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Klf6 Kruppel-like transcription factor 6 [ Mus musculus (house mouse) ]

Gene ID: 23849, updated on 18-Apr-2024

Summary

Official Symbol
Klf6provided by MGI
Official Full Name
Kruppel-like transcription factor 6provided by MGI
Primary source
MGI:MGI:1346318
See related
Ensembl:ENSMUSG00000000078 AllianceGenome:MGI:1346318
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FM2; FM6; Zf9; BCD1; CPBP; Copeb; Ierepo1; Ierepo3
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of connective tissue replacement. Acts upstream of or within cytokine-mediated signaling pathway. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; early conceptus; embryo mesenchyme; genitourinary system; and peripheral nervous system. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human KLF6 (Kruppel like factor 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 23.3), bladder adult (RPKM 19.9) and 26 other tissues See more
Orthologs
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Genomic context

Location:
13 A1; 13 2.94 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (5911488..5920392)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (5861489..5870393)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_33546 Neighboring gene RIKEN cDNA 1700016G22 gene Neighboring gene STARR-seq mESC enhancer starr_33549 Neighboring gene predicted gene, 35464 Neighboring gene STARR-positive B cell enhancer ABC_E1867 Neighboring gene STARR-seq mESC enhancer starr_33553 Neighboring gene predicted gene, 46401 Neighboring gene STARR-seq mESC enhancer starr_33554 Neighboring gene STARR-seq mESC enhancer starr_33556 Neighboring gene STARR-seq mESC enhancer starr_33558 Neighboring gene predicted gene, 35615

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
Krueppel-like factor 6
Names
Kruppel-like factor 6
core promoter element binding protein
immediate early response, erythropoietin 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011803.2NP_035933.2  Krueppel-like factor 6

    See identical proteins and their annotated locations for NP_035933.2

    Status: VALIDATED

    Source sequence(s)
    AK146615, BY128594
    Consensus CDS
    CCDS26229.1
    UniProtKB/TrEMBL
    Q3UGJ1, Q8BPQ2, Q8VDZ7
    Related
    ENSMUSP00000000080.7, ENSMUST00000000080.8
    Conserved Domains (4) summary
    COG5048
    Location:212300
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:240259
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:235259
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:281306
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    5911488..5920392
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)