Format

Send to:

Choose Destination

FLRT1 fibronectin leucine rich transmembrane protein 1 [ Homo sapiens (human) ]

Gene ID: 23769, updated on 19-Jun-2020

Summary

Official Symbol
FLRT1provided by HGNC
Official Full Name
fibronectin leucine rich transmembrane protein 1provided by HGNC
Primary source
HGNC:HGNC:3760
See related
Ensembl:ENSG00000126500 MIM:604806
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPG68
Summary
This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. The family members may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. The encoded protein shares sequence similarity with two other family members, FLRT2 and FLRT3. This gene is expressed in kidney and brain. [provided by RefSeq, Jul 2008]
Expression
Broad expression in brain (RPKM 4.3), adrenal (RPKM 3.2) and 14 other tissues See more
Orthologs

Genomic context

See FLRT1 in Genome Data Viewer
Location:
11q13.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (64035970..64127289)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (63803442..63886655)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927673 Neighboring gene OTU deubiquitinase, ubiquitin aldehyde binding 1 Neighboring gene mono-ADP ribosylhydrolase 1 Neighboring gene uncharacterized LOC105369339 Neighboring gene stress induced phosphoprotein 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC21624

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding, bridging NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
dendrite development ISS
Inferred from Sequence or Structural Similarity
more info
 
fibroblast growth factor receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
fibroblast growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
neuron projection extension ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cell-cell junction ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasmic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular matrix NAS
Non-traceable Author Statement
more info
PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with focal adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
neuron projection terminus ISS
Inferred from Sequence or Structural Similarity
more info
 
neuronal cell body membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
leucine-rich repeat transmembrane protein FLRT1
Names
fibronectin-like domain-containing leucine-rich transmembrane protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001384466.1NP_001371395.1  leucine-rich repeat transmembrane protein FLRT1

    Status: REVIEWED

    Source sequence(s)
    AP000721, AP006333
  2. NM_013280.5NP_037412.2  leucine-rich repeat transmembrane protein FLRT1

    See identical proteins and their annotated locations for NP_037412.2

    Status: REVIEWED

    Source sequence(s)
    AP000721, AP006333
    Consensus CDS
    CCDS8057.1
    UniProtKB/Swiss-Prot
    Q9NZU1
    Related
    ENSP00000246841.3, ENST00000246841.3
    Conserved Domains (4) summary
    TIGR00864
    Location:300406
    PCC; polycystin cation channel protein
    smart00060
    Location:441505
    FN3; Fibronectin type 3 domain
    sd00033
    Location:108128
    LRR_RI; leucine-rich repeat [structural motif]
    cl26018
    Location:58329
    NEL; C-terminal novel E3 ligase, LRR-interacting

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    64035970..64127289
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005273861.2XP_005273918.1  leucine-rich repeat transmembrane protein FLRT1 isoform X1

    UniProtKB/Swiss-Prot
    Q9NZU1
    Conserved Domains (4) summary
    TIGR00864
    Location:300406
    PCC; polycystin cation channel protein
    smart00060
    Location:441505
    FN3; Fibronectin type 3 domain
    sd00033
    Location:108128
    LRR_RI; leucine-rich repeat [structural motif]
    cl26018
    Location:58329
    NEL; C-terminal novel E3 ligase, LRR-interacting
  2. XM_024448413.1XP_024304181.1  leucine-rich repeat transmembrane protein FLRT1 isoform X1

    Conserved Domains (4) summary
    TIGR00864
    Location:300406
    PCC; polycystin cation channel protein
    smart00060
    Location:441505
    FN3; Fibronectin type 3 domain
    sd00033
    Location:108128
    LRR_RI; leucine-rich repeat [structural motif]
    cl26018
    Location:58329
    NEL; C-terminal novel E3 ligase, LRR-interacting
  3. XM_011544883.2XP_011543185.1  leucine-rich repeat transmembrane protein FLRT1 isoform X1

    See identical proteins and their annotated locations for XP_011543185.1

    UniProtKB/Swiss-Prot
    Q9NZU1
    Conserved Domains (4) summary
    TIGR00864
    Location:300406
    PCC; polycystin cation channel protein
    smart00060
    Location:441505
    FN3; Fibronectin type 3 domain
    sd00033
    Location:108128
    LRR_RI; leucine-rich repeat [structural motif]
    cl26018
    Location:58329
    NEL; C-terminal novel E3 ligase, LRR-interacting
Support Center