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Agt angiotensinogen [ Mus musculus (house mouse) ]

Gene ID: 11606, updated on 8-Feb-2024

Summary

Official Symbol
Agtprovided by MGI
Official Full Name
angiotensinogenprovided by MGI
Primary source
MGI:MGI:87963
See related
Ensembl:ENSMUSG00000031980 AllianceGenome:MGI:87963
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AngI; AngII; Aogen; Serpina8
Summary
Enables type 1 angiotensin receptor binding activity and type 2 angiotensin receptor binding activity. Involved in positive regulation of cytokine production. Acts upstream of or within several processes, including nervous system development; positive regulation of protein phosphorylation; and regulation of systemic arterial blood pressure by renin-angiotensin. Located in extracellular space. Is expressed in several structures, including axial skeleton; central nervous system; foregut mesenchyme; genitourinary system; and liver. Human ortholog(s) of this gene implicated in several diseases, including Fabry disease; Henoch-Schoenlein purpura; artery disease (multiple); heart conduction disease (multiple); and hydronephrosis. Orthologous to human AGT (angiotensinogen). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 621.2), liver E18 (RPKM 268.5) and 8 other tissues See more
Orthologs
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Genomic context

See Agt in Genome Data Viewer
Location:
8 E2; 8 72.81 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (125283326..125296445, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (124556587..124569706, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_23007 Neighboring gene predicted gene, 39280 Neighboring gene STARR-positive B cell enhancer ABC_E9122 Neighboring gene component of oligomeric golgi complex 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:127097574-127097727 Neighboring gene STARR-seq mESC enhancer starr_23008 Neighboring gene calpain 9 Neighboring gene RIKEN cDNA 2310022B05 gene Neighboring gene VISTA enhancer mm1665

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (5) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hormone activity ISO
Inferred from Sequence Orthology
more info
 
enables receptor ligand activity ISO
Inferred from Sequence Orthology
more info
 
enables sodium channel regulator activity ISO
Inferred from Sequence Orthology
more info
 
enables type 1 angiotensin receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables type 1 angiotensin receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables type 2 angiotensin receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables type 2 angiotensin receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within aldosterone secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in aldosterone secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in angiotensin-activated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in angiotensin-mediated drinking behavior ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure IDA
Inferred from Direct Assay
more info
PubMed 
involved_in artery smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in associative learning ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within astrocyte activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within blood vessel development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within brain renin-angiotensin system IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within branching involved in ureteric bud morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
NOT acts_upstream_of_or_within branching involved in ureteric bud morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell growth involved in cardiac muscle cell development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell surface receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within drinking behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within establishment of blood-nerve barrier IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within extracellular matrix organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within hormone metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular sodium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within kidney development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in kidney development ISO
Inferred from Sequence Orthology
more info
 
involved_in maintenance of blood vessel diameter homeostasis by renin-angiotensin ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of neurotrophin TRK receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of tissue remodeling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of vascular associated smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in operant conditioning ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of organ growth IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within ovarian follicle rupture IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within peristalsis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of CoA-transferase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of L-arginine import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of L-lysine import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of activation of Janus kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of branching involved in ureteric bud morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cardiac muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cardiac muscle hypertrophy ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of epidermal growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of epithelial to mesenchymal transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of positive regulation of extracellular matrix assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of extracellular matrix constituent secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of fatty acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gap junction assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of macrophage derived foam cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of membrane hyperpolarization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of positive regulation of miRNA transcription ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of organ growth IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of organ growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of protein kinase C activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of superoxide anion generation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transforming growth factor beta1 activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of vascular associated smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vascular associated smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein import into nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cardiac conduction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of extracellular matrix assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of heart rate ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of inflammatory response IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of long-term neuronal synaptic plasticity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of norepinephrine secretion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of renal output by angiotensin IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of systemic arterial blood pressure by circulatory renin-angiotensin IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transmission of nerve impulse ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in renal system process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within renin-angiotensin regulation of aldosterone production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in renin-angiotensin regulation of aldosterone production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of response to angiotensin ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to cold IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to muscle activity involved in regulation of muscle adaptation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to salt stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within smooth muscle cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within smooth muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within smooth muscle cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in stress-activated MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in uterine smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of vascular associated smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vasoconstriction ISO
Inferred from Sequence Orthology
more info
 
involved_in vasodilation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within vasopressin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
angiotensinogen
Names
angiotensin I
angiotensin ll
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
serpin A8

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001416312.1NP_001403241.1  angiotensinogen precursor

    Status: VALIDATED

    Source sequence(s)
    AC126930
    UniProtKB/Swiss-Prot
    P11859
    UniProtKB/TrEMBL
    A0A5F8MPW1
  2. NM_007428.4NP_031454.4  angiotensinogen precursor

    Status: VALIDATED

    Source sequence(s)
    AK139179, BM899343
    Consensus CDS
    CCDS40513.2
    UniProtKB/Swiss-Prot
    P11859
    UniProtKB/TrEMBL
    A0A5F8MPW1
    Related
    ENSMUSP00000159140.2, ENSMUST00000238882.2
    Conserved Domains (1) summary
    cl00137
    Location:97473
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    125283326..125296445 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)