 
establishment of blood-nerve barrier ISO
Inferred from Sequence Orthology
more info
 
excretion ISO
Inferred from Sequence Orthology
more info
 
extracellular matrix organization ISO
Inferred from Sequence Orthology
more info
 
female pregnancy IEP
Inferred from Expression Pattern
more info
PubMed 
fibroblast proliferation IDA
Inferred from Direct Assay
more info
PubMed 
hormone metabolic process ISO
Inferred from Sequence Orthology
more info
 
kidney development IEA
Inferred from Electronic Annotation
more info
 
kidney development ISO
Inferred from Sequence Orthology
more info
 
negative regulation of angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neurotrophin TRK receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neurotrophin TRK receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of tissue remodeling IDA
Inferred from Direct Assay
more info
PubMed 
operant conditioning IDA
Inferred from Direct Assay
more info
PubMed 
ovarian follicle rupture ISO
Inferred from Sequence Orthology
more info
 
peristalsis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of L-arginine import across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of L-lysine import across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of activation of Janus kinase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of activation of Janus kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of blood pressure IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of blood vessel diameter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of branching involved in ureteric bud morphogenesis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of branching involved in ureteric bud morphogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cardiac muscle cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cardiac muscle hypertrophy IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of catalytic activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cellular protein metabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cholesterol esterification IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cholesterol esterification ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cytokine secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cytosolic calcium ion concentration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of endothelial cell migration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of epidermal growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of epidermal growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of extracellular matrix constituent secretion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of extrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of fibroblast proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of gap junction assembly IEA
Inferred from Electronic Annotation
more info
 
positive regulation of gap junction assembly ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of insulin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of multicellular organism growth ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of nitric oxide biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of organ growth ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phosphatidylinositol 3-kinase signaling IEA
Inferred from Electronic Annotation
more info
 
positive regulation of phosphatidylinositol 3-kinase signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein kinase C activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of renal sodium excretion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of renal sodium excretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of superoxide anion generation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
positive regulation of vascular associated smooth muscle cell migration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of vascular smooth muscle cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
protein import into nucleus IDA
Inferred from Direct Assay
more info
PubMed 
regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
regulation of calcium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cardiac conduction IEA
Inferred from Electronic Annotation
more info
 
regulation of cardiac conduction ISO
Inferred from Sequence Orthology
more info
 
regulation of extracellular matrix assembly IEA
Inferred from Electronic Annotation
more info
 
regulation of extracellular matrix assembly ISO
Inferred from Sequence Orthology
more info
 
regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
regulation of heart rate IDA
Inferred from Direct Assay
more info
PubMed 
regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
regulation of long-term neuronal synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of norepinephrine secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of renal output by angiotensin ISO
Inferred from Sequence Orthology
more info
 
regulation of renal sodium excretion IDA
Inferred from Direct Assay
more info
PubMed 
regulation of signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
regulation of systemic arterial blood pressure by circulatory renin-angiotensin ISO
Inferred from Sequence Orthology
more info
 
regulation of transmission of nerve impulse IDA
Inferred from Direct Assay
more info
PubMed 
renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure ISO
Inferred from Sequence Orthology
more info
 
renal system process ISO
Inferred from Sequence Orthology
more info
 
renin-angiotensin regulation of aldosterone production IDA
Inferred from Direct Assay
more info
PubMed 
renin-angiotensin regulation of aldosterone production ISO
Inferred from Sequence Orthology
more info
 
response to cold ISO
Inferred from Sequence Orthology
more info
 
response to estradiol IEP
Inferred from Expression Pattern
more info
PubMed 
response to muscle activity involved in regulation of muscle adaptation IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to salt stress ISO
Inferred from Sequence Orthology
more info
 
smooth muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
smooth muscle cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
stress-activated MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
uterine smooth muscle contraction IDA
Inferred from Direct Assay
more info
PubMed 
vasoconstriction IDA
Inferred from Direct Assay
more info
PubMed 
vasodilation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
NOT mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
angiotensinogen
Names
angiotensin II
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
serpin A8

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_134432.2NP_602308.1  angiotensinogen precursor

    See identical proteins and their annotated locations for NP_602308.1

    Status: PROVISIONAL

    Source sequence(s)
    BC078741
    UniProtKB/Swiss-Prot
    P01015
    Related
    ENSRNOP00000024917.3, ENSRNOT00000024917.4
    Conserved Domains (1) summary
    cl00137
    Location:97473
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005118.4 Reference Rnor_6.0 Primary Assembly

    Range
    57321594..57333460 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008772597.2XP_008770819.1  angiotensinogen isoform X1

    See identical proteins and their annotated locations for XP_008770819.1

    UniProtKB/Swiss-Prot
    P01015
    Conserved Domains (1) summary
    cl00137
    Location:97473
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

Alternate Rn_Celera

Genomic

  1. AC_000087.1 Alternate Rn_Celera

    Range
    51899180..51910819 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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