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Osr1 odd-skipped related transcription factor 1 [ Mus musculus (house mouse) ]

Gene ID: 23967, updated on 10-Feb-2024

Summary

Official Symbol
Osr1provided by MGI
Official Full Name
odd-skipped related transcription factor 1provided by MGI
Primary source
MGI:MGI:1344424
See related
Ensembl:ENSMUSG00000048387 AllianceGenome:MGI:1344424
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Osr; Odd1
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including animal organ development; embryonic limb morphogenesis; and regulation of transcription by RNA polymerase II. Acts upstream of or within animal organ development; cellular response to retinoic acid; and intermediate mesoderm development. Predicted to be located in cytosol. Predicted to be extrinsic component of membrane. Predicted to be active in nucleus. Is expressed in several structures, including branchial arch; central nervous system; embryo mesenchyme; genitourinary system; and limb. Orthologous to human OSR1 (odd-skipped related transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in limb E14.5 (RPKM 25.5), bladder adult (RPKM 22.7) and 14 other tissues See more
Orthologs
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Genomic context

See Osr1 in Genome Data Viewer
Location:
12 A1.1; 12 4.05 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (9624442..9631500)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (9574442..9581500)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_31526 Neighboring gene predicted gene, 57806 Neighboring gene ring finger and WD repeat domain 2 pseudogene Neighboring gene RIKEN cDNA 1700022H16 gene Neighboring gene predicted gene, 23979 Neighboring gene STARR-seq mESC enhancer starr_31527 Neighboring gene predicted gene, 22845

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cell proliferation involved in kidney development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to retinoic acid IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in chondrocyte differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in embryo development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in embryonic digit morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in embryonic forelimb morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in embryonic hindlimb morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in embryonic skeletal joint development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in embryonic skeletal joint morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in embryonic skeletal limb joint morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within gonad development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within intermediate mesoderm development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mesangial cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mesonephric duct morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mesonephros development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in metanephric cap mesenchymal cell proliferation involved in metanephros development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in metanephric epithelium development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in metanephric glomerulus vasculature development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in metanephric interstitial fibroblast development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in metanephric mesenchymal cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in metanephric mesenchyme development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in metanephric mesenchyme morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in metanephric nephron tubule development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in metanephric smooth muscle tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within metanephros development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in middle ear morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of creatine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of epithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of nephron tubule epithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of sodium ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in odontogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in pattern specification involved in metanephros development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of bone mineralization IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of epithelial cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of gastrulation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in posterior mesonephric tubule development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in pronephros development ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in renal vesicle progenitor cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in roof of mouth development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in sodium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in specification of anterior mesonephric tubule identity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in specification of posterior mesonephric tubule identity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in stem cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ureter urothelium development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ureteric bud development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in urogenital system development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in urogenital system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein odd-skipped-related 1
Names
odd-skipped related 1
NP_035989.1
XP_036013300.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011859.3NP_035989.1  protein odd-skipped-related 1

    See identical proteins and their annotated locations for NP_035989.1

    Status: VALIDATED

    Source sequence(s)
    AF117814, AK004397, BQ832175, BU756490
    Consensus CDS
    CCDS25809.1
    UniProtKB/Swiss-Prot
    Q9WVG7
    Related
    ENSMUSP00000055486.8, ENSMUST00000057021.9
    Conserved Domains (3) summary
    sd00017
    Location:177197
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:175197
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:189214
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    9624442..9631500
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157407.1XP_036013300.1  protein odd-skipped-related 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9WVG7
    Conserved Domains (3) summary
    sd00017
    Location:177197
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:175197
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:189214
    zf-H2C2_2; Zinc-finger double domain