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Abce1 ATP-binding cassette, sub-family E member 1 [ Mus musculus (house mouse) ]

Gene ID: 24015, updated on 8-Feb-2024

Summary

Official Symbol
Abce1provided by MGI
Official Full Name
ATP-binding cassette, sub-family E member 1provided by MGI
Primary source
MGI:MGI:1195458
See related
Ensembl:ENSMUSG00000058355 AllianceGenome:MGI:1195458
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RLI; Oabp; RNS41; RNS4I; Rnaseli
Summary
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in liver E14 (RPKM 27.7), CNS E11.5 (RPKM 26.2) and 24 other tissues See more
Orthologs
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Genomic context

See Abce1 in Genome Data Viewer
Location:
8 C1; 8 37.77 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (80410071..80438369, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (79683442..79711740, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 51579 Neighboring gene OTU domain containing 4 Neighboring gene tumor protein D52, pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E9318 Neighboring gene STARR-seq mESC enhancer starr_22015 Neighboring gene anaphase promoting complex subunit 10 Neighboring gene STARR-seq mESC enhancer starr_22017 Neighboring gene STARR-positive B cell enhancer ABC_E9118 Neighboring gene STARR-seq mESC enhancer starr_22019 Neighboring gene 60S ribosomal protein L37 pseudogene Neighboring gene STARR-seq mESC enhancer starr_22022 Neighboring gene predicted gene, 30494

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Transgenic (1) 
  • Gene trapped (1) 
  • Targeted (4) 
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity ISO
Inferred from Sequence Orthology
more info
 
enables CTPase activity ISO
Inferred from Sequence Orthology
more info
 
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
 
enables endoribonuclease inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables iron ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables ribonucleoside triphosphate phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables ribosomal small subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in negative regulation of endoribonuclease activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of translation IEA
Inferred from Electronic Annotation
more info
 
involved_in rescue of stalled ribosome ISO
Inferred from Sequence Orthology
more info
 
involved_in ribosomal subunit export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in ribosome disassembly ISO
Inferred from Sequence Orthology
more info
 
involved_in translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in translational termination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in translational termination ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosolic ribosome ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ATP-binding cassette sub-family E member 1
Names
ATP-binding cassette, sub-family E (OABP), member 1
ATP-binding cassette, subfamily E, member 1
RNS4l (Eye)
RNase L inhibitor
ribonuclease 4 inhibitor
ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent) inhibitor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015751.2NP_056566.2  ATP-binding cassette sub-family E member 1

    See identical proteins and their annotated locations for NP_056566.2

    Status: VALIDATED

    Source sequence(s)
    AK167370, AV213051, BB651928, CD564438
    Consensus CDS
    CCDS22438.1
    UniProtKB/Swiss-Prot
    P61222
    UniProtKB/TrEMBL
    Q3TIU8, Q3TJM9, Q3UHY8
    Related
    ENSMUSP00000079379.7, ENSMUST00000080536.8
    Conserved Domains (1) summary
    COG1245
    Location:4597
    Rli1; Translation initiation factor RLI1, contains Fe-S and AAA+ ATPase domains [Translation, ribosomal structure and biogenesis]

RNA

  1. NR_152614.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC101687, AC158348

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    80410071..80438369 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)