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ABCE1 ATP binding cassette subfamily E member 1 [ Homo sapiens (human) ]

Gene ID: 6059, updated on 4-Oct-2020

Summary

Official Symbol
ABCE1provided by HGNC
Official Full Name
ATP binding cassette subfamily E member 1provided by HGNC
Primary source
HGNC:HGNC:69
See related
Ensembl:ENSG00000164163 MIM:601213
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RLI; OABP; RLI1; ABC38; RNS4I; RNASEL1; RNASELI
Summary
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in appendix (RPKM 18.4), lymph node (RPKM 18.0) and 25 other tissues See more
Orthologs

Genomic context

See ABCE1 in Genome Data Viewer
Location:
4q31.21
Exon count:
18
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (145098311..145129524)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (146019156..146050676)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene heat shock protein family D (Hsp60) member 1 pseudogene 5 Neighboring gene anaphase promoting complex subunit 10 Neighboring gene RN7SK pseudogene 235 Neighboring gene OTU deubiquitinase 4 Neighboring gene uncharacterized LOC105377465

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag The nucleocapsid (NC) domain of Gag is critical for interaction with endogenous ABCE1 in primate cells; basic residues in NC are critical for the Gag-ABCE1 interaction, while the cysteine and histidine residues in the zinc fingers are dispensable PubMed
gag ABCE1, DDX6, and AGO2 proteins are associated with HIV-1 Gag in the intracellular high-molecular-weight assembly intermediates PubMed
gag ABCE1 co-localizes with Gag clusters present at the plasma membrane PubMed
gag Expression of TULA proteins reduces the production of HIV-1 particles and modulates Gag processing. ABCE1 recruits TULA to Gag PubMed
gag HIV-1 GagZip chimeric proteins, in which NC was replaced with a heterologous leucine zipper, form ABCE1-containing intermediates, suggesting exposure of an ABCE1-binding domain located elsewhere in Gag, outside NC PubMed
gag Gag production is significantly increased by fusing HIV-1-infected CD4- and CXCR4-expressing rat fibroblasts with uninfected human T-, B-, and macrophage cell lines. This process is regulated by HP68 and MHC class II transactivator (CIITA) PubMed
gag Cells expressing a protease-deficient HIV-1 molecular clone demonstrate a prolonged association of Gag and ABCE1 PubMed
gag HP68 associates post-translationally with HIV-1 Gag and Vif, an interaction that requires the Nucleocapsid domain of Gag and that is essential for assembly of immature HIV-1 capsids PubMed
Vif vif HuHP68 is essential for HIV-1 capsid assembly and associates with HIV-1 Vif in the form of an HuHP68 complex with HIV-1 Gag PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATPase activity IEA
Inferred from Electronic Annotation
more info
 
endoribonuclease inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
iron ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ribosomal small subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
defense response to virus TAS
Traceable Author Statement
more info
 
negative regulation of endoribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
regulation of type I interferon-mediated signaling pathway TAS
Traceable Author Statement
more info
 
ribosomal subunit export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
translational termination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
colocalizes_with eukaryotic translation initiation factor 3 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane HDA PubMed 
mitochondrial matrix TAS
Traceable Author Statement
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ATP-binding cassette sub-family E member 1
Names
2'-5'-oligoadenylate-binding protein
ATP-binding cassette, sub-family E (OABP), member 1
RNase L inhibitor 1
huHP68
ribonuclease 4 inhibitor
ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) inhibitor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047075.1 RefSeqGene

    Range
    5308..36521
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001040876.2NP_001035809.1  ATP-binding cassette sub-family E member 1

    See identical proteins and their annotated locations for NP_001035809.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC096757, BC016283, DA218189
    Consensus CDS
    CCDS34071.1
    UniProtKB/Swiss-Prot
    P61221
    Conserved Domains (1) summary
    COG1245
    Location:4597
    Rli1; Translation initiation factor RLI1, contains Fe-S and AAA+ ATPase domains [Translation, ribosomal structure and biogenesis]
  2. NM_002940.3NP_002931.2  ATP-binding cassette sub-family E member 1

    See identical proteins and their annotated locations for NP_002931.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC096757, BC016283, DA218189
    Consensus CDS
    CCDS34071.1
    UniProtKB/Swiss-Prot
    P61221
    Related
    ENSP00000296577.4, ENST00000296577.9
    Conserved Domains (1) summary
    COG1245
    Location:4597
    Rli1; Translation initiation factor RLI1, contains Fe-S and AAA+ ATPase domains [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    145098311..145129524
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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